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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Team

Marta González Sepúlveda

Marta González Sepúlveda

Postdoctoral researcher
Neurodegenerative Diseases
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Pau Sarle Valles

Pau Sarle Valles

Predoctoral researcher
Neurodegenerative Diseases
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Roman Serrat  Reñe

Roman Serrat Reñe

Postdoctoral researcher
Neurodegenerative Diseases
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Simone Arndt

Simone Arndt

Research technician
Neurodegenerative Diseases
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Stephen  Mora

Stephen Mora

Neurodegenerative Diseases
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Marta González Sepúlveda

Marta González Sepúlveda

Postdoctoral researcher
Neurodegenerative Diseases
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Pau Sarle Valles

Pau Sarle Valles

Predoctoral researcher
Neurodegenerative Diseases
Read more
Roman Serrat  Reñe

Roman Serrat Reñe

Postdoctoral researcher
Neurodegenerative Diseases
Read more
Simone Arndt

Simone Arndt

Research technician
Neurodegenerative Diseases
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Stephen  Mora

Stephen Mora

Neurodegenerative Diseases
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Projects

Characterization of the CD8 T cell response in Parkinson’s disease for the development of preventive and therapeutic strategies that halt the progression of the disease: SARS-Cov-2-induced long term-hyposmia as a possible prodromal stage

IP: Jordi Bove Badell
Collaborators: Miquel Vila Bover, Alejandro Ferré Masó, Oriol de Fabregues-Boixar Nebot, Carles Lorenzo Bosquet, Antonio Palasi Franco, Maria Sellés Altés
Funding agency: Instituto de Salud Carlos III
Funding: 165770
Reference: PI21/01358
Duration: 01/01/2022 - 30/06/2026

Activity and connectivity drive neuronal vulnerability and disease progression in Parkinson's disease

IP: Miquel Vila Bover
Collaborators: Activity and connectivity drive neuronal vulnerability and disease progression in Parkinson's disease, Javier Hoyo Pérez, Gerard Roch Alba, Marta González Sepúlveda, Ariadna Laguna Tuset, Joana Margalida Cladera Sastre
Funding agency: Michael J. Fox Foundation
Funding: 1936109
Reference: ASAP_MJFF2021
Duration: 01/11/2021 - 31/10/2025

Blog

News

This VHIR initiative promotes well-being, empathy and community participation in Barcelona neighbourhoods through an intergenerational model

PAIR is an intergenerational initiative with people affected by Parkinson's disease and adolescents.

The nomination recognises the work she has led together with Dr. Núria Peñuelas and Dr. Miquel Vila, on the generation of new preclinical models to study Parkinson's disease.

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study