About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
One of our current research goals is to develop a gene editing strategy that combines viral and non-viral vectors to treat Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE), a rare disease due to inactivating mutations in the gene encoding thymidine phosphorylase, which has already demonstrated therapeutic efficacy in an animal model of the disease.
On the other hand, in collaboration with the Neuropediatrics group (Dra. F. Munell) and that of Dr. R. Hernández (University of Navarra), we are investigating another gene therapy approach based on high-capacity adenoviral vectors using a murine model of congenital muscular dystrophy type 1A (CMD1A).
Finally, in collaboration with the group of Dr. J. Verdaguer (University of Lleida), we are studying the mechanism of action, the cytolytic and pro-inflammatory activities, as well as several biomedical applications of a new family of peptides derived from intermediate filaments that were discovered by chance.
Development of a new gene therapy strategy based on high-capacity adenoviral vectors, which we carry out in collaboration with the group of Dr. Rubén Hernández, from the University of Navarra.
IP: Jordi Barquinero Mañez
IP: -
IP: Jordi Barquinero Mañez Collaborators: Laia Perez Lasarte, Maria Pallares Masmitja Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 67400 Reference: JDC2022-049508-I Duration: 01/01/2024 - 31/12/2025
IP: Chaysavanh Manichanh Collaborators: Itxarone Izaskun Bilbao Aguirre, Zaida Soler Luque, Jordi Barquinero Mañez, Oscar Segarra Canton, Gerard Serrano Gomez, Cristina Dopazo Taboada, Rocío Piñera Moreno Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00459 Duration: 01/01/2022 - 30/06/2025
IP: Jordi Barquinero Mañez Collaborators: Laura Costa Comellas, Francina Munell Casadesus, David Gómez Andrés, Rocío Piñera Moreno, Maria Pallares Masmitja Funding agency: Instituto de Salud Carlos III Funding: 117370 Reference: PI22/01027 Duration: 01/01/2023 - 31/12/2025
PMID: 36555453 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 Dec 13;23(24):15808. doi: 10.3390/ijms232415808. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Cuenca, Silvia; Manichanh, Chaysavanh; Roca, Joaquim; Serrano-Gomez, Gerard; Sirvent, Jose-Maria; Soler, Zaida; Xie, Zixuan et al. DOI: 10.3390/ijms232415808
PMID: 36358956 Journal: Biomolecules Year: 2022 Reference: Biomolecules. 2022 Oct 31;12(11). pii: biom12111606. doi: 10.3390/biom12111606. Impact factor: Publication type: Paper in international publication Authors: Badano, Luigi P; Barquinero, Jordi; Blasco-Lucas, Arnau; Casos, Kelly; Costa, Cristina; Cozzi, Emanuele; Evangelista, Arturo; Fellah-Hebia, Imen; Galinanes, Manuel; Galli, Cesare et al. DOI: 10.3390/biom12111606
PMID: 34498979 Journal: HUMAN GENE THERAPY Year: 2021 Reference: Hum Gene Ther. 2021 Oct;32(19-20):1210-1223. doi: 10.1089/hum.2021.152. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Borros, Salvador; Comes, Natalia; Fan, Steven H Y; Fornaguera, Cristina; Marti, Ramon; Oh, Sejin; Pares, Marta; Tam, Ying K; Vidal, Francisco et al. DOI: 10.1089/hum.2021.152
PMID: 31197069 Journal: HAEMATOLOGICA Year: 2020 Reference: Haematologica. 2020 Jan 31;105(2):508-518. doi: 10.3324/haematol.2018.212118. Print 2020. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Cortina, Vicente; Martorell, Lluis; Parra, Rafael; Vidal, Francisco et al. DOI: 10.3324/haematol.2018.212118
PMID: 31848135 Journal: Disease Models & Mechanisms Year: 2020 Reference: Dis Model Mech. 2020 Jan 13;13(1). pii: dmm.043281. doi: 10.1242/dmm.043281. Impact factor: Publication type: Paper in international publication Authors: Andreu, Antoni L; Arenas, Joaquin; Barquinero, Jordi; Brull, Astrid; de Luna, Noemi; Krag, Thomas O; Lucia, Alejandro; Martin, Miguel Angel; Moya, Laura; Pares, Marta et al. DOI: 10.1242/dmm.043281
PMID: 31848135 Journal: Disease Models & Mechanisms Year: 2020 Reference: Dis Model Mech. 2020 Jan 13;13(1). pii: dmm.043281. doi: 10.1242/dmm.043281. Impact factor: 4.651 Publication type: Paper in international publication Authors: Tarraso, Guillermo, Real-Martinez, Alberto, Pares, Marta, Romero-Cortadellas, Lidia, Puigros, Laura, de Luna, Noemi, Brull, Astrid, Martin, Miguel Angel, Arenas, Joaquin, Lucia, Alejandro et al. DOI: 10.1242/dmm.043281
PMID: 31501599 Journal: NATURE MEDICINE Year: 2019 Reference: Nat Med. 2019 Sep;25(9):1396-1401. doi: 10.1038/s41591-019-0550-z. Epub 2019 Sep 9. Impact factor: Publication type: Paper in international publication Authors: Alberquilla, Omaira; Alvarez, Lara; Barquinero, Jordi; Bogliolo, Massimo; Bueren, Juan A; Casado, Jose A; Catala, Albert; Cerrato, Laura; Diaz de Heredia, Cristina; Galvez, Eva et al. DOI: 10.1038/s41591-019-0550-z
PMID: 29420849 Journal: HEPATOLOGY Year: 2018 Reference: Hepatology. 2018 Aug;68(2):691-706. doi: 10.1002/hep.29833. Epub 2018 May 2. Impact factor: Publication type: Paper in international publication Authors: Aguilar-Bravo, Beatriz; Barquinero, Jordi; Blaya, Delia; Caballeria, Juan; Casacuberta-Serra, Silvia; Coll, Mar; Cubero, Francisco Javier; Gines, Pere; Graupera, Isabel; Hao, Fengjie et al. DOI: 10.1002/hep.29833
PMID: 27860364 Journal: Journal of Tissue Engineering and Regenerative Medicine Year: 2017 Reference: J Tissue Eng Regen Med. 2017 Dec;11(12):3408-3416. doi: 10.1002/term.2254. Epub 2016 Nov 18. Impact factor: Publication type: Paper in international publication Authors: Aguirre, Marius; Barquinero, Jordi; Batlle-Morera, Laura; Caminal, Marta; Garcia, Joan; Rabanal, Rosa Maria; Velez, Roberto; Vivas, Daniel; Vives, Joaquim et al. DOI: 10.1002/term.2254
PMID: 28834196 Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS Year: 2017 Reference: J Thromb Haemost. 2017 Nov;15(11):2188-2197. doi: 10.1111/jth.13808. Epub 2017 Sep 25. Impact factor: Publication type: Paper in international publication Authors: Altisent, C; Barquinero, J; Borras, N; Casacuberta-Serra, S; Corrales, I; Dubart-Kupperschmitt, A; Follenzi, A; Jimenez-Delgado, S; Luce, E; Martorell, L et al. DOI: 10.1111/jth.13808
PMID: 28380047 Journal: PLoS One Year: 2017 Reference: PLoS One. 2017 Apr 5;12(4):e0174588. doi: 10.1371/journal.pone.0174588. eCollection 2017. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Blasco-Lucas, Arnau; Casos, Kelly; Castro, Miguel A; Ferrer-Curriu, Gemma; Galinanes, Manuel; Gracia-Baena, Juan Manuel; Perez, Maria L; Permanyer, Eduard; Soler-Ferrer, Paula et al. DOI: 10.1371/journal.pone.0174588
PMID: 28108746 Journal: IMMUNOLOGY AND CELL BIOLOGY Year: 2017 Reference: Immunol Cell Biol. 2017 Jul;95(6):538-548. doi: 10.1038/icb.2017.4. Epub 2017 Jan 21. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Casacuberta-Serra, Silvia; Coves, Elisabet; Espejo, Carmen; Golbano, Arantxa; Pares, Marta et al. DOI: 10.1038/icb.2017.4
PMID: 27693617 Journal: EXPERIMENTAL NEUROLOGY Year: 2016 Reference: Exp Neurol. 2016 Dec;286:50-60. doi: 10.1016/j.expneurol.2016.09.012. Epub 2016 Sep 28. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Casacuberta-Serra, Silvia; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Lopez-Estevez, Sergio; Mansilla, Maria Jose; Martorell, Lluis; Montalban, Xavier; Pares, Marta et al. DOI: 10.1016/j.expneurol.2016.09.012
PMID: 27004974 Journal: HUMAN GENE THERAPY Year: 2016 Reference: Hum Gene Ther. 2016 Sep;27(9):656-67. doi: 10.1089/hum.2015.160. Epub 2016 May 4. Impact factor: Publication type: Paper in international publication Authors: Andreu, Antoni L; Barba, Ignasi; Barquinero, Jordi; Cabrera-Perez, Raquel; Camara, Yolanda; Costa, Carme; de Luna, Noemi; Hirano, Michio; Marti, Ramon; Torres-Torronteras, Javier et al. DOI: 10.1089/hum.2015.160
PMID: 25652415 Journal: HAEMOPHILIA Year: 2015 Reference: Haemophilia. 2015 Mar;21(2):249-57. doi: 10.1111/hae.12562. Epub 2015 Feb 5. Impact factor: Publication type: Paper in international publication Authors: Barquinero, J; Corrales, I; Martorell, L; Parra, R; Ramirez, L; Raya, A; Vidal, F et al. DOI: 10.1111/hae.12562
PMID: 90001001 Journal: Advances in Regenerative Biology Year: 2014 Reference: Advances in Regenerative Biology. 2014 Sept 25 Impact factor: Publication type: Paper in international publication Authors: Barquinero J; Casacuberta-Serra S; Martorell LL et al. DOI: 10.3402/arb.v1.24429
PMID: 24807807 Journal: GENE THERAPY Year: 2014 Reference: Gene Ther. 2014 Jul;21(7):673-81. doi: 10.1038/gt.2014.41. Epub 2014 May 8. Impact factor: Publication type: Paper in international publication Authors: Barquinero, J; Casacuberta-Serra, S; Ferrer, G; Hirano, M; Lopez-Estevez, S; Mansilla, M J; Marti, R; Martorell, L; Torres-Torronteras, J et al. DOI: 10.1038/gt.2014.41
PMID: 24188195 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2014 Reference: Clin Exp Immunol. 2014 Feb;175(2):202-7. doi: 10.1111/cei.12233. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Cermeno, J C; Eixarch, H; Espejo, C; Guaza, C; Mansilla, M J; Marin, N; Mecha, M; Montalban, X; Rodriguez-Martin, E; Villar, L M et al. DOI: 10.1111/cei.12233
PMID: 25153885 Journal: PLoS One Year: 2014 Reference: PLoS One. 2014 Aug 25;9(8):e105737. doi: 10.1371/journal.pone.0105737. eCollection 2014. Impact factor: Publication type: Paper in international publication Authors: Aigrot, Marie-Stephane; Castillo, Mireia; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Lubetzki, Catherine; Mansilla, M Jose; Martin, Roland; Montalban, Xavier; Tepavcevic, Vanja et al. DOI: 10.1371/journal.pone.0105737
PMID: 28800000 Journal: INTERNATIONAL MICROBIOLOGY Year: 2013 Reference: International Microbiology (2013) 16:253-257 Impact factor: Publication type: Paper in international publication Authors: Barquinero Mañez, Jordi et al. DOI: 10.2436/20.1501.01.201
PMID: 23777246 Journal: STEM CELLS AND DEVELOPMENT Year: 2013 Reference: Stem Cells Dev. 2013 Nov 1;22(21):2885-94. doi: 10.1089/scd.2013.0049. Epub 2013 Jul 26. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Diaz-Manera, Jordi; Flix, Barbara; Gallardo, Eduard; Illa, Isabel; Mancuso, Renzo; Navarro, Xavier; Navas-Madronal, Miquel; Santos-Nogueira, Eva; Suarez-Calvet, Xavier et al. DOI: 10.1089/scd.2013.0049
PMID: 23466692 Journal: NEUROSCIENCE LETTERS Year: 2013 Reference: Neurosci Lett. 2013 Apr 29;541:161-6. doi: 10.1016/j.neulet.2013.02.038. Epub 2013 Mar 1. Impact factor: Publication type: Paper in international publication Authors: Costa, Carme; Eixarch, Herena; Espejo, Carmen; Godessart, Nuria; Kunkel, Steve L; Mansilla, M Jose; Montalban, Xavier et al. DOI: 10.1016/j.neulet.2013.02.038
PMID: 22981934 Journal: EXPERIMENTAL HEMATOLOGY Year: 2012 Reference: Exp Hematol. 2012 Dec;40(12):983-993.e4. doi: 10.1016/j.exphem.2012.08.009. Epub 2012 Sep 11. Impact factor: Publication type: Paper in international publication Authors: Azqueta, Carmen; Barquinero, Jordi; Gimeno, Ramon; Gomez, Alba; Pereira-Mendez, Sonia; Querol, Sergi; Sanchez-Dominguez, Rebeca; Torrabadella, Marta et al. DOI: 10.1016/j.exphem.2012.08.009
PMID: 22727044 Journal: Journal of Neuroinflammation Year: 2012 Reference: J Neuroinflammation. 2012 Jun 22;9:139. doi: 10.1186/1742-2094-9-139. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; ; ; ; et al. DOI: 10.1186/1742-2094-9-139
PMID: 22669475 Journal: MOLECULAR MEDICINE Year: 2012 Reference: Mol Med. 2012 Sep 7;18:1018-28. doi: 10.2119/molmed.2012.00119. Impact factor: Publication type: Review in international publication Authors: ; ; et al. DOI: 10.2119/molmed.2012.00119
PMID: 90000002 Journal: Year: 2011 Reference: Inmunologia. 2011; 30: 45-53 Impact factor: Publication type: Letter or abstract Authors: ; et al. DOI:
PMID: 22028223 Journal: ANNALS OF NEUROLOGY Year: 2011 Reference: Ann Neurol. 2011 Oct;70(4):634-45. doi: 10.1002/ana.22511. Impact factor: Publication type: Paper in international publication Authors: Angeles Moro, Maria; Bustamante, Marta F; Carmen Edo, Mari; Comabella, Manuel; Costa, Carme; Espejo, Carmen; Fissolo, Nicolas; Lizasoain, Ignacio; Mansilla, Maria Jose; Montalban, Xavier et al. DOI: 10.1002/ana.22511
PMID: 21451581 Journal: GENE THERAPY Year: 2011 Reference: Gene Ther. 2011 Aug;18(8):795-806. doi: 10.1038/gt.2011.24. Epub 2011 Mar 31. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; ; ; ; et al. DOI: 10.1038/gt.2011.24
PMID: 20010627 Journal: GENE THERAPY Year: 2010 Reference: Gene Ther. 2010 Apr;17(4):469-77. Epub 2009 Dec 10. Impact factor: Publication type: Paper in international publication Authors: Alvarez, E; Barquinero, J; Briones, J; Moga, E; Sierra, J et al. DOI: 10.1038/gt.2009.150
PMID: 19715898 Journal: TRANSPLANTATION PROCEEDINGS Year: 2009 Reference: Transplant Proc. 2009 Jul-Aug;41(6):2282-5. Impact factor: Publication type: Paper in international publication Authors: Barquinero, J; Cruzado, J M; Flaquer, M; Franquesa, M; Grinyo, J M; Gutierrez, C; Lloberas, N; Torras, J et al. DOI: 10.1016/j.transproceed.2009.06.034
PMID: 19277013 Journal: MOLECULAR THERAPY Year: 2009 Reference: Mol Ther. 2009 May;17(5):897-905. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Castillo, Mireia; Eixarch, Herena; Espejo, Carmen; Gimeno, Ramon; Gomez, Alba; Mansilla, Maria Jose; Mildner, Alexander; Montalban, Xavier; Prinz, Marco et al. DOI: 10.1038/mt.2009.42
PMID: 19707185 Journal: MOLECULAR THERAPY Year: 2009 Reference: Mol Ther. 2009 Nov;17(11):1904-9. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Eixarch, Herena; Espejo, Carmen; George, Monica; Gimeno, Ramon; Gomez, Alba; Kadar, Elisabeth; Martinez, Nuria; Petriz, Jordi et al. DOI: 10.1038/mt.2009.198
PMID: 19447103 Journal: EXPERIMENTAL CELL RESEARCH Year: 2009 Reference: Exp Cell Res. 2009 Oct 15;315(17):3004-13. Impact factor: Publication type: Paper in international publication Authors: Barbosa-Desongles, Anna; Barquinero, Jordi; Hurtado, Antoni; Morote, Joan; Munell, Francina; Pinos, Tomas; Poupon, Marie-France; Reventos, Jaume; Santamaria-Martinez, Albert; Seoane, Joan et al. DOI: 10.1016/j.yexcr.2009.05.007
PMID: 18607069 Journal: CELLULAR ONCOLOGY Year: 2008 Reference: Cell Oncol. 2008;30(4):349-65. Impact factor: Publication type: Paper in international publication Authors: Barbosa-Desongles, Anna; Barquinero, Jordi; Bellmunt, Joaquim; de Torres, Ines; Hurtado, Antoni; Lopez-Aviles, Sandra; Morote, Joan; Munell, Francina; Petriz, Jordi; Pinos, Tomas et al. DOI:
PhD student: Penelope Romero Duque Director/s: Francina Munell Casadesus, Jordi Barquinero Mañez University: Universidad Autònoma de Barcelona Year: 2022
PhD student: Marta Parés Casellas Director/s: Jordi Barquinero Mañez University: Universidad Autònoma de Barcelona Year: 2020
PhD student: Silvia Casacuberta Serra Director/s: Jordi Barquinero Mañez, Carmen Espejo Ruiz University: Universidad Autònoma de Barcelona Year: 2016
PhD student: Alba Gomez Morago Director/s: Jordi Barquinero Mañez, Carmen Espejo Ruiz University: Universidad Autònoma de Barcelona Year: 2012
PhD student: Javier Torres Torronteras Director/s: Ramon Martí Seves, Jordi Barquinero Mañez University: Universidad Autònoma de Barcelona Year: 2011
Over the course of two days, experts presented the latest advances in vectors, different gene modification techniques and their transfer to clinical practice.
