Catalogue of procedures based on the 3Rs The following table includes procedures based on the 3Rs principle. They are intended to provide tools for the replacement, reduction and refinement of the use of animals in research. Ref. 3R Procedure/ Technology Brief description Research Area Biological Objective 3R principle Animal Replaced/ Reduced Validation Status Bibliographic Reference Research Group RRR001 Synthrocytes Synthetic erythrocyte-mimicking particles used instead of animal erythrocytes in hemaglutination assays Virology. Vaccine development. Global health (control of influenza seasonal epidemics) Provide improved stability, reproducibility, standardization, and global distribution compared with fresh animal erythrocytes Replace/ Reduce Chiken, guinea pig and turkey erythrocytes Validated in research settings / Patented technology PMID: 33427446 DOI: 10.1021/ acssensors.0c01830 Diagnostic Nanotools (DINA) This catalogue is updated periodically. For further information, you can contact us at 3Rbiomodels@vhir.org.The creation of this catalogue has been made possible thanks to funding from the Carlos III Health Institute (PT23/00040) in support of biomedical research, and thanks to the researchers at the Vall d’Hebron Campus.
