About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models.
Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to:
IP: Miquel Vila Bover Collaborators: Joan Compte Barrón, Javier Hoyo Pérez, Gerard Roch Alba, Marta González Sepúlveda, Ariadna Laguna Tuset, Joana Margalida Cladera Sastre, Alba Nicolau Vera Funding agency: Michael J. Fox Foundation Funding: 1936109 Reference: ASAP_MJFF2021 Duration: 01/11/2021 - 31/10/2025
PMID: 37755405 Journal: ASAIO JOURNAL Year: 2023 Reference: ASAIO J. 2023 Sep 13. doi: 10.1097/MAT.0000000000002038. Impact factor: Publication type: Paper in international publication Authors: Abbasi, Adeel; Alexander, Peta M A; Anders, Marc M; Arachchillage, Deepa J; Barbaro, Ryan P; Fox, Alexander D; Friedman, Matthew L; Malfertheiner, Maximilian V; Rali, Aniket S; Ramanathan, Kollengode et al. DOI: 10.1097/MAT.0000000000002038
PMID: 37769648 Journal: BRAIN Year: 2023 Reference: Brain. 2023 Sep 28:awad331. doi: 10.1093/brain/awad331. Impact factor: Publication type: Paper in international publication Authors: Ariznabarreta, Goiaz; Chocarro, Julia; Collantes, Maria; Honrubia, Adriana; Labandeira-Garcia, Jose L; Lanciego, Jose L; Penuelas, Ivan; Rico, Alberto J; Roda, Elvira; Rodriguez-Perez, Ana I et al. DOI: 10.1093/brain/awad331
PMID: 37791410 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2023 Reference: Eur J Neurol. 2023 Oct 4. doi: 10.1111/ene.16058. Impact factor: Publication type: Paper in international publication Authors: Alpuente, Alicia; Alpuente, Alicia; Caronna, Edoardo; Elosua-Bayes, Iker; Gallardo, Victor J; Gallardo, Victor J; Melgarejo, Laura; Melgarejo, Laura; Pozo-Rosich, Patricia; Pozo-Rosich, Patricia et al. DOI: 10.1111/ene.16058
PMID: 37165368 Journal: Health and Quality of Life Outcomes Year: 2023 Reference: Health Qual Life Outcomes. 2023 May 10;21(1):42. doi: 10.1186/s12955-023-02120-2. Impact factor: Publication type: Paper in international publication Authors: Alonso-Garcia, Lucia; Bruguera, Andreu; Casabona, Jordi; Diaz, Yesika; Egea-Cortes, Laia; Folch, Cinta; Forero, Carlos G; Hernandez, Juan; Mesias-Gazmuri, Jocelyn; Miro, Jose M et al. DOI: 10.1186/s12955-023-02120-2
PMID: 34794916 Journal: Revista Espanola de Medicina Nuclear e Imagen Molecular Year: 2022 Reference: Rev Esp Med Nucl Imagen Mol (Engl Ed). 2022 Jan-Feb;41(1):52-54. doi: 10.1016/j.remnie.2021.05.002. Epub 2021 Nov 16. Impact factor: Publication type: Letter or abstract Authors: Cardozo-Saavedra, A; Cardozo-Saavedra, A; Carrillo-Villamizar, E; Hernandez-Vara, J; Lorenzo-Bosquet, C; Lucas Del Pozo, S; Martinez-Saez, E et al. DOI: 10.1016/j.remnie.2021.05.002
PMID: 35083225 Journal: Frontiers in Cell and Developmental Biology Year: 2022 Reference: Front Cell Dev Biol. 2022 Jan 10;9:826037. doi: 10.3389/fcell.2021.826037. eCollection 2021. Impact factor: Publication type: Editorail in international publication Authors: Coccia, Elena; Comella, Joan X; Solé, Montse et al. DOI: 10.3389/fcell.2021.826037
PMID: 35805133 Journal: Cells Year: 2022 Reference: Cells. 2022 Jun 28;11(13). pii: cells11132046. doi: 10.3390/cells11132046. Impact factor: 6.6 Publication type: Paper in international publication Authors: Rodriguez-Urrutia, Amanda, Torres, Ines de, Santos-Briones, Ignacio, Azpiroz, Fernando, Lobo, Beatriz, Alonso-Cotoner, Carmen, Santos, Javier, Gonzalez-Castro, Ana M, Vicario, Maria, Guagnozzi, Danila et al. DOI: 10.3390/cells11132046
PMID: 35626681 Journal: Cells Year: 2022 Reference: Cells. 2022 May 14;11(10). pii: cells11101644. doi: 10.3390/cells11101644. Impact factor: 6.6 Publication type: Review in international publication Authors: Salvo-Romero, Eloisa, Rodino-Janeiro, Bruno K, Albert-Bayo, Merce, Lobo, Beatriz, Santos, Javier, Farre, Ricard, Martinez, Cristina, Vicario, Maria et al. DOI: 10.3390/cells11101644
PMID: 33823877 Journal: Journal of Neuroinflammation Year: 2021 Reference: J Neuroinflammation. 2021 Apr 6;18(1):88. doi: 10.1186/s12974-021-02132-z. Impact factor: Publication type: Paper in international publication Authors: Bove, Jordi; Rabaneda-Lombarte, Neus; Saura, Josep; Serratosa, Joan; Sola, Carme; Vila, Miquel et al. DOI: 10.1186/s12974-021-02132-z
PMID: 32093570 Journal: Autophagy Year: 2021 Reference: Autophagy. 2021 Mar;17(3):672-689. doi: 10.1080/15548627.2020.1728096. Epub 2020 Feb 24. Impact factor: Publication type: Paper in international publication Authors: Franco-Iborra, Sandra; Martinez-Vicente, Marta; Montpeyo, Marta; Plaza-Zabala, Ainhoa; Sebastian, David; Vila, Miquel et al. DOI: 10.1080/15548627.2020.1728096
PMID: 33804226 Journal: Biomolecules Year: 2021 Reference: Biomolecules. 2021 Mar 15;11(3). pii: biom11030433. doi: 10.3390/biom11030433. Impact factor: Publication type: Review in international publication Authors: Laguna, Ariadna; Lorente-Picon, Marina et al. DOI: 10.3390/biom11030433
PMID: 33169885 Journal: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Year: 2021 Reference: Int J Geriatr Psychiatry. 2021 May;36(5):627-646. doi: 10.1002/gps.5461. Epub 2020 Nov 20. Impact factor: Publication type: Paper in international publication Authors: A, Aneiros; Alonso P, Sanchez; Aramburu, Gonzalez 1st; Ardura J, Gonzalez; Ariztegui N, Lopez; Aymerich L, Valdes; Bartolome C, Cores; C, Borrue; C, Valero; Caldentey J, Garcia et al. DOI: 10.1002/gps.5461
PMID: 32098205 Journal: Cells Year: 2020 Reference: Cells. 2020 Feb 21;9(2). pii: cells9020495. doi: 10.3390/cells9020495. Impact factor: Publication type: Editorail in international publication Authors: Martinez-Vicente, Marta et al. DOI: 10.3390/cells9020495
PMID: 31980808 Journal: Nature Reviews Neurology Year: 2020 Reference: Nat Rev Neurol. 2020 Feb;16(2):97-107. doi: 10.1038/s41582-019-0301-2. Epub 2020 Jan 24. Impact factor: Publication type: Review in international publication Authors: Klein, Christine; Rascol, Olivier; Tolosa, Eduardo; Vila, Miquel et al. DOI: 10.1038/s41582-019-0301-2
PMID: 33147750 Journal: Cells Year: 2020 Reference: Cells. 2020 Nov 2;9(11). pii: cells9112399. doi: 10.3390/cells9112399. Impact factor: 4.366 Publication type: Review in international publication Authors: Navarro-Romero, Alba, Montpeyo, Marta, Martinez-Vicente, Marta et al. DOI: 10.3390/cells9112399
PMID: 33118032 Journal: BRAIN Year: 2020 Reference: Brain. 2020 Dec 1;143(12):3717-3733. doi: 10.1093/brain/awaa269. Impact factor: 11.337 Publication type: Paper in international publication Authors: Galiano-Landeira, Jordi, Torra, Albert, Vila, Miquel, Bove, Jordi et al. DOI: 10.1093/brain/awaa269
The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.
Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.
