Skip to main content

Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Publications

Should we employ preoperative templating in hip hemiarthroplasty after femoral neck fracture? A nested case-control study.

PMID: 33074739
Journal: Hip International
Year: 2022
Reference: Hip Int. 2022 Jul;32(4):537-542. doi: 10.1177/1120700020964776. Epub 2020 Oct 19.
Impact factor: 1.349
Publication type: Paper in international publication
Authors: Barro, Victor, Selga, Jordi, Garcia, Yaiza, Mimendia, Inaki, Vicente, Matias, Carrasco, Maria G, Pujol, Oriol et al.
DOI: 10.1177/1120700020964776

Two-stage strategy in end-stage hip periprosthetic joint infection: utility of industrially prefabricated custom-made antibiotic spacers.

PMID: 35438009
Journal: Hip International
Year: 2022
Reference: Hip Int. 2022 Apr 19:11207000221075356. doi: 10.1177/11207000221075356.
Impact factor: 2.135
Publication type: Paper in international publication
Authors: Vilar, Inca, Soriano, Rosa Fraile, Capo, Irina, Corona, Pablo S, Vicente, Matias et al.
DOI: 10.1177/11207000221075356

Spectrum of Soft-Tissue Lesions of the Finger.

PMID: 35302866
Journal: RADIOGRAPHICS
Year: 2022
Reference: Radiographics. 2022 May-Jun;42(3):E96-E97. doi: 10.1148/rg.210047. Epub 2022 Mar 18.
Impact factor: 5.333
Publication type: Paper in international publication
Authors: Gimeno Cajal, Alfredo, de Albert Delas, Matias, Torrents Odin, Carme, Casas Gomila, Lourdes, Ochoa Sambrizzi, Nicolas, Ramos-Oliver, Irma, Lluch Bergada, Alex, Dominguez Oronoz, Rosa, Veintemillas Araiz, M Teresa, Anton-Jimenez, Alba et al.
DOI: 10.1148/rg.210047

Use of Multipotent Mesenchymal Stromal Cells, Fibrin, and Scaffolds in the Production of Clinical Grade Bone Tissue Engineering Products.

PMID: 32705544
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2021
Reference: Methods Mol Biol. 2021;2286:251-261. doi: 10.1007/7651_2020_280.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vives, Joaquim, Rodriguez, Luciano, Coca, Maria Isabel, Reales, Laura, Cabrera-Perez, Raquel, Martorell, Lluis et al.
DOI: 10.1007/7651_2020_280

Reconstruction of infected post-traumatic bone defects of the distal femur with the Compress() implant. Preliminary results of a staged non-biological strategy.

PMID: 33066985
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2021
Reference: Injury. 2021 Mar;52(3):606-615. doi: 10.1016/j.injury.2020.10.016. Epub 2020 Oct 6.
Impact factor: 2.586
Publication type: Paper in international publication
Authors: Corona, Pablo S, Altayo, Marta, Amat, Carles, Vicente, Matias, Velez, Roberto et al.
DOI: 10.1016/j.injury.2020.10.016

Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord.

PMID: 32914860
Journal: HISTOLOGY AND HISTOPATHOLOGY
Year: 2021
Reference: Histol Histopathol. 2021 Jan;36(1):19-30. doi: 10.14670/HH-18-249. Epub 2020 Sep 11.
Impact factor: 2.303
Publication type: Review in international publication
Authors: Ramallo, Melina, Carreras-Sanchez, Irene, Lopez-Fernandez, Alba, Velez, Roberto, Aguirre, Marius, Feldman, Sara, Vives, Joaquim et al.
DOI: 10.14670/HH-18-249

Transitioning From Preclinical Evidence to Advanced Therapy Medicinal Product: A Spanish Experience.

PMID: 33614746
Journal: Frontiers in Cardiovascular Medicine
Year: 2021
Reference: Front Cardiovasc Med. 2021 Feb 4;8:604434. doi: 10.3389/fcvm.2021.604434. eCollection 2021.
Impact factor: 6.05
Publication type: Paper in international publication
Authors: Gastelurrutia, Paloma, Prat-Vidal, Cristina, Vives, Joaquim, Coll, Ruth, Bayes-Genis, Antoni, Galvez-Monton, Carolina et al.
DOI: 10.3389/fcvm.2021.604434

Core Decompression Combined with Implantation of Autologous Bone Marrow Concentrate with Tricalcium Phosphate Does Not Prevent Radiographic Progression in Early Stage Osteonecrosis of the Hip.

PMID: 32489535
Journal: Clinics in orthopedic surgery
Year: 2020
Reference: Clin Orthop Surg. 2020 Jun;12(2):151-157. doi: 10.4055/cios19033. Epub 2020 May 6.
Impact factor: 0
Publication type: Paper in international publication
Authors: Hernandez, Alejandro, Nunez, Jorge H, Sallent, Andrea, Gargallo-Margarit, Albert, Gallardo-Calero, Irene, Barro, Victor et al.
DOI: 10.4055/cios19033

A Case Series of X-Linked Deafness-2 with Sensorineural Hearing Loss, Stapes Fixation, and Perilymphatic Gusher: MR Imaging and Clinical Features of Hypothalamic Malformations.

PMID: 32409310
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: AJNR Am J Neuroradiol. 2020 Jun;41(6):1087-1093. doi: 10.3174/ajnr.A6541. Epub 2020 May 14.
Impact factor: 3.381
Publication type: Paper in international publication
Authors: Prat Matifoll, J-A, Wilson, M, Goetti, R, Birman, C, Bennett, B, Peadon, E, Prats-Uribe, A, Prelog, K et al.
DOI: 10.3174/ajnr.A6541

First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft.

PMID: 32304998
Journal: EBioMedicine
Year: 2020
Reference: EBioMedicine. 2020 Apr;54:102729. doi: 10.1016/j.ebiom.2020.102729. Epub 2020 Apr 15.
Impact factor: 5.736
Publication type: Paper in international publication
Authors: Coca, Maria Isabel, Reales, Laura, Camara-Rosell, Maria Luisa, Cediel, German, Coll, Ruth, Farre, Ramon, Navajas, Daniel, Vilarrodona, Anna, Garcia-Lopez, Joan, Munoz-Guijosa, Christian et al.
DOI: 10.1016/j.ebiom.2020.102729

Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application.

PMID: 32281925
Journal: Blood Transfusion
Year: 2020
Reference: Blood Transfus. 2020 May;18(3):208-216. doi: 10.2450/2020.0305-19. Epub 2020 Apr 3.
Impact factor: 3.662
Publication type: Paper in international publication
Authors: Samarkanova, Dinara, Rodriguez, Luciano, Vives, Joaquim, Coll, Ruth, Tahull, Elisabet, Azqueta, Carmen, Valdivia, Elena, Codinach, Margarita, Farssac, Elisenda, Gaitan, Jesus et al.
DOI: 10.2450/2020.0305-19

Compliance with Good Manufacturing Practice in the Assessment of Immunomodulation Potential of Clinical Grade Multipotent Mesenchymal Stromal Cells Derived from Wharton's Jelly.

PMID: 31117301
Journal: Cells
Year: 2019
Reference: Cells. 2019 May 21;8(5). pii: cells8050484. doi: 10.3390/cells8050484.
Impact factor: 5.656
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta, Rodriguez, Luciano, Del Mazo-Barbara, Anna, Mirabel, Clementine, Blanco, Margarita, Codinach, Margarita, Gomez, Susana G, Querol, Sergi, Garcia-Lopez, Joan, Vives, Joaquim et al.
DOI: 10.3390/cells8050484

Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application.

PMID: 30965661
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Apr 8;8(4). pii: jcm8040476. doi: 10.3390/jcm8040476.
Impact factor: 5.688
Publication type: Review in international publication
Authors: Alvarez-Palomo, Belen, Vives, Joaquim, Casaroli-Marano, Ricardo P P, G Gomez, Susana G, Rodriguez Gomez, Luciano, Edel, Michael J, Querol Giner, Sergi et al.
DOI: 10.3390/jcm8040476

Vascularized Periosteal Flaps Accelerate Osteointegration and Revascularization of Allografts in Rats.

PMID: 30810538
Journal: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Year: 2019
Reference: Clin Orthop Relat Res. 2019 Apr;477(4):741-755. doi: 10.1097/CORR.0000000000000400.
Impact factor: 4.154
Publication type: Paper in international publication
Authors: Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Manzanares, Maria Cristina, Sallent, Andrea, Vicente, Matias, Lopez-Fernandez, Alba, De Albert, Matias, Aguirre, Marius, Soldado, Francisco, Velez, Roberto et al.
DOI: 10.1097/CORR.0000000000000400

Extracellular vesicles: squeezing every drop of regenerative potential of umbilical cord blood.

PMID: 30831143
Journal: METABOLISM-CLINICAL AND EXPERIMENTAL
Year: 2019
Reference: Metabolism. 2019 Jun;95:102-104. doi: 10.1016/j.metabol.2019.02.006. Epub 2019 Mar 1.
Impact factor: 6.513
Publication type: Paper in international publication
Authors: Roura, Santiago, Vives, Joaquim et al.
DOI: 10.1016/j.metabol.2019.02.006

Derivation of Multipotent Mesenchymal Stromal Cells from Ovine Bone Marrow.

PMID: 29512111
Journal: Current protocols in stem cell biology
Year: 2018
Reference: Curr Protoc Stem Cell Biol. 2018 Feb 28;44:2B.9.1-2B.9.22. doi: 10.1002/cpsc.43.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vives, Joaquim, Vivas, Daniel, Caminal, Marta, Oliver-Vila, Irene et al.
DOI: 10.1002/cpsc.43

Optimisation of a potency assay for the assessment of immunomodulative potential of clinical grade multipotent mesenchymal stromal cells.

PMID: 29322348
Journal: CYTOTECHNOLOGY
Year: 2018
Reference: Cytotechnology. 2018 Feb;70(1):31-44. doi: 10.1007/s10616-017-0186-0. Epub 2018 Jan 10.
Impact factor: 1.461
Publication type: Paper in international publication
Authors: Vives, Joaquim, Oliver-Vila, Irene, Ramirez-Moncayo, Carmen, Grau-Vorster, Marta, Marin-Gallen, Silvia, Caminal, Marta et al.
DOI: 10.1007/s10616-017-0186-0

Blog

News

The creation of hybrid digital-human interaction spaces between avatars and people offers new opportunities for personalized medicine