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Head and Neck Cancer: Biomedical Research Cancer Stem cells

The work of the Biomedical Research in Cancer Stem Cell group focuses mainly on senescence (replicative or stress-induced oncoge). In our laboratory, we carry out several genetic screens based on the detection of new genes / small interfering RNA (siRNA) / microRNAs related to cell proliferation, which have a role in cancer. Therefore, we use different cell models: murine cells, human primary cells or immortalized cells capable of entering senescence.

The objectives of the group are:

  • Identification and characterization of genes / microRNAs in mammary tumors associated with a more aggressive character (triple negative).
  • Identification and characterization of markers in lung, laryngeal and pharyngeal cancer with diagnostic and prognostic value that help to target a more specific chemotherapy treatment.
  • Identification and characterization of populations of cancer stem cells (CSC) in tumors resistant to conventional therapies.
  • Early detection of breast cancer before it manifests itself clinically.
  • Study of new genes involved in cancer from their identification in massive genetic scans at the basic level.

Team

David Virós Porcuna

David Virós Porcuna

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Matilde Lleonart Pajarin

Matilde Lleonart Pajarin

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Juan Lorente Guerrero

Juan Lorente Guerrero

Senior researcher
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Juan Fernando Fuentes Cabrera

Juan Fernando Fuentes Cabrera

Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Almudena Sanchez Garcia

Almudena Sanchez Garcia

Research technician
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Ana María García Arumí

Ana María García Arumí

Head and Neck Cancer: Biomedical Research Cancer Stem cells
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David Virós Porcuna

David Virós Porcuna

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Matilde Lleonart Pajarin

Matilde Lleonart Pajarin

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Juan Lorente Guerrero

Juan Lorente Guerrero

Senior researcher
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Juan Fernando Fuentes Cabrera

Juan Fernando Fuentes Cabrera

Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Almudena Sanchez Garcia

Almudena Sanchez Garcia

Research technician
Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Ana María García Arumí

Ana María García Arumí

Head and Neck Cancer: Biomedical Research Cancer Stem cells
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Research lines

Detección precoz de cáncer mamario antes de que éste se manifieste

A partir de datos preliminares de arrays, hemos caracterizado algunos microRNAs/mRNAs relevantes en tumores. Actualmente los estamos analizando a nivel de pacientes con cáncer en sangre como posible método predictivo antes de la aparición del tumor.

IP: Matilde Lleonart Pajarin

Estudio de proteínas de unión a RNA como nuevos factores pronóstico y diagnóstico en cáncer

En nuestro laboratorio hemos efectuado diversos “screenings” genéticos para detectar nuevos genes implicados en proliferación celular in vitro que además poséan un papel relevante en cáncer humano. De entre ellos descubrimos la proteínas CIRP, la cual hemos descrito como proteína oncogénica. Actualmente estamos valorando la función de CIRP en diversos tipos tumorales en correlación con la evolución clínica de los pacientes.

IP: Matilde Lleonart Pajarin

Gastroesophageal reflux prevalence in patients with obstructive sleep apnea syndrome.

Different studies suggest the association between gastroesophageal reflux disease (GERD) and OSAS, but GERD prevalence in OSAS and the severity influence of OSAS upon  GERD are not known yet.

OBJECTIVES:

The main objective of this study is to determine the prevalence of GERD in patients with obstructive sleep apnea syndrome using conventional polygraphic sleep. Wiht this study we also want to assess the efficacy of a symptom questionnaire in the diagnosis of gastroesophageal reflux in these patients.


PURPOSE:

Identifying patients with gastroesophageal reflux among patients affected by obstructive sleep apnea, in order to establish therapeutic measures to prevent GERD complications.

IP: Juan Lorente Guerrero, Juan Luis Quesada Martínez, Mª Jose Jurado Luque

Identificación y caracterización de genes/microRNAs en tumores humanos asociados a mal pronóstico

En base a arrays de microRNAs y mRNAs efectuados a partir de tumores humanos, identificamos los más desregulados entre tejidos normales y tumorales para caracterizarlos a nivel molecular.

IP: Matilde Lleonart Pajarin

Projects

NANORESCAN

IP: Matilde Lleonart Pajarin
Collaborators: David Virós Porcuna, Josep Castellví Vives, Marina Bataller Fernández, Almudena Sanchez Garcia, Juan Fernando Fuentes Cabrera, Juan Fernando Fuentes Cabrera
Funding agency: Instituto de Salud Carlos III
Funding: 318750
Reference:  AC24/00057
Duration: 01/01/2025 - 31/12/2027

Establecimiento de una estrategia combinada en carcinoma escamoso de cabeza y cuello (HNSCC): una herramienta eficaz para superar los tumores quimiorresistentes.

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Juan Lorente Guerrero, Josep Castellví Vives, Marina Bataller Fernández, Pablo Sanchez Sancho, Almudena Sanchez Garcia, Juan Fernando Fuentes Cabrera, Juan Fernando Fuentes Cabrera
Funding agency: Instituto de Salud Carlos III
Funding: 240000
Reference: PI24/00630
Duration: 01/01/2025 - 31/12/2027

Beca VHIR PhD

IP: Matilde Lleonart Pajarin
Collaborators: Beca VHIR PhD, Laia Perez Lasarte, Marina Bataller Fernández
Funding agency: Fundació Institut de Recerca HUVH
Funding: 69188.74
Reference: VPHD/MARINA_B
Duration: 01/04/2023 - 31/03/2026

ESTUDIO Y DESARROLLO DE LA PRIMERA PLATAFORMA TECNOLÓGICA DE ENSAYOS PARA VIRUS ADENOASOCIADOS EN TERÁPIA GÉNICA

IP: Miguel Chillon Rodriguez
Collaborators: Susana Miravet Delgado, Laia Rubio Ortega, Marina Tarrés Mercader, ESTUDIO Y DESARROLLO DE LA PRIMERA PLATAFORMA TECNOLÓGICA DE ENSAYOS PARA VIRUS ADENOASOCIADOS EN TERÁPIA GÉNICA, Almudena Sanchez Garcia
Funding agency: Instituto de Salud Carlos III
Funding: 296571
Reference: PMPTA22/00048
Duration: 01/01/2023 - 30/06/2025

Publications

Head and Neck Cancer in Fanconi Anemia: Report of 11 Cases and a Systematic Review.

PMID: 39941721
Journal: Cancers
Year: 2025
Reference: Cancers (Basel). 2025 Jan 22;17(3):349. doi: 10.3390/cancers17030349.
Impact factor:
Publication type: Paper in international publication
Authors: Balmana-Gelpi, Judith; Bescos-Atin, Coro; Brana-Garcia, Irene; Carrasco-Lopez, Estela; de Pablo Garcia-Cuenca, Alba; Granado-Carrasco, Raquel; Lorente-Guerrero, Juan; Pujol-Pina, Rosa; Rofin-Fontanet, Pau; Temprana-Salvador, Jordi et al.
DOI: 10.3390/cancers17030349

Increased Rsv-A Bronchiolitis Severity In Rsv Infected Children Admitted To A Reference Center In Catalonia (Spain) Between 2014 And 2018.

PMID: 36744919
Journal: Journal of the Pediatric Infectious Diseases Society
Year: 2023
Reference: J Pediatric Infect Dis Soc. 2023 Apr 18;12(3):180-183. doi: 10.1093/jpids/piad009.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Balcells, Joan; Barcelo, Irene; Carsi, Ariadna; Carsi, Ariadna; Lera, Esther; Martinez, Laia; Peremiquel-Trillas, Paula; Rodrigo, Carlos et al.
DOI: 10.1093/jpids/piad009

Nutritional status associates with immunotherapy clinical outcomes in recurrent or metastatic head and neck squamous cell carcinoma patients.

PMID: 36989964
Journal: ORAL ONCOLOGY
Year: 2023
Reference: Oral Oncol. 2023 May;140:106364. doi: 10.1016/j.oraloncology.2023.106364. Epub 2023 Mar 28.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Susana; Aguilar, Susana; Alberola, Margarita; Alberola, Margarita; Assaf Pastrana, Juan David; Assaf Pastrana, Juan David; Benavente, Sergi; Bescos, Coro; Brana, Irene; Dienstmann, Rodrigo et al.
DOI: 10.1016/j.oraloncology.2023.106364

A single-arm study design with non-inferiority and superiority time-to-event endpoints: a tool for proof-of-concept and de-intensification strategies in breast cancer.

PMID: 37496662
Journal: Frontiers in Oncology
Year: 2023
Reference: Front Oncol. 2023 Jul 11;13:1048242. doi: 10.3389/fonc.2023.1048242. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Abad, Elena; Alcala-Lopez, Daniel; Cortes, Javier; Gion, Maria; Llombart-Cussac, Antonio; Lopez-Miranda, Elena; Malfettone, Andrea; Miguel-Huguet, Bernat; Perez-Escuredo, Jhudit; Perez-Garcia, Jose Manuel et al.
DOI: 10.3389/fonc.2023.1048242

Diagnostic peripheral blood smear for Chediak-Higashi syndrome in a 43-month-old boy, confirmed by sequencing.

PMID: 37651153
Journal: BLOOD
Year: 2023
Reference: Blood. 2023 Aug 31;142(9):856. doi: 10.1182/blood.2023020217.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch-Schips, Marc; Navarrete, Mayda et al.
DOI: 10.1182/blood.2023020217

Transcriptomic and Proteomic Profiles for Elucidating Cisplatin Resistance in Head-and-Neck Squamous Cell Carcinoma.

PMID: 36428603
Journal: Cancers
Year: 2022
Reference: Cancers (Basel). 2022 Nov 9;14(22):5511. doi: 10.3390/cancers14225511.
Impact factor:
Publication type: Paper in international publication
Authors: Bataller, Marina; Benavente, Sergi; Benitez-Alvarez, Lisandra; Canela, Nuria; Carracedo, Angel; Companioni, Osmel; Fernandez-Rozadilla, Ceres; Garcia-Mayea, Yoelsis; LLeonart, Matilde E; Lorente, Juan et al.
DOI: 10.3390/cancers14225511

Editorial: Sphingolipid metabolism and cancer.

PMID: 36408170
Journal: Frontiers in Oncology
Year: 2022
Reference: Front Oncol. 2022 Nov 3;12:1049494. doi: 10.3389/fonc.2022.1049494. eCollection 2022.
Impact factor:
Publication type: Editorail in international publication
Authors: Agoulnik, Irina U; Ivanova, Margarita M; LLeonart, Matilde E et al.
DOI: 10.3389/fonc.2022.1049494

Adaptation and validation into Spanish of a specific questionnaire on quality of life in patients with tracheostomy (TQOL).

PMID: 36031108
Journal: Acta otorrinolaringologica espanola
Year: 2022
Reference: Acta Otorrinolaringol Esp (Engl Ed). 2022 Sep-Oct;73(5):299-309. doi: 10.1016/j.otoeng.2021.11.001. Epub 2022 Aug 26.
Impact factor:
Publication type: Paper in international publication
Authors: Fuentes, Juan F; Lorente, Joan; Lorente, Juan; Naches, Silvia; Pelay, Neus; Perez-Hoyos, Santiago; Sanchez, Serafin; Tabernero, Rocio; Tena, Beatriz; Zuriguel, Esperanza et al.
DOI: 10.1016/j.otoeng.2021.11.001

Understanding RNA-binding proteins.

PMID: 35787942
Journal: SEMINARS IN CANCER BIOLOGY
Year: 2022
Reference: Semin Cancer Biol. 2022 Nov;86(Pt 3):135-136. doi: 10.1016/j.semcancer.2022.06.015. Epub 2022 Jul 3.
Impact factor:
Publication type: Editorail in international publication
Authors: LLeonart, Matilde E et al.
DOI: 10.1016/j.semcancer.2022.06.015

Liver, Renal, and Cardiovascular Failure After Unintentional Overdose of Tizanidine in a 2-Year-Old Child.

PMID: 34421416
Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Year: 2021
Reference: J Pediatr Pharmacol Ther. 2021;26(6):643-646. doi: 10.5863/1551-6776-26.6.643. Epub 2021 Aug 16.
Impact factor:
Publication type: Paper in international publication
Authors: Danés, Imma; Morgenstern, Andrés; Ortega, Juan; Vendrell, Lourdes; Vila, Jorgina et al.
DOI: 10.5863/1551-6776-26.6.643

The Role of Sphingolipids Metabolism in Cancer Drug Resistance.

PMID: 35004331
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Dec 23;11:807636. doi: 10.3389/fonc.2021.807636. eCollection 2021.
Impact factor:
Publication type: Review in international publication
Authors: Bataller, Marina; Garcia-Mayea, Yoelsis; LLeonart, Matilde Esther; Mir, Cristina; Rodriguez, Isabel; Sanchez-Garcia, Almudena et al.
DOI: 10.3389/fonc.2021.807636

Targeting Sphingolipids for Cancer Therapy.

PMID: 34737957
Journal: Frontiers in Oncology
Year: 2021
Reference: Front Oncol. 2021 Oct 19;11:745092. doi: 10.3389/fonc.2021.745092. eCollection 2021.
Impact factor:
Publication type: Review in international publication
Authors: Companioni, Osmel; Garcia-Mayea, Yoelsis; LLeonart, Matilde E; Mir, Cristina et al.
DOI: 10.3389/fonc.2021.745092

SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation.

PMID: 34638436
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Oct 1;13(19). pii: cancers13194952. doi: 10.3390/cancers13194952.
Impact factor:
Publication type: Paper in international publication
Authors: Allonca, Eva; Canela, Nuria; Carracedo, Angel; Castellvi, Josep; Garcia, Laia; Garcia-Mayea, Yoelsis; Garcia-Pedrero, Juana; Herrero, Pol; LLeonart, Matilde Esther; Lorente, Juan et al.
DOI: 10.3390/cancers13194952

Tumor Profiling at the Service of Cancer Therapy.

PMID: 33505911
Journal: Frontiers in Oncology
Year: 2020
Reference: Front Oncol. 2021 Jan 11;10:595613. doi: 10.3389/fonc.2020.595613. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Carnero, Amancio; Carracedo, Angel; Fernandez-Rozadilla, Ceres; Lleonart, Matilde E; Simoes, Ana Rita et al.
DOI: 10.3389/fonc.2020.595613

Five microRNAs in Serum Are Able to Differentiate Breast Cancer Patients From Healthy Individuals.

PMID: 33224883
Journal: Frontiers in Oncology
Year: 2020
Reference: Front Oncol. 2020 Nov 3;10:586268. doi: 10.3389/fonc.2020.586268. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Altes, Anna; Artola, Mireia; Barragan, Nieves; Benavente, Sergi; Castellvi, Josep; Cortes, Javier; Espinosa-Bravo, Martin; Feliciano, Andrea; Garcia-Mayea, Yoelsis; Gonzalez, Lucila et al.
DOI: 10.3389/fonc.2020.586268

Autophagy Takes Center Stage as a Possible Cancer Hallmark.

PMID: 33194736
Journal: Frontiers in Oncology
Year: 2020
Reference: Front Oncol. 2020 Oct 22;10:586069. doi: 10.3389/fonc.2020.586069. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Alvarez-Meythaler, Jose G; Garcia-Mayea, Yoelsis; Kondoh, Hiroshi; LLeonart, Matilde E; Mir, Cristina et al.
DOI: 10.3389/fonc.2020.586069

Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies.

PMID: 33194719
Journal: Frontiers in Oncology
Year: 2020
Reference: Front Oncol. 2020 Oct 23;10:582884. doi: 10.3389/fonc.2020.582884. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Benavente, Sergi; LLeonart, Matilde Esther; Lorente, Juan; Naches, Silvia; Sanchez-Garcia, Almudena et al.
DOI: 10.3389/fonc.2020.582884

Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma.

PMID: 31697737
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Nov 7;14(11):e0224710. doi: 10.1371/journal.pone.0224710. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Bellmunt, Angela Maria; Closa, Daniel; Lopez-Puerto, Laura; Lorente, Juan et al.
DOI: 10.1371/journal.pone.0224710

Update on consensus on diagnosis and treatment of idiopathic sudden sensorineural hearing loss.

PMID: 30093087
Journal: Acta otorrinolaringologica espanola
Year: 2019
Reference: Acta Otorrinolaringol Esp. 2019 Sep - Oct;70(5):290-300. doi: 10.1016/j.otorri.2018.04.010. Epub 2018 Aug 6.
Impact factor:
Publication type: Paper in national publication
Authors: Garcia Arumi, Ana; Garcia Berrocal, Jose Ramon; Herrera, Mayte; Lavilla, Maria Jose; Plaza, Guillermo et al.
DOI: 10.1016/j.otorri.2018.04.010

A quick guide for using Microsoft OneNote as an electronic laboratory notebook.

PMID: 31071077
Journal: PLoS Computational Biology
Year: 2019
Reference: PLoS Comput Biol. 2019 May 9;15(5):e1006918. doi: 10.1371/journal.pcbi.1006918. eCollection 2019 May.
Impact factor:
Publication type: Paper in international publication
Authors: Armendariz-Castillo, Isaac; Garcia-Cardenas, Jennyfer M; Guerrero, Santiago; Guevara-Ramirez, Patricia; Indacochea, Alberto; Leone, Paola E; Lopez-Cortes, Andres; Moscoso-Zea, Oswaldo; Paredes, Joel; Paz-Y-Mino, Cesar et al.
DOI: 10.1371/journal.pcbi.1006918

Autophagy inhibition as a promising therapeutic target for laryngeal cancer.

PMID: 31050705
Journal: CARCINOGENESIS
Year: 2019
Reference: Carcinogenesis. 2019 Dec 31;40(12):1525-1534. doi: 10.1093/carcin/bgz080.
Impact factor:
Publication type: Paper in international publication
Authors: Benavente, Sergi; Castellvi, Josep; Garcia-Mayea, Yoelsis; LLeonart, Matilde E; Lorente, Juan; Maggio, Valentina; Mir, Cristina; Munoz, Lisandra; Paciucci, Rosanna; Temprana, Jordi et al.
DOI: 10.1093/carcin/bgz080

Reactive Oxygen Species-Mediated Autophagy Defines the Fate of Cancer Stem Cells

PMID: 28683561
Journal: ANTIOXIDANTS & REDOX SIGNALING
Year: 2018
Reference: Antioxidants & Redox Signaling. 2018 Apr 10;28(11):1066-79. doi:10.1089/ars.2017.7223
Impact factor:
Publication type: Review in international publication
Authors: Abad Cortel, Etna; Graifer, Dmitry; Lleonart Pajarin, Matilde; Lyakhovich, Alex et al.
DOI: 10.1089/ars.2017.7223

Spontaneous rupture of cervical thoracic duct: A case report.

PMID: 28807324
Journal: Acta otorrinolaringologica espanola
Year: 2018
Reference: Acta Otorrinolaringol Esp. 2018 May - Jun;69(3):178-180. doi: 10.1016/j.otorri.2017.05.002. Epub 2017 Aug 12.
Impact factor:
Publication type: Paper in national publication
Authors: Dyer, Shelagh; Navarrete, Maria Luisa; Ortiz, Cesar; Rodriguez, Natalia et al.
DOI: 10.1016/j.otorri.2017.05.002

Otologic, audiometric and speech findings in patients undergoing surgery for cleft palate.

PMID: 30409226
Journal: BMC Pediatrics
Year: 2018
Reference: BMC Pediatr. 2018 Nov 8;18(1):350. doi: 10.1186/s12887-018-1312-7.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Vaquero, Cristina; Graterol, Domingo; LLeonart, Matilde E; Lorente, Juan; Mir, Cristina; Ortiz, Nuria; Rochera-Villach, Maria Isabel et al.
DOI: 10.1186/s12887-018-1312-7

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients.

PMID: 30250996
Journal: MOLECULAR BIOLOGY REPORTS
Year: 2018
Reference: Mol Biol Rep. 2018 Dec;45(6):2345-2358. doi: 10.1007/s11033-018-4399-x. Epub 2018 Sep 24.
Impact factor:
Publication type: Paper in international publication
Authors: Ati, Nidhal; Blel, Ahlem; Chebil, Mohamed; Derouiche, Amine; Garcia-Mayea, Yoelsis; Hernandez-Losa, Javier; LLeonart, Matilde E; Mir, Cristina; Ouerhani, Slah; Paciucci, Rosanna et al.
DOI: 10.1007/s11033-018-4399-x

Efficacy and Safety of Ciprofloxacin Plus Fluocinolone in Otitis Media With Tympanostomy Tubes in Pediatric Patients: A Randomized Clinical Trial.

PMID: 28006041
Journal: JAMA Otolaryngology-Head & Neck Surgery
Year: 2017
Reference: JAMA Otolaryngol Head Neck Surg. 2017 Apr 1;143(4):341-349. doi: 10.1001/jamaoto.2016.3537.
Impact factor:
Publication type: Paper in international publication
Authors: Ansley, John; Butehorn, Henry F 3rd; Byers, John; Douglis, Franklin; Esterhuizen, Kenneth; Hernandez, F Javier; Hussain, Iftikhar; Ismail, Khaleed; Lanier, Brent; Lansford, Bryan et al.
DOI: 10.1001/jamaoto.2016.3537

Regulation of Fn14 Receptor and NF-kappaB Underlies Inflammation in Meniere's Disease.

PMID: 29326686
Journal: Frontiers in Immunology
Year: 2017
Reference: Front Immunol. 2017 Dec 13;8:1739. doi: 10.3389/fimmu.2017.01739. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Alarcon Riquelme, Marta E; Aran, Ismael; Batuecas-Caletrio, Angel; Benitez-Rosario, Jesus; Del Sol, Antonio; Espinosa-Sanchez, Juan M; Fraile-Rodrigo, Jesus Jose; Frejo, Lidia; Gallego-Martinez, Alvaro; Garcia-Arumi, Ana Maria et al.
DOI: 10.3389/fimmu.2017.01739

The role of prostate tumor overexpressed 1 in cancer progression.

PMID: 28029646
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Feb 14;8(7):12451-12471. doi: 10.18632/oncotarget.14104.
Impact factor:
Publication type: Review in international publication
Authors: Canovas, Veronica; Lleonart, Matilde; Morote, Juan; Paciucci, Rosanna et al.
DOI: 10.18632/oncotarget.14104

Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition.

PMID: 27693455
Journal: CANCER LETTERS
Year: 2017
Reference: Cancer Lett. 2017 Jan 1;384:60-69. doi: 10.1016/j.canlet.2016.09.023. Epub 2016 Sep 28.
Impact factor:
Publication type: Paper in international publication
Authors: Esner, Milan; Graifer, Dmitry; Lleonart, Matilde E; Lyakhovich, Alex et al.
DOI: 10.1016/j.canlet.2016.09.023

Outcome prognostic factors in inoperable malignant bowel obstruction.

PMID: 27286874
Journal: SUPPORTIVE CARE IN CANCER
Year: 2016
Reference: Support Care Cancer. 2016 Nov;24(11):4577-86. doi: 10.1007/s00520-016-3299-7. Epub 2016 Jun 10.
Impact factor:
Publication type: Paper in international publication
Authors: Ahlal, Sara; Cuadra Urteaga, Jose Luis; de Los LLanos Gil, Maria; Font, Albert; Indacochea, Alberto; Pardo, Nuria; Radua, Joaquim; Romeo, Margarita; Tuca, Albert; Vila, Laia et al.
DOI: 10.1007/s00520-016-3299-7

[Bacterial etiology of acute otitis media in Spain in the post-pneumococcal conjugate vaccine era].

PMID: 26969247
Journal: ANALES DE PEDIATRIA
Year: 2016
Reference: An Pediatr (Barc). 2016 Nov;85(5):224-231. doi: 10.1016/j.anpedi.2015.10.016. Epub 2016 Mar 9.
Impact factor:
Publication type: Paper in national publication
Authors: Cardelus, Sara; Devadiga, Raghavendra; Garcia-Corbeira, Pilar; Gomez Martinez, Justo Ramon; Iniesta Turpin, Jesus; McCoig, Cynthia; Moraga-Llop, Fernando A; Pumarola, Felix; Rosell Ferrer, Rosa; Salamanca de la Cueva, Ignacio et al.
DOI: 10.1016/j.anpedi.2015.10.016

Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission.

PMID: 27517150
Journal: Oncotarget
Year: 2016
Reference: Oncotarget. 2016 Sep 6;7(36):58065-58074. doi: 10.18632/oncotarget.11161.
Impact factor:
Publication type: Paper in international publication
Authors: Barvalia, Maunish; Boon, Huat Bay; Esner, Milan; Krejci, Lumir; Lleonart, Matilde E; Loja, Tomas; Lyakhovich, Alex; Shyamsunder, Pavithra; Verma, Rama S; Wu, Yu Jun et al.
DOI: 10.18632/oncotarget.11161

The cancer stem-cell signaling network and resistance to therapy.

PMID: 27434881
Journal: CANCER TREATMENT REVIEWS
Year: 2016
Reference: Cancer Treat Rev. 2016 Sep;49:25-36. doi: 10.1016/j.ctrv.2016.07.001. Epub 2016 Jul 9.
Impact factor:
Publication type: Review in international publication
Authors: Carnero, A; Garcia-Mayea, Y; LLeonart, M E; Lorente, J; Mir, C; Rubio, I T et al.
DOI: 10.1016/j.ctrv.2016.07.001

[Laryngotracheal traumatic injuries (LTI) in children: when to operate?]

PMID: 27775292
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2015
Reference: Cir Pediatr. 2015 Oct 10;28(4):165-171.
Impact factor:
Publication type: Letter or abstract
Authors: Gander, R; Guillen, G; Lain, A; Lloret, J; Lopez-Fernandez, S; Pumarola, F; Santiago-Martinez, S; Seidler, L et al.
DOI:

[Recurrent meningitis due to anatomical defects: The bacteria indicates its origin.]

PMID: 25446794
Journal: AN PEDIATR
Year: 2015
Reference: An Pediatr (Barc). 2015 Jun;82(6):388-96. doi: 10.1016/j.anpedi.2014.09.008. Epub 2014 Oct 29.
Impact factor:
Publication type: Paper in national publication
Authors: Bach Faig, A; Martin-Nalda, A; Martinez, S; Morgenstern Isaak, A; Pumarola Segura, F; Soler-Palacin, P; Vazquez Mendez, E et al.
DOI: 10.1016/j.anpedi.2014.09.008

Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs.

PMID: 26219394
Journal: CURR MED CHEM
Year: 2015
Reference: Curr Med Chem. 2015;22(26):3040-53.
Impact factor:
Publication type: Review in national publication
Authors: Graifer, Dmitri; Lyakhovich, Alex et al.
DOI:

ROMO1 regulates RedOx states and serves as an inducer of NF-kappaB-driven EMT factors in Fanconi anemia.

PMID: 25687884
Journal: CANCER LETT
Year: 2015
Reference: Cancer Lett. 2015 May 28;361(1):33-8. doi: 10.1016/j.canlet.2015.02.020. Epub 2015 Feb 14.
Impact factor:
Publication type: Paper in international publication
Authors: Lyakhovich, Alex; Shyamsunder, Pavithra; Verma, Rama S et al.
DOI: 10.1016/j.canlet.2015.02.020

Frequent carriage of resistance mechanisms to beta-lactams and biofilm formation in Haemophilus influenzae causing treatment failure and recurrent otitis media in young children.

PMID: 24891432
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2014
Reference: J Antimicrob Chemother. 2014 Sep;69(9):2394-9. doi: 10.1093/jac/dku158. Epub 2014 Jun 2.
Impact factor:
Publication type: Paper in international publication
Authors: Aracil, Belen; Arroyo, Margarita; Campos, Jose; Garcia, Ernesto; Garcia-Cobos, Silvia; Lara, Noelia; Moscoso, Miriam; Oteo, Jesus; Perez-Vazquez, Maria; Pumarola, Felix et al.
DOI: 10.1093/jac/dku158

Ribosomal proteins as novel players in tumorigenesis.

PMID: 24375388
Journal: CANCER AND METASTASIS REVIEWS
Year: 2014
Reference: Cancer Metastasis Rev. 2014 Mar;33(1):115-41. doi: 10.1007/s10555-013-9460-6.
Impact factor:
Publication type: Paper in international publication
Authors: de Las Heras-Rubio, A; Lleonart, M E; Paciucci, R; Perucho, L; Vilardell, J et al.
DOI: 10.1007/s10555-013-9460-6

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.

PMID: 24567357
Journal: JOURNAL OF CELL BIOLOGY
Year: 2014
Reference: J Cell Biol. 2014 Mar 3;204(5):729-45. doi: 10.1083/jcb.201306149. Epub 2014 Feb 24.
Impact factor:
Publication type: Paper in international publication
Authors: Beach, David; Hori, Kousuke; Izumi, Taisuke; Kondoh, Hiroshi; Lleonart, Matilde E; Maruyama, Takeshi; Mikawa, Takumi; Murakami, Itsuo; Nakagama, Hitoshi; Okamoto, Koji et al.
DOI: 10.1083/jcb.201306149

RPLP1, a Crucial Ribosomal Protein for Embryonic Development of the Nervous System.

PMID: 24959908
Journal: PLoS One
Year: 2014
Reference: PLoS One. 2014 Jun 24;9(6):e99956. doi: 10.1371/journal.pone.0099956. eCollection 2014.
Impact factor:
Publication type: Paper in international publication
Authors: Artero-Castro, Ana; Guerrero, Sergi; LLeonart, Matilde E; Perucho, Laura; Ramon Y Cajal, Santiago; Wang, Zhao-Qi et al.
DOI: 10.1371/journal.pone.0099956

[Jugular vein thrombosis in a patient addicted to intravenous drugs].

PMID: 21903183
Journal: Acta otorrinolaringologica espanola
Year: 2013
Reference: Acta Otorrinolaringol Esp. 2013 Jan-Feb;64(1):83-4. doi: 10.1016/j.otorri.2011.06.011. Epub 2011 Sep 7.
Impact factor:
Publication type: Letter or abstract
Authors: Bonilla, David; Coscojuela, Pilar; Navarrete Alvaro, Maria Luisa et al.
DOI: 10.1016/j.otorri.2011.06.011

MicroRNAs and cancer stem cells: Therapeutic approaches and future perspectives.

PMID: 22554710
Journal: CANCER LETTERS
Year: 2013
Reference: Cancer Lett. 2013 Sep 10;338(1):174-83. doi: 10.1016/j.canlet.2012.04.020. Epub 2012 Apr 30.
Impact factor:
Publication type: Review in international publication
Authors: ; et al.
DOI: 10.1016/j.canlet.2012.04.020

Microbiology of bacteria causing recurrent acute otitis media (AOM) and AOM treatment failure in young children in Spain: shifting pathogens in the post-pneumococcal conjugate vaccination era.

PMID: 23746414
Journal: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Year: 2013
Reference: Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1231-6. doi: 10.1016/j.ijporl.2013.04.002. Epub 2013 Jun 6.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Ulla; Casanovas, Josep M; Cenoz, Santiago; Gadea, Gloria; Garcia-Corbeira, Pilar; Hausdorff, William P; Losada, Isabel; Marano, Cinzia; Mares, Josep; Minguella, Isabel et al.
DOI: 10.1016/j.ijporl.2013.04.002

miR-125b Acts as a Tumor Suppressor in Breast Tumorigenesis via Its Novel Direct Targets ENPEP, CK2-alpha, CCNJ, and MEGF9.

PMID: 24098452
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Oct 3;8(10):e76247. doi: 10.1371/journal.pone.0076247.
Impact factor:
Publication type: Paper in international publication
Authors: Artero-Castro, Ana; Castellvi, Josep; Fabra, Angels; Feliciano, Andrea; Hernandez-Losa, Javier; Kondoh, Hiroshi; Leal, Jose A; Lleonart, Matilde E; Peg, Vicente; Ramon Y Cajal, Santiago et al.
DOI: 10.1371/journal.pone.0076247

[Postoperative nausea and vomiting in major trauma surgery].

PMID: 23183147
Journal: Enfermeria clinica
Year: 2012
Reference: Enferm Clin. 2012 Nov-Dec;22(6):293-8. doi: 10.1016/j.enfcli.2012.10.002. Epub 2012 Nov 24.
Impact factor:
Publication type: Paper in national publication
Authors: Aige-Cristofol, M Mireya; Albertos-Riera, M Amparo; Alonso-Vicente, M Rosa; Biarnes-Sune, Alfons; Garcia-Gomez, Laura; Gonzalez-Perez, M Gloria; Malpartida-Obon, Mercedes; Moreno-Montes, Olga; Perich-Torrens, Elisenda; Rejon-Vallverdu, M Merce et al.
DOI: 10.1016/j.enfcli.2012.10.002

Evaluation of C-reactive protein, haptoglobin and cardiac troponin 1 levels in brachycephalic dogs with upper airway obstructive syndrome.

PMID: 22937913
Journal: BMC Veterinary Research
Year: 2012
Reference: BMC Vet Res. 2012 Aug 31;8:152. doi: 10.1186/1746-6148-8-152.
Impact factor:
Publication type: Paper in international publication
Authors: Bertolani, Coralie; Ceron, Jose J; Closa, Josep M; Cuenca, Rafaela; Lorente, Juan; Pastor, Josep; Planellas, Marta; Poncet, Cyrill; Tabar, Maria-Dolores et al.
DOI: 10.1186/1746-6148-8-152

Internal auditory canal lipoma.

PMID: 21555113
Journal: Acta Otorrinolaringología
Year: 2012
Reference: Acta Otorrinolaringol Esp. 2012 Nov-Dec;63(6):491-2. doi: 10.1016/j.otorri.2011.03.008. Epub 2011 May 8.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; et al.
DOI: 10.1016/j.otorri.2011.03.008

Mutations of the gene encoding otogelin are a cause of autosomal-recessive nonsyndromic moderate hearing impairment.

PMID: 23122587
Journal: AMERICAN JOURNAL OF HUMAN GENETICS
Year: 2012
Reference: Am J Hum Genet. 2012 Nov 2;91(5):883-9. doi: 10.1016/j.ajhg.2012.09.012.
Impact factor:
Publication type: Paper in international publication
Authors: Admiraal, Ronald J C; Beynon, Andy J; del Campo, Miguel; del Castillo, Francisco J; del Castillo, Ignacio; Dominguez-Ruiz, Maria; Garcia-Arumi, Ana M; Hoefsloot, Lies H; Kalay, Ersan; Kremer, Hannie et al.
DOI: 10.1016/j.ajhg.2012.09.012

Estudio piloto sobre la corrección de la parálisis facial con hilos tensores

PMID: NOPMID032
Journal: Acta Otorrinolaringológica Española
Year: 2011
Reference: Navarrete Álvaro M, Knapper J, Boemo R, Torrent L. Estudio piloto sobre la corrección de la parálisis facial con hilos tensores. Acta Otorrinolarin
Impact factor:
Publication type: Paper in national publication
Authors: Navarrete Álvaro, Ma Luisa et al.
DOI: 10.1016/j.otorri.2010.01.011

MicroRNAs Regulate Key Effector Pathways of Senescence.

PMID: 21629746
Journal: Journal of aging research
Year: 2011
Reference: J Aging Res. 2011;2011:205378. Epub 2011 May 11.
Impact factor:
Publication type: Letter or abstract
Authors: Feliciano, Andrea; Kondoh, Hiroshi; Lleonart, Matilde E; Sanchez-Sendra, Beatriz et al.
DOI: 10.4061/2011/205378

Pilot study on the efficiency of the biostimulation with autologous plasma rich in platelet growth factors in otorhinolaryngology: otologic surgery (tympanoplasty type I).

PMID: 22084757
Journal: ISRN Surgery
Year: 2011
Reference: ISRN Surg. 2011;2011:451020. Epub 2011 Jun 20.
Impact factor:
Publication type: Letter or abstract
Authors: Boemo, R; Fuentes, J F; Mateo, A; Navarrete Alvaro, Maria Luisa; Ortiz, N; Ortiz, P; Rodriguez, L et al.
DOI: 10.5402/2011/451020

Cancer, Senescence, and Aging: Translation from Basic Research to Clinics.

PMID: 22046529
Journal: Journal of aging research
Year: 2011
Reference: J Aging Res. 2011;2011:692301. Epub 2011 Oct 20.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.4061/2011/692301

[Pilot study on the diode laser in stapes surgery].

PMID: 20409508
Journal: Acta Otorrinolaringológica Española
Year: 2010
Reference: Acta Otorrinolaringol Esp. 2010 Nov-Dec;61(6):434-6. doi: 10.1016/j.otorri.2010.02.006. Epub 2010 Apr 20.
Impact factor:
Publication type: Letter whit IF
Authors: Boemo, Rafael; Darwish, Mohamed; Monzon, Jesus; Navarrete, Maria Luisa; Rojas, Pedro et al.
DOI: 10.1016/j.otorri.2010.02.006

Toxina botulínica y parálisis facial. Nuestra experiencia

PMID: NOPMID039
Journal: Acta Otorrinolaringológica Española
Year: 2010
Reference: Toxina botulinica y parálisis facial. Nuestra experiencia. Acta Otorrinolaringológica Española. 2010; 61(4):
Impact factor:
Publication type: Paper in national publication
Authors: Junyent, Josefina; Navarrete Álvaro, Ma Luisa; Torrent Bertran, Ma Lluisa et al.
DOI: 10.1016/j.otorri.2010.02.009

Effects of betahistine on patient-reported outcomes in routine practice in patients with vestibular vertigo and appraisal of tolerability: experience in the OSVaLD study.

PMID: 21609908
Journal: The international tinnitus journal.
Year: 2010
Reference: Int Tinnitus J. 2010;16(1):14-24.
Impact factor:
Publication type: Paper in international publication
Authors: Abdul Ghani, Melati Hj; Abdullah, Asma; Abdullah, Baharudin; Abidin, Zainal Azmi Zainal; Agarwal, V K; Aguila, Artal A; Ajisafe, O; Al'Konee, Raja Ahmad; Alaicescu, M; Alekseeva, N et al.
DOI:

[Endolymphatic sac tumour as an infrequent cause of Meniere's syndrome]

PMID: 20381005
Journal: Acta otorrinolaringológica española
Year: 2010
Reference: Acta Otorrinolaringol Esp. 2010 May-Jun;61(3):236-7. Epub 2010 Apr 8.
Impact factor:
Publication type: Letter or abstract
Authors: Boemo, Rafael Luis; Garcia Arumi, Ana Maria; Huguet, Pere; Knapper, Jenifer M; Navarrete, Maria Luisa; Perello, Enrique et al.
DOI: 10.1016/j.otorri.2008.12.007

Senescence induction; a possible cancer therapy.

PMID: 19133111
Journal: Molecular Cancer
Year: 2009
Reference: Mol Cancer. 2009 Jan 8;8:3.
Impact factor:
Publication type: Review in international publication
Authors: Artero-Castro, Ana; Kondoh, Hiroshi; Lleonart Pajarin, Matilde; Lleonart, Matilde E et al.
DOI: 10.1186/1476-4598-8-3

Low frequency electromagnetic radiation and hearing.

PMID: 19573254
Journal: JOURNAL OF LARYNGOLOGY AND OTOLOGY
Year: 2009
Reference: J Laryngol Otol. 2009 Nov;123(11):1204-11.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia, M; Garcia-Martinez, V; Lopez-Sanchez, C; Morales, J; Perez, C; Quesada, J L; Valverde, J V et al.
DOI: 10.1017/S0022215109005684

Rplp1 bypasses replicative senescence and contributes to transformation.

PMID: 19233166
Journal: EXPERIMENTAL CELL RESEARCH
Year: 2009
Reference: Exp Cell Res. 2009 May 1;315(8):1372-83.
Impact factor:
Publication type: Paper in international publication
Authors: Artero-Castro, A; Fernandez-Marcos, P J; Kondoh, H; Lleonart Pajarin, Matilde; Lleonart, M E; Ramon y Cajal, S; Serrano, M et al.
DOI: 10.1016/j.yexcr.2009.02.007

Metastasis of amelanotic melanoma of unknown origin in the parotid gland.

PMID: 19167137
Journal: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Year: 2009
Reference: Br J Oral Maxillofac Surg. 2009 Oct;47(7):569-71.
Impact factor:
Publication type: Paper in international publication
Authors: Mesa, Margarita; Pinas, Juan; Quesada, Juan Luis et al.
DOI: 10.1016/j.bjoms.2008.10.011

Thesis

Papel de los exosomas en la comunicación entre las células tumorales y los macrófagos en el carcinoma laríngeo

PhD student: Angela maria Bellmunt Fontanet
Director/s: Juan Lorente Guerrero
University: Universidad Autònoma de Barcelona
Year: 2018

Identificación y caracterización funcional de microRNAS en cáncer de mama

PhD student: Andrea F Feliciano Aguirre
Director/s: Matilde Lleonart Pajarin
University: Universidad Autònoma de Barcelona
Year: 2017

In vivo elucidation of the role of Pim kinases in tumorigenesis

PhD student: Maja Narlik , Maja Narlik
Director/s: Amancio Carnero Moya
University: Universidad Autònoma de Barcelona
Year: 2012

Generación de herramientas celulares para validación de drogas antitumorales

PhD student: María Victoria Moneo , María Victoria Moneo
Director/s: Amancio Carnero Moya
University: Universidad Autònoma de Barcelona
Year: 2009

Espinofilina, un tumor supresor dependiente de la ausencia de p53

PhD student: Irene Ferrer , Irene Ferrer
Director/s: Amancio Carnero Moya
University: Universidad Autònoma de Barcelona
Year: 2009

Blog

News

The sessions were aimed at establishing new collaborations to advance the prevention and treatment of this type of tumour.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

The Biomedical Research in Cancer Stem Cells group at VHIR has identified a new therapeutic target and is working to find new therapies for this type of tumor.