About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
IP: Lucas Moreno Martín-Retortillo Collaborators: Cristina Gamez Cenzano, Aroa Soriano Fernández, Luis Riera Soler, Miguel Segura Ginard, Carlota Aguilera Ordoñez Funding agency: Instituto de Salud Carlos III Funding: 826760.77 Reference: ICI21/00076 Duration: 01/01/2022 - 31/12/2025
IP: Lucas Moreno Martín-Retortillo Collaborators: Aroa Soriano Fernández, Marta Garrido Pontnou, Miguel Segura Ginard, Lorena Valero Arrese, Raquel Hladun Alvaro, Elena Antima Martinez Saez, Marta Sese Faustino, Gabriela Guillén Burrieza, Josep Roma Castanyer, Andrea Vilaplana Blanes, Margarita Ortega Blanco, María Rosario Pérez- Torres Lobato, Asbleidy Carolina Torres Barbosa, Berta Campos Estela Funding agency: Instituto de Salud Carlos III Funding: 369260 Reference: PMP21/00073 Duration: 01/01/2022 - 31/12/2025
PMID: 38190578 Journal: JOURNAL OF CLINICAL ONCOLOGY Year: 2024 Reference: J Clin Oncol. 2024 Jan 8:JCO2300458. doi: 10.1200/JCO.23.00458. Impact factor: Publication type: Paper in international publication Authors: Barone, Giuseppe; Bautista, Francisco J; Burchill, Susan A; Caron, Hubert; Castel, Victoria; Castellano, Aurora; Chastagner, Pascal; Chesler, Louis; Corradini, Nadege; De Wilde, Bram et al. DOI: 10.1200/JCO.23.00458
PMID: 37020654 Journal: Frontiers in Pediatrics Year: 2023 Reference: Front Pediatr. 2023 Mar 20;11:1140637. doi: 10.3389/fped.2023.1140637. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Adan Pedroso, Rosa Maria; Aguilar, Yurena; Bautista, Francisco; Dapena, Jose Luis; Diaz de Heredia, Cristina; Fernandez, Jose Maria; Fuentes, Carolina; Fuster, Jose Luis; Gonzaalez Martinez, Berta; Gonzalez-Vicent, Marta et al. DOI: 10.3389/fped.2023.1140637
PMID: 37054980 Journal: EUROPEAN JOURNAL OF PEDIATRIC SURGERY Year: 2023 Reference: Eur J Pediatr Surg. 2023 Apr 13. doi: 10.1055/a-2072-9754. Impact factor: Publication type: Paper in international publication Authors: Andreu Riobello, Eva; Cadaval, Carlos; Guillen, Gabriela; Khan, Haider Ali; Lopez Hierro, Carmen; Lopez, Manuel; Lopez-Fernandez, Sergio; Martos Rodriguez, Marta; Molino, Jose Andres; Ruiz, Cesar W et al. DOI: 10.1055/a-2072-9754
PMID: 37268527 Journal: Anales de pediatria Year: 2023 Reference: An Pediatr (Engl Ed). 2023 May 31:S2341-2879(23)00111-4. doi: 10.1016/j.anpede.2023.03.010. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Alonso, David; Ferres Ramis, Laia; Martinez Campos, Leticia; Mendoza-Palomar, Natalia; Perez-Albert, Paula; Perez-Albert, Paula; Rincon-Lopez, Elena Maria; Soler-Palacin, Pere et al. DOI: 10.1016/j.anpede.2023.03.010
PMID: 37292376 Journal: Frontiers in Pediatrics Year: 2023 Reference: Front Pediatr. 2023 May 24;11:1183295. doi: 10.3389/fped.2023.1183295. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Aerts, Isabelle; Andre, Nicolas; Bautista, Francisco; Croop, James M; De Wilde, Bram; Gerber, Nicolas U; Gros Subias, Luis; Hamidi, Ali; Kunduri, Srinivasa; Lawrence, Tatiana et al. DOI: 10.3389/fped.2023.1183295
PMID: 35574376 Journal: Frontiers in Oncology Year: 2022 Reference: Front Oncol. 2022 Apr 27;12:835642. doi: 10.3389/fonc.2022.835642. eCollection 2022. Impact factor: Publication type: Paper in international publication Authors: Camero, Simona; Cassandri, Matteo; Cervelli, Manuela; Colletti, Marta; Cossetti, Cristina; De Angelis, Biagio; de Billy, Emmanuel; Di Giannatale, Angela; Gallego, Soledad; Locatelli, Franco et al. DOI: 10.3389/fonc.2022.835642
PMID: 35523687 Journal: ANALES DE PEDIATRIA Year: 2022 Reference: An Pediatr (Engl Ed). 2022 Apr;96(4):309-318. doi: 10.1016/j.anpede.2021.02.016. Epub 2022 May 3. Impact factor: Publication type: Paper in international publication Authors: Badell Serra, Isabel; de la Fuente Regano, Lydia; Diaz de Heredia Rubio, Cristina; Galan Gomez, Victor; Gonzalez Vicent, Marta; Isabel Pascual Martinez, Antonia; Lopez Duarte, Monica; Maria Fernandez, Jose; Maria Perez Hurtado, Jose; Perez-Martinez, Antonio et al. DOI: 10.1016/j.anpede.2021.02.016
PMID: 34718043 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2022 Reference: J Allergy Clin Immunol. 2022 May;149(5):1744-1754.e8. doi: 10.1016/j.jaci.2021.10.017. Epub 2021 Oct 27. Impact factor: Publication type: Paper in international publication Authors: Albert, Michael H; Alligon, Mikael; Bader, Peter; Balashov, Dmitry; Beier, Rita; Bertrand, Yves; Blanche, Stephane; Bordon, Victoria; Bredius, Robbert G; Cant, Andrew et al. DOI: 10.1016/j.jaci.2021.10.017
PMID: 35466492 Journal: PEDIATRIC TRANSPLANTATION Year: 2022 Reference: Pediatr Transplant. 2022 Sep;26(6):e14292. doi: 10.1111/petr.14292. Epub 2022 Apr 24. Impact factor: Publication type: Paper in international publication Authors: Bilbao Aguirre, Itxarone; Camacho Soriano, Jessica; Charco Torra, Itzarone; Esperalba, Juliana; Gallego Melcon, Soledad; Garrido Pontnou, Marta; Gros Subias, Luis; Hidalgo Llompart, Ernest; Juamperez, Javier; Larrarte King, Mauricio et al. DOI: 10.1111/petr.14292
PMID: 34212338 Journal: Clinical & Translational Oncology Year: 2021 Reference: Clin Transl Oncol. 2021 Dec;23(12):2460-2473. doi: 10.1007/s12094-021-02654-1. Epub 2021 Jul 1. Impact factor: Publication type: Paper in international publication Authors: Bernabeu, D; Bernabeu, D; Gallego, S; Gallego, S; Garrido-Pontnou, M; Guillen, G; Hindi, N; Hindi, N; Juan-Ribelles, A; Juan-Ribelles, A et al. DOI: 10.1007/s12094-021-02654-1
PMID: 34193899 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Jun 30;11(1):13553. doi: 10.1038/s41598-021-92747-2. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Gonzalez, Begona; Beneitez-Pastor, David; Di Giuseppe, Davide; Lopez-Martinez, Maria Jose; Manu-Pereira, Maria Del Mar; Martinelli, Eugenio; Mencattini, Arianna; Rizzuto, Valeria; Samitier, Josep et al. DOI: 10.1038/s41598-021-92747-2
PMID: 34214481 Journal: Lancet Child & Adolescent Health Year: 2021 Reference: Lancet Child Adolesc Health. 2021 Aug;5(8):546-558. doi: 10.1016/S2352-4642(21)00159-0. Epub 2021 Jun 30. Impact factor: Publication type: Paper in international publication Authors: Alaggio, Rita; Berlanga, Pablo; Bisogno, Gianni; Brennan, Bernadette; Burrieza, Gabriela Guillen; Casanova, Michela; Corradini, Nadege; De Salvo, Gian Luca; Ferrari, Andrea; Giraudo, Chiara et al. DOI: 10.1016/S2352-4642(21)00159-0
PMID: 33231901 Journal: Transplant Infectious Disease Year: 2021 Reference: Transpl Infect Dis. 2021 Jun;23(3):e13525. doi: 10.1111/tid.13525. Epub 2020 Dec 7. Impact factor: Publication type: Review in international publication Authors: Benitez-Carabante, Maria Isabel; Diaz-de-Heredia, Cristina; Navarro, Alexandra; Roca, Isabel; Soques Vallejo, Elena; Valero Arrese, Lorena et al. DOI: 10.1111/tid.13525
PMID: 32558231 Journal: PEDIATRIC BLOOD & CANCER Year: 2020 Reference: Pediatr Blood Cancer. 2020 Oct;67(10):e28351. doi: 10.1002/pbc.28351. Epub 2020 Jun 18. Impact factor: Publication type: Paper in international publication Authors: Brennan, Bernadette; Casanova, Michela; Collini, Paola; Dagrada, Gian Paolo; De Salvo, Gian Luca; Ferrari, Andrea; Francotte, Nadine; Gallego, Soledad; Kelsey, Anna; Orbach, Daniel et al. DOI: 10.1002/pbc.28351
PMID: 32523362 Journal: ClinicoEconomics and outcomes research : CEOR Year: 2020 Reference: Clinicoecon Outcomes Res. 2020 May 15;12:253-264. doi: 10.2147/CEOR.S241880. eCollection 2020. Impact factor: Publication type: Paper in international publication Authors: de Andres Saldana, Alejandra; Diaz de Heredia, Cristina; Garcia-Munoz, Nuria; Gostkorzewicz, Joana; Martinez Llinas, Diana; Ribera Santasusana, Josep Maria et al. DOI: 10.2147/CEOR.S241880
PMID: 32455804 Journal: Cancers Year: 2020 Reference: Cancers (Basel). 2020 May 21;12(5). pii: cancers12051313. doi: 10.3390/cancers12051313. Impact factor: Publication type: Review in international publication Authors: Alonso-Dominguez, Juan M; Amutio, Maria E; Barragan, Eva; Barrios, Manuel; Calasanz, Maria J; Cornago-Navascues, Javier; Escoda, Lourdes; Esteve, Jordi; Fernandez, Isolda; Garcia-Perez, Maria J et al. DOI: 10.3390/cancers12051313
PMID: 32421361 Journal: Expert Opinion on Drug Discovery Year: 2020 Reference: Expert Opin Drug Discov. 2020 Aug;15(8):869-872. doi: 10.1080/17460441.2020.1767064. Epub 2020 May 18. Impact factor: Publication type: Editorail in international publication Authors: Carceller, Fernando; DuBois, Steven G; Fox, Elizabeth; Marshall, Lynley V; Moreno, Lucas; Pearson, Andrew Dj et al. DOI: 10.1080/17460441.2020.1767064
PMID: 30920113 Journal: PEDIATRIC BLOOD & CANCER Year: 2019 Reference: Pediatr Blood Cancer. 2019 Jul;66(7):e27725. doi: 10.1002/pbc.27725. Epub 2019 Mar 28. Impact factor: Publication type: Paper in international publication Authors: Bergeron, Christophe; Bisogno, Gianni; De Corti, Federica; De Salvo, Gian Luca; Ferrari, Andrea; Gaze, Mark N; Guerin, Florent; Guillen Burrieza, Gabriela; Kelsey, Anna; Martelli, Helene et al. DOI: 10.1002/pbc.27725
PMID: 30828868 Journal: EUROPEAN JOURNAL OF HAEMATOLOGY Year: 2019 Reference: Eur J Haematol. 2019 Jun;102(6):465-471. doi: 10.1111/ejh.13226. Epub 2019 Apr 10. Impact factor: Publication type: Paper in international publication Authors: Alonso, L; Batlle, M; Bermudez, A; Calderon-Cabrera, C; Garcia, E; Garcia-Cadenas, I; Gonzalez Vicent, M; Heras, Inmaculada; Jarque, I; Lopez, J et al. DOI: 10.1111/ejh.13226
PMID: 30782268 Journal: Eurosurveillance Year: 2019 Reference: Euro Surveill. 2019 Feb;24(7). doi: 10.2807/1560-7917.ES.2019.24.7.1700857. Impact factor: Publication type: Review in international publication Authors: Alemany, Laia; Borruel, Natalia; Campins, Magda; Castellsague, Xavier; Curran, Adrian; Del Pino, Marta; Diaz-de-Heredia, Cristina; Martinez-Gomez, Xavier; Moraga-Llop, Fernando A; Rodrigo-Pendas, Jose Angel et al. DOI: 10.2807/1560-7917.ES.2019.24.7.1700857
PMID: 30770954 Journal: CELLULAR AND MOLECULAR LIFE SCIENCES Year: 2019 Reference: Cell Mol Life Sci. 2019 Jun;76(11):2231-2243. doi: 10.1007/s00018-019-03041-4. Epub 2019 Feb 15. Impact factor: Publication type: Paper in international publication Authors: Boloix, Ariadna; de Toledo, Josep Sanchez; Gallego, Soledad; Henrich, Kai-Oliver; Jimenez, Carlos; Masanas, Marc; Masia, Nuria; Paris-Coderch, Laia; Piskareva, Olga; Roma, Josep et al. DOI: 10.1007/s00018-019-03041-4
PMID: 29664914 Journal: PLoS One Year: 2018 Reference: PLoS One. 2018 Apr 17;13(4):e0195176. doi: 10.1371/journal.pone.0195176. eCollection 2018. Impact factor: Publication type: Paper in international publication Authors: Fernandez, Gerardo; Fuentes-Monteverde, Juan Carlos; Jimenez, Carlos; Llamas, Inmaculada; Reina, Jose Carlos; Rodriguez, Jaime; Torres, Marta et al. DOI: 10.1371/journal.pone.0195176
PMID: 30887009 Journal: HemaSphere Year: 2018 Reference: Hemasphere. 2018 Oct;2(5):e146. doi: 10.1097/HS9.0000000000000146. Epub 2018 Oct 2. Impact factor: 0 Publication type: Paper in international publication Authors: Petkova-Kirova, Polina, Hertz, Laura, Makhro, Asya, Danielczok, Jens, Huisjes, Rick, Llaudet-Planas, Esther, Manu-Pereira, Maria Del Mar, Vives Corrons, Joan-Luis, van Wijk, Richard, Bogdanova, Anna et al. DOI: 10.1097/HS9.0000000000000146
PMID: 29241729 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2018 Reference: J Allergy Clin Immunol. 2018 Mar;141(3):1036-1049.e5. doi: 10.1016/j.jaci.2017.10.041. Epub 2017 Dec 11. Impact factor: 13.081 Publication type: Paper in international publication Authors: Kiykim, Ayca, Barzaghi, Federica, Amaya Hernandez, Laura Cristina, Neven, Benedicte, Ricci, Silvia, Kucuk, Zeynep Yesim, Bleesing, Jack, Nademi, Zohreh, Slatter, Mary Anne, Ulloa, Erlinda Rose et al. DOI: 10.1016/j.jaci.2017.10.041
PMID: 28694008 Journal: ANALES DE PEDIATRIA Year: 2018 Reference: An Pediatr (Barc). 2018 Apr;88(4):196-203. doi: 10.1016/j.anpedi.2017.02.015. Epub 2017 Jul 8. Impact factor: 1.14 Publication type: Paper in national publication Authors: Diaz de Heredia, Cristina, Argiles, Bienvenida, Pascual, Antonia, Perez-Hurtado, Jose M, Sisinni, Luisa, Diaz, Miguel Angel, Elorza, Izaskun, Dasi, M Angeles, Badell, Isabel, Gonzalez-Vicent, Marta et al. DOI: 10.1016/j.anpedi.2017.02.015
PMID: 28205365 Journal: PEDIATRIC BLOOD & CANCER Year: 2017 Reference: Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26486. Epub 2017 Feb 16. Impact factor: Publication type: Paper in international publication Authors: Bergeron, Christophe; Cozic, Nathalie; Devalck, Christine; Gallego, Soledad; Gaze, Mark N; Jenney, Meriel; Kelsey, Anna; Martelli, Helene; Merks, Johannes H M; Minard-Colin, Veronique et al. DOI: 10.1002/pbc.26486
PMID: 27811020 Journal: BLOOD Year: 2017 Reference: Blood. 2017 Jan 26;129(4):525-532. doi: 10.1182/blood-2016-06-722249. Epub 2016 Nov 3. Impact factor: Publication type: Paper in international publication Authors: Bergamaschi, Paola; Bittencourt, Henrique; Cunha, Renato; Diaz-de-Heredia, Cristina; Fernandes, Francisco; Gluckman, Eliane; Kogler, Gesine; Lamas, Carmen H; Michel, Gerard; Panepucci, Rodrigo A et al. DOI: 10.1182/blood-2016-06-722249
PMID: 28118965 Journal: MEDICINA CLINICA Year: 2017 Reference: Med Clin (Barc). 2017 Mar 3;148(5):225-231. doi: 10.1016/j.medcli.2016.12.006. Epub 2017 Jan 22. Impact factor: Publication type: Paper in national publication Authors: Barba, Pere; Dapena, Jose Luis; Montesinos, Pau; Rives, Susana et al. DOI: 10.1016/j.medcli.2016.12.006
PMID: 28054337 Journal: JOURNAL OF PATHOLOGY Year: 2017 Reference: J Pathol. 2017 May;242(1):39-51. doi: 10.1002/path.4874. Epub 2017 Mar 7. Impact factor: Publication type: Paper in international publication Authors: Bartolome, Ruben A; Calvino, Eva; Fernandez-Acenero, Maria Jesus; Garcia-Palmero, Irene; Ignacio Casal, J; Molina, Elena; Segura, Miguel F; Torres, Sofia et al. DOI: 10.1002/path.4874
PMID: 26824183 Journal: Oncotarget Year: 2016 Reference: Oncotarget. 2016 Feb 23;7(8):9271-87. doi: 10.18632/oncotarget.7005. Impact factor: 5.008 Publication type: Paper in international publication Authors: Segura, Miguel F, Gallego, Soledad, Sanchez de Toledo, Jose, Stallings, Raymond L, Casanovas, Oriol, Soriano, Aroa, Jubierre, Luz, Martinez, Alba, Zhou, Xiangyu, Piskareva, Olga et al. DOI: 10.18632/oncotarget.7005
PMID: 21757412 Journal: ANALES DE PEDIATRIA Year: 2011 Reference: An Pediatr (Barc). 2011 Dec;75(6):396-400. Epub 2011 Jul 14. Impact factor: 0.57 Publication type: Paper in national publication Authors: , , , , , , , et al. DOI: 10.1016/j.anpedi.2011.05.017
PMID: 20228849 Journal: BONE MARROW TRANSPLANTATION Year: 2011 Reference: Bone Marrow Transplant. 2011 Jan;46(1):119-24. Epub 2010 Mar 15. Impact factor: 3.66 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1038/bmt.2010.52
PMID: 21177409 Journal: CLINICAL CANCER RESEARCH Year: 2011 Reference: Clin Cancer Res. 2011 Feb 1;17(3):505-13. Epub 2010 Dec 21. Impact factor: 7.338 Publication type: Paper in international publication Authors: , , , , et al. DOI: 10.1158/1078-0432.CCR-10-0166
PMID: 21345076 Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY Year: 2011 Reference: Pediatr Hematol Oncol. 2011 Aug;28(5):451-3. Epub 2011 Feb 23. Impact factor: 0.81 Publication type: Letter or abstract Authors: , , , , et al. DOI: 10.3109/08880018.2010.543450
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
