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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Team

Sara Lucas del Pozo

Sara Lucas del Pozo

Predoctoral researcher
Neurodegenerative Diseases
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Sara Palacin i Bonson

Sara Palacin i Bonson

Research technician
Neurodegenerative Diseases
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Silvia Enriquez Calzada

Silvia Enriquez Calzada

Predoctoral researcher
Neurodegenerative Diseases
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Gerard Roch Alba

Gerard Roch Alba

Predoctoral researcher
Neurodegenerative Diseases
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Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
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Jorge Hernández Vara

Jorge Hernández Vara

Main researcher
Neurodegenerative Diseases
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Sara Lucas del Pozo

Sara Lucas del Pozo

Predoctoral researcher
Neurodegenerative Diseases
Read more
Sara Palacin i Bonson

Sara Palacin i Bonson

Research technician
Neurodegenerative Diseases
Read more
Silvia Enriquez Calzada

Silvia Enriquez Calzada

Predoctoral researcher
Neurodegenerative Diseases
Read more
Gerard Roch Alba

Gerard Roch Alba

Predoctoral researcher
Neurodegenerative Diseases
Read more
Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
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Jorge Hernández Vara

Jorge Hernández Vara

Main researcher
Neurodegenerative Diseases
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Projects

MECANISMOS MOLECULARES DE NEURODEGENERACION LIGADA A LA NEUROMELANINA EN LA ENFERMEDAD DE PARKINSON Y ENVEJECIMIENTO CEREBRAL

IP: Miquel Vila Bover
Collaborators: Gerard Roch Alba, Miriam Izquierdo Sans
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 99260
Reference: PRE2021-098300
Duration: 01/07/2022 - 30/06/2026

Ministerio de Ciencia

El eje cerebro-cuerpo en la enfermedad de Parkinson: de la fisiopatología a los biomarcadores y enfoques terapéuticos.

IP: Ariadna Laguna Tuset
Collaborators: Miriam Izquierdo Sans, Laia Perez Lasarte
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 236350
Reference: RYC2021-032947-I
Duration: 01/01/2023 - 31/12/2027

Ministerio de Ciencia

New nanotechnological therapy for Parkinson's disease: nose-to-brain delivery of GBA-polymer nanoconjugates (NANOGBAtoBRAIN)

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Eddie Pradas Gracia, Laura Castillo Ribelles, Clara Carnicer Cáceres, David Moreno Martinez, Pablo Castillo Sánchez
Funding agency: Fundació "La Caixa"
Funding: 249950
Reference: HR22-00602
Duration: 01/11/2022 - 30/06/2026

The brain-body axis in Parkinson’s disease patients: from pathophysiology to biomarkers and therapeutic approaches

IP: Ariadna Laguna Tuset
Collaborators: Maria Victoria Gonzalez Martinez, Miquel Vila Bover, Sara Belmonte Calderon
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI21/01603
Duration: 01/01/2022 - 30/06/2026

Blog

News

The event focused on advances in disease-modifying therapies and on the value of alliances between patients and professionals to promote more participatory care and research.

This VHIR initiative promotes well-being, empathy and community participation in Barcelona neighbourhoods through an intergenerational model

PAIR is an intergenerational initiative with people affected by Parkinson's disease and adolescents.

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study