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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Carlota Aguilera Ordoñez

Carlota Aguilera Ordoñez

Research technician
Childhood Cancer and Blood Disorders
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Gabriela Guillén Burrieza

Gabriela Guillén Burrieza

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Juan Manuel López Oliva

Juan Manuel López Oliva

Research technician
Childhood Cancer and Blood Disorders
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Anna Collado Gimbert

Anna Collado Gimbert

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Blanca Espinosa Lopez

Blanca Espinosa Lopez

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Lorena Valero Arrese

Lorena Valero Arrese

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Carlota Aguilera Ordoñez

Carlota Aguilera Ordoñez

Research technician
Childhood Cancer and Blood Disorders
Read more
Gabriela Guillén Burrieza

Gabriela Guillén Burrieza

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Juan Manuel López Oliva

Juan Manuel López Oliva

Research technician
Childhood Cancer and Blood Disorders
Read more
Anna Collado Gimbert

Anna Collado Gimbert

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Blanca Espinosa Lopez

Blanca Espinosa Lopez

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Lorena Valero Arrese

Lorena Valero Arrese

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more

Projects

Integración de datos del mundo real, de salud y de investigación para la mejora de los protocolos clínicos en la enfermedad falciforme y otras anemias raras

IP: M Mar Mañu Pereira
Collaborators: Sara Isabel Reidel , David Beneitez Pastor, Maria Cristina Díaz de Heredia Rubio, Adoración Blanco Alvarez, Anna Collado Gimbert
Funding agency: Instituto de Salud Carlos III
Funding: 152500
Reference: PI24/00477
Duration: 01/01/2025 - 31/12/2027

Unlocking the Power of Liquid Biopsy: Advancing Precision Medicine in Pediatric Brain Tumors

IP: Miguel Segura Ginard
Collaborators: -
Funding agency: Asociación Deporte vs Cáncer Infantil
Funding: 6000
Reference: BARRERA/BECA/SEGURA/2024
Duration: 14/04/2025 - 14/04/2026

Incorporación de terapias dirigidas e inmunoterapia para el tratamiento de niños y adolescentes con neuroblastoma en recaída mediante su caracterización genómica y el desarrollo del ensayo clínico aleatorizado fase 2 BEACON2.

IP: Lucas Moreno Martín-Retortillo
Collaborators: Andrea Vilaplana Blanes, Aroa Soriano Fernández, Jessica Camacho Soriano, Lorena Valero Arrese, Raquel Hladun Alvaro, Gabriela Guillén Burrieza
Funding agency: Instituto de Salud Carlos III
Funding: 240000
Reference: PI24/01576
Duration: 01/01/2025 - 31/12/2027

Desarrollo avanzado de terapias innovadoras contra los sarcomas infantiles: refinamiento del bloqueo farmacológico de los co-receptores de la Vía Hedgehog

IP: Josep Roma Castanyer
Collaborators: Guillem Pons Barcons, Raquel Hladun Alvaro, Júlia Sansa Girona, Lia Garcia Gilabert, Gabriela Guillén Burrieza, Patricia Zarzosa Martinez
Funding agency: Instituto de Salud Carlos III
Funding: 190000
Reference: PI24/00825
Duration: 01/01/2025 - 31/12/2027

Blog

News

The projects, selected under the 2026 Health Research and CaixaImpulse Health Innovation calls, address topics ranging from new therapies for childhood neurological disorders and Parkinson’s disease to the treatment of mitochondrial diseases and cancer.

A new publication describes the creation of this initiative, which has facilitated access to genomic studies for more than 900 pediatric patients with cancer from across Spain.

The families of the professionals had the opportunity to visit the facilities and discover how we work at the institution.