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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
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Patricia González Ruiz

Patricia González Ruiz

Administration and Management
Childhood Cancer and Blood Disorders
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Piqué Ponti, Julia

Piqué Ponti, Julia

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Sara Isabel Reidel

Sara Isabel Reidel

Research technician
Childhood Cancer and Blood Disorders
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Sonia Fuertes Castillo

Sonia Fuertes Castillo

Research technician
Childhood Cancer and Blood Disorders
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Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
Read more
Patricia González Ruiz

Patricia González Ruiz

Administration and Management
Childhood Cancer and Blood Disorders
Read more
Piqué Ponti, Julia

Piqué Ponti, Julia

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Sara Isabel Reidel

Sara Isabel Reidel

Research technician
Childhood Cancer and Blood Disorders
Read more
Sonia Fuertes Castillo

Sonia Fuertes Castillo

Research technician
Childhood Cancer and Blood Disorders
Read more

Projects

ERICA - European Rare dIsease research Coordination and support Action

IP: M Mar Mañu Pereira
Collaborators: ERICA - European Rare dIsease research Coordination and support Action , Raquel Mosull del Campo
Funding agency: EUROPEAN COMMISSION
Funding: 105250
Reference: ERICA_H2020-SC1-BHC-2020
Duration: 01/03/2021 - 28/02/2025

BEACON-BIO: deep biological characterisation and development of biomarkers for relapsed neuroblastoma

IP: Lucas Moreno Martín-Retortillo
Collaborators: Andrea Vilaplana Blanes, María Rosario Pérez- Torres Lobato
Funding agency: European Science Foundation
Funding: 104500
Reference: BEACON-BIO_FKC_2021
Duration: 01/01/2022 - 30/09/2025

Desarrollo de nuevos fármacos basados en la inhibición de los co-receptores de la vía Hedgehog

IP: Josep Roma Castanyer
Collaborators: Guillem Pons Barcons, Constantino Sábado Álvarez, Raquel Hladun Alvaro, Patricia Zarzosa Martinez
Funding agency: Instituto de Salud Carlos III
Funding: 122815
Reference: PI21/00640
Duration: 01/01/2022 - 31/12/2025

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Lorena Valero Arrese, Mariona Morell Daniel
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 30/06/2026

Publications

Risk of developing neuroblastoma influenced by maternal stressful life events during pregnancy and congenital pathologies.

PMID: 39618320
Journal: PEDIATRIC BLOOD & CANCER
Year: 2024
Reference: Pediatr Blood Cancer. 2024 Dec 2:e31402. doi: 10.1002/pbc.31402.
Impact factor:
Publication type: Paper in international publication
Authors: Alvaro, Tomas; Benavent, Nuria; Canete, Adela; Carbonell-Asins, Juan Antonio; Gros, Luis; Moreno, Lucas; Navarro, Samuel; Noguera, Rosa; Salinas, Jose Antonio; Tadeo, Irene et al.
DOI: 10.1002/pbc.31402

Stakeholder Perspectives on Randomized Clinical Trials for Children With Poor-Prognosis Cancers.

PMID: 39641924
Journal: JAMA Network Open
Year: 2024
Reference: JAMA Netw Open. 2024 Dec 2;7(12):e2449239. doi: 10.1001/jamanetworkopen.2024.49239.
Impact factor:
Publication type: Paper in international publication
Authors: Berlanga, Pablo; Bird, Nicholas; Blanc, Patricia; Buenger, Vickie; Campbell-Hewson, Quentin; Casanova, Michela; de Rojas, Teresa; DuBois, Steven; Glade Bender, Julia; Graham, Ann et al.
DOI: 10.1001/jamanetworkopen.2024.49239

Treatment of Pediatric, Adolescent, and Young Adult Patients With Fusion-Positive Alveolar Rhabdomyosarcoma Infiltrating Regional Lymph Nodes in the European CWS-2002P and RMS 2005 Studies and the Soft Tissue Sarcoma Registry.

PMID: 39655886
Journal: PEDIATRIC BLOOD & CANCER
Year: 2024
Reference: Pediatr Blood Cancer. 2024 Dec 10:e31476. doi: 10.1002/pbc.31476.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Gianni; Chisholm, Julia C; Ciuffolotti, Melissa; Fuchs, Jorg; Guillen, Gabriela; Heinz, Amadeus T; Koscielniak, Ewa; Merks, Johannes H M; Minard-Colin, Veronique; Schonstein, Anton et al.
DOI: 10.1002/pbc.31476

Real-World Data of Patients with BRAF V600E-Mutated Metastatic Colorectal Cancer Treated with Trifluridine/Tipiracil.

PMID: 39766040
Journal: Cancers
Year: 2024
Reference: Cancers (Basel). 2024 Dec 12;16(24):4140. doi: 10.3390/cancers16244140.
Impact factor:
Publication type: Paper in international publication
Authors: Alcaraz, Adriana; Alonso, Vicente; Balconi, Francesca; Baraibar, Iosune; Comas, Raquel; Elez, Elena; Garcia, Ariadna; Garcia-Galea, Eduardo; Gomez, Pablo; Martini, Giulia et al.
DOI: 10.3390/cancers16244140

Malignant vaginal tumor: About a case.

PMID: 36941185
Journal: ANALES DE PEDIATRIA
Year: 2023
Reference: An Pediatr. 2023 Mar 18:S2341-2879(23)00053-4. doi: 10.1016/j.anpede.2022.03.009.
Impact factor:
Publication type: Letter or abstract
Authors: Gros Subias, Luis; Morell Daniel, Mariona; Morey Olive, Miriam; Perez-Torres Lobato, Maria Rosario et al.
DOI: 10.1016/j.anpede.2022.03.009

Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon.

PMID: 36980521
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Mar 7;15(6):1636. doi: 10.3390/cancers15061636.
Impact factor:
Publication type: Paper in international publication
Authors: Gallego, Soledad; Gallo-Oller, Gabriel; Garcia-Gilabert, Lia; Magdaleno, Ainara; Moreno, Lucas; Navarro, Natalia; Pons, Guillem; Roma, Josep; Sanchez de Toledo, Josep; Sansa-Girona, Julia et al.
DOI: 10.3390/cancers15061636

Optimising urinary catecholamine metabolite diagnostics for neuroblastoma.

PMID: 37010353
Journal: PEDIATRIC BLOOD & CANCER
Year: 2023
Reference: Pediatr Blood Cancer. 2023 Jun;70(6):e30289. doi: 10.1002/pbc.30289. Epub 2023 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alba, Amparo; Almaraz, Ricardo Lopez; Alvaro, Raquel Hladun; Alvaro, Raquel Hladun; Ash, Shifra; Baka, Margarita; Barco, Sebastiano; Brichard, Benedicte; Bugajska, Jolanta; Canete, Adela et al.
DOI: 10.1002/pbc.30289

Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents.

PMID: 37015036
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2023
Reference: J Clin Oncol. 2023 Jun 20;41(18):3408-3422. doi: 10.1200/JCO.22.02430. Epub 2023 Apr 4.
Impact factor:
Publication type: Paper in international publication
Authors: Bird, Nick; Buenger, Vickie; Casanova, Michela; Doz, Francois; DuBois, Steven G; Fox, Elizabeth; Glade Bender, Julia; Gore, Lia; Hawkins, Douglas S; Iasonos, Alexia et al.
DOI: 10.1200/JCO.22.02430

Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors.

PMID: 34850167
Journal: NEURO-ONCOLOGY
Year: 2022
Reference: Neuro Oncol. 2022 Jun 1;24(6):997-1007. doi: 10.1093/neuonc/noab274.
Impact factor:
Publication type: Paper in international publication
Authors: Boni, Valentina; Capra, Michael; Chisholm, Julia; Chung, Hyun Cheol; De La Cuesta, Esther; Dima, Laura; Doz, Francois; Drilon, Alexander; DuBois, Steven G; Gallego-Melcon, Soledad et al.
DOI: 10.1093/neuonc/noab274

Neuroblastoma in Spain: Linking the national clinical database and epidemiological registries - A study by the Joint Action on Rare Cancers.

PMID: 35344745
Journal: Cancer Epidemiology
Year: 2022
Reference: Cancer Epidemiol. 2022 Jun;78:102145. doi: 10.1016/j.canep.2022.102145. Epub 2022 Mar 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alamo, R; Aleman, A; Almazan, F; Benito, A I; Buedo, M I; Calvo, C; Canete, A; Canete, Adela; Capocaccia, Riccardo; Chico, M et al.
DOI: 10.1016/j.canep.2022.102145

Post thawing viable CD34+ Cells dose is a better predictor of clinical outcome in lymphoma patients undergoing autologous stem cell transplantation.

PMID: 35614316
Journal: BONE MARROW TRANSPLANTATION
Year: 2022
Reference: Bone Marrow Transplant. 2022 Aug;57(8):1341-1343. doi: 10.1038/s41409-022-01722-6. Epub 2022 May 25.
Impact factor:
Publication type: Letter whit IF
Authors: Alonso, Eva; Arroba, Jose Garcia; Azqueta, Carmen; Benitez, Maria Isabel; Carreras, Enric; Castillo-Flores, Nerea; Cid, Joan; Codinach, Margarita; Coll, Rosa; Esquirol, Albert et al.
DOI: 10.1038/s41409-022-01722-6

Southeast Asian ovalocytosis detected in a critical patient with COVID-19 pneumonia.

PMID: 35580896
Journal: International Journal of Laboratory Hematology
Year: 2022
Reference: Int J Lab Hematol. 2022 Oct;44(5):e215-e218. doi: 10.1111/ijlh.13878. Epub 2022 May 17.
Impact factor:
Publication type: Letter whit IF
Authors: Diaz-Ricart, Maribel; Escolar, Gines; Faneca, Joana; Garcia, Estefania; Idrizovic, Amira; Manu-Pereira, Maria Del Mar; Matute, Monica; Merino, Anna; Molina, Angel; Moreno-Castano, Ana Belen et al.
DOI: 10.1111/ijlh.13878

Supportive Care During Pediatric Hematopoietic Stem Cell Transplantation: Prevention of Infections. A Report From Workshops on Supportive Care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).

PMID: 34395344
Journal: Frontiers in Pediatrics
Year: 2021
Reference: Front Pediatr. 2021 Jul 29;9:705179. doi: 10.3389/fped.2021.705179. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Ansari, Marc; Bader, Peter; Bakhtiar, Shahrzad; Balduzzi, Adriana; Bertaina, Alice; Bonig, Halvard; Broggi, Chiara; Buechner, Jochen; Canesi, Marta; Cesaro, Simone et al.
DOI: 10.3389/fped.2021.705179

Role of (18)F-FDG-PET/CT in the staging of metastatic rhabdomyosarcoma: a report from the European paediatric Soft tissue sarcoma Study Group.

PMID: 34385068
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2021
Reference: Eur J Cancer. 2021 Sep;155:155-162. doi: 10.1016/j.ejca.2021.07.006. Epub 2021 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Gianni; Cameron, Alison; Chisholm, Julia; Coppadoro, Beatrice; Corradini, Nadege; Gallego, Soledad; Jehanno, Nina; Mercolini, Federico; Merks, J Hans; Minard-Colin, Veronique et al.
DOI: 10.1016/j.ejca.2021.07.006

Randomized Phase II Trial of Vincristine-Irinotecan With or Without Temozolomide, in Children and Adults With Relapsed or Refractory Rhabdomyosarcoma: A European Paediatric Soft tissue Sarcoma Study Group and Innovative Therapies for Children With Cancer Trial.

PMID: 34343032
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2021
Reference: J Clin Oncol. 2021 Sep 20;39(27):2979-2990. doi: 10.1200/JCO.21.00124. Epub 2021 Aug 3.
Impact factor:
Publication type: Letter whit IF
Authors: Bisogno, Gianni; Bogart, Emilie; Calareso, Giuseppina; Casanova, Michela; Chisholm, Julia C; Defachelles, Anne-Sophie; Gallego Melcon, Soledad; Gatz, Susanne Andrea; Le Deley, Marie-Cecile; McHugh, Kieran et al.
DOI: 10.1200/JCO.21.00124

Voriconazole Use in Children: Therapeutic Drug Monitoring and Control of Inflammation as Key Points for Optimal Treatment.

PMID: 34200506
Journal: Journal of Fungi
Year: 2021
Reference: J Fungi (Basel). 2021 Jun 7;7(6). pii: jof7060456. doi: 10.3390/jof7060456.
Impact factor:
Publication type: Paper in international publication
Authors: Benitez Carabante, Maria Isabel; Diaz-de-Heredia, Cristina; Martin-Gomez, Maria Teresa; Mendoza-Palomar, Natalia; Renedo Miro, Berta; Soler-Palacin, Pere; Valle-T-Figueras, Jose Maria; Vima Bofarull, Jaume et al.
DOI: 10.3390/jof7060456

[Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome].

PMID: 32593520
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Aug;93(2):132-133. doi: 10.1016/j.anpedi.2020.05.002. Epub 2020 Jun 9.
Impact factor:
Publication type: Letter whit IF
Authors: Diaz de Heredia, Cristina; Moreno, Lucas; Riviere, Jacques G; Soler Palacin, Pere; Velasco Puyo, Pablo et al.
DOI: 10.1016/j.anpedi.2020.05.002

Noninvasive MRI native T1 mapping detects response to MYCN-targeted therapies in the Th-MYCN model of neuroblastoma.

PMID: 32595135
Journal: CANCER RESEARCH
Year: 2020
Reference: Cancer Res. 2020 Aug 15;80(16):3424-3435. doi: 10.1158/0008-5472.CAN-20-0133. Epub 2020 Jun 28.
Impact factor:
Publication type: Paper in international publication
Authors: Anderson, John; Barone, Giuseppe; Blackledge, Matthew D; Boult, Jessica K R; Carceller, Fernando; Chesler, Louis; Clarke, Matthew; Jamin, Yann; Jerome, Neil P; Koers, Alexander et al.
DOI: 10.1158/0008-5472.CAN-20-0133

Paratesticular rhabdomyosarcoma-Impact of locoregional approach on patient outcome: A report from the European paediatric Soft tissue sarcoma Study Group (EpSSG).

PMID: 32573979
Journal: PEDIATRIC BLOOD & CANCER
Year: 2020
Reference: Pediatr Blood Cancer. 2020 Sep;67(9):e28479. doi: 10.1002/pbc.28479. Epub 2020 Jun 23.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Gianni; Burrieza, Gabriela Guillen; Coppadoro, Beatrice; Craigie, Ross; De Corti, Federica; De Salvo, Gian Luca; Guerin, Florent; Jenney, Meriel; Kelsey, Anna; Martelli, Helene et al.
DOI: 10.1002/pbc.28479

Phase II results from a phase I/II study to assess the safety and efficacy of weekly nab-paclitaxel in paediatric patients with recurrent or refractory solid tumours: A collaboration with the European Innovative Therapies for Children with Cancer Network.

PMID: 32554315
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2020
Reference: Eur J Cancer. 2020 Aug;135:89-97. doi: 10.1016/j.ejca.2020.04.031. Epub 2020 Jun 15.
Impact factor:
Publication type: Paper in international publication
Authors: Amoroso, Loredana; Bisogno, Gianni; Casanova, Michela; Castel, Victoria; Chen, Nianhang; Chisholm, Julia C; Doz, Francois; Fagioli, Franca; Gerber, Nicolas U; Hingorani, Pooja et al.
DOI: 10.1016/j.ejca.2020.04.031

Prominent venous circulation and thick lips in an 8-year-old boy with congenital neutropenia.

PMID: 31099923
Journal: PEDIATRIC DERMATOLOGY
Year: 2019
Reference: Pediatr Dermatol. 2019 May;36(3):e69-e70. doi: 10.1111/pde.13760.
Impact factor:
Publication type: Paper in international publication
Authors: Diaz de Heredia Rubio, Cristina; Giacaman, Aniza; Martin-Santiago, Ana; Navarro Noguera, Samuel; Salinas Sanz, Jose Antonio et al.
DOI: 10.1111/pde.13760

Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.

PMID: 31040790
Journal: Frontiers in Physiology
Year: 2019
Reference: Front Physiol. 2019 Apr 16;10:386. doi: 10.3389/fphys.2019.00386. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Bogdanova, Anna; Danielczok, Jens; Hertz, Laura; Huisjes, Rick; Kaestner, Lars; Makhro, Asya; Manu-Pereira, Maria Del Mar; Petkova-Kirova, Polina; van Wijk, Richard; Vives Corrons, Joan-Lluis et al.
DOI: 10.3389/fphys.2019.00386

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways.

PMID: 31001323
Journal: Frontiers in Genetics
Year: 2019
Reference: Front Genet. 2019 Apr 2;10:281. doi: 10.3389/fgene.2019.00281. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Hummer, Stefan; Ramon Y Cajal, Santiago; Segura, Miguel F et al.
DOI: 10.3389/fgene.2019.00281

Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.

PMID: 30995915
Journal: Orphanet Journal of Rare Diseases
Year: 2019
Reference: Orphanet J Rare Dis. 2019 Apr 17;14(1):82. doi: 10.1186/s13023-019-1046-0.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Salgado, Elena G; Badell-Serra, Isabel; Bastos-Oreiro, Mariana; Carrillo, Jaime; Catala, Albert; Diaz-Heredia, Cristina; Galera-Minarro, Ana; Galvez, Eva; Gonzalez-Granado, Luis I; Iarriccio, Laura et al.
DOI: 10.1186/s13023-019-1046-0

Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005).

PMID: 29286582
Journal: PEDIATRIC BLOOD & CANCER
Year: 2018
Reference: Pediatr Blood Cancer. 2018 Apr;65(4). doi: 10.1002/pbc.26942. Epub 2017 Dec 29.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Gianni; Brennan, Bernadette; Casanova, Michela; De Salvo, Gian Luca; Ferrari, Andrea; Francotte, Nadine; Gallego, Soledad; Kelsey, Anna; Orbach, Daniel; Van Noesel, Max et al.
DOI: 10.1002/pbc.26942

Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study.

PMID: 29211298
Journal: CANCER
Year: 2018
Reference: Cancer. 2018 Mar 1;124(5):1016-1024. doi: 10.1002/cncr.31157. Epub 2017 Dec 6.
Impact factor:
Publication type: Paper in international publication
Authors: Bergeron, Christophe; Breunis, Willemijn B; Chisholm, Julia C; Cozic, Nathalie; Devalck, Christine; Gallego, Soledad; Gaze, Mark N; Glosli, Heidi; Jenney, Meriel; Kelsey, Anna et al.
DOI: 10.1002/cncr.31157

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer.

PMID: 29206819
Journal: BRITISH JOURNAL OF CANCER
Year: 2018
Reference: Br J Cancer. 2018 Jan;118(1):106-116. doi: 10.1038/bjc.2017.420. Epub 2017 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Anguita, Estefania; Arango, Diego; Bazzocco, Sarah; Bilic, Josipa; Carton-Garcia, Fernando; de Marcondes, Priscila Guimaraes; Dopeso, Higinio; Jimenez-Flores, Lizbeth M; Macaya, Irati; Mariadason, John M et al.
DOI: 10.1038/bjc.2017.420

Role of the Long Non-Coding RNA Growth Arrest-Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease.

PMID: 28722800
Journal: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Year: 2018
Reference: Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):87-93. doi: 10.1111/bcpt.12851. Epub 2017 Aug 9.
Impact factor:
Publication type: Paper in international publication
Authors: Antonelli, Roberta; Avian, Alice; De Iudicibus, Sara; Decorti, Giuliana; Di Silvestre, Alessia; Lucafo, Marianna; Martelossi, Stefano; Naviglio, Samuele; Romano, Maurizio; Stocco, Gabriele et al.
DOI: 10.1111/bcpt.12851

[Early clinical trials in paediatric oncology in Spain: a nationwide perspective].

PMID: 28279690
Journal: ANALES DE PEDIATRIA
Year: 2017
Reference: An Pediatr (Barc). 2017 Sep;87(3):155-163. doi: 10.1016/j.anpedi.2016.07.007. Epub 2017 Mar 6.
Impact factor:
Publication type: Review in national publication
Authors: Acha, Tomas; Astigarraga, Itziar; Bautista, Francisco; Berlanga, Pablo; Canete, Adela; Cela, Maria Elena; Cruz, Ofelia; Diaz de Heredia, Cristina; Fernandez Delgado, Rafael; Fernandez, Jose Maria et al.
DOI: 10.1016/j.anpedi.2016.07.007

A risk factor analysis of outcomes after unrelated cord blood transplantation for children with Wiskott-Aldrich syndrome.

PMID: 28255019
Journal: HAEMATOLOGICA
Year: 2017
Reference: Haematologica. 2017 Jun;102(6):1112-1119. doi: 10.3324/haematol.2016.158808. Epub 2017 Mar 2.
Impact factor:
Publication type: Paper in international publication
Authors: AlSeraihy, Amal; Barriga, Francisco; Bittencourt, Henrique; Boelens, Jaap Jan; Bonfim, Carmem; Chybicka, Alicja; de Toledo Codina, Jose Sanchez; Gennery, Andrew R; Giannotti, Federica; Gluckman, Eliane et al.
DOI: 10.3324/haematol.2016.158808

Thoracic wall reconstruction with bioabsorbable plates in pediatric malignant thoracic wall tumors.

PMID: 27653461
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2017
Reference: J Pediatr Surg. 2017 Mar;52(3):377-381. doi: 10.1016/j.jpedsurg.2016.08.018. Epub 2016 Aug 31.
Impact factor:
Publication type: Paper in international publication
Authors: Fontecha, C G; Garcia, L; Guillen, G; Lloret, J; Lopez, S; Marhuenda, C; Molino, J A; Pellise, F et al.
DOI: 10.1016/j.jpedsurg.2016.08.018

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.

PMID: 28243259
Journal: Stem Cells International
Year: 2017
Reference: Stem Cells Int. 2017;2017:7507380. doi: 10.1155/2017/7507380. Epub 2017 Jan 24.
Impact factor:
Publication type: Paper in international publication
Authors: Alfranca, Arantza; Almazan-Moga, Ana; Gallego, Soledad; Garcia-Castro, Javier; Giralt, Irina; Molist, Carla; Navarro, Natalia; Roma, Josep; Sanchez de Toledo, Jose; Segura, Miguel F et al.
DOI: 10.1155/2017/7507380

Successful Treatment of Sinusitis by Acanthamoeba in a Pediatric Patient After Allogeneic Stem Cell Transplantation.

PMID: 27626919
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2016
Reference: Pediatr Infect Dis J. 2016 Dec;35(12):1350-1351.
Impact factor: 2.587
Publication type: Paper in international publication
Authors: Juan, Antonio, Alonso, Laura, Olive, Teresa, Navarro, Alexandra, Sulleiro, Elena, Sanchez de Toledo, Jose, Diaz de Heredia, Cristina et al.
DOI: 10.1097/INF.0000000000001329

Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience.

PMID: 26849118
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2016
Reference: Eur J Cancer. 2016 Apr;57:1-9. doi: 10.1016/j.ejca.2015.12.028. Epub 2016 Feb 2.
Impact factor: 6.163
Publication type: Paper in international publication
Authors: Gallego, Soledad, Orbach, Daniel, Brennan, Bernadette, De Paoli, Angela, van Noesel, Max, Kelsey, Anna, Alaggio, Rita, Ranchere, Dominique, De Salvo, Gian Luca, Casanova, Michela et al.
DOI: 10.1016/j.ejca.2015.12.028

BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways.

PMID: 26996667
Journal: ONCOGENE
Year: 2016
Reference: Oncogene. 2016 Sep 29;35(39):5179-90. doi: 10.1038/onc.2016.50. Epub 2016 Mar 21.
Impact factor: 7.932
Publication type: Paper in international publication
Authors: Soriano, A, Planells-Ferrer, L, Paris-Coderch, L, Tenbaum, S P, Romero, O A, Moubarak, R S, Almazan-Moga, A, Molist, C, Roma, J, Navarro, S et al.
DOI: 10.1038/onc.2016.50

Editorial: Embryonic signaling pathways as potential targets for the treatment of rhabdomyosarcoma.

PMID: 26947582
Journal: CURRENT DRUG TARGETS
Year: 2016
Reference: Curr Drug Targets. 2016 Jul 29;17(11):1226-7.
Impact factor: 3.029
Publication type: Editorail in international publication
Authors: Gallego, Soledad, Roma, Josep et al.
DOI:

The role of leptin in diencephalic syndrome.

PMID: 24366994
Journal: PEDIATRICS
Year: 2014
Reference: Pediatrics. 2014 Jan;133(1):e263-6. doi: 10.1542/peds.2012-3196. Epub 2013 Dec 23.
Impact factor: 5.297
Publication type: Paper in international publication
Authors: Velasco, Pablo, Clemente, Maria, Lorite, Raquel, Ventura, M Clara, Gros, Luis, Sanchez de Toledo, Jose, Gallego, Soledad et al.
DOI: 10.1542/peds.2012-3196

Conservative approach in localised rhabdomyosarcoma of the bladder and prostate: Results from International Society of Paediatric Oncology (SIOP) studies: Malignant mesenchymal tumour (MMT) 84, 89 and 95.

PMID: 23997024
Journal: PEDIATR BLOOD CANCER
Year: 2014
Reference: Pediatr Blood Cancer. 2014 Feb;61(2):217-22. doi: 10.1002/pbc.24727. Epub 2013 Aug 29.
Impact factor: 2.562
Publication type: Paper in international publication
Authors: Martelli, Helene, Jenney, Meriel, Oberlin, Odile, Audry, Georges, Stevens, Michael Cg, Rey, Annie, Merks, Johannes Hm, Kelsey, Anna, Gallego, Soledad, Haie-Meder, Christine et al.
DOI: 10.1002/pbc.24727

[The Spanish Society of Paediatric Infectious Diseases (SEIP) recommendations on the diagnosis and management of invasive candidiasis.]

PMID: 21396895
Journal: ANALES DE PEDIATRIA
Year: 2011
Reference: An Pediatr (Barc). 2011 May;74(5):337.e1-337.e17. Epub 2011 Mar 10.
Impact factor: 0.57
Publication type: Paper in national publication
Authors: , , , , , , , , et al.
DOI: 10.1016/j.anpedi.2010.12.012

[Spectrum of primary immunodeficiencies in a tertiary hospital over a period of 10 years].

PMID: 21168377
Journal: ANALES DE PEDIATRIA
Year: 2011
Reference: An Pediatr (Barc). 2011 Feb;74(2):74-83. Epub 2010 Dec 17.
Impact factor: 0.57
Publication type: Paper in national publication
Authors: Martin-Nalda, A, Soler-Palacin, P, Espanol Boren, T, Caragol Urgelles, I, Diaz de Heredia Rubio, C, Figueras Nadal, C et al.
DOI: 10.1016/j.anpedi.2010.09.019

B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen.

PMID: 22197976
Journal: NATURE IMMUNOLOGY
Year: 2011
Reference: Nat Immunol. 2011 Dec 25;13(2):170-80. doi: 10.1038/ni.2194.
Impact factor: 25.668
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/ni.2194

Valganciclovir as pre-emptive therapy for cytomegalovirus infection in allogeneic haematopoietic stem cell transplant recipients.

PMID: 22024510
Journal: ANTIVIRAL THERAPY
Year: 2011
Reference: Antivir Ther. 2011;16(7):951-7.
Impact factor: 3.774
Publication type: Paper in international publication
Authors: Ruiz-Camps, Isabel, Len, Oscar, de la Camara, Rafael, Gurgui, Mercedes, Martino, Rodrigo, Jarque, Isidro, Barrenetxea, Cristina, Diaz de Heredia, Cristina, Batlle, Montserrat, Rovira, Montserrat et al.
DOI: 10.3851/IMP1858

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News

The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.

The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.