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Cell Signaling and Apoptosis

Our work is focused in the characterization of novel physiological roles of FAIM-L, a neuronal protein acting as a death receptor antagonist. Other than preventing cell death, FAIM-L interacts with XIAP and Siva-1, modulating caspases activity, thus participating in some neuronal plasticity processes, such as pruning and long-term depression. In addition, FAIM-L controls neurodegeneration by modulating TNF effects, and we have demonstrated regulation of its expression by some microRNAs altered in Alzheimer’s disease.

We think that FAIM-L could be an interesting target for the future treatment of Alzheimer’s disease. With this goal, we are at present characterizing the interaction of FAIM-L with other relevant proteins for neurodegeneration, and developing tools to characterize FAIM-L expression, and also to modulate its levels in animal models of the disease. In addition, in collaboration with other VHIR groups, we are investigating its role in diabetic retinopathy.

Team

Joan Xavier Comella Carnicé

Joan Xavier Comella Carnicé

Head of group
Cell Signaling and Apoptosis
Director
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Anna Martinez Sires

Anna Martinez Sires

Predoctoral researcher
Cell Signaling and Apoptosis
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Mireia Turch Anguera

Mireia Turch Anguera

Predoctoral researcher
Cell Signaling and Apoptosis
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Montserrat Solé Piñol

Montserrat Solé Piñol

Postdoctoral researcher
Cell Signaling and Apoptosis
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Raquel Badillos Rodriguez

Raquel Badillos Rodriguez

Predoctoral researcher
Cell Signaling and Apoptosis
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Joan Xavier Comella Carnicé

Joan Xavier Comella Carnicé

Head of group
Cell Signaling and Apoptosis
Director
Read more
Anna Martinez Sires

Anna Martinez Sires

Predoctoral researcher
Cell Signaling and Apoptosis
Read more
Mireia Turch Anguera

Mireia Turch Anguera

Predoctoral researcher
Cell Signaling and Apoptosis
Read more
Montserrat Solé Piñol

Montserrat Solé Piñol

Postdoctoral researcher
Cell Signaling and Apoptosis
Read more
Raquel Badillos Rodriguez

Raquel Badillos Rodriguez

Predoctoral researcher
Cell Signaling and Apoptosis
Read more

Research lines

Characterization of the role of LFG (lifeguard) as an antiapoptotic protein, antagonist of Fas receptor and highly expressed in nervous system.

We want to know its antiapoptotic mechanism of action, and to characterize the proteins functionally interacting with it, in particular SoxN.

IP: -

Functions of death receptor antagonists in the development of neuroblastoma

We will generate in vivo and in vitro models that will allow us to study the apoptotic/antiapoptotic machinery expression status, and the role of certain death receptor antagonists in the resistance to apoptosis in these tumors. We are also interested in demonstrating the existence of cancer stem cells in this kind of tumor.

IP: -

Generation and characterization of transgenic animals overexpressing death receptor antagonists (FAIM, Lifeguard) in the nervous system

IP: -

Relevance and function of the two isoforms of FAIM, the short form (S) and the long form (L), in the nervous system.

Faim-S promotes neural differentiation, while Faim-L is an antagonist of different death receptors. We want to know why there is a dual function, through identification and characterization of proteins selectively associated with each isoform.

IP: -

Projects

Papel del antagonista de receptores de muerte, FAIM-L en la progresión de la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Raquel Badillos Rodriguez, Joaquin Lopez Soriano, Maria Jose Pérez García, Anna Martinez Sires
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 166980
Reference: PID2019-107286RB-I00
Duration: 01/06/2020 - 31/05/2023

Ministerio de Ciencia

Papel del antagonista de receptores de muerte, FAIM-L en la progresión de la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Raquel Badillos Rodriguez, Joaquin Lopez Soriano, Maria Jose Pérez García, Anna Martinez Sires
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 166980
Reference: PID2019-107286RB-I00
Duration: 01/06/2020 - 31/05/2023

Ministerio de Ciencia

Caracterizacion de Siva--1 en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: VHIR/PREDOC/2017/COCCIA
Duration: 01/04/2018 - 08/07/2020

Relevancia del antagonista de receptores de muerte, FAIM-L, en la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 273460
Reference: SAF2016-80236-R
Duration: 30/12/2016 - 29/03/2020

Papel del antagonista de receptores de muerte, FAIM-L en la progresión de la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Raquel Badillos Rodriguez, Joaquin Lopez Soriano, Maria Jose Pérez García, Anna Martinez Sires
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 166980
Reference: PID2019-107286RB-I00
Duration: 01/06/2020 - 31/05/2023

Ministerio de Ciencia

Caracterizacion de Siva--1 en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: VHIR/PREDOC/2017/COCCIA
Duration: 01/04/2018 - 08/07/2020

Relevancia del antagonista de receptores de muerte, FAIM-L, en la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 273460
Reference: SAF2016-80236-R
Duration: 30/12/2016 - 29/03/2020

Determinants pronòstics de mortalitat i reingrés en pacients amb insuficiència cardíaca avançada (ICA) atesos en atenció primària: estudi HADES

IP: -
Collaborators: -
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 26191.2
Reference: SLT002/16/00073
Duration: 01/01/2017 - 31/12/2019

Caracterizacion de Siva--1 en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: VHIR/PREDOC/2017/COCCIA
Duration: 01/04/2018 - 08/07/2020

Deciphering the link between astrocyte reactivity and neuronal damage in Alzheimer's disease

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Fundació La Marató de TV3
Funding: 96000
Reference: 20141433
Duration: 22/05/2015 - 21/05/2018

Relevancia del antagonista de receptores de muerte, FAIM-L, en la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 273460
Reference: SAF2016-80236-R
Duration: 30/12/2016 - 29/03/2020

Determinants pronòstics de mortalitat i reingrés en pacients amb insuficiència cardíaca avançada (ICA) atesos en atenció primària: estudi HADES

IP: -
Collaborators: -
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 26191.2
Reference: SLT002/16/00073
Duration: 01/01/2017 - 31/12/2019

Deciphering the link between astrocyte reactivity and neuronal damage in Alzheimer's disease

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Fundació La Marató de TV3
Funding: 96000
Reference: 20141433
Duration: 22/05/2015 - 21/05/2018

Relevancia del antagonista de receptores de muerte, FAIM-L, en la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 273460
Reference: SAF2016-80236-R
Duration: 30/12/2016 - 29/03/2020

Determinants pronòstics de mortalitat i reingrés en pacients amb insuficiència cardíaca avançada (ICA) atesos en atenció primària: estudi HADES

IP: -
Collaborators: -
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 26191.2
Reference: SLT002/16/00073
Duration: 01/01/2017 - 31/12/2019

Neuroinflamación, TNF y antagonistas de los receptores de muerte (FAIM-L): Relevancia en neurodegeneración

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 290400
Reference: SAF2013-47989-R
Duration: 01/01/2014 - 31/12/2016

Deciphering the link between astrocyte reactivity and neuronal damage in Alzheimer's disease

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Fundació La Marató de TV3
Funding: 96000
Reference: 20141433
Duration: 22/05/2015 - 21/05/2018

Relevancia del antagonista de receptores de muerte, FAIM-L, en la enfermedad de Alzheimer

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 273460
Reference: SAF2016-80236-R
Duration: 30/12/2016 - 29/03/2020

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 70408
Reference: BES-2011-046114
Duration: 01/09/2011 - 31/08/2015

Ministerio de Ciencia

Neuroinflamación, TNF y antagonistas de los receptores de muerte (FAIM-L): Relevancia en neurodegeneración

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio Economía, Industria y Competitividad
Funding: 290400
Reference: SAF2013-47989-R
Duration: 01/01/2014 - 31/12/2016

Deciphering the link between astrocyte reactivity and neuronal damage in Alzheimer's disease

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Fundació La Marató de TV3
Funding: 96000
Reference: 20141433
Duration: 22/05/2015 - 21/05/2018

Caracterització de l'antagonista de receptors de mort Lifeguard en el sistema nerviós

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 30000
Reference: 2011FI_B 00581
Duration: 01/02/2011 - 31/01/2014

Relevance of Death Receptor antagonists, FAIM and LFG, in Alzheimer's disease

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 73246.08
Reference: 2010 BP_B 00137
Duration: 15/01/2012 - 06/05/2014

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 70408
Reference: BES-2011-046114
Duration: 01/09/2011 - 31/08/2015

Ministerio de Ciencia

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 484000
Reference: SAF2010-19953
Duration: 01/01/2011 - 30/06/2014

Ministerio de Ciencia

Caracterització de l'antagonista de receptors de mort Lifeguard en el sistema nerviós

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 30000
Reference: 2011FI_B 00581
Duration: 01/02/2011 - 31/01/2014

Relevance of Death Receptor antagonists, FAIM and LFG, in Alzheimer's disease

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 73246.08
Reference: 2010 BP_B 00137
Duration: 15/01/2012 - 06/05/2014

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 70408
Reference: BES-2011-046114
Duration: 01/09/2011 - 31/08/2015

Ministerio de Ciencia

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 484000
Reference: SAF2010-19953
Duration: 01/01/2011 - 30/06/2014

Ministerio de Ciencia

Congrés Biennal de la Federació Europea de Societats de Neurociències (FENS)

IP: -
Collaborators: -
Funding agency: AGAUR
Funding: 3000
Reference: 2011 ARCS 00187
Duration: 18/07/2011 - 18/07/2012

Caracterització de l'antagonista de receptors de mort Lifeguard en el sistema nerviós

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 30000
Reference: 2011FI_B 00581
Duration: 01/02/2011 - 31/01/2014

Relevance of Death Receptor antagonists, FAIM and LFG, in Alzheimer's disease

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 73246.08
Reference: 2010 BP_B 00137
Duration: 15/01/2012 - 06/05/2014

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 70408
Reference: BES-2011-046114
Duration: 01/09/2011 - 31/08/2015

Ministerio de Ciencia

Congrés Biennal de la Federació Europea de Societats de Neurociències (FENS)

IP: -
Collaborators: -
Funding agency: AGAUR
Funding: 3000
Reference: 2011 ARCS 00187
Duration: 18/07/2011 - 18/07/2012

Caracterització de l'antagonista de receptors de mort Lifeguard en el sistema nerviós

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: AGAUR
Funding: 30000
Reference: 2011FI_B 00581
Duration: 01/02/2011 - 31/01/2014

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: -
Collaborators: Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 70408
Reference: BES-2011-046114
Duration: 01/09/2011 - 31/08/2015

Ministerio de Ciencia

Relevancia fisiológica y patológica de los antagonistas de los receptores de muerte (FAIM, Lifeguard y FLIP) en el sistema nervioso

IP: Joan Xavier Comella Carnicé
Collaborators: Joaquin Lopez Soriano
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 484000
Reference: SAF2010-19953
Duration: 01/01/2011 - 30/06/2014

Ministerio de Ciencia

Publications

FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function.

PMID: 35083225
Journal: Frontiers in Cell and Developmental Biology
Year: 2021
Reference: Front Cell Dev Biol. 2022 Jan 10;9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021.
Impact factor: 6.684
Publication type: Review in international publication
Authors: Coccia, Elena, Sole, Montse, Comella, Joan X et al.
DOI: 10.3389/fcell.2021.826037

Intracellular pathways involved in cell survival are deregulated in mouse and human spinal muscular atrophy motoneurons.

PMID: 33845129
Journal: NEUROBIOLOGY OF DISEASE
Year: 2021
Reference: Neurobiol Dis. 2021 Jul;155:105366. doi: 10.1016/j.nbd.2021.105366. Epub 2021 Apr 13.
Impact factor: 5.996
Publication type: Paper in international publication
Authors: Sansa, Alba, de la Fuente, Sandra, Comella, Joan X, Garcera, Ana, Soler, Rosa M et al.
DOI: 10.1016/j.nbd.2021.105366

FAIM Is Regulated by MiR-206, MiR-1-3p and MiR-133b.

PMID: 33425889
Journal: Frontiers in Cell and Developmental Biology
Year: 2020
Reference: Front Cell Dev Biol. 2020 Dec 23;8:584606. doi: 10.3389/fcell.2020.584606. eCollection 2020.
Impact factor: 5.201
Publication type: Paper in international publication
Authors: Coccia, Elena, Masanas, Marc, Lopez-Soriano, Joaquin, Segura, Miguel F, Comella, Joan X, Perez-Garcia, M Jose et al.
DOI: 10.3389/fcell.2020.584606

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.

PMID: 32015347
Journal: Cell Death & Disease
Year: 2020
Reference: Cell Death Dis. 2020 Feb 3;11(2):82. doi: 10.1038/s41419-020-2282-x.
Impact factor: 6.304
Publication type: Paper in international publication
Authors: Pascual, Marta, Segura, Miguel F, Fernandez-Hernandez, Rita, Lopez-Soriano, Joaquin, Gari, Eloi, Soriano, Eduardo, Barneda-Zahonero, Bruna, Moubarak, Rana S, Perez-Garcia, M Jose, Comella, Joan X et al.
DOI: 10.1038/s41419-020-2282-x

Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease.

PMID: 31723151
Journal: Scientific Reports
Year: 2019
Reference: Sci Rep. 2019 Nov 13;9(1):16665. doi: 10.1038/s41598-019-52724-2.
Impact factor: 4.011
Publication type: Paper in international publication
Authors: Saez, M E, Hernandez-Olasagarre, B, Bea, A, Moreno-Grau, S, de Rojas, I, Monte-Rubio, G, Orellana, A, Valero, S, Comella, J X, Sanchis, D et al.
DOI: 10.1038/s41598-019-52724-2

Combining magnetic nanoparticles and icosahedral boron clusters in biocompatible inorganic nanohybrids for cancer therapy.

PMID: 31059794
Journal: Nanomedicine-Nanotechnology Biology and Medicine
Year: 2019
Reference: Nanomedicine. 2019 Aug;20:101986. doi: 10.1016/j.nano.2019.03.008. Epub 2019 May 3.
Impact factor: 5.57
Publication type: Paper in international publication
Authors: Crich, Simonetta Geninatti, Alberti, Diego, Protti, Nicoletta, Comella, Joan X, Teixidor, Francesc, Rosell, Anna, Vinas, Clara, Grayston, Alba, Galenkamp, Koen M O, Morancho, Anna et al.
DOI: 10.1016/j.nano.2019.03.008

Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth.

PMID: 30542508
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2018 Nov 13;9(89):35922-35940. doi: 10.18632/oncotarget.26307. eCollection 2018 Nov 13.
Impact factor: 0
Publication type: Paper in international publication
Authors: Fuschini, Giulia, Cotrufo, Tiziana, Ros, Oriol, Muhaisen, Ashraf, Andres, Rosa, Comella, Joan X, Soriano, Eduardo et al.
DOI: 10.18632/oncotarget.26307

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease.

PMID: 29178139
Journal: GLIA
Year: 2018
Reference: Glia. 2018 Mar;66(3):637-653. doi: 10.1002/glia.23270. Epub 2017 Nov 27.
Impact factor: 5.846
Publication type: Paper in international publication
Authors: Gomez-Arboledas, Angela, Davila, Jose C, Sanchez-Mejias, Elisabeth, Navarro, Victoria, Sanchez-Varo, Raquel, Sanchez-Mico, Maria Virtudes, Trujillo-Estrada, Laura, Fernandez-Valenzuela, Juan Jose, Vizuete, Marisa, Comella, Joan X et al.
DOI: 10.1002/glia.23270

Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM).

PMID: 28981531
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Oct 5;12(10):e0185327. doi: 10.1371/journal.pone.0185327. eCollection 2017.
Impact factor: 2.806
Publication type: Paper in international publication
Authors: Coccia, Elena, Calleja-Yague, Isabel, Planells-Ferrer, Laura, Sanuy, Blanca, Sanz, Belen, Lopez-Soriano, Joaquin, Moubarak, Rana S, Munell, Francina, Barneda-Zahonero, Bruna, Comella, Joan X et al.
DOI: 10.1371/journal.pone.0185327

FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.

PMID: 27767058
Journal: Scientific Reports
Year: 2016
Reference: Sci Rep. 2016 Oct 21;6:35775. doi: 10.1038/srep35775.
Impact factor: 5.228
Publication type: Paper in international publication
Authors: Barneda-Zahonero, Bruna, Soto, David, Andres, Rosa Maria, Coccia, Elena, Gasull, Xavier, Planells-Ferrer, Laura, Moubarak, Rana S, Soriano, Eduardo, Comella, Joan X, Martinez-Marmol, Ramon et al.
DOI: 10.1038/srep35775

Corrigendum: FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons.

PMID: 27766074
Journal: Frontiers in Neuroanatomy
Year: 2016
Reference: Front Neuroanat. 2016 Oct 18;10:100. eCollection 2016.
Impact factor: 3.26
Publication type: Paper in international publication
Authors: Bosch, Carles, Martinez, Albert, Masachs, Nuria, Teixeira, Catia M, Fernaud, Isabel, Ulloa, Fausto, Perez-Martinez, Esther, Lois, Carlos, Comella, Joan X, DeFelipe, Javier et al.
DOI: 10.3389/fnana.2016.00100

Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.

PMID: 27624722
Journal: CEREBRAL CORTEX
Year: 2016
Reference: Cereb Cortex. 2016 Oct 17;26(11):4282-4298. doi: 10.1093/cercor/bhw216.
Impact factor: 8.285
Publication type: Paper in international publication
Authors: Merchan-Perez, Angel, Soriano, Eduardo, DeFelipe, Javier, Comella, Joan X, Pujadas, Lluis, Bosch, Carles, Masachs, Nuria, Exposito-Alonso, David, Martinez, Albert, Teixeira, Catia M et al.
DOI: 10.1093/cercor/bhw216

FAIMs: more than death-receptor antagonists in the nervous system.

PMID: 27385439
Journal: JOURNAL OF NEUROCHEMISTRY
Year: 2016
Reference: J Neurochem. 2016 Oct;139(1):11-21. doi: 10.1111/jnc.13729. Epub 2016 Aug 3.
Impact factor: 3.842
Publication type: Paper in international publication
Authors: Planells-Ferrer, Laura, Urresti, Jorge, Coccia, Elena, Galenkamp, Koen M O, Calleja-Yague, Isabel, Lopez-Soriano, Joaquin, Carriba, Paulina, Barneda-Zahonero, Bruna, Segura, Miguel F, Comella, Joan X et al.
DOI: 10.1111/jnc.13729

Neurodegeneration and neuroinflammation: two processes, one target.

PMID: 26692848
Journal: Neural Regeneration Research
Year: 2015
Reference: Neural Regen Res. 2015 Oct;10(10):1581-3. doi: 10.4103/1673-5374.165269.
Impact factor: 0.22
Publication type: Paper in international publication
Authors: Carriba, Paulina, Comella, Joan X et al.
DOI: 10.4103/1673-5374.165269

Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer's Disease.

PMID: 25613099
Journal: JOURNAL OF ALZHEIMERS DISEASE
Year: 2015
Reference: J Alzheimers Dis. 2015;45(2):621-9. doi: 10.3233/JAD-142721.
Impact factor: 4.151
Publication type: Paper in international publication
Authors: Moreno-Grau, Sonia, Barneda, Bruna, Carriba, Paulina, Marin, Juan, Sotolongo-Grau, Oscar, Hernandez, Isabel, Vargas, Liliana, Espinosa, Ana, Alegret, Montserrat, Rodriguez, Octavio et al.
DOI: 10.3233/JAD-142721

Amyloid-beta reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFalpha from neuronal protection to death.

PMID: 25675299
Journal: Cell Death & Disease
Year: 2015
Reference: Cell Death Dis. 2015 Feb 12;6:e1639. doi: 10.1038/cddis.2015.6.
Impact factor: 5.014
Publication type: Paper in international publication
Authors: Lopez-Soriano, J, Gutierrez, A, Vitorica, J, Comella, J X, Moubarak, R S, Barneda-Zahonero, B, Navarro, V, Carriba, P, Jimenez, S, Moreno-Gonzalez, I et al.
DOI: 10.1038/cddis.2015.6

TNFalpha sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-kappaB-mediated expression of Fas.

PMID: 25890358
Journal: Molecular Cancer
Year: 2015
Reference: Mol Cancer. 2015 Mar 19;14:62. doi: 10.1186/s12943-015-0329-x.
Impact factor: 4.257
Publication type: Paper in international publication
Authors: Galenkamp, Koen Mo, Carriba, Paulina, Urresti, Jorge, Planells-Ferrer, Laura, Coccia, Elena, Lopez-Soriano, Joaquin, Barneda-Zahonero, Bruna, Moubarak, Rana S, Segura, Miguel F, Comella, Joan X et al.
DOI: 10.1186/s12943-015-0329-x

Amyloid Beta, TNFalpha and FAIM-L; Approaching New Therapeutic Strategies for AD.

PMID: 25566181
Journal: FRONT PHYS-BEIJING
Year: 2014
Reference: Front Neurol. 2014 Dec 18;5:276. doi: 10.3389/fneur.2014.00276. eCollection 2014.
Impact factor:
Publication type: Letter or abstract
Authors: Carriba, Paulina, Comella, Joan X et al.
DOI: 10.3389/fneur.2014.00276

Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe.

PMID: 25275596
Journal: CELL DEATH DIS
Year: 2014
Reference: Cell Death Dis. 2014 Oct 2;5:e1435. doi: 10.1038/cddis.2014.412.
Impact factor: 5.177
Publication type: Paper in international publication
Authors: Sanchis, D, Llovera, M, Comella, J X, Herreros, J, Vall-Llaura, N, Cornago, M, Garcia-Alberich, C, Blasco-Angulo, N, Nager, M et al.
DOI: 10.1038/cddis.2014.412

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.

PMID: 25188511
Journal: CELL DEATH DIS
Year: 2014
Reference: Cell Death Dis. 2014 Sep 4;5:e1401. doi: 10.1038/cddis.2014.356.
Impact factor: 5.177
Publication type: Paper in international publication
Authors: Planells-Ferrer, L, Urresti, J, Soriano, A, Reix, S, Murphy, D M, Ferreres, J C, Borras, F, Gallego, S, Stallings, R L, Moubarak, R S et al.
DOI: 10.1038/cddis.2014.356

Activation-induced cell death in T lymphocytes from multiple sclerosis patients.

PMID: 24793898
Journal: J NEUROIMMUNOL
Year: 2014
Reference: J Neuroimmunol. 2014 Jul 15;272(1-2):51-5. doi: 10.1016/j.jneuroim.2014.04.007. Epub 2014 Apr 16.
Impact factor: 2.786
Publication type: Paper in international publication
Authors: Moreno, Montserrat, Negrotto, Laura, Rio, Jordi, Moubarak, Rana, Martin, Isabel, Bustamante, Marta F, Comella, Joan X, Vidal-Jordana, Angela, Perez-Boza, Jennifer, Montalban, Xavier et al.
DOI: 10.1016/j.jneuroim.2014.04.007

A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching.

PMID: 23598414
Journal: Cell Death & Disease
Year: 2013
Reference: Cell Death Dis. 2013 Apr 18;4:e602. doi: 10.1038/cddis.2013.99.
Impact factor: 6.044
Publication type: Paper in international publication
Authors: Urena, J M, Soriano, E, del Rio, J A, La Torre, A, del Mar Masdeu, M, Cotrufo, T, Moubarak, R S, Comella, J X et al.
DOI: 10.1038/cddis.2013.99

Neurobehavioral characterization of Endonuclease G knockout mice reveals a new putative molecular player in the regulation of anxiety.

PMID: 23603365
Journal: EXPERIMENTAL NEUROLOGY
Year: 2013
Reference: Exp Neurol. 2013 Sep;247:122-9. doi: 10.1016/j.expneurol.2013.03.028. Epub 2013 Apr 18.
Impact factor: 4.645
Publication type: Paper in international publication
Authors: Giralt, Albert, Sanchis, Daniel, Cherubini, Marta, Gines, Silvia, Canas, Xavier, Comella, Joan X, Alberch, Jordi et al.
DOI: 10.1016/j.expneurol.2013.03.028

FAIM-L Is an IAP-Binding Protein That Inhibits XIAP Ubiquitinylation and Protects from Fas-Induced Apoptosis.

PMID: 24305822
Journal: JOURNAL OF NEUROSCIENCE
Year: 2013
Reference: J Neurosci. 2013 Dec 4;33(49):19262-75. doi: 10.1523/JNEUROSCI.2479-13.2013.
Impact factor: 6.908
Publication type: Paper in international publication
Authors: Moubarak, Rana S, Planells-Ferrer, Laura, Urresti, Jorge, Reix, Stephanie, Segura, Miguel F, Carriba, Paulina, Marques-Fernandez, Fernando, Sole, Carme, Llecha-Cano, Nuria, Lopez-Soriano, Joaquin et al.
DOI: 10.1523/JNEUROSCI.2479-13.2013

X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk.

PMID: 23928917
Journal: Scientific Reports
Year: 2013
Reference: Sci Rep. 2013;3:2397. doi: 10.1038/srep02397.
Impact factor: 2.927
Publication type: Paper in international publication
Authors: Fado, Rut, Moubarak, Rana S, Minano-Molina, Alfredo J, Barneda-Zahonero, Bruna, Valero, Jorge, Saura, Carlos A, Moran, Julio, Comella, Joan X, Rodriguez-Alvarez, Jose et al.
DOI: 10.1038/srep02397

Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip.

PMID: 22946563
Journal: EUROPEAN JOURNAL OF NEUROSCIENCE
Year: 2012
Reference: Eur J Neurosci. 2012 Nov;36(9):3152-64. doi: 10.1111/j.1460-9568.2012.08259.x. Epub 2012 Sep 4.
Impact factor: 3.631
Publication type: Paper in international publication
Authors: Pascual, Marta, Comella, Joan X, Soriano, Eduardo, Martinez, Ramon, Fuschini, Giulia, Perez-Branguli, Francesc, Cotrufo, Tiziana, Andres, Rosa Maria, Ros, Oriol, Muhaisen, Ashraf et al.
DOI: 10.1111/j.1460-9568.2012.08259.x

Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway.

PMID: 22850285
Journal: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Year: 2012
Reference: J Mol Cell Cardiol. 2012 Oct;53(4):578-87. doi: 10.1016/j.yjmcc.2012.07.013. Epub 2012 Jul 28.
Impact factor: 5.166
Publication type: Paper in international publication
Authors: Ye, Junmei, Cardona, Maria, Llovera, Marta, Comella, Joan X, Sanchis, Daniel et al.
DOI: 10.1016/j.yjmcc.2012.07.013

Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD.

PMID: 22253444
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2012
Reference: J Biol Chem. 2012 Mar 2;287(10):7766-79. doi: 10.1074/jbc.M111.290718. Epub 2012 Jan 17.
Impact factor: 4.773
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1074/jbc.M111.290718

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.

PMID: 21979051
Journal: NATURE
Year: 2011
Reference: Nature. 2011 Oct 5;478(7367):114-8. doi: 10.1038/nature10490.
Impact factor: 36.101
Publication type: Paper in international publication
Authors: Mancini, Massimiliano, Hauton, David, Marti, Ramon, Garcia-Arumi, Elena, Hubner, Norbert, Jacob, Howard, Serikawa, Tadao, Zidek, Vaclav, Papousek, Frantisek, Kolar, Frantisek et al.
DOI: 10.1038/nature10490

EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes.

PMID: 21437288
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011 Mar 17;6(3):e17998.
Impact factor: 4.411
Publication type: Paper in international publication
Authors: Llovera, Marta, Zhang, Jisheng, Ye, Junmei, Altafaj, Albert, Cardona, Maria, Bahi, Nuria, Comella, Joan X, Sanchis, Daniel, Cook, Stuart A, Canas, Xavier et al.
DOI: 10.1371/journal.pone.0017998

A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-X(L) Overexpression in motoneurons.

PMID: 21333739
Journal: NEUROBIOLOGY OF DISEASE
Year: 2011
Reference: Neurobiol Dis. 2011 Jun;42(3):415-26. Epub 2011 Feb 16.
Impact factor: 5.121
Publication type: Paper in international publication
Authors: Garcera, Ana, Mincheva, Stefka, Gou-Fabregas, Myriam, Caraballo-Miralles, Victor, Llado, Jeronia, Comella, Joan X, Soler, Rosa M et al.
DOI: 10.1016/j.nbd.2011.02.003

Ubiquitination of TrkA by Nedd4-2 regulates receptor lysosomal targeting and mediates receptor signaling.

PMID: 21332718
Journal: JOURNAL OF NEUROCHEMISTRY
Year: 2011
Reference: J Neurochem. 2011 May;117(3):479-93. doi: 10.1111/j.1471-4159.2011.07218.x. Epub 2011 Mar 15.
Impact factor: 4.337
Publication type: Paper in international publication
Authors: Georgieva, Maya V, de Pablo, Yolanda, Sanchis, Daniel, Comella, Joan X, Llovera, Marta et al.
DOI: 10.1111/j.1471-4159.2011.07218.x

The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins.

PMID: 20427667
Journal: JOURNAL OF NEUROSCIENCE
Year: 2010
Reference: J Neurosci. 2010 Apr 28;30(17):6094-105.
Impact factor: 7.178
Publication type: Paper in international publication
Authors: Moubarak, Rana S, Sole, Carme, Pascual, Marta, Gutierrez, Humberto, Llovera, Marta, Perez-Garcia, M Jose, Segura, Miguel F, Iglesias-Guimarais, Victoria, Reix, Stephanie, Soler, Rosa M et al.
DOI: 10.1523/JNEUROSCI.0537-10.2010

Thesis

SIVA-1 role in neurons: a novel FAIM-L functional antagonist

PhD student: Elena Coccia
Director/s: Joan X. Comella Carnice, Maria Jose Pérez García
University: Universitat Autònoma de Barcelona
Year: 2020

Neuronal phenotype characterization of faim-ko mice

PhD student: Mª Isabel Calleja Yagüe
Director/s: Joan X. Comella Carnice, Maria Jose Pérez García
University: Universitat Autònoma de Barcelona
Year: 2019

The Genetic Basis of Alzheimer's disease and its related endophenotypes

PhD student: Sonia Moreno Grau
Director/s:
University: Universitat Autònoma de Barcelona
Year: 2019

Priming neuroblastoma for cisplatin and etoposide drug therapy: Role of NF-?B in TNF?-induced expression of Fas

PhD student: Koen Marius Galenkamp
Director/s: Joan Xavier Comella Carnicé
University: Universitat Autònoma de Barcelona
Year: 2015

Estudio de la participación de la endonucleasa DFF40/CAD en el proceso de fragmentación nuclear durante la muerte celular apoptótica en ausencia de degradación oligonucleosomal del ADN.

PhD student: Victoria Iglesias Guimarais
Director/s: Victoria Martín Yuste, Joan X. Comella Carnice
University: Universitat Autònoma de Barcelona
Year: 2011

Job offers

Predoctoral Researcher
Start date:
14/09/2021
End date:
28/09/2021
Document: Download
Predoctoral - Cell Signalling & Apoptosis Research Group.
Start date:
23/01/2020
End date:
30/01/2020
Document: Download
Research technician - Cell Signalling & Apoptosis Research Group.
Start date:
22/01/2020
End date:
29/01/2020
Document: Download