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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Javier Esparcia Estrela

Javier Esparcia Estrela

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Jelena Simunovic

Jelena Simunovic

Senior researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejos

Joaquin Ruiz Altarejos

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Luz María Cruz Carlos

Luz María Cruz Carlos

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Magalí Sureda de la Fuente

Magalí Sureda de la Fuente

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Javier Esparcia Estrela

Javier Esparcia Estrela

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Jelena Simunovic

Jelena Simunovic

Senior researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Joaquin Ruiz Altarejos

Joaquin Ruiz Altarejos

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Luz María Cruz Carlos

Luz María Cruz Carlos

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Magalí Sureda de la Fuente

Magalí Sureda de la Fuente

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas

IP: Begoña Benito Villabriga
Collaborators: Carmen Escudero Iriarte, Laia Ventura i Expósito, Susana Otero Romero, Ignacio Ferreira González, José Antonio Barrabés Riu, Carlos Nos Llopis, Pablo Velasco Puyó, Jose Fernando Rodríguez Palomares, Belen Perez Dueñas, Jaume Sastre Garriga, Joan López Hellin, Antonia Sambola Ayala, Jordi Rio Izquierdo, Nuria Rivas Gandara, Jordi Perez Rodon, Aroa Soriano Fernández, Manuel Comabella Lopez, Antonio Rodríguez Sinovas, Gisela Teixido i Tura, Antonia Pijuan Domenech, Roser Ferrer Costa, Carmen Tur Gomez, Maria Cristina Díaz de Heredia Rubio, Laia Yañez Bisbe, Maria Jose Pérez García, Miguel Segura Ginard, TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas, Cristina Auger Acosta, Neus Bellera Gotarda, TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas, Herena Eixarch Ahufinger, M Mar Mañu Pereira, Deborah Pareto Onghena, Lorena Valero Arrese, Aitor Uribarri Gonzalez, Jordi Bañeras Rius, Alex Rovira Cañellas, Mar Tintore Subirana, Bruno Garcia del Blanco, Ana Vivancos Prellezo, Maria Teresa Salcedo Allende, Marisol Ruiz Meana, Ana Belén Méndez Fernández, Anna Llort Sales, Carmen Espejo Ruiz, Raquel Hladun Alvaro, Sandra Mancilla Zamora, Ana Zabalza de Torres, Marc Miquel Moltó Abad, Javier Inserte Igual, Luciana Midaglia Fernandez, Gabriela Guillén Burrieza, David Gómez Andrés, Alvaro Cobo Calvo, Alvaro Calabuig Goena, Joaquin Castillo Justribo, Lucas Moreno Martín-Retortillo, Andres Miguez Gonzalez, Josep Roma Castanyer, Laura Dos Subirá, Jaume Capdevila Castillon, Nicolás Miguel Fissolo , Maria Nazarena Pizzi, Paolo Giovanni Nuciforo, Tian Tian, Andrea Guala , Juan Pablo Betancur Rengifo
Funding agency: Instituto de Salud Carlos III
Funding: 2494527.53
Reference: FORT23/00034
Duration: 01/01/2024 - 31/12/2027

Efecto de la reposición de hierro sobre el remodelado ventricular después de la oclusi´pon coronaria transitoria en un modelo animal de ferropenia inducida por dieta

IP: José Antonio Barrabés Riu
Collaborators: Ignacio Ferreira González, David Beneitez Pastor, David Aluja Gonzalez, Sara Delgado Tomás, Laura Castellote Bellés, Javier Inserte Igual
Funding agency: Sociedad Española de Cardiologia
Funding: 15000
Reference: SEC/FEC-INV-BAS 23/11
Duration: 01/01/2024 - 31/12/2027

Impact of stem-related tumor extracellular vesicles subsets in TNBC progression.

IP: Joaquin Seras Franzoso
Collaborators: Maria Fidel Lledò, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI23/00223
Duration: 15/01/2024 - 14/01/2028

Funciones Alternativas de la Sex Hormone-Binding Globulin: Mecanismos Moleculares y Papel en Fisiología y Fisiopatología

IP: David Martinez Selva
Collaborators: Maria Teresa Salcedo Allende, Lorena Ramos Pérez, Pablo Gabriel Medina, Pilar Costa Forner
Funding agency: Instituto de Salud Carlos III
Funding: 190000
Reference: PI23/00544
Duration: 01/01/2024 - 31/12/2026

Blog

News

The project’s 4th annual meeting was recently held as part of the Fortalece–Salud programme of the Carlos III Health Institute.

The families of the professionals had the opportunity to visit the facilities and discover how we work at the institution.

The new system, made of cellulose and chitosan, enables sustained release of docetaxel and has demonstrated antitumor activity in preclinical models of ovarian cancer and glioblastoma.