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Yolanda Riba Llena

Institutions of which they are part

Postdoctoral researcher
Neurovascular Diseases
Vall Hebron Institut de Recerca

Research lines

L6 Stroke Prevention

Since cerebrovascular diseases and dementia are responsible for a huge economic burden, the early detection of patients at high risk for them, and the implementation of preventive measures as soon as possible, might be of great interest and profit. The purposes of our research are: - To promote awareness and knowledge of stroke in the general population and enhance collaboration between primary care services and hospital departments. - To accurately predict those patients at high-risk for first stroke by the determination of novel risk factors or markers (neuroimaging or biological markers), and therefore to improve stroke risk stratification. - To incorporate a standardized assessment of cognition in stroke research. - To determine why interventions may be or not widely applied by means of cost-efficiency studies. - To study quantitative predictors of preventive treatment compliance. Future project: “Silent cerebral infarction detection and biomarkers associated with the risk of stroke in hypertensive spanish population”. Silent cerebral infarctions (SCI) detected with neuroimaging techniques, particularly with brain MRI, are common in aged healthy population and even more frequent in selected patients at risk, such as hypertensive patients. SCI constitute a preclinical stage of cerebrovascular disease and might precede both stroke and cognitive decline; therefore we think that their identification in hypertensive patients would be an adequate and cost-efficient tool, to avoid further strokes and dementia. Our current project will include a estimated sample size of 1000 hypertensive patients, without known history of cerebrovascular disease or dementia. Silent Cerebral Infarctions (SCI) will be detected by MRI and the determination of several clinical and biological factors (plasma and genetic biomarkers) will be performed on baseline. The patients will be followed-up for at least 3 years, to assess the presence of incident strokes and/or cognitive impairment. This study will allow us to determine the prevalence of silent cerebral infarctions in our setting, which is largely unknown. Also, the identification of SCI will help us to better define the risk stratification in hypertensive patients. Patients at higher risk will be our target population for the development of new preventive strategies based on the results of randomized clinical trials. Finally, this project will be carried out thanks to the collaboration between Neurovascular Research Laboratory, Primary Care Physicians Services and Nephrology Department of Vall d’Hebron, among others, and therefore, the improvement of the link between Primary Care Systems and the remaining hospitalary services, will favor in the future the preventive treatment and care of the patients.

IP: Maria Pilar Delgado Martínez, Yolanda Riba Llena

Projects

Estudio del papel de parámetros hemodinámicos, de rigidez arterial y biomarcadores plasmásticos en pacientes con deterioro cognitivo tras ictus lacunar

IP: Yolanda Riba Llena
Collaborators: -
Funding agency:
Funding:
Reference: PR(AG)405/2017
Duration: -

Estudio del papel de parámetros hemodinámicos, de rigidez arterial y biomarcadores plasmásticos en pacientes con deterioro cognitivo tras ictus lacunar.

IP: Francesc Pujadas Navinés
Collaborators: Yolanda Riba Llena, María Eugenia Espinel Garuz, Maria Belén Gutiérrez Iglesias
Funding agency: Instituto de Salud Carlos III
Funding: 81070
Reference: PI17/02222
Duration: 01/01/2018 - 30/06/2022

MAGNETIC RESONANCE IMAGE-PET AMYLOID PATTERNS IN SMALL VESSEL DISEASE. MAPS (Magnetic resonance imaging Amyloid Patterns Small vessel disease) STUDY

IP: Yolanda Riba Llena
Collaborators: -
Funding agency:
Funding:
Reference: PR(IR)225/2017
Duration: -

Incorporació a l'àrea de Neurociències

IP: Joan Montaner Villalonga
Collaborators: Yolanda Riba Llena, Laia Perez Lasarte
Funding agency: Instituto de Salud Carlos III
Funding: 135000
Reference: JR15/00032
Duration: 01/01/2016 - 31/12/2018

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