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Yolanda Riba Llena

Instituciones de las que forman parte

Investigador postdoctoral
Enfermedades Neurovasculares
Vall Hebron Institut de Recerca
Yolanda Riba Llena

Líneas de investigación

L6 Stroke Prevention

Since cerebrovascular diseases and dementia are responsible for a huge economic burden, the early detection of patients at high risk for them, and the implementation of preventive measures as soon as possible, might be of great interest and profit.


The purposes of our research are:


- To promote awareness and knowledge of stroke in the general population and enhance collaboration between primary care services and hospital departments.


- To accurately predict those patients at high-risk for first stroke by the determination of novel risk factors or markers (neuroimaging or biological markers), and therefore to improve stroke risk stratification.


- To incorporate a standardized assessment of cognition in stroke research.


- To determine why interventions may be or not widely applied by means of cost-efficiency studies.


- To study quantitative predictors of preventive treatment compliance.



Future project: “Silent cerebral infarction detection and biomarkers associated with the risk of stroke in hypertensive spanish population”.


Silent cerebral infarctions (SCI) detected with neuroimaging techniques, particularly with brain MRI, are common in aged healthy population and even more frequent in selected patients at risk, such as hypertensive patients.  SCI constitute a preclinical stage of cerebrovascular disease and might precede both stroke and cognitive decline; therefore we think that their identification in hypertensive patients would be an adequate and cost-efficient tool, to avoid further strokes and dementia.


Our current project will include a estimated sample size of 1000 hypertensive patients, without known history of cerebrovascular disease or dementia. Silent Cerebral Infarctions (SCI) will be detected by MRI and the determination of several clinical and biological factors (plasma and genetic biomarkers) will be performed on baseline. The patients will be followed-up for at least 3 years, to assess the presence of incident strokes and/or cognitive impairment.

This study will allow us to determine the prevalence of silent cerebral infarctions in our setting, which is largely unknown.


Also, the identification of SCI will help us to better define the risk stratification in hypertensive patients. Patients at higher risk will be our target population for the development of new preventive strategies based on the results of randomized clinical trials.


Finally, this project will be carried out thanks to the collaboration between Neurovascular Research Laboratory, Primary Care Physicians Services and Nephrology Department of Vall d’Hebron, among others, and therefore, the improvement of the link between Primary Care Systems and the remaining hospitalary services, will favor in the future the preventive treatment and care of the patients.

IP: Maria Pilar Delgado Martínez, Yolanda Riba Llena

Proyectos

Estudio del papel de parámetros hemodinámicos, de rigidez arterial y biomarcadores plasmásticos en pacientes con deterioro cognitivo tras ictus lacunar.

IP: Francesc Pujadas Navinés
Colaboradores: Yolanda Riba Llena, María Eugenia Espinel Garuz, Maria Belén Gutiérrez Iglesias
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 81070
Referencia: PI17/02222
Duración: 01/01/2018 - 30/06/2022

Estudio del papel de parámetros hemodinámicos, de rigidez arterial y biomarcadores plasmásticos en pacientes con deterioro cognitivo tras ictus lacunar

IP: Yolanda Riba Llena
Colaboradores: -
Entidad financiadora:
Financiación:
Referencia: PR(AG)405/2017
Duración: -

MAGNETIC RESONANCE IMAGE-PET AMYLOID PATTERNS IN SMALL VESSEL DISEASE. MAPS (Magnetic resonance imaging Amyloid Patterns Small vessel disease) STUDY

IP: Yolanda Riba Llena
Colaboradores: -
Entidad financiadora:
Financiación:
Referencia: PR(IR)225/2017
Duración: -

Incorporació a l'àrea de Neurociències

IP: Joan Montaner Villalonga
Colaboradores: Yolanda Riba Llena, Laia Perez Lasarte
Entidad financiadora: Instituto de Salud Carlos III
Financiación: 135000
Referencia: JR15/00032
Duración: 01/01/2016 - 31/12/2018

Noticias relacionadas

El trabajo internacional ha identificado 89 genes implicados en el riesgo de desarrollar un ictus, 61 de los cuales no se habían descrito previamente.

Entre los proyectos se encuentran 12 investigaciones en las que participan investigadores e investigadoras de Vall d'Hebron.

El estudio internacional incorpora nuevos marcadores de resonancia magnética que permiten incrementar la sensibilidad en el diagnóstico de esta enfermedad.

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