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Head and Neck Cancer: Biomedical Research Cancer Stem cells

The work of the Biomedical Research in Cancer Stem Cell group focuses mainly on senescence (replicative or stress-induced oncoge). In our laboratory, we carry out several genetic screens based on the detection of new genes / small interfering RNA (siRNA) / microRNAs related to cell proliferation, which have a role in cancer. Therefore, we use different cell models: murine cells, human primary cells or immortalized cells capable of entering senescence.

The objectives of the group are:

  • Identification and characterization of genes / microRNAs in mammary tumors associated with a more aggressive character (triple negative).
  • Identification and characterization of markers in lung, laryngeal and pharyngeal cancer with diagnostic and prognostic value that help to target a more specific chemotherapy treatment.
  • Identification and characterization of populations of cancer stem cells (CSC) in tumors resistant to conventional therapies.
  • Early detection of breast cancer before it manifests itself clinically.
  • Study of new genes involved in cancer from their identification in massive genetic scans at the basic level.

Team

Matilde Lleonart Pajarin

Matilde Lleonart Pajarin

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Juan Lorente Guerrero

Juan Lorente Guerrero

Senior researcher
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Yoelsis Garcia Mayea

Yoelsis Garcia Mayea

Postdoctoral researcher
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Almudena Sanchez Garcia

Almudena Sanchez Garcia

Research technician
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Ana María García Arumí

Ana María García Arumí

Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Ana Mª Moreno Perni

Ana Mª Moreno Perni

Research technician
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Matilde Lleonart Pajarin

Matilde Lleonart Pajarin

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Juan Lorente Guerrero

Juan Lorente Guerrero

Senior researcher
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Yoelsis Garcia Mayea

Yoelsis Garcia Mayea

Postdoctoral researcher
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Almudena Sanchez Garcia

Almudena Sanchez Garcia

Research technician
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Ana María García Arumí

Ana María García Arumí

Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Ana Mª Moreno Perni

Ana Mª Moreno Perni

Research technician
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Research lines

Detección precoz de cáncer mamario antes de que éste se manifieste

A partir de datos preliminares de arrays, hemos caracterizado algunos microRNAs/mRNAs relevantes en tumores. Actualmente los estamos analizando a nivel de pacientes con cáncer en sangre como posible método predictivo antes de la aparición del tumor.

IP: Matilde Lleonart Pajarin

Estudio de proteínas de unión a RNA como nuevos factores pronóstico y diagnóstico en cáncer

En nuestro laboratorio hemos efectuado diversos “screenings” genéticos para detectar nuevos genes implicados en proliferación celular in vitro que además poséan un papel relevante en cáncer humano. De entre ellos descubrimos la proteínas CIRP, la cual hemos descrito como proteína oncogénica. Actualmente estamos valorando la función de CIRP en diversos tipos tumorales en correlación con la evolución clínica de los pacientes.

IP: Matilde Lleonart Pajarin

Gastroesophageal reflux prevalence in patients with obstructive sleep apnea syndrome.

Different studies suggest the association between gastroesophageal reflux disease (GERD) and OSAS, but GERD prevalence in OSAS and the severity influence of OSAS upon  GERD are not known yet.

OBJECTIVES:

The main objective of this study is to determine the prevalence of GERD in patients with obstructive sleep apnea syndrome using conventional polygraphic sleep. Wiht this study we also want to assess the efficacy of a symptom questionnaire in the diagnosis of gastroesophageal reflux in these patients.


PURPOSE:

Identifying patients with gastroesophageal reflux among patients affected by obstructive sleep apnea, in order to establish therapeutic measures to prevent GERD complications.

IP: Juan Lorente Guerrero, Juan Luis Quesada Martínez, Mª Jose Jurado Luque

Identificación y caracterización de genes/microRNAs en tumores humanos asociados a mal pronóstico

En base a arrays de microRNAs y mRNAs efectuados a partir de tumores humanos, identificamos los más desregulados entre tejidos normales y tumorales para caracterizarlos a nivel molecular.

IP: Matilde Lleonart Pajarin

Projects

Degradadores moleculares de SFN para sensibilizar células tumorales de cabeza y cuello (HNSCC) resistentes a terapias convencionales (ANTCANRES)

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea
Funding agency: Fundació Institut Bioenginyeria de Catalunya
Funding: 0.01
Reference: K9086
Duration: 24/07/2023 - 24/07/2024

New compounds targeting head and neck cancer as Trojan horses against chemoresistant cells

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Marina Bataller Fernández, Gabriela Isabel Fuentes Llopis, Almudena Sanchez Garcia
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 20000
Reference: 2023 LLAV 00102
Duration: 01/02/2024 - 31/07/2024

Beca VHIR PhD

IP: Matilde Lleonart Pajarin
Collaborators: Sira Rodrigo Bosch, Laia Perez Lasarte, Marina Bataller Fernández
Funding agency: Fundació Institut de Recerca HUVH
Funding: 69188.74
Reference: VPHD/MARINA_B
Duration: 01/04/2023 - 31/03/2026

Therapeutical approaches against chemoresistant cancers

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Fco. Xavier De la Cruz Montserrat, Juan Lorente Guerrero, Natalia Padilla Sirera, Marina Bataller Fernández, Almudena Sanchez Garcia, Selen Ozkan
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 01205
Duration: 01/01/2022 - 30/06/2025

Publications

Nutritional status associates with immunotherapy clinical outcomes in recurrent or metastatic head and neck squamous cell carcinoma patients.

PMID: 36989964
Journal: ORAL ONCOLOGY
Year: 2023
Reference: Oral Oncol. 2023 May;140:106364. doi: 10.1016/j.oraloncology.2023.106364. Epub 2023 Mar 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Susana; Aguilar, Susana; Alberola, Margarita; Alberola, Margarita; Assaf Pastrana, Juan David; Assaf Pastrana, Juan David; Benavente, Sergi; Bescos, Coro; Brana, Irene; Dienstmann, Rodrigo et al.
DOI: 10.1016/j.oraloncology.2023.106364

Diagnostic peripheral blood smear for Chediak-Higashi syndrome in a 43-month-old boy, confirmed by sequencing.

PMID: 37651153
Journal: BLOOD
Year: 2023
Reference: Blood. 2023 Aug 31;142(9):856. doi: 10.1182/blood.2023020217.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch-Schips, Marc; Navarrete, Mayda et al.
DOI: 10.1182/blood.2023020217

The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain.

PMID: 37178807
Journal: JOURNAL OF INFECTION
Year: 2023
Reference: J Infect. 2023 May 11:S0163-4453(23)00262-1. doi: 10.1016/j.jinf.2023.05.004.
Impact factor:
Publication type: Paper in international publication
Authors: Abanto, Michel; Andres, Cristina; Anton, Andres; Codina, Maria Gema; Creus, Anna; Espartosa, Elena; Esperalba, Juliana; Folgueira, Dolores; Gonzalez-Sanchez, Alejandra; Martinez-Urtaza, Jaime et al.
DOI: 10.1016/j.jinf.2023.05.004

Tracheostomy Patient Care Unit. An innovative Otorhinolaryngology solution of a transversal nature for the hospital.

PMID: 37149132
Journal: Acta otorrinolaringologica espanola
Year: 2023
Reference: Acta Otorrinolaringol Esp (Engl Ed). 2023 May 4:S2173-5735(23)00039-X. doi: 10.1016/j.otoeng.2022.04.004.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez Cendrero, Marta; Cuello Entrena, Santiago; Lopez Gonzalez, Nuria; Lorente Guerrero, Juan; Martin Jimenez, Daniel Ivan; Molina-Fernandez, Elena; Palacios-Garcia, Jose Maria; Sanchez-Gomez, Serafin; Tabernero Gallego, Rocio; Tena-Garcia, Beatriz et al.
DOI: 10.1016/j.otoeng.2022.04.004

TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance.

PMID: 34979155
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Year: 2022
Reference: Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188674. doi: 10.1016/j.bbcan.2021.188674. Epub 2021 Dec 31.
Impact factor: 10.68
Publication type: Review in international publication
Authors: Mir, Cristina; Carballo, Laia; Sanchez-Garcia, Almudena; Bataller, Marina; LLeonart, Matilde E; Garcia-Mayea, Yoelsis et al.
DOI: 10.1016/j.bbcan.2021.188674

RNA-binding proteins: underestimated contributors in tumorigenesis.

PMID: 35124196
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2022
Reference: Semin Cancer Biol. 2022 Feb 3. pii: S1044-579X(22)00020-7. doi: 10.1016/j.semcancer.2022.01.010.
Impact factor: 15.707
Publication type: Paper in international publication
Authors: LLeonart, M E; Kondoh, H; Garcia-Mayea, Y; Zhao, Y; Mir, C; Paciucci, R et al.
DOI: 10.1016/j.semcancer.2022.01.010

Targeting the "undruggable": RNA-binding proteins in the spotlight in cancer therapy.

PMID: 35772609
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2022
Reference: Semin Cancer Biol. 2022 Jun 27. pii: S1044-579X(22)00152-3. doi: 10.1016/j.semcancer.2022.06.008.
Impact factor: 15.707
Publication type: Review in international publication
Authors: Garcia-Mayea, Y; LLeonart, M E; Mir, C et al.
DOI: 10.1016/j.semcancer.2022.06.008

Liver, Renal, and Cardiovascular Failure After Unintentional Overdose of Tizanidine in a 2-Year-Old Child.

PMID: 34421416
Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Year: 2021
Reference: J Pediatr Pharmacol Ther. 2021;26(6):643-646. doi: 10.5863/1551-6776-26.6.643. Epub 2021 Aug 16.
Impact factor: 0
Publication type: Paper in international publication
Authors: Danés, Imma, Ortega, Juan, Vila, Jorgina, Morgenstern, Andrés, Vendrell, Lourdes et al.
DOI: 10.5863/1551-6776-26.6.643

Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells.

PMID: 34394703
Journal: Nano Today
Year: 2021
Reference: Nano Today. 2021 Feb;36. doi: 10.1016/j.nantod.2020.101056. Epub 2020 Dec 20.
Impact factor: 20.722
Publication type: Paper in international publication
Authors: Buzon, Maria J, Puntes, Victor, Genesca, Meritxell, Astorga-Gamaza, Antonio, Vitali, Michele, Borrajo, Mireya L, Jaime, Carlos, Bastus, Neus, Serra-Peinado, Carla, Luque-Ballesteros, Laura et al.
DOI: 10.1016/j.nantod.2020.101056

Enhanced DNA damage response through RAD50 in triple negative breast cancer resistant and cancer stem-like cells contributes to chemoresistance.

PMID: 33090711
Journal: FEBS Journal
Year: 2021
Reference: FEBS J. 2021 Apr;288(7):2184-2202. doi: 10.1111/febs.15588. Epub 2020 Nov 3.
Impact factor: 5.542
Publication type: Paper in international publication
Authors: Abad, Etna, Civit, Laia, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex et al.
DOI: 10.1111/febs.15588

Identification of metabolic changes leading to cancer susceptibility in Fanconi anemia cells.

PMID: 33316348
Journal: CANCER LETTERS
Year: 2021
Reference: Cancer Lett. 2021 Apr 10;503:185-196. doi: 10.1016/j.canlet.2020.12.010. Epub 2020 Dec 11.
Impact factor: 8.679
Publication type: Paper in international publication
Authors: Potesil, David, Zdrahal, Zbynek, OscarYanes, Lyakhovich, Alex, Graifer, Dmitry, Trifuoggi, Marco, Pagano, Giovanni, Grodzicki, Robert L, Abad, Etna, Samino, Sara et al.
DOI: 10.1016/j.canlet.2020.12.010

TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance.

PMID: 33167355
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Nov 5;12(11). pii: cancers12113269. doi: 10.3390/cancers12113269.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Garcia-Mayea, Yoelsis, Mir, Cristina, Carballo, Laia, Castellvi, Josep, Temprana-Salvador, Jordi, Lorente, Juan, Benavente, Sergi, Garcia-Pedrero, Juana M, Allonca, Eva, Rodrigo, Juan P et al.
DOI: 10.3390/cancers12113269

Drug-induced sleep endoscopy.

PMID: 31174844
Journal: Acta otorrinolaringologica espanola
Year: 2020
Reference: Acta Otorrinolaringol Esp. 2020 Sep-Oct;71(5):316-320. doi: 10.1016/j.otorri.2019.02.007. Epub 2019 Jun 4.
Impact factor: 0
Publication type: Paper in national publication
Authors: Carrasco Llatas, Marina, Martinez Ruiz de Apodaca, Paula, Baptista Jardin, Peter, O'Connor Reina, Carlos, Plaza Mayor, Guillermo, Vicente Gonzalez, Eugenio, Vilaseca Gonzalez, Isabel, Navazo Egia, Ana Isabel, Samara Pinol, Laura, Alvarez Garcia, Irene et al.
DOI: 10.1016/j.otorri.2019.02.007

Mandibular movement analisys by means of a kinematic model applied to the design of oral appliances for the treatment of obstructive sleep apnea.

PMID: 32769030
Journal: SLEEP MEDICINE
Year: 2020
Reference: Sleep Med. 2020 Sep;73:29-37. doi: 10.1016/j.sleep.2020.04.016. Epub 2020 Apr 30.
Impact factor: 3.038
Publication type: Paper in international publication
Authors: Garcia, Marcos, Cabrera, Juan A, Bataller, Alex, Vila, Javier, Mayoral, Pedro et al.
DOI: 10.1016/j.sleep.2020.04.016

Insights into new mechanisms and models of cancer stem cell multidrug resistance.

PMID: 31369817
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2020
Reference: Semin Cancer Biol. 2020 Feb;60:166-180. doi: 10.1016/j.semcancer.2019.07.022. Epub 2019 Jul 29.
Impact factor: 11.09
Publication type: Review in international publication
Authors: Garcia-Mayea, Y, Mir, C, Masson, F, Paciucci, R, LLeonart, M E et al.
DOI: 10.1016/j.semcancer.2019.07.022

A quick guide for using Microsoft OneNote as an electronic laboratory notebook.

PMID: 31071077
Journal: PLoS Computational Biology
Year: 2019
Reference: PLoS Comput Biol. 2019 May 9;15(5):e1006918. doi: 10.1371/journal.pcbi.1006918. eCollection 2019 May.
Impact factor: 4.428
Publication type: Paper in international publication
Authors: Garcia-Cardenas, Jennyfer M, Saa, Pablo, Indacochea, Alberto, Armendariz-Castillo, Isaac, Zambrano, Ana Karina, Yumiceba, Veronica, Perez-Villa, Andy, Guevara-Ramirez, Patricia, Moscoso-Zea, Oswaldo, Paredes, Joel et al.
DOI: 10.1371/journal.pcbi.1006918

Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer.

PMID: 30373788
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2019
Reference: Mol Cell Proteomics. 2019 Feb;18(2):231-244. doi: 10.1074/mcp.RA118.001102. Epub 2018 Oct 29.
Impact factor: 4.828
Publication type: Paper in international publication
Authors: Abad, Etna, Garcia-Mayea, Yoelsis, Mir, Cristina, Sebastian, David, Zorzano, Antonio, Potesil, David, Zdrahal, Zbynek, Lyakhovich, Alex, Lleonart, Matilde et al.
DOI: 10.1074/mcp.RA118.001102

Clinical Practice Guideline recommendations on examination of the upper airway for adults with suspected obstructive sleep apnoea-hypopnoea syndrome.

PMID: 30616837
Journal: Acta otorrinolaringologica espanola
Year: 2019
Reference: Acta Otorrinolaringol Esp. 2019 Nov - Dec;70(6):364-372. doi: 10.1016/j.otorri.2018.06.008. Epub 2019 Jan 5.
Impact factor: 0
Publication type: Paper in national publication
Authors: Esteller, Eduard, Carrasco, Marina, Diaz-Herrera, Miguel Angel, Sampol, Gabriel, Juvanteny, Joan, Sieira, Ramon, Farre, Alex, Vilaseca, Isabel, Vila, Javier et al.
DOI: 10.1016/j.otorri.2018.06.008

Reactive Oxygen Species-Mediated Autophagy Defines the Fate of Cancer Stem Cells

PMID: 28683561
Journal: ANTIOXIDANTS & REDOX SIGNALING
Year: 2018
Reference: Antioxidants & Redox Signaling. 2018 Apr 10;28(11):1066-79. doi:10.1089/ars.2017.7223
Impact factor: 6.53
Publication type: Review in international publication
Authors: Lleonart Pajarin, Matilde, Abad Cortel, Etna, Graifer, Dmitry, Lyakhovich, Alex et al.
DOI: 10.1089/ars.2017.7223

Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies.

PMID: 30228363
Journal: Scientific Reports
Year: 2018
Reference: Sci Rep. 2018 Sep 18;8(1):13978. doi: 10.1038/s41598-018-32264-x.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Gonzalez, Diana Abigail, Leone, Paola E, Paz-Y-Mino, Cesar, Guevara-Ramirez, Patricia, Cabrera-Andrade, Alejandro, Garcia-Cardenas, Jennyfer M, Guerrero, Santiago, Lopez-Cortes, Andres, Indacochea, Alberto, Zambrano, Ana Karina et al.
DOI: 10.1038/s41598-018-32264-x

The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.

PMID: 28464404
Journal: BIOLOGICAL REVIEWS
Year: 2018
Reference: Biol Rev Camb Philos Soc. 2018 Feb;93(1):152-165. doi: 10.1111/brv.12337. Epub 2017 May 2.
Impact factor: 11.7
Publication type: Paper in international publication
Authors: Lorente, Juan, Velandia, Carolina, Leal, Jose A, Garcia-Mayea, Yoelsis, Lyakhovich, Alex, Kondoh, Hiroshi, LLeonart, Matilde E et al.
DOI: 10.1111/brv.12337

Efficacy and Safety of Ciprofloxacin Plus Fluocinolone in Otitis Media With Tympanostomy Tubes in Pediatric Patients: A Randomized Clinical Trial.

PMID: 28006041
Journal: JAMA Otolaryngology-Head & Neck Surgery
Year: 2017
Reference: JAMA Otolaryngol Head Neck Surg. 2017 Apr 1;143(4):341-349. doi: 10.1001/jamaoto.2016.3537.
Impact factor: 2.951
Publication type: Paper in international publication
Authors: Hernandez, F Javier, Lansford, Bryan, Douglis, Franklin, Esterhuizen, Kenneth, Spektor, Zorik, Pumarola, Felix, Ismail, Khaleed, Lanier, Brent, Hussain, Iftikhar, Ansley, John et al.
DOI: 10.1001/jamaoto.2016.3537

Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition.

PMID: 27693455
Journal: CANCER LETTERS
Year: 2017
Reference: Cancer Lett. 2017 Jan 1;384:60-69. doi: 10.1016/j.canlet.2016.09.023. Epub 2016 Sep 28.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Lyakhovich, Alex, Lleonart, Matilde E, Graifer, Dmitry, Esner, Milan et al.
DOI: 10.1016/j.canlet.2016.09.023

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

PMID: 29072692
Journal: Cell Death & Disease
Year: 2017
Reference: Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544.
Impact factor: 5.965
Publication type: Paper in international publication
Authors: Mir, Cristina, Feliciano, Andrea, Garcia-Mayea, Yoelsis, Jubierre, Luz, Hernandez-Losa, Javier, Paciucci, Rosanna, Sansano, Irene, Sun, Yilin, Cajal, Santiago Ramon Y, Kondon, Hiroshi et al.
DOI: 10.1038/cddis.2017.544

Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss.

PMID: 28757873
Journal: International journal of otolaryngology
Year: 2017
Reference: Int J Otolaryngol. 2017;2017:5185268. doi: 10.1155/2017/5185268. Epub 2017 Jul 3.
Impact factor: 0
Publication type: Paper in international publication
Authors: Graterol, D, Mir, C, Garcia-Vaquero, C, Brana, I, Pardo, A N, Rochera-Villach, M I, Lyakhovich, A, LLeonart, M E, Lorente, J et al.
DOI: 10.1155/2017/5185268

Outcome prognostic factors in inoperable malignant bowel obstruction.

PMID: 27286874
Journal: SUPPORTIVE CARE IN CANCER
Year: 2016
Reference: Support Care Cancer. 2016 Nov;24(11):4577-86. doi: 10.1007/s00520-016-3299-7. Epub 2016 Jun 10.
Impact factor: 2.535
Publication type: Paper in international publication
Authors: Romeo, Margarita, de Los LLanos Gil, Maria, Cuadra Urteaga, Jose Luis, Vila, Laia, Ahlal, Sara, Indacochea, Alberto, Pardo, Nuria, Radua, Joaquim, Font, Albert, Tuca, Albert et al.
DOI: 10.1007/s00520-016-3299-7

[Bacterial etiology of acute otitis media in Spain in the post-pneumococcal conjugate vaccine era].

PMID: 26969247
Journal: ANALES DE PEDIATRIA
Year: 2016
Reference: An Pediatr (Barc). 2016 Nov;85(5):224-231. doi: 10.1016/j.anpedi.2015.10.016. Epub 2016 Mar 9.
Impact factor: 0.773
Publication type: Paper in national publication
Authors: Devadiga, Raghavendra, Rosell Ferrer, Rosa, Pumarola, Felix, Salamanca de la Cueva, Ignacio, Sistiaga-Hernando, Alessandra, Garcia-Corbeira, Pilar, Moraga-Llop, Fernando A, Cardelus, Sara, McCoig, Cynthia, Gomez Martinez, Justo Ramon et al.
DOI: 10.1016/j.anpedi.2015.10.016

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission.

PMID: 27517150
Journal: Oncotarget
Year: 2016
Reference: Oncotarget. 2016 Sep 6;7(36):58065-58074. doi: 10.18632/oncotarget.11161.
Impact factor: 5.008
Publication type: Paper in international publication
Authors: Shyamsunder, Pavithra, Esner, Milan, Barvalia, Maunish, Wu, Yu Jun, Loja, Tomas, Verma, Rama S, Krejci, Lumir, Lyakhovich, Alex, Lleonart, Matilde E, Boon, Huat Bay et al.
DOI: 10.18632/oncotarget.11161

Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy.

PMID: 26697128
Journal: Oxidative Medicine and Cellular Longevity
Year: 2016
Reference: Oxid Med Cell Longev. 2016;2016:1716341. doi: 10.1155/2016/1716341. Epub 2015 Nov 30.
Impact factor: 4.492
Publication type: Review in national publication
Authors: Lyakhovich, Alex, Lleonart, Matilde E et al.
DOI: 10.1155/2016/1716341

[Laryngotracheal traumatic injuries (LTI) in children: when to operate?]

PMID: 27775292
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2015
Reference: Cir Pediatr. 2015 Oct 10;28(4):165-171.
Impact factor: 0
Publication type: Letter or abstract
Authors: Lloret, J, Seidler, L, Lopez-Fernandez, S, Santiago-Martinez, S, Lain, A, Guillen, G, Gander, R, Pumarola, F et al.
DOI:

[Recurrent meningitis due to anatomical defects: The bacteria indicates its origin.]

PMID: 25446794
Journal: ANALES DE PEDIATRIA
Year: 2015
Reference: An Pediatr (Barc). 2015 Jun;82(6):388-96. doi: 10.1016/j.anpedi.2014.09.008. Epub 2014 Oct 29.
Impact factor: 0.722
Publication type: Paper in national publication
Authors: Morgenstern Isaak, A, Bach Faig, A, Martinez, S, Martin-Nalda, A, Vazquez Mendez, E, Pumarola Segura, F, Soler-Palacin, P et al.
DOI: 10.1016/j.anpedi.2014.09.008

Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs.

PMID: 26219394
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2015
Reference: Curr Med Chem. 2015;22(26):3040-53.
Impact factor: 3.853
Publication type: Review in national publication
Authors: Lyakhovich, Alex, Graifer, Dmitri et al.
DOI:

ROMO1 regulates RedOx states and serves as an inducer of NF-kappaB-driven EMT factors in Fanconi anemia.

PMID: 25687884
Journal: CANCER LETTERS
Year: 2015
Reference: Cancer Lett. 2015 May 28;361(1):33-8. doi: 10.1016/j.canlet.2015.02.020. Epub 2015 Feb 14.
Impact factor: 5.621
Publication type: Paper in international publication
Authors: Shyamsunder, Pavithra, Verma, Rama S, Lyakhovich, Alex et al.
DOI: 10.1016/j.canlet.2015.02.020

Frequent carriage of resistance mechanisms to beta-lactams and biofilm formation in Haemophilus influenzae causing treatment failure and recurrent otitis media in young children.

PMID: 24891432
Journal: J ANTIMICROB CHEMOTH
Year: 2014
Reference: J Antimicrob Chemother. 2014 Sep;69(9):2394-9. doi: 10.1093/jac/dku158. Epub 2014 Jun 2.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: Campos, Jose, Garcia, Ernesto, Garcia-Cobos, Silvia, Moscoso, Miriam, Pumarola, Felix, Arroyo, Margarita, Lara, Noelia, Perez-Vazquez, Maria, Aracil, Belen, Oteo, Jesus et al.
DOI: 10.1093/jac/dku158

[Usefulness of the basic exploration of the upper airways and neighbor structures in patients with adult obstructive sleep apnea-hypopnea syndrome.]

PMID: 23830550
Journal: MED CLIN-BARCELONA
Year: 2014
Reference: Med Clin (Barc). 2014 Apr 7;142(7):310-6. doi: 10.1016/j.medcli.2013.04.035. Epub 2013 Jul 3.
Impact factor: 1.252
Publication type: Paper in national publication
Authors: Ferre, Alex, Vila, Javier, Arcalis, Nuria et al.
DOI: 10.1016/j.medcli.2013.04.035

Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era.

PMID: 23746414
Journal: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Year: 2013
Reference: Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1231-6. doi: 10.1016/j.ijporl.2013.04.002. Epub 2013 Jun 6.
Impact factor: 1.35
Publication type: Paper in international publication
Authors: Hausdorff, William P, Marano, Cinzia, Pircon, Jean-Yves, Pumarola, Felix, Mares, Josep, Losada, Isabel, Minguella, Isabel, Moraga, Fernando, Tarrago, David, Aguilera, Ulla et al.
DOI: 10.1016/j.ijporl.2013.04.002

[Postoperative nausea and vomiting in major trauma surgery].

PMID: 23183147
Journal: Enfermeria clinica
Year: 2012
Reference: Enferm Clin. 2012 Nov-Dec;22(6):293-8. doi: 10.1016/j.enfcli.2012.10.002. Epub 2012 Nov 24.
Impact factor: 0
Publication type: Paper in national publication
Authors: Biarnes-Sune, Alfons, Malpartida-Obon, Mercedes, Moreno-Montes, Olga, Garcia-Gomez, Laura, Aige-Cristofol, M Mireya, Rejon-Vallverdu, M Merce, Gonzalez-Perez, M Gloria, Perich-Torrens, Elisenda, Alonso-Vicente, M Rosa, Albertos-Riera, M Amparo et al.
DOI: 10.1016/j.enfcli.2012.10.002

Thesis

Papel de los exosomas en la comunicación entre las células tumorales y los macrófagos en el carcinoma laríngeo

PhD student: Angela maria Bellmunt Fontanet
Director/s: Juan Lorente Guerrero
University: Universidad Autònoma de Barcelona
Year: 2018

Identificación y caracterización funcional de microRNAS en cáncer de mama

PhD student: Andrea F Feliciano Aguirre
Director/s: Matilde Lleonart Pajarin
University: Universidad Autònoma de Barcelona
Year: 2017

In vivo elucidation of the role of Pim kinases in tumorigenesis

PhD student: Maja Narlik , Maja Narlik
Director/s: Amancio Carnero Moya
University: Universidad Autònoma de Barcelona
Year: 2012

Espinofilina, un tumor supresor dependiente de la ausencia de p53

PhD student: Irene Ferrer , Irene Ferrer
Director/s: Amancio Carnero Moya
University: Universidad Autònoma de Barcelona
Year: 2009

Generación de herramientas celulares para validación de drogas antitumorales

PhD student: María Victoria Moneo , María Victoria Moneo
Director/s: Amancio Carnero Moya
University: Universidad Autònoma de Barcelona
Year: 2009

Blog

News

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

The Biomedical Research in Cancer Stem Cells group at VHIR has identified a new therapeutic target and is working to find new therapies for this type of tumor.

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.