About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
IP: M Mar Mañu Pereira Collaborators: Reidel , Sara Isabel, Ali Haidar, Ferran Balbastre Ubeda, Amira Idrizovic, Sara Isabel Reidel Funding agency: EUROPEAN COMMISSION Funding: 434000 Reference: GENOMED4ALL_H2020-SC1-FA-DTS-2018-20 Duration: 01/01/2021 - 31/12/2024
IP: Josep Roma Castanyer Collaborators: Soledad Gallego Melcón, Guillem Pons Barcons, Constantino Sábado Álvarez, Raquel Hladun Alvaro, Patricia Zarzosa Martinez Funding agency: Instituto de Salud Carlos III Funding: 122815 Reference: PI21/00640 Duration: 01/01/2022 - 31/12/2024
IP: Lucas Moreno Martín-Retortillo Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Paula Cabre Fernandez, Lorena Valero Arrese, Sergio Manresa Vera, Mariona Morell Daniel Funding agency: Instituto de Salud Carlos III Funding: 214170 Reference: PI21/01661 Duration: 01/01/2022 - 31/12/2024
IP: Lucas Moreno Martín-Retortillo Collaborators: Soledad Gallego Melcón, Cristina Gamez Cenzano, Aroa Soriano Fernández, Luis Riera Soler, Miguel Segura Ginard, Carlota Aguilera Ordoñez, Sergio Manresa Vera Funding agency: Instituto de Salud Carlos III Funding: 826760.77 Reference: ICI21/00076 Duration: 01/01/2022 - 31/12/2025
PMID: 38008809 Journal: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY Year: 2023 Reference: J Cancer Res Clin Oncol. 2023 Nov 26. doi: 10.1007/s00432-023-05500-9. Impact factor: Publication type: Paper in international publication Authors: Aldamiz, Teresa; Alonso, Lucia; Alvarez-Lopez, Patricia; Amador Prous, Concha; Asensi, Victor; Blanco, Jose Luis; Bruguera, Andreu; Calzado Isbert, Sonia; Casabona, Jordi; Curran, Adrian et al. DOI: 10.1007/s00432-023-05500-9
PMID: 35523687 Journal: ANALES DE PEDIATRIA Year: 2022 Reference: An Pediatr (Engl Ed). 2022 Apr;96(4):309-318. doi: 10.1016/j.anpede.2021.02.016. Epub 2022 May 3. Impact factor: 1.5 Publication type: Paper in international publication Authors: de la Fuente Regano, Lydia, Rodriguez Villa, Antonia, Diaz de Heredia Rubio, Cristina, Gonzalez Vicent, Marta, Badell Serra, Isabel, Maria Fernandez, Jose, Isabel Pascual Martinez, Antonia, Maria Perez Hurtado, Jose, Lopez Duarte, Monica, Soledad Maldonado Regalado, M et al. DOI: 10.1016/j.anpede.2021.02.016
PMID: 34718043 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2022 Reference: J Allergy Clin Immunol. 2022 May;149(5):1744-1754.e8. doi: 10.1016/j.jaci.2021.10.017. Epub 2021 Oct 27. Impact factor: 10.793 Publication type: Paper in international publication Authors: Courteille, Virginie, Lankester, Arjan C, Neven, Benedicte, Mahlaoui, Nizar, von Asmuth, Erik Gj, Kansoy, Savas, Kupesiz, Alphan, Lanfranchi, Arnalda, Lindemans, Caroline A, Meisel, Roland et al. DOI: 10.1016/j.jaci.2021.10.017
PMID: 35466492 Journal: PEDIATRIC TRANSPLANTATION Year: 2022 Reference: Pediatr Transplant. 2022 Apr 24:e14292. doi: 10.1111/petr.14292. Impact factor: 1.502 Publication type: Paper in international publication Authors: Navarro Jimenez, Alexandra, Garrido Pontnou, Marta, Camacho Soriano, Jessica, Hidalgo Llompart, Ernest, Bilbao Aguirre, Itxarone, Charco Torra, Itzarone, Esperalba, Juliana, Melendo Perez, Susana, Sabado Alvarez, Constantino, Quintero Bernabeu, Jesus et al. DOI: 10.1111/petr.14292
PMID: 35393436 Journal: Cell Death Discovery Year: 2022 Reference: Cell Death Discov. 2022 Apr 7;8(1):172. doi: 10.1038/s41420-022-00959-w. Impact factor: 5.241 Publication type: Paper in international publication Authors: Alcon, Clara, Martin, Fernando, Prada, Estela, Mora, Jaume, Soriano, Aroa, Guillen, Gabriela, Gallego, Soledad, Roma, Josep, Samitier, Josep, Villanueva, Alberto et al. DOI: 10.1038/s41420-022-00959-w
PMID: 34077956 Journal: NEURO-ONCOLOGY Year: 2021 Reference: Neuro Oncol. 2021 Sep 1;23(9):1597-1611. doi: 10.1093/neuonc/noab136. Impact factor: 12.3 Publication type: Paper in international publication Authors: von Hoff, Katja, Snuderl, Matija, Zheludkova, Olga, Golanov, Andrey, Okonechnikov, Konstantin, Mynarek, Martin, Juhnke, B Ole, Rutkowski, Stefan, Schuller, Ulrich, Pizer, Barry et al. DOI: 10.1093/neuonc/noab136
PMID: 34076861 Journal: Clinical & Translational Oncology Year: 2021 Reference: Clin Transl Oncol. 2021 Dec;23(12):2489-2496. doi: 10.1007/s12094-021-02649-y. Epub 2021 Jun 2. Impact factor: 3.405 Publication type: Paper in international publication Authors: Canete, A, Rives, S, Perez-Martinez, A, Mora, J, Patino-Garcia, A, Lassaleta, A, Llort, A, Ramirez, M, Mata, C, Gallego, S et al. DOI: 10.1007/s12094-021-02649-y
PMID: 34025429 Journal: Frontiers in Pharmacology Year: 2021 Reference: Front Pharmacol. 2021 May 5;12:670945. doi: 10.3389/fphar.2021.670945. eCollection 2021. Impact factor: 5.811 Publication type: Paper in international publication Authors: Amaro-Hosey, Kristopher, Danes, Immaculada, Vendrell, Lourdes, Alonso, Laura, Renedo, Berta, Gros, Luis, Vidal, Xavier, Cereza, Gloria, Agusti, Antonia et al. DOI: 10.3389/fphar.2021.670945
PMID: 33984160 Journal: AMERICAN JOURNAL OF HEMATOLOGY Year: 2021 Reference: Am J Hematol. 2021 Aug 1;96(8):989-999. doi: 10.1002/ajh.26234. Epub 2021 May 25. Impact factor: 10.047 Publication type: Paper in international publication Authors: Ramirez, Maria Jose, Pujol, Roser, Trujillo-Quintero, Juan Pablo, Minguillon, Jordi, Bogliolo, Massimo, Rio, Paula, Navarro, Susana, Casado, Jose A, Badell, Isabel, Carrasco, Estela et al. DOI: 10.1002/ajh.26234
PMID: 32455804 Journal: Cancers Year: 2020 Reference: Cancers (Basel). 2020 May 21;12(5). pii: cancers12051313. doi: 10.3390/cancers12051313. Impact factor: 6.126 Publication type: Review in international publication Authors: Montesinos, Pau, Sobas, Marta, Talarn-Forcadell, Maria Carme, Martinez-Cuadron, David, Escoda, Lourdes, Garcia-Perez, Maria J, Mariz, Jose, Mela-Osorio, Maria J, Fernandez, Isolda, Alonso-Dominguez, Juan M et al. DOI: 10.3390/cancers12051313
PMID: 32421361 Journal: Expert Opinion on Drug Discovery Year: 2020 Reference: Expert Opin Drug Discov. 2020 Aug;15(8):869-872. doi: 10.1080/17460441.2020.1767064. Epub 2020 May 18. Impact factor: 4.887 Publication type: Editorail in international publication Authors: Moreno, Lucas, DuBois, Steven G, Marshall, Lynley V, Fox, Elizabeth, Carceller, Fernando, Pearson, Andrew Dj et al. DOI: 10.1080/17460441.2020.1767064
PMID: 31147440 Journal: HAEMATOLOGICA Year: 2020 Reference: Haematologica. 2020 Jan 31;105(2):338-347. doi: 10.3324/haematol.2018.188151. Print 2020. Impact factor: 7.116 Publication type: Paper in international publication Authors: van Wijk, Richard, Bogdanova, Anna, Manu-Pereira, Maria, Kaestner, Lars, Corrons, Joan-LLuis Vives, Makhro, Asya, Llaudet-Planas, Esther, Hertz, Laura, Petkova-Kirova, Polina, Verhagen, Liesbeth P et al. DOI: 10.3324/haematol.2018.188151
PMID: 32335674 Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY Year: 2020 Reference: J Antimicrob Chemother. 2020 Aug 1;75(8):2264-2271. doi: 10.1093/jac/dkaa149. Impact factor: 5.439 Publication type: Paper in international publication Authors: Mendoza-Palomar, Natalia, Soques, Elena, Benitez-Carabante, Maria Isabel, Gonzalez-Amores, Miriam, Fernandez-Polo, Aurora, Renedo, Berta, Martin, Maria Teresa, Soler-Palacin, Pere, Diaz-de-Heredia, Cristina et al. DOI: 10.1093/jac/dkaa149
PMID: 30001893 Journal: MEDICINA CLINICA Year: 2019 Reference: Med Clin (Barc). 2019 Feb 15;152(4):135-140. doi: 10.1016/j.medcli.2018.05.013. Epub 2018 Jul 9. Impact factor: 1.277 Publication type: Paper in national publication Authors: Alonso, Laura, Gonzalez-Vicent, Marta, Belendez, Cristina, Badell, Isabel, Sastre, Ana, Rodriguez-Villa, Antonia, Bermudez-Cortes, Mar, Hladun, Raquel, Diaz de Heredia, Cristina et al. DOI: 10.1016/j.medcli.2018.05.013
PMID: 30679331 Journal: HAEMATOLOGICA Year: 2019 Reference: Haematologica. 2019 Aug;104(8):e335-e339. doi: 10.3324/haematol.2018.206623. Epub 2019 Jan 24. Impact factor: 7.57 Publication type: Letter whit IF Authors: Sierra, Jorge, Uckan-Cetinkaya, Duygu, Skorobogatova, Elena, Antmen, Ali Bulent, Dalle, Jean-Hugues, Markiewicz, Miroslaw, Hamladji, Rose Marie, Kitra-Roussou, Vassiliki, La Nasa, Giorgio, Krivan, Gergely et al. DOI: 10.3324/haematol.2018.206623
PMID: 30660643 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2019 Reference: J Allergy Clin Immunol. 2019 Jun;143(6):2238-2253. doi: 10.1016/j.jaci.2018.12.1010. Epub 2019 Jan 17. Impact factor: 14.11 Publication type: Paper in international publication Authors: Lindemans, Caroline A, Soncini, Elena, Porta, Fulvio, Al-Mousa, Hamoud, Al-Saud, Bandar, Al-Dhekri, Hasan, Arnaout, Rand, Formankova, Renata, Bertrand, Yves, Lange, Andrzej et al. DOI: 10.1016/j.jaci.2018.12.1010
PMID: 27811020 Journal: BLOOD Year: 2017 Reference: Blood. 2017 Jan 26;129(4):525-532. doi: 10.1182/blood-2016-06-722249. Epub 2016 Nov 3. Impact factor: 13.164 Publication type: Paper in international publication Authors: Rocha, Vanderson, Cunha, Renato, Zago, Marco A, Querol, Sergio, Volt, Fernanda, Ruggeri, Annalisa, Sanz, Guillermo, Pouthier, Fabienne, Kogler, Gesine, Vicario, Jose L et al. DOI: 10.1182/blood-2016-06-722249
La iniciativa "Sin Piedad" explica la història d'en David, un nen que s'està tractant d'un càncer pediàtric, un exemple d'actitud lluitadora davant la malaltia.
The money will allow research into paediatric nervous system tumours and childhood sarcomas to continue, with the aim of improving children's chances of survival and reducing the side effects of treatment.
The association makes the fifth annual donation of 52,390€ that will finance a project to study new therapies for this childhood tumor.
