Diagnostic Nanotools (DINA)
At Diagnostic Nanotools, we work to ameliorate the diagnosis of diseases. On the one hand, we produce rapid assays and electrochemical biosensors, with a special emphasis on point-of-care diagnosis of infectious diseases.
In this context, we develop single-step immunoassays, classical biosensors (in which a sensor is modified with bioreceptors for the specific detection of the analyte of interest) and magneto-biosensors (in which the assay is performed on magnetic particles). We explore the implementation of nanomaterials to obtain improved transducers and as signal amplifiers to generate faster and more sensitive biosensors. We also seek to automate the tests using extremely simple and economical paper microfluidics. On the other hand, we are developing "synthrocytes," a synthetic reagent that could replace animal erythrocytes in the hemagglutination assays used currently for the global surveillance of influenza viruses and in the control of vaccine production.
Publications
Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?
PMID: 37027026
Journal: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
Year: 2023
Reference: Eur Child Adolesc Psychiatry. 2023 Apr 7. doi: 10.1007/s00787-023-02196-7.
Impact factor:
Publication type: Paper in international publication
Authors: Amoretti, Silvia; Ayora, Miriam; Baeza, Inmaculada; Balanza-Martinez, Vicent; Bernardo, Miquel; Bioque, Miquel; Butjosa, Anna; Casanovas, Francesc; Castro-Fornieles, Josefina; Contreras, Fernando et al.
DOI: 10.1007/s00787-023-02196-7
Paper-based microfluidic electro-analytical device (PMED) for magneto-assay automation: Towards generic point-of-care diagnostic devices.
PMID: 38039728
Journal: BIOSENSORS & BIOELECTRONICS
Year: 2023
Reference: Biosens Bioelectron. 2023 Nov 26;246:115875. doi: 10.1016/j.bios.2023.115875.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelrahman Soliman, Dina Sameh; Al-Shemari, Salem; Alcoceba, Miguel; Alvarez-Carulla, A; Angelopoulou, Maria; Antic, Darko; Arias-Alpizar, K; Aurran-Schleinitz, Therese; Bacchiarri, Francesca; Baldrich, E et al.
DOI: 10.1016/j.bios.2023.115875
Magnetic Bead Handling Using a Paper-Based Device for Quantitative Point-of-Care Testing.
PMID: 36140066
Journal: Biosensors-Basel
Year: 2022
Reference: Biosensors (Basel). 2022 Aug 25;12(9). pii: bios12090680. doi: 10.3390/bios12090680.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Alpizar, Kevin; Baldrich, Eva; Bosch-Nicolau, Pau; Molina, Israel; Oliveira, Ines; Prat-Trunas, Judit; Salvador, Fernando; Sanchez-Cano, Ana; Sanchez-Montalva, Adrian; Sulleiro, Elena et al.
DOI: 10.3390/bios12090680
Malaria quantitative POC testing using magnetic particles, a paper microfluidic device and a hand-held fluorescence reader.
PMID: 35917611
Journal: BIOSENSORS & BIOELECTRONICS
Year: 2022
Reference: Biosens Bioelectron. 2022 Nov 1;215:114513. doi: 10.1016/j.bios.2022.114513. Epub 2022 Jun 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, O; Arias-Alpizar, K; Baldrich, E; de la Serna Serna, E; Dieguez, A; Prat-Trunas, J; Sanchez-Cano, A; Sanchez-Montalva, A; Sulleiro, E et al.
DOI: 10.1016/j.bios.2022.114513
Electrochemical Capillary-Flow Immunoassay for Detecting Anti-SARS-CoV-2 Nucleocapsid Protein Antibodies at the Point of Care.
PMID: 34694794
Journal: ACS Sensors
Year: 2021
Reference: ACS Sens. 2021 Nov 26;6(11):4067-4075. doi: 10.1021/acssensors.1c01527. Epub 2021 Oct 25.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Dandy, David S; Geiss, Brian J; Henry, Charles S; Jang, Ilhoon; Khamcharoen, Wisarut; Samper, Isabelle C; Sanchez-Cano, Ana; Siangproh, Weena et al.
DOI: 10.1021/acssensors.1c01527
Development of a Fast Chemiluminescent Magneto-Immunoassay for Sensitive Plasmodium falciparum Detection in Whole Blood.
PMID: 34496566
Journal: ANALYTICAL CHEMISTRY
Year: 2021
Reference: Anal Chem. 2021 Sep 21;93(37):12793-12800. doi: 10.1021/acs.analchem.1c03242. Epub 2021 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; de la Serna, Erica; Molina, Israel; Ruiz-Vega, Gisela; Sanchez-Cano, Ana; Sanchez-Montalva, Adrian; Sulleiro, Elena; Vicente-Gomez, Sergi et al.
DOI: 10.1021/acs.analchem.1c03242
Smartphone-Enabled Personalized Diagnostics: Current Status and Future Prospects.
PMID: 34207908
Journal: Diagnostics
Year: 2021
Reference: Diagnostics (Basel). 2021 Jun 9;11(6). pii: diagnostics11061067. doi: 10.3390/diagnostics11061067.
Impact factor:
Publication type: Review in international publication
Authors: Baldrich, Eva; Del Campo, F Javier; Fernandez-Martin, Eduardo; Merazzo, Karla Jaimes; Totoricaguena-Gorrino, Joseba et al.
DOI: 10.3390/diagnostics11061067
Detection of Plasmodium falciparum malaria in 1 h using a simplified enzyme-linked immunosorbent assay.
PMID: 33648654
Journal: ANALYTICA CHIMICA ACTA
Year: 2021
Reference: Anal Chim Acta. 2021 Apr 1;1152:338254. doi: 10.1016/j.aca.2021.338254. Epub 2021 Jan 30.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Alpizar, Kevin; Baldrich, Eva; Borgheti-Cardoso, Livia Neves; Bosch-Nicolau, Pau; de la Serna, Erica; Fernandez-Busquets, Xavier; Molina, Israel; Ramirez, Miriam; Salvador, Fernando; Sanchez-Cano, Ana et al.
DOI: 10.1016/j.aca.2021.338254
Electrochemical POC device for fast malaria quantitative diagnosis in whole blood by using magnetic beads, Poly-HRP and microfluidic paper electrodes.
PMID: 31818756
Journal: BIOSENSORS & BIOELECTRONICS
Year: 2020
Reference: Biosens Bioelectron. 2020 Feb 15;150:111925. doi: 10.1016/j.bios.2019.111925. Epub 2019 Nov 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Alpizar, Kevin; Baldrich, Eva; Borgheti-Cardoso, Livia Neves; de la Serna, Erica; Del Campo, F Javier; Fernandez-Busquets, Xavier; Molina, Israel; Ruiz-Vega, Gisela; Sanchez-Montalva, Adrian; Sulleiro, Elena et al.
DOI: 10.1016/j.bios.2019.111925
An internet of things-based intensity and time-resolved fluorescence reader for point-of-care testing.
PMID: 32056969
Journal: BIOSENSORS & BIOELECTRONICS
Year: 2020
Reference: Biosens Bioelectron. 2020 Apr 15;154:112074. doi: 10.1016/j.bios.2020.112074. Epub 2020 Feb 7.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, O; Arias-Alpizar, K; Baldrich, E; Canals, J; de la Serna, E; Dieguez, A; Franch, N et al.
DOI: 10.1016/j.bios.2020.112074
Competitive USB-Powered Hand-Held Potentiostat for POC Applications: An HRP Detection Case.
PMID: 31817657
Journal: SENSORS
Year: 2019
Reference: Sensors (Basel). 2019 Dec 6;19(24). pii: s19245388. doi: 10.3390/s19245388.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Carulla, Albert; Baldrich, Eva; Colomer-Farrarons, Jordi; Miribel-Catala, Pere Ll; Montes-Cebrian, Yaiza; Puig-Vidal, Manel; Ruiz-Vega, Gisela et al.
DOI: 10.3390/s19245388
AuNPs/methylene blue dual-signal nanoimmunoconjugates and electrode activation for electrochemical biosensors
PMID: NOPMID0066
Journal: JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Year: 2019
Reference: Journal of Electroanalytical Chemistry. 2019 Dec;855:113500. doi: 10.1016/j.jelechem.2019.113500
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich Rubio, Eva; López Marzo, Adaris Maria et al.
DOI: 10.1016/j.jelechem.2019.113500
Paper microfluidics on screen-printed electrodes for simple electrochemical magneto-immunosensor performance
PMID: NOPMID0050
Journal: SENSORS AND ACTUATORS B-CHEMICAL
Year: 2019
Reference: Sensors and Actuators B: Chemical. 2019 Nov;298:126897. doi:10.1016/j.snb.2019.126897
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich-Rubio, Eva; Garcia-Berrocoso, Teresa; Montaner-Villalonga, Joan; Ruiz-Vega, Gisela et al.
DOI: 10.1016/j.snb.2019.126897
Using polyHRP to produce simplified immunoassays and electrochemical immunosensors. Application to MMP-9 detection in plasma and uterine aspirates
PMID: NOPMID011
Journal: SENSORS AND ACTUATORS B-CHEMICAL
Year: 2018
Reference: doi.org/10.1016/j.snb.2018.05.003
Impact factor:
Publication type: Paper in international publication
Authors: Colas, E; de la Serna, E; García-Berrocoso, T; Gil-Moreno, A; Martinez-García, E; Penalba, A et al.
DOI: 10.1016/j.snb.2018.05.003
Detection of plasma MMP-9 within minutes. Unveiling some of the clues to develop fast and simple electrochemical magneto-immunosensors.
PMID: 29800830
Journal: BIOSENSORS & BIOELECTRONICS
Year: 2018
Reference: Biosens Bioelectron. 2018 Sep 15;115:45-52. doi: 10.1016/j.bios.2018.05.020. Epub 2018 May 11.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Ben Ismail, Manel; Del Campo, F Javier; Garcia-Berrocoso, Teresa; Garcia-Robaina, Alicia; Montaner, Joan; Othmane, Ali; Pasamar, Helena; Ruiz-Vega, Gisela; Zourob, Mohammed et al.
DOI: 10.1016/j.bios.2018.05.020
NaNO3/NaCl oxidant and Polyethylene glycol (PEG) capped gold nanoparticles (AuNPs) as a novel green route for AuNPs detection in electrochemical biosensors.
PMID: 29498271
Journal: ANALYTICAL CHEMISTRY
Year: 2018
Reference: Anal Chem. 2018 Mar 20;90(6):4010-4018. doi: 10.1021/acs.analchem.7b05150. Epub 2018 Mar 9.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Hoyos-de-la-Torre, Raquel; Lopez-Marzo, Adaris M et al.
DOI: 10.1021/acs.analchem.7b05150
Using magnetic beads and signal amplifiers to produce short and simple immunoassays: Application to MMP-9 detection in plasma samples.
PMID: 29254566
Journal: ANALYTICA CHIMICA ACTA
Year: 2018
Reference: Anal Chim Acta. 2018 Jan 25;999:144-154. doi: 10.1016/j.aca.2017.11.013. Epub 2017 Nov 10.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Ben Ismail, Manel; de la Serna, Erica; Garcia-Berrocoso, Teresa; Montaner, Joan; Othmane, Ali; Ruiz-Vega, Gisela; Zourob, Mohammed et al.
DOI: 10.1016/j.aca.2017.11.013
Electrochemical lateral flow devices: towards rapid immunomagnetic-assays
PMID: NOPMID001
Journal: ChemElectroChem
Year: 2017
Reference:
Impact factor:
Publication type: Paper in international publication
Authors: Aller Pellitero, Miguel; Baldrich Rubio, Eva; del Campo, F. Javier; Kitsara, Maria; Ruiz-Vega, Gisela et al.
DOI: 10.1002/celc.201600902
Effect of agitation in magneto-assay performance
PMID: NOPMID002
Journal: SENSORS AND ACTUATORS B-CHEMICAL
Year: 2017
Reference:
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich Rubio, Eva; Ruiz-vega, Gisela et al.
DOI: 10.1016/j.snb.2017.03.076
Detection of Uric Acid at Reversibly Nanostructured Thin-Film Microelectrodes
PMID: NOPMID9
Journal: SENSORS AND ACTUATORS B-CHEMICAL
Year: 2016
Reference: Sens Act B, 2013, 181: 816-822. doi: 10.1016/j.snb.2013.02.066
Impact factor:
Publication type: Paper in international publication
Authors: ; ; Eva Baldrich et al.
DOI: 10.1016/j.snb.2013.02.066
Developing enhanced magnetoimmunosensors based on low-cost screen-printed electrode devices
PMID: NOPMID10
Journal: REVIEWS IN ANALYTICAL CHEMISTRY
Year: 2016
Reference: Reviews in Analytical Chemistry, 2016, 35: 53–85 (Invited review). doi 10.1515/revac-2016-0004.
Impact factor:
Publication type: Review in international publication
Authors: Baldrich Rubio, Eva; de la Serna Botello, Erica; Herrasti, Zorione; Ruiz Vega, Gisela et al.
DOI: 10.1515/revac-2016-0004
Miniaturized metal oxide pH sensors for bacteria detection.
PMID: 26592620
Journal: TALANTA
Year: 2016
Reference: Talanta. 2016 Jan 15;147:364-9. doi: 10.1016/j.talanta.2015.10.011. Epub 2015 Oct 9.
Impact factor:
Publication type: Paper in international publication
Authors: Abramova, Natalia; Baldrich, Eva; Bratov, Andrey; Munoz-Pascual, Francesc-Xavier; Uria, Naroa et al.
DOI: 10.1016/j.talanta.2015.10.011
Reversible nanostructuration of microfluidic electrode devices by CNT magnetic co-entrapment.
PMID: 26155767
Journal: LAB CHIP
Year: 2015
Reference: Lab Chip. 2015 Jul 28;15(16):3269-73. doi: 10.1039/c5lc00573f.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Herrasti, Zorione; Martinez, Fernando et al.
DOI: 10.1039/c5lc00573f
Dual chronoamperometric detection of enzymatic biomarkers using magnetic beads and a low-cost flow cell.
PMID: 25791338
Journal: BIOSENS BIOELECTRON
Year: 2015
Reference: Biosens Bioelectron. 2015 Jul 15;69:328-36. doi: 10.1016/j.bios.2015.02.042. Epub 2015 Mar 6.
Impact factor:
Publication type: Paper in international publication
Authors: Abad, Llibertat; Baldrich, Eva; Barallat, Jaume; Del Campo, F Javier; Galan Ortega, Amparo; Moral-Vico, Javier; Munoz-Pascual, Francesc Xavier; Olive-Monllau, Rosa et al.
DOI: 10.1016/j.bios.2015.02.042
CNT wiring for signal amplification in electrochemical magnetosensors
PMID: NOPMID0075
Journal: Procedia Engineering
Year: 2014
Reference: CNT Wiring for Signal Amplification in Electrochemical Magnetosensors. Procedia Engineering. 2014;87:712-5.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Herrasti, Zorione; Martinez, Fernando et al.
DOI: 10.1016/j.proeng.2014.11.637
Interdigitated Microelectrode Arrays Integrated in Microfluidic Cell for Biosensor Applications
PMID: 91000012
Journal: Journal of Nanomedicine and Nanotechnology
Year: 2014
Reference: J Nanomed Nanotechnol 2014;5:243. doi:10.4172/2157-7439.1000243
Impact factor:
Publication type: Paper in international publication
Authors: Abdelghani A; Baccar H; Baldrich E; del Campo FJ; Mandeville R; Mejri MB; Prehn R et al.
DOI: 10.4172/2157-7439.1000243
Electrochemical detection of dopamine using streptavidin-coated magnetic particles and carbon nanotube wiring
PMID: 91000007
Journal: SENSORS AND ACTUATORS B-CHEMICAL
Year: 2014
Reference: SNB 17164
Impact factor:
Publication type: Paper in international publication
Authors: ; ; et al.
DOI: 10.1016/j.snb.2014.07.011
Electrochemical biosensing of non-electroactive targets using ferrocene-labeled magnetic particles and CNT wiring.
PMID: 24482799
Journal: ANALYST
Year: 2014
Reference: Analyst. 2014 Mar 21;139(6):1334-9. doi: 10.1039/c3an02276e.
Impact factor:
Publication type: Paper in international publication
Authors: Baldrich, Eva; Herrasti, Zorione; Martinez, Fernando; Munoz-Pascual, Francesc Xavier; Olive-Monllau, Rosa et al.
DOI: 10.1039/c3an02276e
News
The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.
The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.
The head of the Diagnostic Nanotools (DINA) group was part of a Spanish delegation that also participated in activities to establish contracts between national and international centers.