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Infectious Diseases

The VHIR Infectious Diseases research group is made up of medical professionals, with healthcare and clinical or basic translational research activities; of Biomedicine dedicated to basic research; and Nursing, with activities to support clinical research.

The group's lines of research are mainly focused on four areas:

Infections related to immunosuppression. Includes infectious diseases related to immunocompromised patients, solid organ or hematopoietic stem cell transplant recipients and recipients of biological therapies.

Sexually transmitted diseases, including HIV infection and other highly prevalent infections in our country (syphilis, gonorrhea, lymphogranuloma venere or infections caused by the human papillomavirus).

Infections related to health care, with special emphasis on those difficult to treat (cardiovascular infections or infections related to prosthetic materials) or caused by multi-resistant pathogens (MDRO) or affecting vulnerable populations.

Global Health and Tropical Diseases with special emphasis on prevalent diseases in our environment that affect the immigrant or displaced population.

Publications

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells.

PMID: 35025963
Journal: PLoS Pathogens
Year: 2022
Reference: PLoS Pathog. 2022 Jan 13;18(1):e1010171. doi: 10.1371/journal.ppat.1010171. eCollection 2022 Jan.
Impact factor: 6.823
Publication type: Paper in international publication
Authors: Grau-Exposito, Judith, Perea, David, Suppi, Marina, Massana, Nuria, Vergara, Ander, Soler, Maria Jose, Trinite, Benjamin, Blanco, Julia, Garcia-Perez, Javier, Alcami, Jose et al.
DOI: 10.1371/journal.ppat.1010171

Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain.

PMID: 35018339
Journal: Journal of Epidemiology and Global Health
Year: 2022
Reference: Glob Epidemiol. 2022 Jan 7:100071. doi: 10.1016/j.gloepi.2022.100071.
Impact factor: 1.719
Publication type: Paper in international publication
Authors: Gudiol, Carlota, Moreno, Anna Maria, Morales-Rull, Jose Luis, Rexach, Maria, Sabater, Gladis, Auguet, Teresa, Vidal, Francesc, Lerida, Ana, Rebull, Josep, Khunti, Kamlesh et al.
DOI: 10.1016/j.gloepi.2022.100071

"Moving Fourth": Introduction of a practical toolkit for shared decision-making to facilitate healthy living beyond HIV viral suppression.

PMID: 34077406
Journal: AIDS REVIEWS
Year: 2021
Reference: AIDS Rev. 2021 Dec 29;23(4):204-213. doi: 10.24875/AIDSRev.20000130.
Impact factor: 2.5
Publication type: Paper in international publication
Authors: Curran, Adrian, Arends, Joop, Buhk, Thomas, Cascio, Mario, Teofilo, Eugenio, van den Berk, Guido, Guaraldi, Giovanni et al.
DOI: 10.24875/AIDSRev.20000130

Peripheral and lung resident memory T cell responses against SARS-CoV-2.

PMID: 34021148
Journal: Nature Communications
Year: 2021
Reference: Nat Commun. 2021 May 21;12(1):3010. doi: 10.1038/s41467-021-23333-3.
Impact factor: 14.919
Publication type: Paper in international publication
Authors: Perea, David, Rosado, Joel, Falco, Anna, Kirkegaard, Cristina, Torrella, Ariadna, Planas, Bibiana, Navarro, Jordi, Suanzes, Paula, Alvarez-Sierra, Daniel, Ayora, Alfonso et al.
DOI: 10.1038/s41467-021-23333-3

Low frequency of cytomegalovirus (CMV) disease despite high prevalence of CMV viraemia in patients with advanced HIV infection: a clinical and immunological 48-week follow-up study.

PMID: 33998115
Journal: HIV MEDICINE
Year: 2021
Reference: HIV Med. 2021 Sep;22(8):682-689. doi: 10.1111/hiv.13115. Epub 2021 May 17.
Impact factor: 3.18
Publication type: Paper in international publication
Authors: Garcia, J N, Albasanz-Puig, A, Suanzes, P, Esperalba, J, Fernandez, C, Sellares-Nadal, J, Torrella, A, Planas, B, Segura, A, Burgos, J et al.
DOI: 10.1111/hiv.13115

Digital technology for anaphylaxis management impact on patient behaviour. A randomised clinical Trial.

PMID: 33043475
Journal: ALLERGY
Year: 2021
Reference: Allergy. 2021 May;76(5):1507-1516. doi: 10.1111/all.14626. Epub 2020 Nov 4.
Impact factor: 13.146
Publication type: Paper in international publication
Authors: Galvan-Blasco, Paula, Sala-Cunill, Anna, Luengo, Olga, Curran, Adrian, Moreno, Nuria, Labrador-Horrillo, Moises, Guilarte, Mar, Gonzalez-Medina, Monica, Victoria, Cardona et al.
DOI: 10.1111/all.14626

An overview of ceftolozane sulfate + tazobactam for treating hospital acquired pneumonia.

PMID: 32212866
Journal: EXPERT OPINION ON PHARMACOTHERAPY
Year: 2020
Reference: Expert Opin Pharmacother. 2020 Jun;21(9):1005-1013. doi: 10.1080/14656566.2020.1739269. Epub 2020 Mar 26.
Impact factor: 2.878
Publication type: Paper in international publication
Authors: Los-Arcos, Ibai, Burgos, Joaquin, Falco, Vicenc, Almirante, Benito et al.
DOI: 10.1080/14656566.2020.1739269

Genetic polymorphisms of IL17A associated with Chagas disease: results from a meta-analysis in Latin American populations.

PMID: 32193469
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Mar 19;10(1):5015. doi: 10.1038/s41598-020-61965-5.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Palma-Vega, Miriam, Casares-Marfil, Desire, Bosch-Nicolau, Pau, Lo Presti, Maria Silvina, Molina, Israel, Gonzalez, Clara Isabel, Martin, Javier, Acosta-Herrera, Marialbert, Paglini, Patricia A, Schijman, Alejandro G et al.
DOI: 10.1038/s41598-020-61965-5

Imported Arbovirus Infections in Spain, 2009-2018.

PMID: 32186486
Journal: EMERGING INFECTIOUS DISEASES
Year: 2020
Reference: Emerg Infect Dis. 2020 Apr;26(4):658-666. doi: 10.3201/eid2604.190443.
Impact factor: 6.259
Publication type: Paper in international publication
Authors: Norman, Francesca F, Henriquez-Camacho, Cesar, Diaz-Menendez, Marta, Chamorro, Sandra, Pou, Diana, Molina, Israel, Goikoetxea, Josune, Rodriguez-Guardado, Azucena, Calabuig, Eva, Crespillo, Clara et al.
DOI: 10.3201/eid2604.190443

Primary genital lymphogranuloma venereum in the HIV pre-exposure prophylaxis era.

PMID: 32181529
Journal: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Year: 2020
Reference: J Eur Acad Dermatol Venereol. 2020 Aug;34(8):e427-e429. doi: 10.1111/jdv.16374. Epub 2020 Apr 30.
Impact factor: 5.248
Publication type: Letter or abstract
Authors: Arandes-Marcocci, J, Collgros, H, Serra-Pladevall, J, Vall-Mayans, M et al.
DOI: 10.1111/jdv.16374

Lung transplantation in two cystic fibrosis patients infected with previously pandrug-resistant Burkholderia cepacia complex treated with ceftazidime-avibactam.

PMID: 30565008
Journal: INFECTION
Year: 2019
Reference: Infection. 2019 Apr;47(2):289-292. doi: 10.1007/s15010-018-1261-y. Epub 2018 Dec 19.
Impact factor: 2.927
Publication type: Paper in international publication
Authors: Roman, Antonio, Los-Arcos, Ibai, Len, Oscar, Martin-Gomez, Maria Teresa, Gonzalez-Lopez, Juan Jose, Saez-Gimenez, Berta, Deu, Maria, Nuvials, Xavier, Ferrer, Ricard, Gavalda, Joan et al.
DOI: 10.1007/s15010-018-1261-y

Corrigendum to "Multidrug-resistant and extensively drug-resistant Gram-negative prosthetic joint infections: Role of surgery and impact of colistin administration" [International Journal of Antimicrobial Agents 53(3) (2019) 294-301].

PMID: 30910479
Journal: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Year: 2019
Reference: Int J Antimicrob Agents. 2019 Apr;53(4):538-539. doi: 10.1016/j.ijantimicag.2019.03.005. Epub 2019 Mar 23.
Impact factor: 4.615
Publication type: Letter or abstract
Authors: Papagelopoulos, Panayiotis J, Rodriguez-Pardo, Dolors, Bonnet, Eric, JoseSalles, Mauro, Dolores Del Toro, Maria, Nguyen, Sophie, Blanco-Garcia, Antonio, Skaliczki, Gabor, Soriano, Alejandro, Benito, Natividad et al.
DOI: 10.1016/j.ijantimicag.2019.03.005

Simplification of Antiretroviral Treatment from Darunavir/Ritonavir Monotherapy to Darunavir/Cobicistat Monotherapy: Effectiveness and Safety in Routine Clinical Practice.

PMID: 30909716
Journal: AIDS RESEARCH AND HUMAN RETROVIRUSES
Year: 2019
Reference: AIDS Res Hum Retroviruses. 2019 Jun;35(6):513-518. doi: 10.1089/AID.2018.0178. Epub 2019 May 8.
Impact factor: 1.805
Publication type: Paper in international publication
Authors: Molto, Jose, Paredes, Roger, Perez-Alvarez, Nuria, Santos, Jose Ramon, Curran, Adrian, Navarro-Mercade, Jordi, Ampuero, Mario F, Pelaez, Pablo, Clotet, Bonaventura et al.
DOI: 10.1089/AID.2018.0178

Acute spinal implant infection treated with debridement: does extended antibiotic treatment improve the prognosis?

PMID: 30904996
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2019
Reference: Eur J Clin Microbiol Infect Dis. 2019 May;38(5):951-958. doi: 10.1007/s10096-019-03537-8. Epub 2019 Mar 23.
Impact factor: 2.591
Publication type: Paper in international publication
Authors: Bosch-Nicolau, Pau, Rodriguez-Pardo, Dolors, Pigrau, Carles, Pellise, Ferran, Haddad, Sleiman, Lung, Mayli, Almirante, Benito et al.
DOI: 10.1007/s10096-019-03537-8

Clinical efficacy of beta-lactam/beta-lactamase inhibitor combinations for the treatment of bloodstream infection due to extended-spectrum beta-lactamase-producing Enterobacteriaceae in haematological patients with neutropaenia: a study protocol for a retrospective observational study (BICAR).

PMID: 28115333
Journal: BMJ Open
Year: 2017
Reference: BMJ Open. 2017 Jan 23;7(1):e013268. doi: 10.1136/bmjopen-2016-013268.
Impact factor: 2.369
Publication type: Paper in international publication
Authors: Gudiol, C, Royo-Cebrecos, C, Tebe, C, Abdala, E, Akova, M, Alvarez, R, Maestro-de la Calle, G, Cano, A, Cervera, C, Clemente, W T et al.
DOI: 10.1136/bmjopen-2016-013268

Reply to "Activity of Fosfomycin on Clinical Isolates of Campylobacter jejuni and Campylobacter coli of Enteric Origin".

PMID: 28119318
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2017
Reference: Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e02448-16. doi: 10.1128/AAC.02448-16. Print 2017 Feb.
Impact factor: 4.302
Publication type: Paper in international publication
Authors: Aguilar-Company, Juan, Los-Arcos, Ibai, Pigrau, Carlos, Almirante, Benito et al.
DOI: 10.1128/AAC.02448-16

MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae.

PMID: 28093484
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2017
Reference: J Antimicrob Chemother. 2017 May 1;72(5):1478-1487. doi: 10.1093/jac/dkw562.
Impact factor: 5.071
Publication type: Paper in international publication
Authors: Martinez-Martinez, Luis, Canton, Rafael, Antonio Lepe, Jose, Causse, Manuel, Gutierrez-Gutierrez, Belen, Pascual, Alvaro, Rodriguez-Bano, Jesus, Bou, German, Sanz, Mercedes, Gurgui, Mercedes et al.
DOI: 10.1093/jac/dkw562

Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extended-spectrum-beta-lactamase-producing Enterobacteriaceae.

PMID: 28062685
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2017
Reference: J Antimicrob Chemother. 2017 Mar 1;72(3):906-913. doi: 10.1093/jac/dkw513.
Impact factor: 5.071
Publication type: Paper in international publication
Authors: Tumbarello, Mario, Tacconelli, Evelina, Origuen, Julia, Prim, Nuria, Bou, German, Giamarellou, Helen, Bermejo, Joaquin, Hamprecht, Axel, Perez, Federico, Almela, Manuel et al.
DOI: 10.1093/jac/dkw513

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

Vall d'Hebron has coordinated this initiative that has carried out numerous training and community awareness activities aimed at empowering young people in sexual and reproductive health issues.