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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Team

Berta Sofia Fernandez Ledesma

Berta Sofia Fernandez Ledesma

Predoctoral researcher
Infection and immunity in pediatric patients
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Laura Batlle Masó

Laura Batlle Masó

Postdoctoral researcher
Infection and immunity in pediatric patients
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Jacques Gabriel Rivière

Jacques Gabriel Rivière

Predoctoral researcher
Infection and immunity in pediatric patients
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Jorgina Vila Soler

Jorgina Vila Soler

Predoctoral researcher
Infection and immunity in pediatric patients
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Marina García Prat

Marina García Prat

Postdoctoral researcher
Infection and immunity in pediatric patients
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Núria Worner Tomasa

Núria Worner Tomasa

Senior researcher
Infection and immunity in pediatric patients
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Berta Sofia Fernandez Ledesma

Berta Sofia Fernandez Ledesma

Predoctoral researcher
Infection and immunity in pediatric patients
Read more
Laura Batlle Masó

Laura Batlle Masó

Postdoctoral researcher
Infection and immunity in pediatric patients
Read more
Jacques Gabriel Rivière

Jacques Gabriel Rivière

Predoctoral researcher
Infection and immunity in pediatric patients
Read more
Jorgina Vila Soler

Jorgina Vila Soler

Predoctoral researcher
Infection and immunity in pediatric patients
Read more
Marina García Prat

Marina García Prat

Postdoctoral researcher
Infection and immunity in pediatric patients
Read more
Núria Worner Tomasa

Núria Worner Tomasa

Senior researcher
Infection and immunity in pediatric patients
Read more

Research lines

The use of biomarkers in pediatric patients with IEI [Innate errors of immunity (IEI)]

IP: Jacques Gabriel Rivière, Pere Soler Palacín

Viral infections in children [Infectious diseases]

IP: Jorgina Vila Soler, Pere Soler Palacín

Projects

RECOMB: Stem-cell based gene therapy for recombination deficient SCID

IP: Pere Soler Palacín
Collaborators: Mónica Martínez Gallo
Funding agency: EUROPEAN COMMISSION
Funding: 62500
Reference: RECOMB_H2020SCI2017
Duration: 01/01/2018 - 31/12/2024

Estudio fase IV, aleatorizado, abierto, controlado para evaluar la terminación temprana del tratamiento con antibioticos en pacientes oncohematológicos con neutropenia febril (e-STOP

IP: Pere Soler Palacín
Collaborators: Luís Gros Subias, Juliana Esperalba Esquerra, Natalia Ana Mendoza Palomar, Núria Worner Tomasa, Berta Sofia Fernandez Ledesma, Susana Melendo Perez
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI19/01522
Duration: 01/01/2020 - 30/06/2024

Integrating genome and transcriptome profiling for the identification of novel genetic basis of primary immunodeficiencies.

IP: Roger Colobran Oriol
Collaborators: Aina Aguiló Cucurull, Marina García Prat, Clara Franco Jarava, Andrea Martín Nalda, Laura Batlle Masó
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI20/00761
Duration: 01/01/2021 - 30/06/2025

SARS-CoV-2 and other respiratory viruses in childhood: different approaches to define predictive models for their diagnosis and epidemiological evolution

IP: Antoni Soriano Arandes
Collaborators: Jorgina Vila Soler, Joan Balcells Ramirez, Núria Worner Tomasa, Clara Franco Jarava, Cristina Andrés Vergés
Funding agency: Fundació La Marató de TV3
Funding: 161075
Reference: 202134
Duration: 23/09/2021 - 22/09/2024

Publications

ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease.

PMID: 37351850
Journal: Journal of Crohns & Colitis
Year: 2023
Reference: J Crohns Colitis. 2023 Jun 23:jjad108. doi: 10.1093/ecco-jcc/jjad108.
Impact factor:
Publication type: Paper in international publication
Authors: Allocca, Mariangela; Bamias, Giorgos; Barreiro-de Acosta, Manuel; Braithwaite, Tasanee; Burisch, Johan; Ellul, Pierre; Gordon, Hannah; Greuter, Thomas; Harwood, Catherine; Juillerat, Pascal et al.
DOI: 10.1093/ecco-jcc/jjad108

Description of reinfection of joint prosthesis after 2-stage replacement (infection of the 2nd stage prosthesis): A multicenter study.

PMID: 37479562
Journal: Enfermedades infecciosas y microbiologia clinica (
Year: 2023
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2023 Jul 19:S2529-993X(23)00196-X. doi: 10.1016/j.eimce.2023.07.002.
Impact factor:
Publication type: Paper in international publication
Authors: Barbero Allende, Jose M; Escudero-Sanchez, Rosa; Fernandez Sampedro, Marta; Garcia Gutierrez, Manuel; Gomez-Junyent, Joan; Guio Carrion, Laura; Morata Ruiz, Laura; Murillo Rubio, Oscar; Portillo, M Eugenia; Rico Nieto, Alicia et al.
DOI: 10.1016/j.eimce.2023.07.002

Universal screening programme for cytomegalovirus infection in the first trimester of pregnancy: study protocol for an observational multicentre study in the area of Barcelona (CITEMB study).

PMID: 37474185
Journal: BMJ Open
Year: 2023
Reference: BMJ Open. 2023 Jul 19;13(7):e071997. doi: 10.1136/bmjopen-2023-071997.
Impact factor:
Publication type: Paper in international publication
Authors: Andreu, Meritxell Fors; Arijon, Mercedes Rey; Ariza, Margarita Mendoza; Bedos, Laia Alcoverro; Bielsa-Pascual, Jofre; Calahorro, Asun Teva; Campi, Astrid Francesch; Carcana, Marina Raja; Carrasco, Julia Mitjans; Carreno, Rocio Garrido et al.
DOI: 10.1136/bmjopen-2023-071997

Molecular Challenges in the Diagnosis of X-Linked Chronic Granulomatous Disease: CNVs, Intronic Variants, Skewed X-Chromosome Inactivation, and Gonosomal Mosaicism.

PMID: 37597073
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2023
Reference: J Clin Immunol. 2023 Aug 19. doi: 10.1007/s10875-023-01556-x.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilo-Cucurull, Aina; Batlle-Maso, Laura; Castells, Neus; Colobran, Roger; Franco-Jarava, Clara; Garcia-Prat, Marina; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Parra-Martinez, Alba; Riviere, Jacques G et al.
DOI: 10.1007/s10875-023-01556-x

Impact of vaccinating pregnant women against pertussis on hospitalizations of children under one year of age in a tertiary hospital in Catalonia.

PMID: 35752569
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2022
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2022 Jun 22. pii: S2529-993X(22)00132-0. doi: 10.1016/j.eimce.2022.06.002.
Impact factor: 1.731
Publication type: Paper in international publication
Authors: Ruiz-Botia, Irene; Riera-Bosch, M Teresa; Rodriguez-Losada, Olalla; Soler-Palacin, Pere; Melendo, Susana; Moraga-Llop, Fernando; Balcells-Ramirez, Joan; Otero-Romero, Susana; Armadans-Gil, Lluis et al.
DOI: 10.1016/j.eimce.2022.06.002

Comparison of pneumonia features in children caused by SARS-CoV-2 and other viral respiratory pathogens.

PMID: 35754093
Journal: PEDIATRIC PULMONOLOGY
Year: 2022
Reference: Pediatr Pulmonol. 2022 Jun 26. doi: 10.1002/ppul.26042.
Impact factor: 3.039
Publication type: Paper in international publication
Authors: Mesa, Juan Miguel; Dominguez-Rodriguez, Sara; Moraleda, Cinta; Tagarro, Alfredo; Rodriguez, Maria Jose; Galan, Juan Carlos; Barrios, Ana; Del Valle-Perez, Rut; Ballesteros, Alvaro; Calvo, Cristina et al.
DOI: 10.1002/ppul.26042

Headache and Vomiting in an 8-Year-Old Girl.

PMID: 35766460
Journal: CLINICAL PEDIATRICS
Year: 2022
Reference: Clin Pediatr (Phila). 2022 Jun 29:99228221106429. doi: 10.1177/00099228221106429.
Impact factor: 1.168
Publication type: Paper in international publication
Authors: Erika, Arno; Alfons, Macaya; Ignacio, Delgado-Alvarez; Ana, Felipe-Rucian; Jorgina, Vila; Duna, Casadesus-Cabral et al.
DOI: 10.1177/00099228221106429

Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study.

PMID: 35770252
Journal: EClinicalMedicine
Year: 2022
Reference: EClinicalMedicine. 2022 Jun 25;50:101515. doi: 10.1016/j.eclinm.2022.101515. eCollection 2022 Aug.
Impact factor: 0
Publication type: Paper in international publication
Authors: Davalos, Veronica; Garcia-Prieto, Carlos A; Alegria, Iosune; Aguilera-Albesa, Sergio; Valencia-Ramos, Juan; Rodriguez-Palmero, Agusti; Ruiz, Montserrat; Planas-Serra, Laura; Jordan, Iolanda; Ferrer, Gerardo et al.
DOI: 10.1016/j.eclinm.2022.101515

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

PMID: 34413139
Journal: Science Immunology
Year: 2021
Reference: Sci Immunol. 2021 Aug 19;6(62). pii: 6/62/eabl4340. doi: 10.1126/sciimmunol.abl4340.
Impact factor: 17.727
Publication type: Paper in international publication
Authors: Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jeremie, Philippot, Quentin, Manry, Jeremy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina et al.
DOI: 10.1126/sciimmunol.abl4340

Newborn Screening for SCID. Experience in Spain (Catalonia).

PMID: 34294672
Journal: International journal of neonatal screening
Year: 2021
Reference: Int J Neonatal Screen. 2021 Jul 20;7(3). pii: ijns7030046. doi: 10.3390/ijns7030046.
Impact factor: 0
Publication type: Paper in international publication
Authors: Argudo-Ramirez, Ana, Martin-Nalda, Andrea, Gonzalez de Aledo-Castillo, Jose Manuel, Lopez-Galera, Rosa, Marin-Soria, Jose Luis, Pajares-Garcia, Sonia, Martinez-Gallo, Monica, Garcia-Prat, Marina, Colobran, Roger, Riviere, Jacques G et al.
DOI: 10.3390/ijns7030046

Treatment of Multisystem Inflammatory Syndrome in Children.

PMID: 34133854
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2021
Reference: N Engl J Med. 2021 Jul 1;385(1):11-22. doi: 10.1056/NEJMoa2102968. Epub 2021 Jun 16.
Impact factor: 91.253
Publication type: Paper in international publication
Authors: Cruces, Pablo, McArdle, Andrew J, Vito, Ortensia, Patel, Harsita, Seaby, Eleanor G, Shah, Priyen, Wilson, Clare, Broderick, Claire, Nijman, Ruud, Tremoulet, Adriana H et al.
DOI: 10.1056/NEJMoa2102968

Enterovirus-A71 Rhombencephalitis Outbreak in Catalonia: Characteristics, Management and Outcome.

PMID: 34097655
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2021
Reference: Pediatr Infect Dis J. 2021 Jul 1;40(7):628-633. doi: 10.1097/INF.0000000000003114.
Impact factor: 2.129
Publication type: Paper in international publication
Authors: Anton, Andres, Castellarnau, Ester, Delgado, Ignacio, Vazquez, Elida, Gonzalez, Sebastia, Mayol, Lluis, Mendez, Maria, Sole, Eduard, Rosal, Jaume, Andres, Cristina et al.
DOI: 10.1097/INF.0000000000003114

Auto-antibodies against type I IFNs in patients with life-threatening COVID-19.

PMID: 32972996
Journal: SCIENCE
Year: 2020
Reference: Science. 2020 Oct 23;370(6515). pii: science.abd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24.
Impact factor: 41.845
Publication type: Paper in international publication
Authors: Manry, Jeremy, Shaw, Elana, Haljasmagi, Liis, Peterson, Part, Lorenzo, Lazaro, Bizien, Lucy, Trouillet-Assant, Sophie, Dobbs, Kerry, de Jesus, Adriana Almeida, Belot, Alexandre et al.
DOI: 10.1126/science.abd4585

Adverse Events Associated With New Injectable-Free Multidrug-Resistant Tuberculosis Drug Regimens.

PMID: 32800388
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2020
Reference: Arch Bronconeumol. 2020 Dec;56(12):823-825. doi: 10.1016/j.arbres.2020.07.006. Epub 2020 Aug 13.
Impact factor: 4.957
Publication type: Letter whit IF
Authors: Mendoza-Palomar, Natalia, Soler-Palacin, Pere, Schaaf, H Simon, Soriano-Arandes, Antoni, Melendo-Perez, Susana, Martin-Nalda, Andrea, Lopez-Seguer, Laura, Carreras-Abad, Clara, Espiau, Maria, Martin-Begue, Nieves et al.
DOI: 10.1016/j.arbres.2020.07.006

Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis.

PMID: 32638196
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Clin Immunol. 2020 Aug;40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub 2020 Jul 7.
Impact factor: 6.78
Publication type: Paper in international publication
Authors: Ehl, Stephan, Elmaksoud, Marwa Abd, Astigarraga, Itziar, Kurjane, Natalja, Bulina, Inita, Kenina, Viktorija, Bryceson, Yenan, Rascon, Jelena, Lortie, Anne, Goldstein, Gal et al.
DOI: 10.1007/s10875-020-00814-6

[Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome].

PMID: 32593520
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Aug;93(2):132-133. doi: 10.1016/j.anpedi.2020.05.002. Epub 2020 Jun 9.
Impact factor: 1.313
Publication type: Letter whit IF
Authors: Velasco Puyo, Pablo, Riviere, Jacques G, Soler Palacin, Pere, Diaz de Heredia, Cristina, Moreno, Lucas et al.
DOI: 10.1016/j.anpedi.2020.05.002

Blog

News

The results show that, in some patients with mutations in the X chromosome, the healthy gene is inactivated and the mutated gene manifests itself, which favors the onset of the disease.

The study, which is part of the European RECOMB project, is currently recruiting volunteers.

This clinical trial is part of the European project RBDCOV, led by HIPRA in which Vall d'Hebron participates, whose recruitment is still open.

Job offers

Data manager - Infection in the immunocompromised child Research Group
Start date:
25/05/2023
End date:
08/06/2023
Document: Download
Psychologist - Research group of immunodepressed paediatric patients
Start date:
27/04/2023
End date:
11/05/2023
Document: Download
Data manager Infection in the immunocompromised child Research Group
Start date:
02/03/2023
End date:
17/03/2023
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