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Yolanda Riba Llena

Institucions de les que formen part

Investigador postdoctoral
Malalties neurovasculars
Vall Hebron Institut de Recerca
Yolanda Riba Llena

Línies de recerca

L6 Stroke Prevention

Since cerebrovascular diseases and dementia are responsible for a huge economic burden, the early detection of patients at high risk for them, and the implementation of preventive measures as soon as possible, might be of great interest and profit.


The purposes of our research are:


- To promote awareness and knowledge of stroke in the general population and enhance collaboration between primary care services and hospital departments.


- To accurately predict those patients at high-risk for first stroke by the determination of novel risk factors or markers (neuroimaging or biological markers), and therefore to improve stroke risk stratification.


- To incorporate a standardized assessment of cognition in stroke research.


- To determine why interventions may be or not widely applied by means of cost-efficiency studies.


- To study quantitative predictors of preventive treatment compliance.



Future project: “Silent cerebral infarction detection and biomarkers associated with the risk of stroke in hypertensive spanish population”.


Silent cerebral infarctions (SCI) detected with neuroimaging techniques, particularly with brain MRI, are common in aged healthy population and even more frequent in selected patients at risk, such as hypertensive patients.  SCI constitute a preclinical stage of cerebrovascular disease and might precede both stroke and cognitive decline; therefore we think that their identification in hypertensive patients would be an adequate and cost-efficient tool, to avoid further strokes and dementia.


Our current project will include a estimated sample size of 1000 hypertensive patients, without known history of cerebrovascular disease or dementia. Silent Cerebral Infarctions (SCI) will be detected by MRI and the determination of several clinical and biological factors (plasma and genetic biomarkers) will be performed on baseline. The patients will be followed-up for at least 3 years, to assess the presence of incident strokes and/or cognitive impairment.

This study will allow us to determine the prevalence of silent cerebral infarctions in our setting, which is largely unknown.


Also, the identification of SCI will help us to better define the risk stratification in hypertensive patients. Patients at higher risk will be our target population for the development of new preventive strategies based on the results of randomized clinical trials.


Finally, this project will be carried out thanks to the collaboration between Neurovascular Research Laboratory, Primary Care Physicians Services and Nephrology Department of Vall d’Hebron, among others, and therefore, the improvement of the link between Primary Care Systems and the remaining hospitalary services, will favor in the future the preventive treatment and care of the patients.

IP: Maria Pilar Delgado Martínez, Yolanda Riba Llena

Projectes

Estudio del papel de parámetros hemodinámicos, de rigidez arterial y biomarcadores plasmásticos en pacientes con deterioro cognitivo tras ictus lacunar

IP: Yolanda Riba Llena
Col·laboradors: -
Entitat finançadora:
Finançament:
Referència: PR(AG)405/2017
Durada: -

Estudio del papel de parámetros hemodinámicos, de rigidez arterial y biomarcadores plasmásticos en pacientes con deterioro cognitivo tras ictus lacunar.

IP: Francesc Pujadas Navinés
Col·laboradors: Yolanda Riba Llena, María Eugenia Espinel Garuz, Maria Belén Gutiérrez Iglesias
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 81070
Referència: PI17/02222
Durada: 01/01/2018 - 30/06/2022

MAGNETIC RESONANCE IMAGE-PET AMYLOID PATTERNS IN SMALL VESSEL DISEASE. MAPS (Magnetic resonance imaging Amyloid Patterns Small vessel disease) STUDY

IP: Yolanda Riba Llena
Col·laboradors: -
Entitat finançadora:
Finançament:
Referència: PR(IR)225/2017
Durada: -

Incorporació a l'àrea de Neurociències

IP: Joan Montaner Villalonga
Col·laboradors: Yolanda Riba Llena, Laia Perez Lasarte
Entitat finançadora: Instituto de Salud Carlos III
Finançament: 135000
Referència: JR15/00032
Durada: 01/01/2016 - 31/12/2018

Notícies relacionades

El treball internacional ha identificat 89 gens implicats en el risc de desenvolupar un ictus, 61 dels quals no s’havien descrit prèviament.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

L’estudi internacional incorpora nous marcadors de ressonància magnètica que permeten incrementar la sensibilitat en el diagnòstic d’aquesta malaltia.

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