About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models.
Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to:
IP: Sara Marsal Barril Collaborators: Antonio Julia Cano, Javier Hoyo Pérez, Elena Granell Pallares, Adria Aterido Ballonga, Montse Sender Beleta, Nuria Palau Balaña, Edgar Nuñez Gallardo, Raul Tortosa Mendez, Maria Alba Erra Duran Funding agency: EUROPEAN COMMISSION Funding: 1079085 Reference: DOCTIS_H2020_SC1-BHC2019 Duration: 01/01/2020 - 31/12/2025
IP: Marta Martínez Vicente Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, Eddie Pradas Gracia, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Jordi Riera Heredia, The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies an, Daniela Samaniego Toro, Laura Castillo Ribelles, Daniela Samaniego Toro Funding agency: Instituto de Salud Carlos III Funding: 245932.5 Reference: PI20/00728 Duration: 01/01/2021 - 30/06/2025
IP: Jordi Bove Badell Collaborators: Miquel Vila Bover, Alejandro Ferré Masó, Oriol de Fabregues-Boixar Nebot, Carles Lorenzo Bosquet, Characterization of the CD8 T cell response in Parkinson’s disease for the development of preventive and therapeutic strategies , Antonio Palasi Franco Funding agency: Instituto de Salud Carlos III Funding: 165770 Reference: PI21/01358 Duration: 01/01/2022 - 30/06/2026
IP: Ariadna Laguna Tuset Collaborators: Maria Victoria Gonzalez Martinez, Miquel Vila Bover, Marina Lorente Picón, Helena Xicoy Cortada, Daniela Samaniego Toro, Daniela Samaniego Toro, Sara Belmonte Calderon Funding agency: Instituto de Salud Carlos III Funding: 171820 Reference: PI21/01603 Duration: 01/01/2022 - 30/06/2026
PMID: 39675054 Journal: Autophagy Year: 2024 Reference: Autophagy. 2024 Dec 15. doi: 10.1080/15548627.2024.2440843. Impact factor: Publication type: Paper in international publication Authors: Arauz-Garofalo, Gianluca; Gay, Marina; Gordaliza-Alaguero, Isabel; Ivanova, Saska; Macias, Maria J; Martin-Malpartida, Pau; Martinez-Vicente, Marta; Palacin, Manuel; Radivojevikj, Dragana; Sanchez-Fernandez-de-Landa, Paula et al. DOI: 10.1080/15548627.2024.2440843
PMID: 39694692 Journal: Cold Spring Harbor Perspectives in Medicine Year: 2024 Reference: Cold Spring Harb Perspect Med. 2024 Dec 18:a041619. doi: 10.1101/cshperspect.a041619. Impact factor: Publication type: Paper in international publication Authors: Martinez-Vicente, Marta; Vila, Miquel et al. DOI: 10.1101/cshperspect.a041619
PMID: 39795868 Journal: Year: 2024 Reference: Int J Mol Sci. 2024 Dec 24;26(1):9. doi: 10.3390/ijms26010009. Impact factor: Publication type: Paper in international publication Authors: Bellotto, Manolo; Carrillo, Jokin; Cubero, Elena; Delgado, Aida; Garcia-Collazo, Ana Maria; Martinez-Vicente, Marta; Montpeyo, Marta; Perez-Carmona, Natalia; Ruano, Ana et al. DOI: 10.3390/ijms26010009
PMID: 39974625 Journal: Year: 2024 Reference: Resusc Plus. 2024 Dec 19;20:100735. doi: 10.1016/j.resplu.2024.100735. eCollection 2024 Dec. Impact factor: Publication type: Paper in international publication Authors: Argudo, Eduard; Martinez-Martinez, Maria; Riera, Jordi; Torrella, Pau; Vidal-Burdeus, Maria et al. DOI: 10.1016/j.resplu.2024.100735
PMID: 37509344 Journal: Cancers Year: 2023 Reference: Cancers (Basel). 2023 Jul 19;15(14):3683. doi: 10.3390/cancers15143683. Impact factor: Publication type: Paper in international publication Authors: Carrion, Albert; Dinares, Carme; Hernandez, Javier; Hernandez, Javier; Lozano, Fernando; Morote, Juan; Raventos, Carles X; Trilla, Enrique et al. DOI: 10.3390/cancers15143683
PMID: 37661559 Journal: ARCHIVOS DE BRONCONEUMOLOGIA Year: 2023 Reference: Arch Bronconeumol. 2023 Aug 7:S0300-2896(23)00267-3. doi: 10.1016/j.arbres.2023.07.029. Impact factor: Publication type: Letter or abstract Authors: Abril, Elena; Barbe, Ferran; Barbera, Carme; Bustamante-Munguira, Elena; Bustamante-Munguira, Elena; Caballero, Jesus; Caballero, Jesus; Canseco, Joan; Carbonell, Nieves; Ceccato, Adrian et al. DOI: 10.1016/j.arbres.2023.07.029
PMID: 37726343 Journal: npj Parkinsons Disease Year: 2023 Reference: NPJ Parkinsons Dis. 2023 Sep 19;9(1):135. doi: 10.1038/s41531-023-00579-w. Impact factor: Publication type: Paper in international publication Authors: Arotcarena, Marie-Laure; Bezard, Erwan; Bourdenx, Mathieu; Darricau, Morgane; Dehay, Benjamin; Dovero, Sandra; Estrada, Cristina; Garcia-Carrillo, Nuria; Herrero, Maria Trinidad; Obeso, Jose A et al. DOI: 10.1038/s41531-023-00579-w
PMID: 37741513 Journal: NEUROBIOLOGY OF DISEASE Year: 2023 Reference: Neurobiol Dis. 2023 Sep 21:106308. doi: 10.1016/j.nbd.2023.106308. Impact factor: Publication type: Paper in international publication Authors: Bove, Jordi; de Fabregues, Oriol; de Fabregues, Oriol; Ramos-Vicente, David; Ramos-Vicente, David; Roch, Gerard; Roch, Gerard; Selles, Maria; Selles, Maria; Vila, Miquel et al. DOI: 10.1016/j.nbd.2023.106308
PMID: 34890878 Journal: PARKINSONISM & RELATED DISORDERS Year: 2022 Reference: Parkinsonism Relat Disord. 2022 Jan;94:67-78. doi: 10.1016/j.parkreldis.2021.11.014. Epub 2021 Nov 25. Impact factor: Publication type: Paper in international publication Authors: Adarmes, A; Artuch, R; Beyer, Katrin; Castano-de la Mota, C; De la Torre-Aguilar, Maria Jose; Fernandez-Ramos, Joaquin A; Garcia Cazorla, A; Gomez-Esteban, J C; Gonzalez Gutierrez-Solana, L; Hernandez-Vara, J et al. DOI: 10.1016/j.parkreldis.2021.11.014
PMID: 35085959 Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES Year: 2022 Reference: J Neurol Sci. 2022 Mar 15;434:120148. doi: 10.1016/j.jns.2022.120148. Epub 2022 Jan 12. Impact factor: Publication type: Paper in international publication Authors: Adarmes-Gomez, Astrid; Aramburu, Isabel Gonzalez; Arroyo, Sonia Escalante; Avila, Asuncion; Barbera, Miquel Aguilar; Bejr-Kasem, Helena; Campolongo, Antonia; Carrillo, Fatima; Ceberio, Jon Infante; de Deus Fonticoba, Teresa et al. DOI: 10.1016/j.jns.2022.120148
PMID: 34229512 Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Year: 2022 Reference: J Cereb Blood Flow Metab. 2022 Feb;42(2):237-252. doi: 10.1177/0271678X211028816. Epub 2021 Jul 6. Impact factor: Publication type: Paper in international publication Authors: Arrue, Mercedes; Belloli, Sara; Castellote, Laura; Garcia-Gabilondo, Miguel; Grayston, Alba; Kopcansky, Peter; Kovac, Jozef; Martin, Abraham; Moresco, Rosa M; Picchio, Maria et al. DOI: 10.1177/0271678X211028816
PMID: 34602501 Journal: Journal of Parkinsons Disease Year: 2022 Reference: J Parkinsons Dis. 2022;12(1):315-331. doi: 10.3233/JPD-212868. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarez Sauco, Maria; Avila Rivera, Maria A; Blazquez Estrada, Marta; Borrue, Carmen; Caballol, Nuria; Cabo, Iria; Canfield, Hector et al. DOI: 10.3233/JPD-212868
PMID: 33978742 Journal: BRAIN Year: 2021 Reference: Brain. 2021 Nov 29;144(10):3114-3125. doi: 10.1093/brain/awab191. Impact factor: Publication type: Paper in international publication Authors: Arnulf, Isabelle; Biondetti, Emma; Corvol, Jean-Christophe; Dodet, Pauline; Gaurav, Rahul; Habert, Marie-Odile; Hutchison, Matthew; Lehericy, Stephane; Leu-Semenescu, Smaranda; Mangone, Graziella et al. DOI: 10.1093/brain/awab191
PMID: 33924567 Journal: Journal of Clinical Medicine Year: 2021 Reference: J Clin Med. 2021 Apr 13;10(8). pii: jcm10081664. doi: 10.3390/jcm10081664. Impact factor: Publication type: Review in international publication Authors: Agraz-Pamplona, Irene; Armengol-Bellapart, Mar; Arranz-Amo, Jose Antonio; Camprodon-Gomez, Maria; Carnicer-Caceres, Clara; Cea-Arestin, Cristina; Del-Toro-Riera, Mireia; Hernandez-Vara, Jorge; Lucas-Del-Pozo, Sara; Molto-Abad, Marc et al. DOI: 10.3390/jcm10081664
PMID: 33902111 Journal: HUMAN MOLECULAR GENETICS Year: 2021 Reference: Hum Mol Genet. 2021 Jul 28;30(16):1469-1483. doi: 10.1093/hmg/ddab118. Impact factor: Publication type: Paper in international publication Authors: Alexakos, Pavlos; Argyrofthalmidou, Maria; Katsianou, Maira A; Maniati, Matina; Manousaki, Maria; Papadopoulou-Daifoti, Zeta; Papapanagiotou, Ioanna; Perier, Celine; Pitychoutis, Pothitos M; Poula, Amalia et al. DOI: 10.1093/hmg/ddab118
PMID: 33885286 Journal: ACS Nano Year: 2021 Reference: ACS Nano. 2021 May 25;15(5):8592-8609. doi: 10.1021/acsnano.1c00453. Epub 2021 Apr 22. Impact factor: Publication type: Paper in international publication Authors: Bove, Jordi; Candiota, Ana Paula; Cavaliere, Ivana; Garcia-Pardo, Javier; Lope-Piedrafita, Silvia; Lorenzo, Julia; Nador, Fabiana; Novio, Fernando; Rodriguez-Galvan, Beatriz; Romero-Gimenez, Jordi et al. DOI: 10.1021/acsnano.1c00453
PMID: 32346016 Journal: Scientific Reports Year: 2020 Reference: Sci Rep. 2020 Apr 28;10(1):7118. doi: 10.1038/s41598-020-64093-2. Impact factor: Publication type: Paper in international publication Authors: Calvo-Barreiro, Laura; Carballo-Carbajal, Iria; Comabella, Manuel; Gonzalo, Ricardo; Matute-Blanch, Clara; Montalban, Xavier; Sanchez, Alex; Vila, Miquel et al. DOI: 10.1038/s41598-020-64093-2
PMID: 32333181 Journal: NEUROLOGICAL SCIENCES Year: 2020 Reference: Neurol Sci. 2020 Oct;41(10):2883-2892. doi: 10.1007/s10072-020-04404-7. Epub 2020 Apr 24. Impact factor: Publication type: Paper in international publication Authors: Alonso-Losada, Maria G; Alvarez-Sauco, Maria; Avila-Rivera, Maria A; Caballol, Nuria; Catalan, Maria J; Cubo, Esther; de Deus-Fonticoba, Teres; Escalante, Sonia; Feal-Painceiras, Maria J; Garcia-Caldentey, Juan et al. DOI: 10.1007/s10072-020-04404-7
PMID: 32202078 Journal: Brain and Behavior Year: 2020 Reference: Brain Behav. 2020 May;10(5):e01596. doi: 10.1002/brb3.1596. Epub 2020 Mar 22. Impact factor: Publication type: Paper in international publication Authors: Auger, Cristina; Cardona, Ignasi; De Fabregues, Oriol; Palasi, Antoni; Quintana, Manuel; Vargas, Victor; Vinas, Jaume et al. DOI: 10.1002/brb3.1596
PMID: 32181979 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2020 Reference: Eur J Neurol. 2020 Jul;27(7):1210-1223. doi: 10.1111/ene.14221. Epub 2020 Apr 24. Impact factor: Publication type: Paper in international publication Authors: Aguilar, M; Almeria, Marta; Alonso Canovas, Araceli; Alonso-Frech, F; Alvarez Sauco, Maria; Aneiros Diaz, A; Angel Labrador Espinosa, Miguel; Angeles Boti Gonzalez, Maria; Angeles Prats, Marian; Arnaiz, Sandra et al. DOI: 10.1111/ene.14221
PMID: 29217686 Journal: JOURNAL OF NEUROSCIENCE Year: 2018 Reference: J Neurosci. 2018 Jan 24;38(4):814-825. doi: 10.1523/JNEUROSCI.2276-17.2017. Epub 2017 Dec 7. Impact factor: Publication type: Paper in international publication Authors: Alarcon-Aris, Diana; Belen Munoz-Manchado, Ana; Belenguer, German; Bezard, Erwan; Bortolozzi, Analia; Dehay, Benjamin; Farinas, Isabel; Jose Toledo-Aral, Juan; Perez-Sanchez, Francisco; Perez-Villalba, Ana et al. DOI: 10.1523/JNEUROSCI.2276-17.2017
The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.
Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.
