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Gene Therapy at Nervous System

Medicine still has many challenges to solve specially on complex diseases were a large number of both, genetic and environmental factors are involved. Among them, neurodegenerative and autoimmune disorders affecting the central nervous system have attracted attention because CNS is difficult to access and to manipulate with classical pharmacological treatments and, in addition, there are no effective curative treatments for these diseases. To address these problems, we have focused our research interests in gene therapy strategies for autoimmune diseases and neurodegenerative disorders specially those associated to aging.
 

Team

Miguel Chillon Rodriguez

Miguel Chillon Rodriguez

Head of group
Gene Therapy at Nervous System
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Anna Jeanne Behr

Anna Jeanne Behr

Predoctoral researcher
Gene Therapy at Nervous System
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Chiara Piccinini

Chiara Piccinini

Predoctoral researcher
Gene Therapy at Nervous System
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David Ramirez Gomez

David Ramirez Gomez

Predoctoral researcher
Gene Therapy at Nervous System
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Edo Salvador, Angel

Edo Salvador, Angel

Postdoctoral researcher
Gene Therapy at Nervous System
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Jiménez Hernández, Nerea

Jiménez Hernández, Nerea

Research technician
Gene Therapy at Nervous System
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Miguel Chillon Rodriguez

Miguel Chillon Rodriguez

Head of group
Gene Therapy at Nervous System
Read more
Anna Jeanne Behr

Anna Jeanne Behr

Predoctoral researcher
Gene Therapy at Nervous System
Read more
Chiara Piccinini

Chiara Piccinini

Predoctoral researcher
Gene Therapy at Nervous System
Read more
David Ramirez Gomez

David Ramirez Gomez

Predoctoral researcher
Gene Therapy at Nervous System
Read more
Edo Salvador, Angel

Edo Salvador, Angel

Postdoctoral researcher
Gene Therapy at Nervous System
Read more
Jiménez Hernández, Nerea

Jiménez Hernández, Nerea

Research technician
Gene Therapy at Nervous System
Read more

Research lines

Gene Therapy Strategies for Esclerosis Multiple, an autoimmune disease affecting the nervous system

IP: -

Generation and development of more selective and less immunogenic viral vectors

IP: -

Molecular mechanisms involved in memory formation: Study of altered signaling pathways in CNS in non-pathogenic aging and in Alzheimer's Disease

IP: -

Projects

Towards an effective and safe therapy for hormonal-deficiency osteoporosis based on klotho protein

IP: Joan Roig Soriano
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 15000
Reference: VHIR-FIT-2025-005
Duration: 01/07/2025 - 30/06/2026

Bringing Klotho protein as a new therapy against age-associated muscle degeneration

IP: Joan Roig Soriano
Collaborators: Miguel Chillon Rodriguez, Elsa Ibarrola Carrasco, David Ramirez Gomez
Funding agency: Fundació Institut de Recerca HUVH
Funding: 10000
Reference: VHIR-FIT-24-002
Duration: 13/12/2024 - 12/12/2025

Towards an effective and safe therapy for hormonal-deficiency osteoporosis based on klotho protein

IP: Joan Roig Soriano
Collaborators: Miguel Chillon Rodriguez
Funding agency: Fundació "La Caixa"
Funding: 64450
Reference: CI24-20581
Duration: 15/10/2024 - 14/10/2026

ERDERA: European Rare Disease Research Alliance

IP: M Mar Mañu Pereira
Collaborators: Augusto Cesar Sao Aviles, Patricia González Ruiz, Claire Diot, Miguel Chillon Rodriguez, Simon Schwartz Navarro, Sara Isabel Reidel
Funding agency: EUROPEAN COMMISSION
Funding: 1252083.33
Reference: ERDERA/EC/HLTH-2023-DISEASE-07-01/2023/MAÑU
Duration: 01/09/2024 - 31/08/2031

Thesis

Novel chronokine-based approaches to tackle multiple pathways in Alzheimer’s disease: secreted Klotho and newly designed chimeric HEBE.

PhD student: Jon Esandi Jauregui
Director/s: Miguel Chillon Rodriguez
University: Universitat Autònoma de Barcelona
Year: 2024

AAV-mediated expression of Secreted Klotho as a therapeutic strategy for Alzheimer’s disease

PhD student: Rebeca Blanch Garcia
Director/s: Miguel Chillon Rodriguez
University: Universitat Autònoma de Barcelona
Year: 2023

Safety and therapeutical efficacy of the antiageing protein klotho for treating age-associated deficits and increasing longevity

PhD student: Joan Roig Soriano, Joan Roig Soriano
Director/s: Miguel Chillon Rodriguez
University: Universitat Autònoma de Barcelona
Year: 2023

Desarrollo de nuevas estrategias de terapia génica como tratamiento inmunomodulador de la esclerosis múltiple

PhD student: Angel Edo Salvador
Director/s: Miguel Chillon Rodriguez, Xavier Montalban Gairín, Xavier Montalban Gairín
University:
Year: 2020

Generación de un adenovirus quimérico Ad5/52s pseudotipado con la proteína fiber corta del Ad52 para su caracterización in vitro e in vivo como vector de terapia génica

PhD student: Marc García Moure
Director/s: Miguel Chillon Rodriguez
University: Universidad Autònoma de Barcelona
Year: 2016

Blog

News

The treatment, licensed to Klotho Neurosciences, is based on a technology developed at the Universitat Autònoma de Barcelona (UAB) with the participation of VHIR.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

This gene therapy protects mice against cognitive deficits associated with aging, improves motor function, and delays the onset of diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.

Rates

Check the current rates for the services offered by the Gene Therapy at Nervous System research group.