About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Our work is focused in the characterization of novel physiological roles of FAIM-L, a neuronal protein acting as a death receptor antagonist. Other than preventing cell death, FAIM-L interacts with XIAP and Siva-1, modulating caspases activity, thus participating in some neuronal plasticity processes, such as pruning and long-term depression. In addition, FAIM-L controls neurodegeneration by modulating TNF effects, and we have demonstrated regulation of its expression by some microRNAs altered in Alzheimer’s disease.
We think that FAIM-L could be an interesting target for the future treatment of Alzheimer’s disease. With this goal, we are at present characterizing the interaction of FAIM-L with other relevant proteins for neurodegeneration, and developing tools to characterize FAIM-L expression, and also to modulate its levels in animal models of the disease. In addition, in collaboration with other VHIR groups, we are investigating its role in diabetic retinopathy.
IP: -
IP: Joan Xavier Comella Carnicé Collaborators: Raquel Badillos Rodriguez, Joaquin Lopez Soriano, Maria Jose Pérez García, Anna Martinez Sires Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 166980 Reference: PID2019-107286RB-I00 Duration: 01/06/2020 - 31/05/2023
IP: - Collaborators: Miriam Izquierdo Sans Funding agency: Fundació Institut de Recerca HUVH Funding: 46800 Reference: VHIR/PREDOC/2017/COCCIA Duration: 01/04/2018 - 08/07/2020
IP: Joan Xavier Comella Carnicé Collaborators: Joaquin Lopez Soriano Funding agency: Ministerio Economía, Industria y Competitividad Funding: 273460 Reference: SAF2016-80236-R Duration: 30/12/2016 - 29/03/2020
IP: - Collaborators: - Funding agency: Generalitat de Catalunya - Departament de Salut Funding: 26191.2 Reference: SLT002/16/00073 Duration: 01/01/2017 - 31/12/2019
IP: Joan Xavier Comella Carnicé Collaborators: Joaquin Lopez Soriano Funding agency: Fundació La Marató de TV3 Funding: 96000 Reference: 20141433 Duration: 22/05/2015 - 21/05/2018
IP: Joan Xavier Comella Carnicé Collaborators: Joaquin Lopez Soriano Funding agency: Ministerio Economía, Industria y Competitividad Funding: 290400 Reference: SAF2013-47989-R Duration: 01/01/2014 - 31/12/2016
IP: - Collaborators: Miriam Izquierdo Sans Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 70408 Reference: BES-2011-046114 Duration: 01/09/2011 - 31/08/2015
IP: - Collaborators: Miriam Izquierdo Sans Funding agency: AGAUR Funding: 30000 Reference: 2011FI_B 00581 Duration: 01/02/2011 - 31/01/2014
IP: - Collaborators: Miriam Izquierdo Sans Funding agency: AGAUR Funding: 73246.08 Reference: 2010 BP_B 00137 Duration: 15/01/2012 - 06/05/2014
IP: Joan Xavier Comella Carnicé Collaborators: Joaquin Lopez Soriano Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 484000 Reference: SAF2010-19953 Duration: 01/01/2011 - 30/06/2014
IP: - Collaborators: - Funding agency: AGAUR Funding: 3000 Reference: 2011 ARCS 00187 Duration: 18/07/2011 - 18/07/2012
PMID: 35083225 Journal: Frontiers in Cell and Developmental Biology Year: 2021 Reference: Front Cell Dev Biol. 2022 Jan 10;9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021. Impact factor: 6.684 Publication type: Review in international publication Authors: Coccia, Elena, Sole, Montse, Comella, Joan X et al. DOI: 10.3389/fcell.2021.826037
PMID: 33845129 Journal: NEUROBIOLOGY OF DISEASE Year: 2021 Reference: Neurobiol Dis. 2021 Jul;155:105366. doi: 10.1016/j.nbd.2021.105366. Epub 2021 Apr 13. Impact factor: 5.996 Publication type: Paper in international publication Authors: Sansa, Alba, de la Fuente, Sandra, Comella, Joan X, Garcera, Ana, Soler, Rosa M et al. DOI: 10.1016/j.nbd.2021.105366
PMID: 33425889 Journal: Frontiers in Cell and Developmental Biology Year: 2020 Reference: Front Cell Dev Biol. 2020 Dec 23;8:584606. doi: 10.3389/fcell.2020.584606. eCollection 2020. Impact factor: 5.201 Publication type: Paper in international publication Authors: Coccia, Elena, Masanas, Marc, Lopez-Soriano, Joaquin, Segura, Miguel F, Comella, Joan X, Perez-Garcia, M Jose et al. DOI: 10.3389/fcell.2020.584606
PMID: 32015347 Journal: Cell Death & Disease Year: 2020 Reference: Cell Death Dis. 2020 Feb 3;11(2):82. doi: 10.1038/s41419-020-2282-x. Impact factor: 6.304 Publication type: Paper in international publication Authors: Pascual, Marta, Segura, Miguel F, Fernandez-Hernandez, Rita, Lopez-Soriano, Joaquin, Gari, Eloi, Soriano, Eduardo, Barneda-Zahonero, Bruna, Moubarak, Rana S, Perez-Garcia, M Jose, Comella, Joan X et al. DOI: 10.1038/s41419-020-2282-x
PMID: 31723151 Journal: Scientific Reports Year: 2019 Reference: Sci Rep. 2019 Nov 13;9(1):16665. doi: 10.1038/s41598-019-52724-2. Impact factor: 4.011 Publication type: Paper in international publication Authors: Saez, M E, Hernandez-Olasagarre, B, Bea, A, Moreno-Grau, S, de Rojas, I, Monte-Rubio, G, Orellana, A, Valero, S, Comella, J X, Sanchis, D et al. DOI: 10.1038/s41598-019-52724-2
PMID: 31059794 Journal: Nanomedicine-Nanotechnology Biology and Medicine Year: 2019 Reference: Nanomedicine. 2019 Aug;20:101986. doi: 10.1016/j.nano.2019.03.008. Epub 2019 May 3. Impact factor: 5.57 Publication type: Paper in international publication Authors: Crich, Simonetta Geninatti, Alberti, Diego, Protti, Nicoletta, Comella, Joan X, Teixidor, Francesc, Rosell, Anna, Vinas, Clara, Grayston, Alba, Galenkamp, Koen M O, Morancho, Anna et al. DOI: 10.1016/j.nano.2019.03.008
PMID: 30542508 Journal: Oncotarget Year: 2018 Reference: Oncotarget. 2018 Nov 13;9(89):35922-35940. doi: 10.18632/oncotarget.26307. eCollection 2018 Nov 13. Impact factor: 0 Publication type: Paper in international publication Authors: Fuschini, Giulia, Cotrufo, Tiziana, Ros, Oriol, Muhaisen, Ashraf, Andres, Rosa, Comella, Joan X, Soriano, Eduardo et al. DOI: 10.18632/oncotarget.26307
PMID: 29178139 Journal: GLIA Year: 2018 Reference: Glia. 2018 Mar;66(3):637-653. doi: 10.1002/glia.23270. Epub 2017 Nov 27. Impact factor: 5.846 Publication type: Paper in international publication Authors: Gomez-Arboledas, Angela, Davila, Jose C, Sanchez-Mejias, Elisabeth, Navarro, Victoria, Sanchez-Varo, Raquel, Sanchez-Mico, Maria Virtudes, Trujillo-Estrada, Laura, Fernandez-Valenzuela, Juan Jose, Vizuete, Marisa, Comella, Joan X et al. DOI: 10.1002/glia.23270
PMID: 28981531 Journal: PLoS One Year: 2017 Reference: PLoS One. 2017 Oct 5;12(10):e0185327. doi: 10.1371/journal.pone.0185327. eCollection 2017. Impact factor: 2.806 Publication type: Paper in international publication Authors: Coccia, Elena, Calleja-Yague, Isabel, Planells-Ferrer, Laura, Sanuy, Blanca, Sanz, Belen, Lopez-Soriano, Joaquin, Moubarak, Rana S, Munell, Francina, Barneda-Zahonero, Bruna, Comella, Joan X et al. DOI: 10.1371/journal.pone.0185327
PMID: 27766074 Journal: Frontiers in Neuroanatomy Year: 2016 Reference: Front Neuroanat. 2016 Oct 18;10:100. eCollection 2016. Impact factor: 3.26 Publication type: Paper in international publication Authors: Bosch, Carles, Martinez, Albert, Masachs, Nuria, Teixeira, Catia M, Fernaud, Isabel, Ulloa, Fausto, Perez-Martinez, Esther, Lois, Carlos, Comella, Joan X, DeFelipe, Javier et al. DOI: 10.3389/fnana.2016.00100
PMID: 27767058 Journal: Scientific Reports Year: 2016 Reference: Sci Rep. 2016 Oct 21;6:35775. doi: 10.1038/srep35775. Impact factor: 5.228 Publication type: Paper in international publication Authors: Barneda-Zahonero, Bruna, Soto, David, Andres, Rosa Maria, Coccia, Elena, Gasull, Xavier, Planells-Ferrer, Laura, Moubarak, Rana S, Soriano, Eduardo, Comella, Joan X, Martinez-Marmol, Ramon et al. DOI: 10.1038/srep35775
PMID: 27624722 Journal: CEREBRAL CORTEX Year: 2016 Reference: Cereb Cortex. 2016 Oct 17;26(11):4282-4298. doi: 10.1093/cercor/bhw216. Impact factor: 8.285 Publication type: Paper in international publication Authors: Merchan-Perez, Angel, Soriano, Eduardo, DeFelipe, Javier, Comella, Joan X, Pujadas, Lluis, Bosch, Carles, Masachs, Nuria, Exposito-Alonso, David, Martinez, Albert, Teixeira, Catia M et al. DOI: 10.1093/cercor/bhw216
PMID: 27385439 Journal: JOURNAL OF NEUROCHEMISTRY Year: 2016 Reference: J Neurochem. 2016 Oct;139(1):11-21. doi: 10.1111/jnc.13729. Epub 2016 Aug 3. Impact factor: 3.842 Publication type: Paper in international publication Authors: Planells-Ferrer, Laura, Urresti, Jorge, Coccia, Elena, Galenkamp, Koen M O, Calleja-Yague, Isabel, Lopez-Soriano, Joaquin, Carriba, Paulina, Barneda-Zahonero, Bruna, Segura, Miguel F, Comella, Joan X et al. DOI: 10.1111/jnc.13729
PMID: 26692848 Journal: Neural Regeneration Research Year: 2015 Reference: Neural Regen Res. 2015 Oct;10(10):1581-3. doi: 10.4103/1673-5374.165269. Impact factor: 0.22 Publication type: Paper in international publication Authors: Carriba, Paulina, Comella, Joan X et al. DOI: 10.4103/1673-5374.165269
PMID: 25613099 Journal: JOURNAL OF ALZHEIMERS DISEASE Year: 2015 Reference: J Alzheimers Dis. 2015;45(2):621-9. doi: 10.3233/JAD-142721. Impact factor: 4.151 Publication type: Paper in international publication Authors: Moreno-Grau, Sonia, Barneda, Bruna, Carriba, Paulina, Marin, Juan, Sotolongo-Grau, Oscar, Hernandez, Isabel, Vargas, Liliana, Espinosa, Ana, Alegret, Montserrat, Rodriguez, Octavio et al. DOI: 10.3233/JAD-142721
PMID: 25675299 Journal: Cell Death & Disease Year: 2015 Reference: Cell Death Dis. 2015 Feb 12;6:e1639. doi: 10.1038/cddis.2015.6. Impact factor: 5.014 Publication type: Paper in international publication Authors: Lopez-Soriano, J, Gutierrez, A, Vitorica, J, Comella, J X, Moubarak, R S, Barneda-Zahonero, B, Navarro, V, Carriba, P, Jimenez, S, Moreno-Gonzalez, I et al. DOI: 10.1038/cddis.2015.6
PMID: 25890358 Journal: Molecular Cancer Year: 2015 Reference: Mol Cancer. 2015 Mar 19;14:62. doi: 10.1186/s12943-015-0329-x. Impact factor: 4.257 Publication type: Paper in international publication Authors: Galenkamp, Koen Mo, Carriba, Paulina, Urresti, Jorge, Planells-Ferrer, Laura, Coccia, Elena, Lopez-Soriano, Joaquin, Barneda-Zahonero, Bruna, Moubarak, Rana S, Segura, Miguel F, Comella, Joan X et al. DOI: 10.1186/s12943-015-0329-x
PMID: 25566181 Journal: FRONT PHYS-BEIJING Year: 2014 Reference: Front Neurol. 2014 Dec 18;5:276. doi: 10.3389/fneur.2014.00276. eCollection 2014. Impact factor: Publication type: Letter or abstract Authors: Carriba, Paulina, Comella, Joan X et al. DOI: 10.3389/fneur.2014.00276
PMID: 25275596 Journal: CELL DEATH DIS Year: 2014 Reference: Cell Death Dis. 2014 Oct 2;5:e1435. doi: 10.1038/cddis.2014.412. Impact factor: 5.177 Publication type: Paper in international publication Authors: Sanchis, D, Llovera, M, Comella, J X, Herreros, J, Vall-Llaura, N, Cornago, M, Garcia-Alberich, C, Blasco-Angulo, N, Nager, M et al. DOI: 10.1038/cddis.2014.412
PMID: 25188511 Journal: CELL DEATH DIS Year: 2014 Reference: Cell Death Dis. 2014 Sep 4;5:e1401. doi: 10.1038/cddis.2014.356. Impact factor: 5.177 Publication type: Paper in international publication Authors: Planells-Ferrer, L, Urresti, J, Soriano, A, Reix, S, Murphy, D M, Ferreres, J C, Borras, F, Gallego, S, Stallings, R L, Moubarak, R S et al. DOI: 10.1038/cddis.2014.356
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PMID: 23598414 Journal: Cell Death & Disease Year: 2013 Reference: Cell Death Dis. 2013 Apr 18;4:e602. doi: 10.1038/cddis.2013.99. Impact factor: 6.044 Publication type: Paper in international publication Authors: Urena, J M, Soriano, E, del Rio, J A, La Torre, A, del Mar Masdeu, M, Cotrufo, T, Moubarak, R S, Comella, J X et al. DOI: 10.1038/cddis.2013.99
PMID: 23603365 Journal: EXPERIMENTAL NEUROLOGY Year: 2013 Reference: Exp Neurol. 2013 Sep;247:122-9. doi: 10.1016/j.expneurol.2013.03.028. Epub 2013 Apr 18. Impact factor: 4.645 Publication type: Paper in international publication Authors: Giralt, Albert, Sanchis, Daniel, Cherubini, Marta, Gines, Silvia, Canas, Xavier, Comella, Joan X, Alberch, Jordi et al. DOI: 10.1016/j.expneurol.2013.03.028
PMID: 24305822 Journal: JOURNAL OF NEUROSCIENCE Year: 2013 Reference: J Neurosci. 2013 Dec 4;33(49):19262-75. doi: 10.1523/JNEUROSCI.2479-13.2013. Impact factor: 6.908 Publication type: Paper in international publication Authors: Moubarak, Rana S, Planells-Ferrer, Laura, Urresti, Jorge, Reix, Stephanie, Segura, Miguel F, Carriba, Paulina, Marques-Fernandez, Fernando, Sole, Carme, Llecha-Cano, Nuria, Lopez-Soriano, Joaquin et al. DOI: 10.1523/JNEUROSCI.2479-13.2013
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PhD student: Elena Coccia Director/s: Joan X. Comella Carnice, Maria Jose Pérez García University: Universitat Autònoma de Barcelona Year: 2020
PhD student: Mª Isabel Calleja Yagüe Director/s: Joan X. Comella Carnice, Maria Jose Pérez García University: Universitat Autònoma de Barcelona Year: 2019
PhD student: Sonia Moreno Grau Director/s: University: Universitat Autònoma de Barcelona Year: 2019
PhD student: Koen Marius Galenkamp Director/s: Joan Xavier Comella Carnicé University: Universitat Autònoma de Barcelona Year: 2015
PhD student: Victoria Iglesias Guimarais Director/s: Victoria Martín Yuste, Joan X. Comella Carnice University: Universitat Autònoma de Barcelona Year: 2011
