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Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Publications

Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit.

PMID: 35739187
Journal: Communications Biology
Year: 2022
Reference: Commun Biol. 2022 Jun 23;5(1):620. doi: 10.1038/s42003-022-03568-6.
Impact factor: 6.268
Publication type: Paper in international publication
Authors: Molina-Granada, David; Gonzalez-Vioque, Emiliano; Dibley, Marris G; Cabrera-Perez, Raquel; Vallbona-Garcia, Antoni; Torres-Torronteras, Javier; Sazanov, Leonid A; Ryan, Michael T; Camara, Yolanda; Marti, Ramon et al.
DOI: 10.1038/s42003-022-03568-6

Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies.

PMID: 35830540
Journal: Stem Cells Translational Medicine
Year: 2022
Reference: Stem Cells Transl Med. 2022 Jul 13. pii: 6643345. doi: 10.1093/stcltm/szac046.
Impact factor: 6.94
Publication type: Paper in international publication
Authors: Vives, Joaquim, Sanchez-Pernaute, Rosario, Torrents, Silvia, Lopez-Navas, Luis et al.
DOI: 10.1093/stcltm/szac046

The Quality Management Ecosystem in Cell Therapy in Catalonia (Spain): An Opportunity for Integrating Standards and Streamlining Quality Compliance.

PMID: 35805196
Journal: Cells
Year: 2022
Reference: Cells. 2022 Jul 5;11(13). pii: cells11132112. doi: 10.3390/cells11132112.
Impact factor: 6.6
Publication type: Paper in international publication
Authors: Soria, Maria Gloria, McGrath, Eoin, Magri, Mara, Vives, Joaquim et al.
DOI: 10.3390/cells11132112

Comparison of three different minimally invasive intramedullary screw for proximal phalanx fractures. A biomechanical study.

PMID: 35709951
Journal: Revista espanola de cirugia ortopedica y traumatol
Year: 2022
Reference: Rev Esp Cir Ortop Traumatol. 2022 Jun 13. pii: S1888-4415(22)00150-3. doi: 10.1016/j.recot.2022.06.004.
Impact factor: 0
Publication type: Paper in national publication
Authors: Sevil-Mayayo, Raquel, Gallardo-Calero, Irene, Lluch-Bergada, Alex, Vidal-Tarrason, Nuria, Esteban-Feliu, Ignacio, Rodriguez-Baeza, Alfonso et al.
DOI: 10.1016/j.recot.2022.06.004

Wharton's Jelly Mesenchymal Stromal Cells and Derived Extracellular Vesicles as Post-Myocardial Infarction Therapeutic Toolkit: An Experienced View.

PMID: 34575412
Journal: Pharmaceutics
Year: 2021
Reference: Pharmaceutics. 2021 Aug 26;13(9). pii: pharmaceutics13091336. doi: 10.3390/pharmaceutics13091336.
Impact factor: 6.321
Publication type: Review in international publication
Authors: Munoz-Dominguez, Noelia, Roura, Santiago, Prat-Vidal, Cristina, Vives, Joaquim et al.
DOI: 10.3390/pharmaceutics13091336

Correction to: Uniplanar versus biplanar monolateral external fixator knee arthrodesis after end-stage failed infected total knee arthroplasty: a comparative study.

PMID: 34402988
Journal: European journal of orthopaedic surgery & traumato
Year: 2021
Reference: Eur J Orthop Surg Traumatol. 2021 Oct;31(7):1545. doi: 10.1007/s00590-021-03090-1.
Impact factor: 0
Publication type: Letter or abstract
Authors: Jurado Ruiz, Maria, Scott-Tennent, Ana, Fraile, Rosa, Carrera, Luis, Vicente, Matias, Corona, Pablo S et al.
DOI: 10.1007/s00590-021-03090-1

Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study.

PMID: 32981857
Journal: CYTOTHERAPY
Year: 2021
Reference: Cytotherapy. 2021 Feb;23(2):146-156. doi: 10.1016/j.jcyt.2020.08.008. Epub 2020 Sep 25.
Impact factor: 5.414
Publication type: Paper in international publication
Authors: Albu, Sergiu, Kumru, Hatice, Coll, Ruth, Vives, Joaquim, Valles, Margarita, Benito-Penalva, Jesus, Rodriguez, Luciano, Codinach, Margarita, Hernandez, Joaquim, Navarro, Xavier et al.
DOI: 10.1016/j.jcyt.2020.08.008

Towards the standardization of methods of tissue processing for the isolation of mesenchymal stromal cells for clinical use.

PMID: 33994662
Journal: CYTOTECHNOLOGY
Year: 2021
Reference: Cytotechnology. 2021 May 10;73(3):1-10. doi: 10.1007/s10616-021-00474-3.
Impact factor: 2.058
Publication type: Paper in international publication
Authors: Garcia-Munoz, Elisabeth, Vives, Joaquim et al.
DOI: 10.1007/s10616-021-00474-3

Strategies for large-scale expansion of clinical-grade human multipotent mesenchymal stromal cells

PMID: NOPMID0085
Journal: BIOCHEMICAL ENGINEERING JOURNAL
Year: 2020
Reference: Biochemical Engineering Journal. 2020 Jul;159:107601. doi: 10.1016/j.bej.2020.107601
Impact factor: 3.475
Publication type: Review in international publication
Authors: García-Fernández, Coral, López-Fernández, Alba, Borrós, Salvador, Lecina, Martí, Vives, Joaquim et al.
DOI: 10.1016/j.bej.2020.107601

Should we employ preoperative templating in hip hemiarthroplasty after femoral neck fracture? A nested case-control study.

PMID: 33074739
Journal: Hip International
Year: 2020
Reference: Hip Int. 2020 Oct 19:1120700020964776. doi: 10.1177/1120700020964776.
Impact factor: 1.349
Publication type: Paper in international publication
Authors: Pujol, Oriol, Carrasco, Maria G, Vicente, Matias, Mimendia, Inaki, Garcia, Yaiza, Selga, Jordi, Barro, Victor et al.
DOI: 10.1177/1120700020964776

Randomized clinical trial: expanded autologous bone marrow mesenchymal cells combined with allogeneic bone tissue, compared with autologous iliac crest graft in lumbar fusion surgery.

PMID: 32730985
Journal: Spine Journal
Year: 2020
Reference: Spine J. 2020 Jul 28. pii: S1529-9430(20)31003-2. doi: 10.1016/j.spinee.2020.07.014.
Impact factor: 3.191
Publication type: Paper in international publication
Authors: Garcia de Frutos, Ana, Gonzalez-Tartiere, Pilar, Coll Bonet, Ruth, Ubierna Garces, Maria Teresa, Del Arco Churruca, Alejandro, Rivas Garcia, Antoni, Matamalas Adrover, Antonia, Salo Bru, Guillem, Velazquez, Juan Jose, Vila-Canet, Gemma et al.
DOI: 10.1016/j.spinee.2020.07.014

Evaluation of a cell-based osteogenic formulation compliant with good manufacturing practice for use in tissue engineering.

PMID: 32562174
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2020
Reference: Mol Biol Rep. 2020 Jul;47(7):5145-5154. doi: 10.1007/s11033-020-05588-z. Epub 2020 Jun 19.
Impact factor: 1.402
Publication type: Paper in international publication
Authors: Vivas, Daniel, Grau-Vorster, Marta, Oliver-Vila, Irene, Garcia-Lopez, Joan, Vives, Joaquim et al.
DOI: 10.1007/s11033-020-05588-z

Prevalence and Clinical Features of Mazabraud Syndrome: A Multicenter European Study.

PMID: 30653046
Journal: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
Year: 2019
Reference: J Bone Joint Surg Am. 2019 Jan 16;101(2):160-168. doi: 10.2106/JBJS.18.00062.
Impact factor:
Publication type: Paper in international publication
Authors: Appelman-Dijkstra, Natasha M; Bovee, Judith V M G; Dijkstra, Sander P D; Hamdy, Neveen A T; Jutte, Paul C; Leithner, Andreas; Majoor, Bas C J; Perlaky, Tamas; Staals, Eric L; van de Sande, Michiel A J et al.
DOI: 10.2106/JBJS.18.00062

Levels of IL-17F and IL-33 correlate with HLA-DR activation in clinical-grade human bone marrow-derived multipotent mesenchymal stromal cell expansion cultures.

PMID: 30447901
Journal: CYTOTHERAPY
Year: 2019
Reference: Cytotherapy. 2019 Jan;21(1):32-40. doi: 10.1016/j.jcyt.2018.09.009. Epub 2018 Nov 15.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco, Margarita; Codinach, Margarita; Garcia-Lopez, Joan; Grau-Vorster, Marta; Oliver-Vila, Irene; Rodriguez, Luciano; Torrents-Zapata, Silvia; Vivas, Daniel; Vives, Joaquim et al.
DOI: 10.1016/j.jcyt.2018.09.009

Osteogenic commitment of Wharton's jelly mesenchymal stromal cells: mechanisms and implications for bioprocess development and clinical application.

PMID: 31779673
Journal: Stem Cell Research & Therapy
Year: 2019
Reference: Stem Cell Res Ther. 2019 Nov 28;10(1):356. doi: 10.1186/s13287-019-1450-3.
Impact factor: 4.627
Publication type: Paper in international publication
Authors: Cabrera-Perez, Raquel, Monguio-Tortajada, Marta, Gamez-Valero, Ana, Rojas-Marquez, Raquel, Borras, Francesc Enric, Roura, Santiago, Vives, Joaquim et al.
DOI: 10.1186/s13287-019-1450-3

HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study.

PMID: 31196185
Journal: Stem Cell Research & Therapy
Year: 2019
Reference: Stem Cell Res Ther. 2019 Jun 13;10(1):164. doi: 10.1186/s13287-019-1279-9.
Impact factor: 4.627
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta, Laitinen, Anita, Nystedt, Johanna, Vives, Joaquim et al.
DOI: 10.1186/s13287-019-1279-9

Triple elastofibromas located in the supra- and infrascapular regions-a case report.

PMID: 29170811
Journal: SKELETAL RADIOLOGY
Year: 2018
Reference: Skeletal Radiol. 2018 Apr;47(4):569-573. doi: 10.1007/s00256-017-2813-4. Epub 2017 Nov 23.
Impact factor: 1.737
Publication type: Paper in international publication
Authors: Olchowy, Cyprian, de Delas-Vigo, Matias de Albert, Perez, Manolo, Ciriaco, Nikaoly, Oronoz, Rosa Dominguez et al.
DOI: 10.1007/s00256-017-2813-4

TRest as a New Diagnostic Variable for Chronic Exertional Compartment Syndrome of the Forearm: A Prospective Cohort Analysis of 124 Athletes.

PMID: 28817409
Journal: CLINICAL JOURNAL OF SPORT MEDICINE
Year: 2018
Reference: Clin J Sport Med. 2018 Nov;28(6):516-523. doi: 10.1097/JSM.0000000000000482.
Impact factor: 2.189
Publication type: Paper in international publication
Authors: Campillo-Recio, David, Mir-Bullo, Xavier, Soldado, Francisco, Sallent, Andrea, Haddad, Sleiman, Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Correa-Vazquez, Eva et al.
DOI: 10.1097/JSM.0000000000000482

Septic Nonunion Caused by Mycobacterium canariasense: A Case Report.

PMID: 30431479
Journal: JBJS case connector
Year: 2018
Reference: JBJS Case Connect. 2018 Oct-Dec;8(4):e90. doi: 10.2106/JBJS.CC.18.00033.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vicente, Matias, Lung, Mayli, Gulin, Carlos, Tortola, Maria Teresa, Corona, Pablo S et al.
DOI: 10.2106/JBJS.CC.18.00033

Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products.

PMID: 30355298
Journal: Journal of Translational Medicine
Year: 2018
Reference: J Transl Med. 2018 Oct 24;16(1):291. doi: 10.1186/s12967-018-1659-4.
Impact factor: 4.197
Publication type: Paper in international publication
Authors: Vives, Joaquim, Godia, Francesc, Morton, Philip, Reyes, Blanca, Del Mazo-Barbara, Anna, Mirabel, Clementine, Puente-Massaguer, Eduard et al.
DOI: 10.1186/s12967-018-1659-4

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