Skip to main content

Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Diana Fernandes de Rafael

Diana Fernandes de Rafael

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Fernanda Raquel Da Silva Andrade

Fernanda Raquel Da Silva Andrade

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Maria del Pilar Reimundo Diaz-Fierros

Maria del Pilar Reimundo Diaz-Fierros

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Diego Baranda Martínez-Abasca

Diego Baranda Martínez-Abasca

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Marc Miquel Moltó Abad

Marc Miquel Moltó Abad

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Angels Alcina Mila

Angels Alcina Mila

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Diana Fernandes de Rafael

Diana Fernandes de Rafael

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Fernanda Raquel Da Silva Andrade

Fernanda Raquel Da Silva Andrade

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Maria del Pilar Reimundo Diaz-Fierros

Maria del Pilar Reimundo Diaz-Fierros

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Diego Baranda Martínez-Abasca

Diego Baranda Martínez-Abasca

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Marc Miquel Moltó Abad

Marc Miquel Moltó Abad

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Angels Alcina Mila

Angels Alcina Mila

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more

Research lines

Disseny, síntesi i caracterització de nanosistemes terapèutics biodegradables

IP: Fernanda Raquel Da Silva Andrade

Estudi de les bases moleculars i cel·lulars del càncer

IP: Joaquin Seras Franzoso

Estudi i Millora del procés de fecundació in vitro

IP: Maria del Pilar Reimundo Diaz-Fierros

Obtenció i us de vesícules extracel·lulars com vehicles per proteïnes i biomolècules

IP: Ibane Abasolo Olaortua

Projects

SPM4.0: Autonomous Scanning Probe Microscopy for Life Sciences and Medicine powered by Artificial Intelligence

IP: Fernanda Raquel Da Silva Andrade
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 251971.2
Reference: SPM40_F.ANDRADE_MSCA-DN2023
Duration: 01/11/2024 - 31/10/2028

Project-COMFORT: Patient-Centric blOod saMpling FOr impRoved healThcare

IP: Simon Schwartz Navarro
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 288262.5
Reference: COMFORT- HE--JU-IHI-2023-04
Duration: 01/11/2024 - 30/04/2028

ERDERA: European Rare Disease Research Alliance

IP: M Mar Mañu Pereira
Collaborators: Augusto Cesar Sao Aviles, Patricia González Ruiz, ERDERA: European Rare Disease Research Alliance, Miguel Chillon Rodriguez, Simon Schwartz Navarro
Funding agency: EUROPEAN COMMISSION
Funding: 1080135.58
Reference: ERDERA/EC/HLTH-2023-DISEASE-07-01/2023/MAÑU
Duration: 01/09/2024 - 31/08/2031

Evaluation of an innovative strategy based on nanoparticles-loaded hydrogels as a safe and sustained intraperitoneal chemotherapy in mucinous adenocarcinomas

IP: Fernanda Raquel Da Silva Andrade
Collaborators: Roser Ferrer Costa, Julia German Cortes, Angels Alcina Mila, Diana Fernandes de Rafael
Funding agency: Asociación Española Contra el Cáncer
Funding: 10000
Reference: SNRGS247164DASI
Duration: 01/06/2024 - 31/05/2026

Publications

Comparing Aluminum Concentrations in Adult and Pediatric Parenteral Nutrition Solutions: Multichamber-Bag versus Compounded Parenteral Nutrition.

PMID: 38613056
Journal: Nutrients
Year: 2024
Reference: Nutrients. 2024 Apr 1;16(7):1024. doi: 10.3390/nu16071024.
Impact factor:
Publication type: Paper in international publication
Authors: Berlana, David; Ferrer-Costa, Roser; Lopez-Hellin, Juan; Pau-Parra, Alba et al.
DOI: 10.3390/nu16071024

Metabolic-associated fatty liver voxel-based quantification on CT images using a contrast adapted automatic tool.

PMID: 38718716
Journal: MEDICAL IMAGE ANALYSIS
Year: 2024
Reference: Med Image Anal. 2024 Apr 20;95:103185. doi: 10.1016/j.media.2024.103185.
Impact factor:
Publication type: Paper in international publication
Authors: Aguade-Bruix, Santiago; Ciudin, Andreea; Escobar, Manuel; Gonzalez Ballester, Miguel A; Herance, Jose Raul; Martin-Saladich, Queralt; Pericas, Juan M; Ramirez-Serra, Clara; Rivera-Esteban, Jesus et al.
DOI: 10.1016/j.media.2024.103185

3D Bioprinted Tumor-Stroma Models of Triple-Negative Breast Cancer Stem Cells for Preclinical Targeted Therapy Evaluation.

PMID: 38764168
Journal: ACS Applied Materials & Interfaces
Year: 2024
Reference: ACS Appl Mater Interfaces. 2024 May 19. doi: 10.1021/acsami.4c04135.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Garcia-Astrain, Clara; Gonzalez-Callejo, Patricia; Henriksen-Lacey, Malou; Herrero-Ruiz, Ada; Liz-Marzan, Luis M; Seras-Franzoso, Joaquin et al.
DOI: 10.1021/acsami.4c04135

Genotyping Hepatitis B virus by Next-Generation Sequencing: Detection of Mixed Infections and Analysis of Sequence Conservation.

PMID: 38791519
Journal:
Year: 2024
Reference: Int J Mol Sci. 2024 May 17;25(10):5481. doi: 10.3390/ijms25105481.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Buti, Maria; Cortese, Maria Francesca; Costa, Josep; Dopico, Eva; Ferrer-Costa, Roser; Gonzalez-Sanchez, Alejandra; Gregori, Josep; Guerrero, Laura; Martinez, Miguel J et al.
DOI: 10.3390/ijms25105481

Myocardial tissue characterization by cardiovascular magnetic resonance T1 mapping and pericardial fat quantification in adolescents with morbid obesity. Cardiac dimorphism by gender.

PMID: 36508057
Journal: INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
Year: 2023
Reference: Int J Cardiovasc Imaging. 2023 Apr;39(4):781-792. doi: 10.1007/s10554-022-02773-y. Epub 2022 Dec 12.
Impact factor:
Publication type: Paper in international publication
Authors: Ferrer-Costa, Roser; Giralt, Marina; Gran, Ferran; Riaza, Lucia; Riera, Luis; Roses-Noguer, Ferran; Sabate-Rotes, Anna; Siurana, Jose M; Vazquez, Elida; Ventura, Paula S et al.
DOI: 10.1007/s10554-022-02773-y

Recommendations for the integral diagnosis of chronic viral hepatitis in a single analytical extraction.

PMID: 36257502
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Feb;46(2):150-162. doi: 10.1016/j.gastrohep.2022.09.009. Epub 2022 Oct 17.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Antonio; Berenguer, Marina; Buti, Maria; Cabezas, Joaquin; Calleja, Jose Luis; Casado, Miguel Angel; Crespo, Javier; Dominguez-Hernandez, Raquel; Forns, Xavier; Garcia, Federico et al.
DOI: 10.1016/j.gastrohep.2022.09.009

Perspectives toward the development of advanced materials based on bacterial polysaccharides.

PMID: 35770400
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2023
Reference: Curr Med Chem. 2023;30(17):1963-1970. doi: 10.2174/0929867329666220629152008.
Impact factor:
Publication type: Paper in international publication
Authors: Duran-Lara, Esteban F; Marican, Adolfo; Rafael, Diana; Vijayakumar, Sekar et al.
DOI: 10.2174/0929867329666220629152008

Long-term follow-up of HCV-infected patients with end-stage chronic kidney disease after sustained virological response with direct-acting antiviral therapy.

PMID: 36584754
Journal: Gastroenterologia y Hepatologia
Year: 2023
Reference: Gastroenterol Hepatol. 2023 Oct;46(8):594-602. doi: 10.1016/j.gastrohep.2022.12.004. Epub 2022 Dec 27.
Impact factor:
Publication type: Paper in national publication
Authors: Azancot, Maria A; Azancot, Maria A; Buti, Maria; Carmona, Isabel; Delgado, Manuel; Escudero-Garcia, Desamparados; Garcia-Samaniego, Javier; Gutierrez, Maria L; Londono, Maria-Carlota; Losa-Garcia, Juan E et al.
DOI: 10.1016/j.gastrohep.2022.12.004

Enhanced Cardiorenal Protective Effects of Combining SGLT2 Inhibition, Endothelin Receptor Antagonism and RAS Blockade in Type 2 Diabetic Mice.

PMID: 36361612
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Oct 24;23(21). pii: ijms232112823. doi: 10.3390/ijms232112823.
Impact factor:
Publication type: Paper in international publication
Authors: Benito, Begona; Bermejo, Sheila; Dominguez-Baez, Pamela; Jacobs-Cacha, Conxita; Llorens-Cebria, Carmen; Martinez-Diaz, Irene; Martos, Nerea; Ortiz, Alberto; Pieper, Michael Paul; Soler, Maria Jose et al.
DOI: 10.3390/ijms232112823

Oxidative Stress in Structural Valve Deterioration: A Longitudinal Clinical Study.

PMID: 36358956
Journal: Biomolecules
Year: 2022
Reference: Biomolecules. 2022 Oct 31;12(11). pii: biom12111606. doi: 10.3390/biom12111606.
Impact factor:
Publication type: Paper in international publication
Authors: Badano, Luigi P; Barquinero, Jordi; Blasco-Lucas, Arnau; Casos, Kelly; Costa, Cristina; Cozzi, Emanuele; Evangelista, Arturo; Fellah-Hebia, Imen; Galinanes, Manuel; Galli, Cesare et al.
DOI: 10.3390/biom12111606

Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology.

PMID: 36202848
Journal: npj Parkinsons Disease
Year: 2022
Reference: NPJ Parkinsons Dis. 2022 Oct 6;8(1):126. doi: 10.1038/s41531-022-00397-6.
Impact factor:
Publication type: Paper in international publication
Authors: Albert-Bayo, Merce; Arranz-Amo, Jose Antonio; Carnicer-Caceres, Clara; Casas, Josefina; Castillo-Ribelles, Laura; Castillo-Sanchez, Pablo; Fernandez-Gonzalez, Irene; Lopez-Royo, Tresa; Martinez-Vicente, Marta; Montpeyo, Marta et al.
DOI: 10.1038/s41531-022-00397-6

Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide.

PMID: 36233074
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Oct 4;23(19). pii: ijms231911760. doi: 10.3390/ijms231911760.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Camara-Sanchez, Patricia; Diaz-Riascos, Zamira V; Garcia-Aranda, Natalia; Gener, Petra; Giani-Alonso, Micaela; Royo, Miriam; Schwartz, Simo Jr; Seras-Franzoso, Joaquin; Vazquez, Esther et al.
DOI: 10.3390/ijms231911760

Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting.

PMID: 34943471
Journal: Diagnostics
Year: 2021
Reference: Diagnostics (Basel). 2021 Nov 29;11(12). pii: diagnostics11122236. doi: 10.3390/diagnostics11122236.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Blanco-Grau, Albert; Buti, Maria; Casis, Ernesto; Cruz, Luz-Maria; Enfedaque, Belen; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Lopez-Martinez, Rosa; Pons, Monica et al.
DOI: 10.3390/diagnostics11122236

Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach.

PMID: 34946123
Journal: Microorganisms
Year: 2021
Reference: Microorganisms. 2021 Dec 6;9(12). pii: microorganisms9122518. doi: 10.3390/microorganisms9122518.
Impact factor:
Publication type: Review in international publication
Authors: Cortese, Maria Francesca; Garcia-Garcia, Selene; Pumarola, Tomas; Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.3390/microorganisms9122518

Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?

PMID: 34887634
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2021
Reference: World J Gastroenterol. 2021 Nov 7;27(41):7144-7158. doi: 10.3748/wjg.v27.i41.7144.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casillas, Rosario; Casis, Ernesto; Castillo-Ribelles, Laura; Cortese, Maria Francesca; Esteban, Rafael; Ferrer-Costa, Roser; Garcia-Garcia, Selene; Gregori, Josep; Pacin, Beatriz et al.
DOI: 10.3748/wjg.v27.i41.7144

Development of "on-demand" thermo-responsive hydrogels for anti-cancer drugs sustained release: Rational design, in silico prediction and in vitro validation in colon cancer models.

PMID: 34857269
Journal: Materials Science & Engineering C-Materials for Biological Applications
Year: 2021
Reference: Mater Sci Eng C Mater Biol Appl. 2021 Dec;131:112483. doi: 10.1016/j.msec.2021.112483. Epub 2021 Oct 13.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Avila-Salas, Fabian; Carreno, Gustavo; Duran-Lara, Esteban F; Marican, Adolfo; Pereira, Alfredo; Rafael, Diana; Roca-Melendres, Maria Merce; Schwartz, Simo Jr et al.
DOI: 10.1016/j.msec.2021.112483

Trends in Diagnosis of Alpha-1 Antitrypsin Deficiency Between 2015 and 2019 in a Reference Laboratory.

PMID: 33116457
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2020
Reference: Int J Chron Obstruct Pulmon Dis. 2020 Oct 7;15:2421-2431. doi: 10.2147/COPD.S269641. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Barrecheguren, Miriam; Belmonte, Irene; Blanco-Grau, Albert; Esquinas, Cristina; Ferrer, Roser; Genesca, Joan; Lopez-Martinez, Rosa M; Miravitlles, Marc; Nunez, Alexa; Pons, Monica et al.
DOI: 10.2147/COPD.S269641

Amino acid substitutions associated with treatment failure of hepatitis C virus infection.

PMID: 32999010
Journal: JOURNAL OF CLINICAL MICROBIOLOGY
Year: 2020
Reference: J Clin Microbiol. 2020 Nov 18;58(12). pii: JCM.01985-20. doi: 10.1128/JCM.01985-20. Print 2020 Nov 18.
Impact factor:
Publication type: Paper in international publication
Authors: Briones, Carlos; Buti, Maria; Chen, Qian; de Avila, Ana Isabel; Domingo, Esteban; Esteban, Juan Ignacio; Ferrer-Orta, Cristina; Gallego, Isabel; Garcia-Cehic, Damir; Garcia-Crespo, Carlos et al.
DOI: 10.1128/JCM.01985-20

A bibliometric evaluation of the top 100 cited natalizumab articles.

PMID: 33007648
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2020
Reference: J Neuroimmunol. 2020 Dec 15;349:577379. doi: 10.1016/j.jneuroim.2020.577379. Epub 2020 Sep 8.
Impact factor:
Publication type: Review in international publication
Authors: Del Pozo, Julian Solis Garcia; Galindo, Maria F; Garcia-Fernandez, Alba Estela; Garcia-Fernandez, Francisco Javier; Ikuta, Ichiro; Jordan, Joaquin; Nava, Eduardo et al.
DOI: 10.1016/j.jneuroim.2020.577379

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.

PMID: 31857134
Journal: ANTIVIRAL RESEARCH
Year: 2020
Reference: Antiviral Res. 2020 Feb;174:104694. doi: 10.1016/j.antiviral.2019.104694. Epub 2019 Dec 16.
Impact factor:
Publication type: Paper in international publication
Authors: Acero, Doroteo; Albillos, Agustin; Andrade, Raul Jesus; Antonio Del-Campo, Jose; Arenas, Juan Ignacio; Augustin, Salvador; Baliellas, Carme; Baluja-Pino, Raquel; Barenys, Merce; Bernet, Albert et al.
DOI: 10.1016/j.antiviral.2019.104694

Deep-sequencing study of HCV G4a resistance-associated substitutions in Egyptian patients failing DAA treatment.

PMID: 31571936
Journal: Infection and Drug Resistance
Year: 2019
Reference: Infect Drug Resist. 2019 Sep 10;12:2799-2807. doi: 10.2147/IDR.S214735. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Amer, Fatma; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Hammad, Noha M; Nieto-Aponte, Leonardo; Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Yousif, Monkez M et al.
DOI: 10.2147/IDR.S214735

Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice.

PMID: 31561638
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Sep 26;8(10). pii: jcm8101549. doi: 10.3390/jcm8101549.
Impact factor:
Publication type: Paper in international publication
Authors: Aulinas, Anna; Biagetti, Betina; Castano, J P; Ferrer, Roser; Herance, J R; Luque, Raul M; Mesa, Jordi; Palomino-Schatzlein, Martina; Simo, Rafael et al.
DOI: 10.3390/jcm8101549

Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies.

PMID: 31559131
Journal: Advanced Science
Year: 2019
Reference: Adv Sci (Weinh). 2019 Jul 24;6(18):1900849. doi: 10.1002/advs.201900849. eCollection 2019 Sep 18.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Balta-Foix, Ricardo; Beaulieu, Marie-Eve; Diaz-Riascos, Zamira V; Fernandez, Yolanda; Jauset, Toni; Mancilla, Sandra; Pesarrodona, Mireia; Rinas, Ursula; Sanchez-Chardi, Alejandro et al.
DOI: 10.1002/advs.201900849

Urea cycle disorders in Argentine patients: clinical presentation, biochemical and genetic findings.

PMID: 31426867
Journal: Orphanet Journal of Rare Diseases
Year: 2019
Reference: Orphanet J Rare Dis. 2019 Aug 19;14(1):203. doi: 10.1186/s13023-019-1177-3.
Impact factor:
Publication type: Paper in international publication
Authors: Angaroni, Celia J; Arranz, Jose A; Becerra, Adriana; Bezard, Miriam; de Kremer, Raquel Dodelson; Guelbert, Norberto; Haberle, Johannes; Larovere, Laura E; Peralta, Fernanda; Silvera-Ruiz, Silene M et al.
DOI: 10.1186/s13023-019-1177-3

Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.

PMID: 30519058
Journal: Infection and Drug Resistance
Year: 2018
Reference: Infect Drug Resist. 2018 Nov 8;11:2207-2210. doi: 10.2147/IDR.S172226. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Castells, Lluis; Chen, Qian; Domingo, Esteban; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Imaz, Arkaitz; Llorens-Revull, Meritxell; Nieto-Aponte, Leonardo et al.
DOI: 10.2147/IDR.S172226

HDV evolution-will viral resistance be an issue in HDV infection?

PMID: 30415162
Journal: Current Opinion in Virology
Year: 2018
Reference: Curr Opin Virol. 2018 Oct;32:100-107. doi: 10.1016/j.coviro.2018.10.003. Epub 2018 Nov 8.
Impact factor:
Publication type: Review in national publication
Authors: Buti, Maria; Cortese, Maria Francesca; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.1016/j.coviro.2018.10.003

Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells.

PMID: 30405720
Journal: Stem Cells International
Year: 2018
Reference: Stem Cells Int. 2018 Oct 10;2018:4516454. doi: 10.1155/2018/4516454. eCollection 2018.
Impact factor:
Publication type: Review in national publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Arango, Diego; Callejo, Patricia Gonzalez; Gener, Petra; Martinez, Francesc; Montero, Sara; Rafael, Diana; Sayos, Joan; Schwartz, Simo Jr et al.
DOI: 10.1155/2018/4516454

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients.

PMID: 30250996
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2018
Reference: Mol Biol Rep. 2018 Dec;45(6):2345-2358. doi: 10.1007/s11033-018-4399-x. Epub 2018 Sep 24.
Impact factor:
Publication type: Paper in international publication
Authors: Ati, Nidhal; Blel, Ahlem; Chebil, Mohamed; Derouiche, Amine; Garcia-Mayea, Yoelsis; Hernandez-Losa, Javier; LLeonart, Matilde E; Mir, Cristina; Ouerhani, Slah; Paciucci, Rosanna et al.
DOI: 10.1007/s11033-018-4399-x

Free Testosterone During Androgen Deprivation Therapy Predicts Castration-Resistant Progression Better Than Total Testosterone.

PMID: 27800640
Journal: PROSTATE
Year: 2017
Reference: Prostate. 2017 Jan;77(1):114-120. doi: 10.1002/pros.23256. Epub 2016 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Joan; Comas, Inma; Ferrer, Roser; Maldonado, Xavier; Morote, Juan; Planas, Jacques; Regis, Lucas et al.
DOI: 10.1002/pros.23256

The role of prostate tumor overexpressed 1 in cancer progression.

PMID: 28029646
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Feb 14;8(7):12451-12471. doi: 10.18632/oncotarget.14104.
Impact factor:
Publication type: Review in international publication
Authors: Canovas, Veronica; Lleonart, Matilde; Morote, Juan; Paciucci, Rosanna et al.
DOI: 10.18632/oncotarget.14104

Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report.

PMID: 27785789
Journal: TRANSFUSION
Year: 2017
Reference: Transfusion. 2017 Feb;57(2):244-247. doi: 10.1111/trf.13876. Epub 2016 Oct 26.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Gregori, Josep; Piron, Maria; Quer, Josep; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Salvador, Fernando; Sauleda, Silvia et al.
DOI: 10.1111/trf.13876

Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency.

PMID: 29238183
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2017
Reference: Int J Chron Obstruct Pulmon Dis. 2017 Nov 29;12:3381-3390. doi: 10.2147/COPD.S145445. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Barrecheguren, Miriam; Belmonte, Irene; Esquinas, Cristina; Gonzalo, Ricardo; Janciauskiene, Sabina; Mas de Xaxars, Gemma; Miravitlles, Marc; Nunez, Alexa; Olejnicka, Beata; Rodriguez, Esther et al.
DOI: 10.2147/COPD.S145445

Application of a diagnostic algorithm for the rare deficient variant Mmalton of alpha-1-antitrypsin deficiency: a new approach.

PMID: 27877030
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2016
Reference: Int J Chron Obstruct Pulmon Dis. 2016 Oct 11;11:2535-2541. eCollection 2016.
Impact factor:
Publication type: Paper in international publication
Authors: Barrecheguren, Miriam; Belmonte, Irene; Esquinas, Cristina; Lopez-Martinez, Rosa M; Miravitlles, Marc; Rodriguez, Esther; Rodriguez-Frias, Francisco et al.
DOI: 10.2147/COPD.S115940

Design of chalcogen-containing norepinephrines: efficient GPx mimics and strong cytotoxic agents against HeLa cells.

PMID: 27845568
Journal: Future Medicinal Chemistry
Year: 2016
Reference: Future Med Chem. 2016 Dec;8(18):2185-2195. doi: 10.4155/fmc-2016-0139. Epub 2016 Nov 15.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Begines, Paloma; Fernandez-Bolanos, Jose G; Garcia-Aranda, Natalia; Lopez, Oscar; Marset, Azucena; Maya, Ines; Schwartz, Simo Jr et al.
DOI: 10.4155/fmc-2016-0139

Impact of ornithine phenylacetate (OCR-002) in lowering plasma ammonia after upper gastrointestinal bleeding in cirrhotic patients.

PMID: 27803737
Journal: Therapeutic Advances in Gastroenterology
Year: 2016
Reference: Therap Adv Gastroenterol. 2016 Nov;9(6):823-835. Epub 2016 Jul 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado-Tapias, Edilmar; Arranz, Jose Antonio; Blanco-Grau, Albert; Concepcion, Mar; Cordoba, Juan; Fuentes, Inma; Gely, Cristina; Genesca, Joan; Minguez, Beatriz; Roman, Eva et al.
DOI: 10.1177/1756283X16658252

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

PMID: 27775083
Journal: Scientific Reports
Year: 2016
Reference: Sci Rep. 2016 Oct 24;6:35765. doi: 10.1038/srep35765.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Alamo, Patricia; Cespedes, Maria Virtudes; Corchero, Jose Luis; Fernandez, Yolanda; Ferrer-Miralles, Neus; Mangues, Ramon; Mendoza, Rosa; Sanchez-Chardi, Alejando; Schwartz, Simo et al.
DOI: 10.1038/srep35765

The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study).

PMID: 26109396
Journal: INTENS CARE MED
Year: 2015
Reference: Intensive Care Med. 2015 Sep;41(9):1620-8. doi: 10.1007/s00134-015-3906-y. Epub 2015 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Beale, Richard; Cecconi, Maurizio; Chiche, Jean Daniel; De Backer, Daniel; Divatia, Jigeeshu; Du, Bin; Evans, Laura; Ferrer, Ricard; Girardis, Massimo; Koulenti, Despoina et al.
DOI: 10.1007/s00134-015-3906-y

Early and adequate empirical antibiotic treatment in sepsis saves lives, but how should it be provided?

PMID: 26233587
Journal: MED INTENSIVA
Year: 2015
Reference: Med Intensiva. 2015 Nov;39(8):457-8. doi: 10.1016/j.medin.2015.05.007. Epub 2015 Jul 29.
Impact factor:
Publication type: Editorail in international publication
Authors: Ferrer, R; Piacentini, E et al.
DOI: 10.1016/j.medin.2015.05.007

Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX).

PMID: 25083980
Journal: CRIT CARE MED
Year: 2015
Reference: Crit Care Med. 2015 Jan;43(1):57-64. doi: 10.1097/CCM.0000000000000554.
Impact factor:
Publication type: Clinical guide
Authors: Boehm, Erwin; Darius, Harald; DeAngelo, Joseph; Ferrer, Ricard; Lorente, Jose A; Marx, Gernot; Meier-Hellmann, Andreas; Privalle, Christopher T; Singer, Mervyn; Sirvent, Josep-Maria et al.
DOI: 10.1097/CCM.0000000000000554

Immunogenicity of hepatitis B vaccine in patients with inflammatory bowel disease and the benefits of revaccination.

PMID: 25160690
Journal: J GASTROEN HEPATOL
Year: 2015
Reference: J Gastroenterol Hepatol. 2015 Jan;30(1):92-8. doi: 10.1111/jgh.12712.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel-Sainz, Natalia; Campins-Marti, Magda; Casellas-Jorda, Francesc; Cossio-Gil, Yolima; Martinez-Gomez, Xavier; Rodrigo-Pendas, Jose Angel; Rodriguez-Frias, Francisco et al.
DOI: 10.1111/jgh.12712

Ribosomal proteins as novel players in tumorigenesis.

PMID: 24375388
Journal: CANCER AND METASTASIS REVIEWS
Year: 2014
Reference: Cancer Metastasis Rev. 2014 Mar;33(1):115-41. doi: 10.1007/s10555-013-9460-6.
Impact factor:
Publication type: Paper in international publication
Authors: de Las Heras-Rubio, A; Lleonart, M E; Paciucci, R; Perucho, L; Vilardell, J et al.
DOI: 10.1007/s10555-013-9460-6

Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects

PMID: 90010002
Journal: JOURNAL OF NANOPARTICLE RESEARCH
Year: 2014
Reference: Journal of Nanoparticle Research, 2014, 16(3): 2292
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo I; Acosta M; Arus C; Bomati-Miguel Oscar; Candiota AP; Marquina C; Martinez G; Miguel-Sancho N ; Roca AG; Santamaria J et al.
DOI:

Decreased lipases and fatty acid and glycerol transporter could explain reduced fat in diabetic morbidly obese.

PMID: 25132069
Journal: Obesity Facts
Year: 2014
Reference: Obesity (Silver Spring). 2014 Nov;22(11):2379-87. doi: 10.1002/oby.20861. Epub 2014 Aug 6.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Balibrea, Jose Maria; Caubet, Enric; Ferrer, Roser; Fort, Jose Manuel; Gonzalez, Oscar; Lecube, Albert; Pardina, Eva; Peinado-Onsurbe, Julia; Rossell, Joana et al.
DOI: 10.1002/oby.20861

Cirrhosis, liver transplantation and HIV infection are risk factors associated with hepatitis E virus infection.

PMID: 25068388
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Jul 28;9(7):e103028. doi: 10.1371/journal.pone.0103028. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Campos-Varela, Isabel; Cantarell, Carmen; Castells, Lluis; Crespo, Manuel; Esteban, Rafael; Homs, Maria; Quer, Josep; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco et al.
DOI: 10.1371/journal.pone.0103028

Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach.

PMID: 24222943
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2013
Reference: World J Gastroenterol. 2013 Nov 7;19(41):6995-7023. doi: 10.3748/wjg.v19.i41.6995.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Homs, Maria; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.3748/wjg.v19.i41.6995

Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.

PMID: 24900725
Journal: J ADV MODEL EARTH SY
Year: 2013
Reference: ACS Med Chem Lett. 2013 May 28;4(7):651-5. doi: 10.1021/ml400125z. eCollection 2013 Jul 11.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bermejo, Marival; Cabanas, Maria Jose Diaz; Corma, Avelino; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Mangas-Sanjuan, Victor; Rodriguez-Berna, Guillermo; Schwartz, Simo Jr et al.
DOI: 10.1021/ml400125z

Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina.

PMID: 24124326
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2013
Reference: World J Gastroenterol. 2013 Sep 21;19(35):5813-27. doi: 10.3748/wjg.v19.i35.5813.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Camos, Silvia; Casillas, Rosario; Cubero, Maria; del Pino, Noemi; Esteban, Juan Ignacio; Esteban, Rafael; Garcia-Cehic, Damir; Gregori, Josep; Guardia, Jaume et al.
DOI: 10.3748/wjg.v19.i35.5813

Identification and biochemical characterization of the novel mutation m.8839G>C in the mitochondrial ATP6 gene associated with NARP syndrome.

PMID: 24118886
Journal: GENES BRAIN AND BEHAVIOR
Year: 2013
Reference: Genes Brain Behav. 2013 Nov;12(8):812-20. doi: 10.1111/gbb.12089. Epub 2013 Oct 25.
Impact factor:
Publication type: Paper in international publication
Authors: Andreu, Antoni L; Blanco-Grau, Albert; Bonaventura-Ibars, Inmaculada; Coll-Canti, Jaume; Garcia-Arumi, Elena; Martinez, Ramiro; Martinez-Gallo, Monica; Melia, Maria Jesus; Pinos, Tomas et al.
DOI: 10.1111/gbb.12089

Quasispecies dynamics in main core epitopes of hepatitis B virus by ultra-deep-pyrosequencing.

PMID: 23155338
Journal: WORLD JOURNAL OF GASTROENTEROLOGY
Year: 2012
Reference: World J Gastroenterol. 2012 Nov 14;18(42):6096-105. doi: 10.3748/wjg.v18.i42.6096.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Corral, Noelia; Esteban, Rafael; Homs, Maria; Quer, Josep; Rodriguez-Frias, Francisco; Sanchez, Alex; Tabernero, David et al.
DOI: 10.3748/wjg.v18.i42.6096

alpha1-Antitrypsin in Fibromyalgia: Results of a Randomized, Placebo-Controlled, Double-Blind and Crossover Pilot Trial.

PMID: 22190533
Journal: Musculoskeletal care
Year: 2012
Reference: Musculoskeletal Care. 2012 Sep;10(3):178-83. doi: 10.1002/msc.1000. Epub 2011 Dec 22.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.1002/msc.1000

Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target

PMID: 23095742
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2012
Reference: J Biol Chem. 2012 Dec 21;287(52):43472-81. doi: 10.1074/jbc.M112.428466. Epub 2012 Oct 24.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Arango, Diego; Ariza, Aurelio; Armengol, Manel; Castano, Julio; Davalos, Veronica; Espin, Eloy; Fernandez, Yolanda; Guerra-Moreno, Angel; Messent, Anthea et al.
DOI: 10.1074/jbc.M112.428466

Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino Acid changes in the hepatitis B virus genome.

PMID: 22666402
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(5):e37874. doi: 10.1371/journal.pone.0037874. Epub 2012 May 30.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Camos, Silvia; Cubero, Maria; Domingo, Esteban; Esteban, Juan I; Esteban, Rafael; Ferrer-Costa, Carles; Garcia-Cehic, Damir; Guardia, Jaume; Homs, Maria et al.
DOI: 10.1371/journal.pone.0037874

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins.

PMID: 22077971
Journal: AMERICAN JOURNAL OF HUMAN GENETICS
Year: 2011
Reference: Am J Hum Genet. 2011 Nov 11;89(5):656-67.
Impact factor:
Publication type: Paper in international publication
Authors: Arranz, Jose Antonio; Briones, Paz; Campistol, Jaume; Del Toro, Mireia; Elpeleg, Orly; Font, Aida; Garcia-Cazorla, Angels; Garcia-Villoria, Judit; Gutierrez-Solana, Luis Gonzalez; Labayru, M Teresa et al.
DOI: 10.1016/j.ajhg.2011.10.005

Cancer, Senescence, and Aging: Translation from Basic Research to Clinics.

PMID: 22046529
Journal: Journal of aging research
Year: 2011
Reference: J Aging Res. 2011;2011:692301. Epub 2011 Oct 20.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.4061/2011/692301

KAP Degradation by Calpain Is Associated with CK2 Phosphorylation and Provides a Novel Mechanism for Cyclosporine A-Induced Proximal Tubule Injury.

PMID: 21980535
Journal: PLoS One
Year: 2011
Reference: PLoS One. 2011;6(9):e25746. Epub 2011 Sep 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bardaji, Beatriz; Itarte, Emilio; Lopez-Hellin, Joan; Meseguer, Anna; Montero, M Angeles; Pascual, Gloria; Plana, Maria; Salcedo, M Teresa; Sarro, Eduard; Tornavaca, Olga et al.
DOI: 10.1371/journal.pone.0025746

Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome.

PMID: 21742757
Journal: NUCLEIC ACIDS RESEARCH
Year: 2011
Reference: Nucleic Acids Res. 2011 Oct;39(19):8457-71. Epub 2011 Jul 8.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1093/nar/gkr451

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

PMID: 20371676
Journal: CLINICAL CANCER RESEARCH
Year: 2010
Reference: Clin Cancer Res. 2010 Apr 15;16(8):2375-82. Epub 2010 Apr 6.
Impact factor:
Publication type: Paper in international publication
Authors: Arango, Diego; Armengol, Manel; Bazzocco, Sarah; Carreras, Maria Josep; Dopeso, Higinio; Elez, Elena; Espin, Eloy; Hernandez-Losa, Javier; Landolfi, Stefania; Mariadason, John M et al.
DOI: 10.1158/1078-0432.CCR-09-3275

Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis.

PMID: 20890898
Journal: HEPATOLOGY
Year: 2010
Reference: Hepatology. 2010 Dec;52(6):2077-85. doi: 10.1002/hep.23938. Epub 2010 Oct 1.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1002/hep.23938

Regulation of Aurora B kinase by the lipid raft protein Flotillin-1.

PMID: 20430883
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2010
Reference: J Biol Chem. 2010 Jul 2;285(27):20683-90. Epub 2010 Apr 29.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1074/jbc.M110.130591

Laboratory testing of individuals with severe alpha1-antitrypsin deficiency in three European centres.

PMID: 20436173
Journal: EUROPEAN RESPIRATORY JOURNAL
Year: 2010
Reference: Eur Respir J. 2010 May;35(5):960-8.
Impact factor:
Publication type: Paper in international publication
Authors: Bals, R; Ferrarotti, I; Herr, C; Jardi, R; Luisetti, M; Miravitlles, M; Rodriguez-Frias, F et al.
DOI: 10.1183/09031936.00069709

TRPC6 mutational analysis in a large cohort of patients with focal segmental glomerulosclerosis.

PMID: 19458060
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2009
Reference: Nephrol Dial Transplant. 2009 Oct;24(10):3089-96.
Impact factor:
Publication type: Paper in international publication
Authors: Alexandra, Simona; Aparicio, Cristina; Ars, Elisabet; Ballarin, Jose; Bernis, Carmen; Camacho, Juan Antonio; Caramelo, Carlos; Cobo, M Angeles; Cots, Jorge Vila; Daza, Antonio Maria et al.
DOI: 10.1093/ndt/gfp229

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.

PMID: 19208682
Journal: GENOME RESEARCH
Year: 2009
Reference: Genome Res. 2009 Mar;19(3):438-51.
Impact factor:
Publication type: Paper in international publication
Authors: Acquadro, Francesco; Allende, Helena; Ballestar, Esteban; Bosch, Francesc X; Buti, Maria; Cahir-McFarland, Ellen; Capella, Gabriel; Capello, Daniela; Carmona, Francisco J; Castellsague, Xavier et al.
DOI: 10.1101/gr.083550.108

A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression.

PMID: 19398921
Journal: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Year: 2009
Reference: J Acquir Immune Defic Syndr. 2009 Jul 1;51(3):290-7.
Impact factor:
Publication type: Paper in international publication
Authors: Agell, Helena; Anton, Esperanza; Aponte, John J; Arnaiz, Joan A; Arnedo, Mireia; Arranz, Jose A; Arribas, Jose R; Barragan, Patricia; Barrufet, Pilar; Berenguer, Juan et al.
DOI: 10.1097/QAI.0b013e3181aa12d5

Differential proteomic analysis of cyclosporine A-induced toxicity in renal proximal tubule cells.

PMID: 19369687
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2009
Reference: Nephrol Dial Transplant. 2009 Sep;24(9):2672-86.
Impact factor:
Publication type: Paper in international publication
Authors: Camano, Sonia; Lopez-Hellin, Joan; Meseguer, Anna; Puigmule, Marta; Sune, Guillermo; Tejedor, Alberto; Tornavaca, Olga et al.
DOI: 10.1093/ndt/gfp149

Blog

News

Based on the study led by VHIR, a clinical trial has been approved for patients with locally advanced pancreatic cancer.

Vall d'Hebron participates in a project to develop innovative microsampling technology, making blood collection more accessible and patient-centered.

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.