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Biomedical Research in Gynaecology

The Biomedical Research Group in Gynaecology is a multidisciplinary team made up of clinical specialists in gynaecology and pathology and basic and translational researchers. Our research is clearly translational. Although we take into account the obvious importance of understanding the mechanism at the cellular and molecular level and try to incorporate it into our research, our research is always focused on having a direct applicability to patients and their clinical benefit. On our way to transferring scientific results to clinical practice, we promote innovation and entrepreneurship.

Our group comprises four main research groups, which are closely connected: The clinical research group devoted mainly to clinical projects in all gynaecological cancers; and three translational research groups dedicated to ovarian cancer; endometrial cancer and endometriosis; diseases of the lower female genital tract.

Team

Montserrat Cubo Abert

Montserrat Cubo Abert

Biomedical Research in Gynaecology
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Elena Suarez Salvador

Elena Suarez Salvador

Biomedical Research in Gynaecology
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Melissa Bradbury Lobato

Melissa Bradbury Lobato

Biomedical Research in Gynaecology
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Ruano Lopez, Anna

Ruano Lopez, Anna

Research technician
Biomedical Research in Gynaecology
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Abdessayed , Nihed

Abdessayed , Nihed

Predoctoral researcher
Biomedical Research in Gynaecology
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Ana Luzarraga Aznar

Ana Luzarraga Aznar

Predoctoral researcher
Biomedical Research in Gynaecology
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Montserrat Cubo Abert

Montserrat Cubo Abert

Biomedical Research in Gynaecology
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Elena Suarez Salvador

Elena Suarez Salvador

Biomedical Research in Gynaecology
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Melissa Bradbury Lobato

Melissa Bradbury Lobato

Biomedical Research in Gynaecology
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Ruano Lopez, Anna

Ruano Lopez, Anna

Research technician
Biomedical Research in Gynaecology
Read more
Abdessayed , Nihed

Abdessayed , Nihed

Predoctoral researcher
Biomedical Research in Gynaecology
Read more
Ana Luzarraga Aznar

Ana Luzarraga Aznar

Predoctoral researcher
Biomedical Research in Gynaecology
Read more

Projects

Formación en cirugía ginecológica e investigación clínica con desarrollo del proyecto de tesis doctoral sobre el papel de la linfadenectomía aórtica extraperitoneal en el cáncer de cérvix localmente avanzado.

IP: Antonio Gil Moreno
Collaborators: Úrsula Acosta Sánchez, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM22/00150
Duration: 01/01/2023 - 31/12/2024

Recerca biomèdica en ginecologia

IP: Eva Colas Ortega
Collaborators: Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 308600
Reference: CP22/00147
Duration: 01/03/2023 - 29/02/2028

Development of a personalised non-invasive diagnosis of endometrial cancer using proteomic markers in cervical fluids and clinical data

IP: Antonio Gil Moreno
Collaborators: Irene De la Calle Fuentes, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 89900
Reference: IFI22/00019
Duration: 01/01/2023 - 31/12/2026

WomEC, desenvolupament d'una eina molecular per la millora del diagnòstic en càncer d'endometri.

IP: Eva Colas Ortega
Collaborators: Antonio Gil Moreno, Miriam Izquierdo Sans, Francisco Javier Carvajal Rodriguez
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 33960
Reference: AGAUR/DI2022_1/GIL
Duration: 01/08/2022 - 31/07/2025

Publications

Early-Stage Breast Cancer Detection in Breast Milk.

PMID: 37704212
Journal: Cancer Discovery
Year: 2023
Reference: Cancer Discov. 2023 Sep 14:OF1-OF12. doi: 10.1158/2159-8290.CD-22-1340.
Impact factor:
Publication type: Paper in international publication
Authors: Arenas, Enrique J; Arenas, Enrique J; Arevalo, Silvia; Arevalo, Silvia; Arribas, Joaquin; Balmana, Judith; Balmana, Judith; Bayo-Puxan, Neus; Carrasco, Estela; Carrasco, Estela et al.
DOI: 10.1158/2159-8290.CD-22-1340

Endometrial adenocarcinoma recurring in the lung: impact of molecular profile and role of local therapies on prognosis.

PMID: 37726197
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Year: 2023
Reference: Int J Gynecol Cancer. 2023 Sep 19:ijgc-2023-004534. doi: 10.1136/ijgc-2023-004534.
Impact factor:
Publication type: Paper in international publication
Authors: Bebia, Vicente; Bebia, Vicente; Cabrera, Silvia; Cabrera, Silvia; Castellvi, Josep; Castellvi, Josep; Colas, Eva; Gil-Moreno, Antonio; Gil-Moreno, Antonio; Giraldo, Alexandra et al.
DOI: 10.1136/ijgc-2023-004534

Decoding the endometrial niche of Asherman's Syndrome at single-cell resolution.

PMID: 37735465
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Sep 21;14(1):5890. doi: 10.1038/s41467-023-41656-1.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez, Estefania; Fernandez, Estefania; Gonzalez-Fernandez, Javier; Llera-Oyola, Jaime; Moreno, Inmaculada; Pardo-Figuerez, Maria; Perez-Moraga, Raul; Roson, Beatriz; Salumets, Andres; Santamaria, Xavier et al.
DOI: 10.1038/s41467-023-41656-1

Clinical effectiveness of routine first-trimester combined screening for pre-eclampsia in Spain with the addition of placental growth factor.

PMID: 37814344
Journal: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Year: 2023
Reference: Acta Obstet Gynecol Scand. 2023 Oct 9. doi: 10.1111/aogs.14687.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol-Alsina, Mireia; Bonacina, Erika; Caamina, Sara; Carreras, Elena; Catalan, Sara; Dalmau, Marta; Del Barco, Ester; Garcia-Manau, Pablo; Hernandez, Alina; Lopez, Monica et al.
DOI: 10.1111/aogs.14687

Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression.

PMID: 35145232
Journal: ONCOGENE
Year: 2022
Reference: Oncogene. 2022 Mar;41(13):1835-1850. doi: 10.1038/s41388-022-02221-0. Epub 2022 Feb 10.
Impact factor: 9.867
Publication type: Paper in international publication
Authors: Moiola, Cristian P; Casas-Arozamena, Carlos; Lopez-Gil, Carlos; Diaz, Eva; Gatius, Sonia; Ruiz-Miro, Maria; Calvo, Ana; Rojo-Sebastian, Alejandro; Hurtado, Pablo; Pineiro, Roberto et al.
DOI: 10.1038/s41388-022-02221-0

The Impact of Surgical Practice on Oncological Outcomes in Robot-Assisted Radical Hysterectomy for Early-Stage Cervical Cancer, Spanish National Registry.

PMID: 35158966
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Jan 29;14(3). pii: cancers14030698. doi: 10.3390/cancers14030698.
Impact factor: 6.639
Publication type: Paper in international publication
Authors: Marti, Lola; Fernandez-Gonzalez, Sergi; Ponce, Jordi; Martinez-Maestre, Maria Angeles; Barahona, Marc; Gomez-Hidalgo, Natalia R; Diaz-Feijoo, Berta; Casajuana, Andrea; Gracia, Myriam; Frias-Gomez, Jon et al.
DOI: 10.3390/cancers14030698

First-trimester screening for preeclampsia and small-for-gestational-age: A comparison of the Gaussian and FMF algorithms.

PMID: 35695395
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
Year: 2022
Reference: Int J Gynaecol Obstet. 2022 Jun 13. doi: 10.1002/ijgo.14306.
Impact factor: 3.561
Publication type: Paper in international publication
Authors: Carreras, Elena, Mendoza, Manel, Armengol-Alsina, Mireia, Perestelo, Ana, Murcia, Maria Teresa, Serrano, Berta, Bonacina, Erika, Rodo, Carlota, Garcia-Manau, Pablo, Sanchez-Duran, Maria Angeles et al.
DOI: 10.1002/ijgo.14306

Genomic Validation of Endometrial Cancer Patient-Derived Xenograft Models as a Preclinical Tool.

PMID: 35682944
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Jun 3;23(11). pii: ijms23116266. doi: 10.3390/ijms23116266.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Villafranca-Magdalena, Beatriz, Masferrer-Ferragutcasas, Carina, Lopez-Gil, Carlos, Coll-de la Rubia, Eva, Rebull, Marta, Parra, Genis, Garcia, Angel, Reques, Armando, Cabrera, Silvia, Colas, Eva et al.
DOI: 10.3390/ijms23116266

Clinical Challenges in Managing Cervical Intraepithelial Neoplasia 2: A Report From a Cross-sectional Survey.

PMID: 33631780
Journal: Journal of Lower Genital Tract Disease
Year: 2021
Reference: J Low Genit Tract Dis. 2021 Apr 1;25(2):119-125. doi: 10.1097/LGT.0000000000000594.
Impact factor: 1.925
Publication type: Paper in international publication
Authors: Centeno, Cristina, Perez-Benavente, Assumpcio, Gil-Moreno, Antonio, Bradbury, Melissa et al.
DOI: 10.1097/LGT.0000000000000594

Follicular Thyroid Carcinoma Metastases on Round Ligament of Liver.

PMID: 33512955
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2021
Reference: Clin Nucl Med. 2021 Apr 1;46(4):326-328. doi: 10.1097/RLU.0000000000003526.
Impact factor: 7.794
Publication type: Letter or abstract
Authors: Monturiol-Duran, Jaime Alejando, Iglesias-Felip, Carmela, Villasboas-Rosciolesi, Diego, Castell-Conesa, Joan, Garcia-Burillo, Amparo et al.
DOI: 10.1097/RLU.0000000000003526

Surgical complications comparing extraperitoneal vs transperitoneal laparoscopic aortic staging in early stage ovarian and endometrial cancer.

PMID: 33160695
Journal: GYNECOLOGIC ONCOLOGY
Year: 2021
Reference: Gynecol Oncol. 2021 Jan;160(1):83-90. doi: 10.1016/j.ygyno.2020.10.038. Epub 2020 Nov 5.
Impact factor: 5.482
Publication type: Paper in international publication
Authors: Bebia, Vicente, Hernandez, Alicia, Gilabert-Estalles, Juan, Franco-Camps, Silvia, de la Torre, Javier, Segrist, Jaime, Chipirliu, Anca, Cabrera, Silvia, Perez-Benavente, Assumpcio, Gil-Moreno, Antonio et al.
DOI: 10.1016/j.ygyno.2020.10.038

Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer.

PMID: 32268485
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Apr 6;12(4). pii: cancers12040886. doi: 10.3390/cancers12040886.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Barber, Marta, Parrilla, Alfonso, Morote, Juan, Sanchez, Jose Luis, Perez-Benavente, Asuncion, Segura, Miguel F, Gil-Moreno, Antonio, Santamaria, Anna, Castellvi, Josep, Majem, Blanca et al.
DOI: 10.3390/cancers12040886

Prognostic Value and Therapeutic Implication of Laparoscopic Extraperitoneal Paraaortic Staging in Locally Advanced Cervical Cancer: A Spanish Multicenter Study.

PMID: 32152774
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2020
Reference: Ann Surg Oncol. 2020 Aug;27(8):2829-2839. doi: 10.1245/s10434-020-08329-5. Epub 2020 Mar 9.
Impact factor: 4.061
Publication type: Paper in international publication
Authors: Diaz-Feijoo, Berta, Torne, Aureli, Tejerizo, Alvaro, Benito, Virginia, Hernandez, Alicia, Ruiz, Ruben, Domingo, Santiago, Chipiriliu, Dra, Llueca, Antonio, Piquer, Lola et al.
DOI: 10.1245/s10434-020-08329-5

Technetium-99m-indocyanine green versus technetium-99m-methylene blue for sentinel lymph node biopsy in early-stage endometrial cancer.

PMID: 31992599
Journal: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Year: 2020
Reference: Int J Gynecol Cancer. 2020 Mar;30(3):311-317. doi: 10.1136/ijgc-2019-000923. Epub 2020 Jan 27.
Impact factor: 2.095
Publication type: Paper in international publication
Authors: Cabrera, Silvia, Bebia, Vicente, Franco-Camps, Silvia, Forcada, Cristina, Villasboas-Rosciolesi, Diego, Navales, Ignacio, Perez-Benavente, Assumpcio, Gil-Moreno, Antonio et al.
DOI: 10.1136/ijgc-2019-000923

Evaluation of the intraoperative human papilloma virus test as a marker of early cure at 12 months after electrosurgical excision procedure in patients with cervical High Grade Squamous Intraepithelial Lesion: a prospective cohort study.

PMID: 31502397
Journal: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Year: 2020
Reference: BJOG. 2020 Jan;127(1):99-105. doi: 10.1111/1471-0528.15932. Epub 2019 Sep 25.
Impact factor: 4.663
Publication type: Paper in international publication
Authors: Garcia, A, Centeno, C, Gil-Moreno, A, Dinares, C, Hernandez, J, Cabrera, S, Rabasa, J, Bradbury, M, Sanchez-Iglesias, J L, Guerrero, D et al.
DOI: 10.1111/1471-0528.15932

Poor outcome in hypoxic endometrial carcinoma is related to vascular density.

PMID: 31011231
Journal: BRITISH JOURNAL OF CANCER
Year: 2019
Reference: Br J Cancer. 2019 May;120(11):1037-1044. doi: 10.1038/s41416-019-0461-2. Epub 2019 Apr 23.
Impact factor: 5.416
Publication type: Paper in international publication
Authors: Bronsert, Peter, Reijnen, Casper, van Weelden, Willem Jan, Arts, Martijn S J P, Peters, Johan P, Rijken, Paul F, van de Vijver, Koen, Santacana, Maria, Colas, Eva, Gil-Moreno, Antonio et al.
DOI: 10.1038/s41416-019-0461-2

Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer.

PMID: 30853360
Journal: GYNECOLOGIC ONCOLOGY
Year: 2019
Reference: Gynecol Oncol. 2019 May;153(2):425-435. doi: 10.1016/j.ygyno.2019.03.002. Epub 2019 Mar 7.
Impact factor: 4.393
Publication type: Paper in international publication
Authors: Colas, Eva, Felip, Isidre, Moiola, Cristian Pablo, Megino-Luque, Cristina, Lopez-Gil, Carlos, Cabrera, Silvia, Sole-Sanchez, Sonia, Munoz-Guardiola, Pau, Megias-Roda, Elisabet, Perez-Montoyo, Hector et al.
DOI: 10.1016/j.ygyno.2019.03.002

Vaginal Intraepithelial Neoplasia: Clinical Presentation, Management, and Outcomes in Relation to HIV Infection Status.

PMID: 30161052
Journal: Journal of Lower Genital Tract Disease
Year: 2019
Reference: J Low Genit Tract Dis. 2019 Jan;23(1):7-12. doi: 10.1097/LGT.0000000000000431.
Impact factor: 1.458
Publication type: Paper in international publication
Authors: Perez-Benavente, Asuncion, Franco-Camps, Silvia, Cabrera, Silvia, Sanchez-Iglesias, Jose Luis, De La Torre, Javier, Diaz-Feijoo, Berta, Gil-Moreno, Antonio, Centeno-Mediavilla, Cristina, Garcia-Jimenez, Angel, Xercavins, Natalia et al.
DOI: 10.1097/LGT.0000000000000431

Targeted proteomics identifies proteomic signatures in liquid-biopsies of the endometrium to diagnose endometrial cancer and assist in the prediction of the optimal surgical treatment.

PMID: 28790116
Journal: CLINICAL CANCER RESEARCH
Year: 2017
Reference: Clin Cancer Res. 2017 Nov 1;23(21):6458-6467. doi: 10.1158/1078-0432.CCR-17-0474. Epub 2017 Aug 8.
Impact factor: 9.619
Publication type: Paper in international publication
Authors: Martinez, Elena, Lesur, Antoine, Devis, Laura, Cabrera, Silvia, Matias-Guiu, Xavier, Hirschfeld, Marc, Asberger, Jasmin, van Oostrum, Jan, Casares de Cal, Maria de Los Angeles, Gomez-Tato, Antonio et al.
DOI: 10.1158/1078-0432.CCR-17-0474

Endometrial Carcinoma: Specific Targeted Pathways.

PMID: 27910068
Journal: Advances in Experimental Medicine and Biology
Year: 2017
Reference: Adv Exp Med Biol. 2017;943:149-207.
Impact factor: 1.881
Publication type: Review in international publication
Authors: Eritja, Nuria, Yeramian, Andree, Chen, Bo-Juen, Llobet-Navas, David, Ortega, Eugenia, Colas, Eva, Abal, Miguel, Dolcet, Xavier, Reventos, Jaume, Matias-Guiu, Xavier et al.
DOI: 10.1007/978-3-319-43139-0_6

Integrating gene expression and epidemiological data for the discovery of genetic interactions associated with cancer risk.

PMID: 24296589
Journal: CARCINOGENESIS
Year: 2014
Reference: Carcinogenesis. 2014 Mar;35(3):578-85. doi: 10.1093/carcin/bgt403. Epub 2013 Dec 2.
Impact factor: 5.266
Publication type: Paper in international publication
Authors: Bonifaci, Nuria, Colas, Eva, Serra Musach, Jordi, Karbalai, Nazanin, Brunet, Joan, Gomez, Antonio, Esteller, Manel, Berenguer, Antoni, Reventos, Jaume, Muller-Myhsok, Bertram et al.
DOI: 10.1093/carcin/bgt403

Blog

News

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

From 6th to 7th March, more than 60 European researchers have shared the advances in translational research in endometrial cancer

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.