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Biomedical Research in Gynaecology

The Biomedical Research Group in Gynaecology is a multidisciplinary team made up of clinical specialists in gynaecology and pathology and basic and translational researchers. Our research is clearly translational. Although we take into account the obvious importance of understanding the mechanism at the cellular and molecular level and try to incorporate it into our research, our research is always focused on having a direct applicability to patients and their clinical benefit. On our way to transferring scientific results to clinical practice, we promote innovation and entrepreneurship.

Our group comprises four main research groups, which are closely connected: The clinical research group devoted mainly to clinical projects in all gynaecological cancers; and three translational research groups dedicated to ovarian cancer; endometrial cancer and endometriosis; diseases of the lower female genital tract.

Team

Irene De la Calle Fuentes

Irene De la Calle Fuentes

Predoctoral researcher
Biomedical Research in Gynaecology
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Jose Luis Poza  Barrasus

Jose Luis Poza Barrasus

Biomedical Research in Gynaecology
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José Luis Sánchez Iglesias

José Luis Sánchez Iglesias

Biomedical Research in Gynaecology
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Maria Cristina Centeno Mediavilla

Maria Cristina Centeno Mediavilla

Biomedical Research in Gynaecology
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Marina Rigau Resina

Marina Rigau Resina

Postdoctoral researcher
Biomedical Research in Gynaecology
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Marta Rebull Santamaria

Marta Rebull Santamaria

Research technician
Biomedical Research in Gynaecology
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Irene De la Calle Fuentes

Irene De la Calle Fuentes

Predoctoral researcher
Biomedical Research in Gynaecology
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Jose Luis Poza  Barrasus

Jose Luis Poza Barrasus

Biomedical Research in Gynaecology
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José Luis Sánchez Iglesias

José Luis Sánchez Iglesias

Biomedical Research in Gynaecology
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Maria Cristina Centeno Mediavilla

Maria Cristina Centeno Mediavilla

Biomedical Research in Gynaecology
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Marina Rigau Resina

Marina Rigau Resina

Postdoctoral researcher
Biomedical Research in Gynaecology
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Marta Rebull Santamaria

Marta Rebull Santamaria

Research technician
Biomedical Research in Gynaecology
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Projects

ADVANCING ON THE DEVELOPMENT OF A NON-INVASIVE TOOL TO EARLY DIAGNOSE ENDOMETRIAL CANCER

IP: Eva Colas Ortega
Collaborators: Beatriz Villafranca Magdalena, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI21/00271
Duration: 01/01/2022 - 31/12/2025

Targeting the most aggressive type of endometrial carcinoma

IP: Antonio Gil Moreno
Collaborators: Carina Masferrer Ferragutcasas, Marta Rebull Santamaria, Irene De la Calle Fuentes, Beatriz Villafranca Magdalena, Melek Denizli, Melissa Bradbury Lobato, Raquel Delgado Gil
Funding agency: Asociación Española Contra el Cáncer
Funding: 199250
Reference: GCTRA18014MATI
Duration: 18/02/2019 - 31/10/2024

Enhancing CD8+ Resident Memory T cell function to control and eliminate viral reservoirs

IP: Meritxell Genesca Ferrer
Collaborators: Vicente Descalzo Jorro, Josep Castellví Vives, Laura Mañalich Barrachina
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI20/00160
Duration: 01/01/2021 - 30/06/2025

New therapeutic approaches in head and neck cancer

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Jordi Temprana Salvador, Angel García Jiménez, Josep Castellví Vives, Laia Josa Culleré, Marina Bataller Fernández
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI20/00556
Duration: 01/01/2021 - 30/06/2025

Publications

Can the microcystic, elongated and fragmented pattern of invasion influence the evaluation of the depth of myometrial invasion in low-grade endometrioid endometrial cancer using imaging techniques?

PMID: 37929250
Journal:
Year: 2023
Reference: Ultrasound. 2023 Nov;31(4):292-299. doi: 10.1177/1742271X231157618. Epub 2023 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Eliseo; Amat, Paula; Balaguer, Aitana; Barba, Pere; Beas, Francisco; Benzaquen, Ana; Bradbury, Melissa; Campos, Diana; Capell-Morell, Montserrat; Carpio, Cecilia et al.
DOI: 10.1177/1742271X231157618

Economic burden of Cardiac Arrest in Spain: analyzing healthcare costs drivers and treatment strategies cost-effectiveness.

PMID: 37936221
Journal: BMC HEALTH SERVICES RESEARCH
Year: 2023
Reference: BMC Health Serv Res. 2023 Nov 7;23(1):1220. doi: 10.1186/s12913-023-10274-4.
Impact factor:
Publication type: Paper in international publication
Authors: Ariza-Sole, Albert; Bradbury, Melissa; Capell-Morell, Montserrat; Cubo-Abert, Montserrat; Diaz-Feijoo, Berta; Ferrer, Ricard; Garcia-Jimenez, Angel; Gil-Moreno, Antonio; Gomez-Cabeza, Juan-Jose; Gomez-Lopez, Rocio et al.
DOI: 10.1186/s12913-023-10274-4

Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY.

PMID: 38033506
Journal: EClinicalMedicine
Year: 2023
Reference: EClinicalMedicine. 2023 Nov 15;65:102307. doi: 10.1016/j.eclinm.2023.102307. eCollection 2023 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Abdelrahman Soliman, Dina Sameh; Al-Shemari, Salem; Alcoceba, Miguel; Alobid, Isam; Angelopoulou, Maria; Antic, Darko; Aurran-Schleinitz, Therese; Bacchiarri, Francesca; Bellido, Mar; Biderman, Bella et al.
DOI: 10.1016/j.eclinm.2023.102307

Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition.

PMID: 38062117
Journal: npj Precision Oncology
Year: 2023
Reference: NPJ Precis Oncol. 2023 Dec 8;7(1):127. doi: 10.1038/s41698-023-00478-6.
Impact factor:
Publication type: Paper in international publication
Authors: Bonazzi, Vanessa; Chetty, Naven; Colas, Eva; Frentzas, Sophia; Gil-Moreno, Antonio; Lourie, Rohan; Moiola, Cristian P; Perrin, Lewis; Pollock, Pamela M; Rogers, Rebecca et al.
DOI: 10.1038/s41698-023-00478-6

Angiogenic factors for planning fetal surveillance in fetal growth restriction and small-for-gestational-age fetuses: a prospective observational study.

PMID: 35303394
Journal: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Year: 2022
Reference: BJOG. 2022 Mar 18. doi: 10.1111/1471-0528.17151.
Impact factor: 6.531
Publication type: Paper in international publication
Authors: Carreras, Elena, Armengol, Mireia, Bonacina, Erika, Mendoza, Manel, Farras, Alba, Garcia-Manau, Pablo, Serrano, Berta, Hurtado, Ivan, Ferrer-Oliveras, Raquel, Illan, Lidia et al.
DOI: 10.1111/1471-0528.17151

BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling.

PMID: 35292711
Journal: Scientific Reports
Year: 2022
Reference: Sci Rep. 2022 Mar 15;12(1):4445. doi: 10.1038/s41598-022-08461-0.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Gil-Moreno, Antonio, Sabido, Eduard, Santamaria, Anna, Perez-Benavente, Assumpcio, Sanchez-Iglesias, Jose Luis, Castellvi, Josep, Bradbury, Melissa, Borras, Eva, Mendez, Olga et al.
DOI: 10.1038/s41598-022-08461-0

Laparoscopic debulking of enlarged pelvic nodes during surgical paraaortic staging in locally advanced cervical cancer: a retrospective comparative cohort study.

PMID: 34217852
Journal: Journal of Minimally Invasive Gynecology
Year: 2022
Reference: J Minim Invasive Gynecol. 2022 Jan;29(1):103-113. doi: 10.1016/j.jmig.2021.06.027. Epub 2021 Jul 1.
Impact factor: 4.137
Publication type: Paper in international publication
Authors: Diaz-Feijoo, Berta, Acosta, Ursula, Torne, Aureli, Gil-Ibanez, Blanca, Hernandez, Alicia, Domingo, Santiago, Gil-Moreno, Antonio et al.
DOI: 10.1016/j.jmig.2021.06.027

Blog

News

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

From 6th to 7th March, more than 60 European researchers have shared the advances in translational research in endometrial cancer

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.