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Stroke Research

The search for quality and innovation has always been an inherent part of the activity of the Stroke Research Group and represents the common thread that leads us to excellence and continuous improvement.

In recent years, the Stroke Research Group has established itself as a leader in the management, recruitment and international coordination of multicenter clinical trials, as well as in the development of patents for new thrombectomy devices and the creation of new technological solutions and digital platforms to improve the diagnosis, treatment and follow-up of stroke patients. Robust strategic alliances have also been consolidated with public and private entities that ensure the viability and scalability of the research projects initiated in our group.

The Stroke Research Group is made up of a transversal and multidisciplinary team that shares a common idea: to contribute from its area of knowledge to the care and management of stroke through the effective transfer of knowledge and the complementarity of the processes of clinical research.

Team

Marta Aurora Rubiera Del Fueyo

Marta Aurora Rubiera Del Fueyo

Main researcher
Stroke research
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Giorgio Colangelo

Giorgio Colangelo

Administration and Management
Stroke research
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Ana Torcida Alonso

Ana Torcida Alonso

Research technician
Stroke research
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Claudia Meza Burgos

Claudia Meza Burgos

Research technician
Stroke research
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Federica Rizzo

Federica Rizzo

Predoctoral researcher
Stroke research
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Jesús David González Riveros

Jesús David González Riveros

Research technician
Stroke research
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Marta Aurora Rubiera Del Fueyo

Marta Aurora Rubiera Del Fueyo

Main researcher
Stroke research
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Giorgio Colangelo

Giorgio Colangelo

Administration and Management
Stroke research
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Ana Torcida Alonso

Ana Torcida Alonso

Research technician
Stroke research
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Claudia Meza Burgos

Claudia Meza Burgos

Research technician
Stroke research
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Federica Rizzo

Federica Rizzo

Predoctoral researcher
Stroke research
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Jesús David González Riveros

Jesús David González Riveros

Research technician
Stroke research
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Research lines

Advanced neuroimaging in patient selection for cerebral reperfusion

Responsible: Dr. Marta Rubiera

IP: -

Clinical markers and vascular image of progression of carotid and intracranial atherosclerosis

Responsible: Dr. David Rodríguez Luna

IP: -

Development of haemostatic and hemodynamic strategies for reducing acute hematoma growth

Responsible: Dr. David Rodríguez Luna

IP: -

Diagnostic and therapeutic implications of thrombus analysis obtained by mechanical thrombectomy

Responsible: Dr. Jorge Pagola

IP: -

Projects

POC4TRIAGE: Point-of-Care Devices for Urgent Care Triage

IP: Carlos Molina Cateriano
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 672750
Reference: POC4TRIAGE_HE-HLTH2023
Duration: 01/07/2024 - 30/06/2028

Early identification of intracranial atherosclerosis-related large vessel occlusion (ICAS-LVO) and implications in endovascular treatment

IP: Marc Ribó Jacobi
Collaborators: Marc Rodrigo Gisbert
Funding agency: Fundació Institut de Recerca HUVH
Funding: 59681.19
Reference: DORADO/2024/RODRIGO
Duration: 08/06/2024 - 07/06/2026

BIOBANCOS Y BIOMODELOS

IP: Isabel Novoa Garcia
Collaborators: Joaquim Vives Armengol, Anna Duarri Piqué, Eva Colas Ortega, Oriol Bestard Matamoros, Marta Rosal Fontana, Carmen Espejo Ruiz, Marielle Esteves Coelho, Juan Jose Gonzalez Lopez, Sheyla Pascual Martín, Alejandro Tomasello Weitz
Funding agency: Instituto de Salud Carlos III
Funding: 137460
Reference: PT23/00040
Duration: 01/01/2024 - 31/12/2026

Aplicación de estrategias para agilizar el tratamiento de pacientes con ictus agudo

IP: Marc Ribó Jacobi
Collaborators: Marta Olive Gadea, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM23/00280
Duration: 31/03/2024 - 30/03/2026

Publications

APRIL: A double-blind, placebo-controlled, randomized, Phase Ib/IIa clinical study of ApTOLL for the treatment of acute ischemic stroke.

PMID: 36908619
Journal: Frontiers in Neurology
Year: 2023
Reference: Front Neurol. 2023 Feb 24;14:1127585. doi: 10.3389/fneur.2023.1127585. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Abad-Santos, Francisco; Casariego, Joaquin; Cobo, Erik; Cotgreave, Ian; Dalsgaard, Mads; Flores, Alan; Gallego, Jaime; Hernandez-Jimenez, Macarena; Hernandez-Perez, Maria; Jilma, Bernd et al.
DOI: 10.3389/fneur.2023.1127585

Effect of atherosclerosis on 5-year risk of major vascular events in patients with transient ischaemic attack or minor ischaemic stroke: an international prospective cohort study.

PMID: 36931807
Journal: LANCET NEUROLOGY
Year: 2023
Reference: Lancet Neurol. 2023 Apr;22(4):320-329. doi: 10.1016/S1474-4422(23)00067-4.
Impact factor:
Publication type: Paper in international publication
Authors: Albers, Gregory W; Amarenco, Pierre; Caplan, Louis R; Charles, Hugo; Donnan, Geoffrey A; Ferro, Jose M; Hennerici, Michael G; Labreuche, Julien; Lavallee, Philippa C; Molina, Carlos et al.
DOI: 10.1016/S1474-4422(23)00067-4

Clinical Reasoning: An 82-Year-Old Woman With Subacute Ophthalmoparesis and Ataxia.

PMID: 36990717
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Aug 1;101(5):e570-e575. doi: 10.1212/WNL.0000000000207246. Epub 2023 Mar 29.
Impact factor:
Publication type: Letter or abstract
Authors: Auger, Cristina; Baucells, Andres; Gonzalez, Victoria; Llaurado, Arnau; Rodrigo-Gisbert, Marc et al.
DOI: 10.1212/WNL.0000000000207246

The use of amino acid formulas in pediatric patients with allergy to cow's milk proteins: Recommendations from a group of experts.

PMID: 37033186
Journal: Frontiers in Pediatrics
Year: 2023
Reference: Front Pediatr. 2023 Mar 22;11:1110380. doi: 10.3389/fped.2023.1110380. eCollection 2023.
Impact factor:
Publication type: Review in international publication
Authors: Amil-Dias, Jorge; Diaz-Martin, Juan J; Espin, Beatriz; Molina, Manuel; Ribes-Koninckx, Carmen; Segarra, Oscar et al.
DOI: 10.3389/fped.2023.1110380

Herpes simplex encephalitis in the context of immune checkpoint inhibitors: a complex interplay.

PMID: 34988947
Journal: ACTA NEUROLOGICA BELGICA
Year: 2022
Reference: Acta Neurol Belg. 2022 Jun;122(3):823-825. doi: 10.1007/s13760-021-01864-2. Epub 2022 Jan 6.
Impact factor: 2.396
Publication type: Letter or abstract
Authors: Lallana, Sofia; Sanchez-Tejerina, Daniel; Auger, Cristina; Callejo, Ana; Rio, Jordi; Cobo-Calvo, Alvaro et al.
DOI: 10.1007/s13760-021-01864-2

Disentangling Workflow Paradigms and Treatment Decision-Making in Acute Ischemic Stroke-Reply.

PMID: 35129613
Journal: JAMA Neurology
Year: 2022
Reference: JAMA Neurol. 2022 Mar 1;79(3):312. doi: 10.1001/jamaneurol.2021.5346.
Impact factor: 18.302
Publication type: Letter or abstract
Authors: Ribo, Marc; Requena, Manuel et al.
DOI: 10.1001/jamaneurol.2021.5346

Effect of Intra-arterial Alteplase vs Placebo Following Successful Thrombectomy on Functional Outcomes in Patients With Large Vessel Occlusion Acute Ischemic Stroke: The CHOICE Randomized Clinical Trial.

PMID: 35143603
Journal: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
Year: 2022
Reference: JAMA. 2022 Mar 1;327(9):826-835. doi: 10.1001/jama.2022.1645.
Impact factor: 56.274
Publication type: Paper in international publication
Authors: Avellaneda, C; Camps-Renom, Pol; Zarco, Federico; Oleaga, Laura; Cardona, Pere; Castano, Carlos; Macho, Juan; Cuadrado-Godia, Elisa; Vivas, Elio; Lopez-Rueda, Antonio et al.
DOI: 10.1001/jama.2022.1645

REACT Aspiration Catheters: Clinical Experience and Technical Considerations.

PMID: 35718472
Journal: Neurointervention
Year: 2022
Reference: Neurointervention. 2022 Jul;17(2):70-77. doi: 10.5469/neuroint.2022.00255. Epub 2022 Jun 20.
Impact factor: 0
Publication type: Review in international publication
Authors: Li, Jiahui; Ribo, Marc et al.
DOI: 10.5469/neuroint.2022.00255

Systematic CT perfusion acquisition in acute stroke increases vascular occlusion detection and thrombectomy rates.

PMID: 34857668
Journal: Journal of NeuroInterventional Surgery
Year: 2021
Reference: J Neurointerv Surg. 2021 Dec 2. pii: neurintsurg-2021-018241. doi: 10.1136/neurintsurg-2021-018241.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Olive-Gadea, Marta, Requena, Manuel, Diaz, Facundo, Boned, Sandra, Garcia-Tornel, Alvaro, Muchada, Marian, Deck, Matias, Lozano, Prudencio, Rodriguez-Villatoro, Noelia, Juega, Jesus et al.
DOI: 10.1136/neurintsurg-2021-018241

Direct Transfer to Angiosuite in Acute Stroke: Why, When, and How?

PMID: 34785602
Journal: NEUROLOGY
Year: 2021
Reference: Neurology. 2021 Nov 16;97(20 Supplement 2):S34-S41. doi: 10.1212/WNL.0000000000012799.
Impact factor: 9.91
Publication type: Review in international publication
Authors: Requena, Manuel, Ren, Zeguang, Ribo, Marc et al.
DOI: 10.1212/WNL.0000000000012799

Monocyte-to-Lymphocyte Ratio in Clot Analysis as a Marker of Cardioembolic Stroke Etiology.

PMID: 34586594
Journal: Translational Stroke Research
Year: 2021
Reference: Transl Stroke Res. 2021 Sep 29. pii: 10.1007/s12975-021-00946-w. doi: 10.1007/s12975-021-00946-w.
Impact factor: 6.829
Publication type: Paper in international publication
Authors: Ribo, Marc, Juega, Jesus, Palacio-Garcia, Carlos, Rodriguez, Maite, Deck, Matias, Rodriguez-Luna, David, Requena, Manuel, Garcia-Tornel, Alvaro, Rodriguez-Villatoro, Noelia, Rubiera, Marta et al.
DOI: 10.1007/s12975-021-00946-w

Impact of COVID-19 Infection on the Outcome of Patients With Ischemic Stroke.

PMID: 34455823
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 Dec;52(12):3908-3917. doi: 10.1161/STROKEAHA.121.034883. Epub 2021 Aug 30.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Martinez-Domeno, Alejandro, Prats-Sanchez, Luis, Guasch-Jimenez, Marina, Cardona, Pere, Nunez-Guillen, Ana, Requena, Manuel, Rubiera, Marta, Olive, Marta, Bustamante, Alejandro, Gomis, Meritxell et al.
DOI: 10.1161/STROKEAHA.121.034883

Spontaneous systolic blood pressure drop early after mechanical thrombectomy predicts dramatic neurological recovery in ischaemic stroke patients.

PMID: 33598554
Journal: European stroke journal
Year: 2020
Reference: Eur Stroke J. 2020 Dec;5(4):362-369. doi: 10.1177/2396987320933384. Epub 2020 Jun 11.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ribo, Marc, Tomasello, Alejandro, Molina, Carlos A, Rubiera, Marta, Deck, Matias, Juega, Jesus, Pagola, Jorge, Rodriguez-Villatoro, Noelia, Carvalho Dias, Mariana, Gabriel, Denis et al.
DOI: 10.1177/2396987320933384

Management of acute stroke. Specific nursing care and treatments in the stroke unit.

PMID: 33153769
Journal: NEUROLOGIA
Year: 2020
Reference: Neurologia. 2020 Nov 2. pii: S0213-4853(20)30291-7. doi: 10.1016/j.nrl.2020.07.025.
Impact factor: 2.283
Publication type: Review in national publication
Authors: Rodriguez-Luna, D, Sanjuan, E, Pancorbo, O, Santana, K, Minarro, O, Sala, V, Muchada, M, Boned, S, Juega, J M, Pagola, J et al.
DOI: 10.1016/j.nrl.2020.07.025

COVID-19 and Stroke: Incidence and Etiological Description in a High-Volume Center.

PMID: 33066917
Journal: Journal of Stroke & Cerebrovascular Diseases
Year: 2020
Reference: J Stroke Cerebrovasc Dis. 2020 Nov;29(11):105225. doi: 10.1016/j.jstrokecerebrovasdis.2020.105225. Epub 2020 Aug 5.
Impact factor: 1.787
Publication type: Paper in international publication
Authors: Ribo, Marc, Molina, Carlos A, Tomasello, Alejandro, Rubiera, Marta, Requena, Manuel, Muchada, Marian, Garcia-Tornel, Alvaro, Deck, Matias, Juega, Jesus, Boned, Sandra et al.
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105225

Effect of Pre- and In-Hospital Delay on Reperfusion in Acute Ischemic Stroke Mechanical Thrombectomy.

PMID: 32933420
Journal: STROKE
Year: 2020
Reference: Stroke. 2020 Oct;51(10):2934-2942. doi: 10.1161/STROKEAHA.120.030208. Epub 2020 Sep 16.
Impact factor: 7.19
Publication type: Paper in international publication
Authors: Berndt, Maria, Kaesmacher, Johannes, Maamari, Basel, Meinel, Thomas R, Piechowiak, Eike I, Mosimann, Pascal J, Mordasini, Pasquale, Goeldlin, Martina, Arnold, Marcel, Dobrocky, Tomas et al.
DOI: 10.1161/STROKEAHA.120.030208

Implementation of a protocol for direct stroke patient transfer and mobilization of a stroke team to reduce times to reperfusion.

PMID: 31777209
Journal: Emergencias
Year: 2019
Reference: Emergencias. 2019 Dic;31(6):385-390.
Impact factor: 3.35
Publication type: Paper in international publication
Authors: Sanjuan Menendez, Estela, Giron Espot, Pilar, Calleja Macho, Laura, Rodriguez-Samaniego, Maria Teresa, Santana Roman, Katherine E, Rubiera Del Fueyo, Marta et al.
DOI:

The ADAN Scale: A proposed scale for prehospital use to identify status epilepticus.

PMID: 30565357
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2019
Reference: Eur J Neurol. 2019 May;26(5):760-e55. doi: 10.1111/ene.13885. Epub 2019 Jan 20.
Impact factor: 4.621
Publication type: Paper in international publication
Authors: Requena, Manuel, Fonseca, Elena, Olive, Marta, Abraira, Laura, Quintana, Manuel, Mazuela, Gonzalo, Toledo, Manuel, Salas-Puig, Xavier, Santamarina, Estevo et al.
DOI: 10.1111/ene.13885

Peri-ictal magnetic resonance imaging in status epilepticus: Temporal relationship and prognostic value in 60 patients.

PMID: 31499473
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Oct;71:289-294. doi: 10.1016/j.seizure.2019.08.013. Epub 2019 Aug 31.
Impact factor: 2.765
Publication type: Paper in international publication
Authors: Requena, Manuel, Sarria-Estrada, Silvana, Santamarina, Estevo, Quintana, Manuel, Sueiras, Maria, Rovira, Alex, Toledo, Manuel et al.
DOI: 10.1016/j.seizure.2019.08.013

Mechanical thrombectomy for basilar artery occlusion: efficacy, outcomes, and futile recanalization in comparison with the anterior circulation.

PMID: 31239331
Journal: Journal of NeuroInterventional Surgery
Year: 2019
Reference: J Neurointerv Surg. 2019 Dec;11(12):1174-1180. doi: 10.1136/neurintsurg-2018-014516. Epub 2019 Jun 25.
Impact factor: 3.925
Publication type: Paper in international publication
Authors: Michel, Patrik, Hajdu, Steven, Ribo, Marc, Requena, Manuel, Maegerlein, Christian, Friedrich, Benjamin, Costalat, V, Benali, Amel, Pierot, Laurent, Gawlitza, Matthias et al.
DOI: 10.1136/neurintsurg-2018-014516

Predictors of Endovascular Treatment Among Stroke Codes Activated Within 6 Hours From Symptom Onset.

PMID: 30354973
Journal: STROKE
Year: 2018
Reference: Stroke. 2018 Sep;49(9):2116-2121. doi: 10.1161/STROKEAHA.118.021316.
Impact factor: 6.239
Publication type: Paper in international publication
Authors: Requena, Manuel, Perez de la Ossa, Natalia, Abilleira, Sonia, Cardona, Pere, Urra, Xabier, Marti-Fabregas, Joan, Rodriguez-Campello, Anna, Boned, Sandra, Rubiera, Marta, Tomasello, Alejandro et al.
DOI: 10.1161/STROKEAHA.118.021316

Blood pressure lowering in acute intracerebral hemorrhage.

PMID: 30404950
Journal: Aging-US
Year: 2018
Reference: Aging (Albany NY). 2018 Nov 7;10(11):3056-3057. doi: 10.18632/aging.101637.
Impact factor: 5.179
Publication type: Paper in international publication
Authors: Pancorbo, Olalla, Rodriguez-Luna, David et al.
DOI: 10.18632/aging.101637

Reliability of the early syndromic diagnosis in adults with new-onset epileptic seizures: A retrospective study of 116 patients attended in the emergency room.

PMID: 30172139
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Oct;61:158-163. doi: 10.1016/j.seizure.2018.08.016. Epub 2018 Aug 18.
Impact factor: 2.839
Publication type: Clinical guide
Authors: Toledo, M, Salas Puig, X, Abraira Del Fresno, L, Fonseca Hernandez, E, Olive Gadea, M, Requena Ruiz, M, Quintana, M, Santamarina Perez, E, Alvarez Sabin, J et al.
DOI: 10.1016/j.seizure.2018.08.016

Long-term retention rates of antiepileptic drugs used in acute seizures.

PMID: 30118928
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2018
Reference: Seizure. 2018 Oct;61:78-82. doi: 10.1016/j.seizure.2018.08.007. Epub 2018 Aug 11.
Impact factor: 2.839
Publication type: Paper in international publication
Authors: Toledo, Manuel, Fonseca, Elena, Olive, Marta, Requena, Manuel, Quintana, Manuel, Abraira-Del-Fresno, Laura, Salas-Puig, Xavier, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2018.08.007

[Karnosfsky index as a mortality predicting factor in patients on home-based enteral nutrition].

PMID: 19593485
Journal: Nutricion Hospitalaria
Year: 2009
Reference: Nutr Hosp. 2009 Mar-Apr;24(2):156-60.
Impact factor: 1.096
Publication type: Paper in national publication
Authors: Puiggros, C, Lecha, M, Rodriguez, T, Perez-Portabella, C, Planas, M et al.
DOI:

Thesis

Caracterització de catèters de trombectomia per l’optimització d’estratègies de tractament endovascular d’ictus isquèmic agut

PhD student: Jiahui Li , Jiahui Li
Director/s: Marc Ribó Jacobi
University: Universitat Autònoma de Barcelona
Year: 2022

Particularidades técnicas del tratamiento endovascular en población adulta y pediátrica con ictus isquémico agudo

PhD student: María del Carmen Parra Fariñas
Director/s: Marc Ribó Jacobi
University: Universitat Autònoma de Barcelona
Year: 2022

Estratègies per a agilitzar la detecció d'oclusions vasculars en pacients amb ictus isquèmic agut

PhD student: Marta Olive Gadea, Marta Olive Gadea
Director/s: José Alvarez Sabin, Marta Aurora Rubiera Del Fueyo
University:
Year: 2022

Diagnóstico avanzado en la fase aguda del ictus criptogénico

PhD student: Jesus Maria Juega Mariño
Director/s: Carlos Molina Cateriano, Jorge Pagola Pérez Blanca
University:
Year: 2021

Desarrollo de estrategias de optimización del tiempo intrahospitalario en el tratamiento endovascular del ictus isquémico agudo en un centro de referencia

PhD student: Manuel Requena Ruiz, Manuel Requena Ruiz
Director/s: Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2020

Estrategias de mejora en la eficacia del tratamiento endovascular en el ictus isquémico agudo

PhD student: Sandra Boned Riera
Director/s: Marc Ribó Jacobi, Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2019

Tratamiento hiperagudo de las lesiones de la arteria carótida interna extracraneal en las oclusiones en tándem: comparación de diferentes opciones terapéuticas y de su impacto en la aparición de complicaciones y en el pronóstico funcional

PhD student: Noelia Rodríguez Villatoro
Director/s: José Alvarez Sabin, David Rodriguez Luna, Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2019

Estrategias de mejora en la eficacia del tratamiento endovascular en el ictus isquémico agudo

PhD student: Sandra Boned Riera
Director/s: José Alvarez Sabin, Marc Ribó Jacobi, Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2019

Predictores clínicos y hemodinámicos de respuesta al tratamiento trombolítico endovenoso en pacientes con ictus isquémico agudo

PhD student: Mª Ángeles Muchada López
Director/s: José Alvarez Sabin, Marta Aurora Rubiera Del Fueyo, Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2014

Análisis de la aplicación de los criterios de activación del código ictus en Cataluña

PhD student: Estela Sanjuan Menendez, Estela Sanjuan Menendez
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2014

Predictores de crecimiento de la hemorragia intracerebral aguda y su impacto en la evolución clínica y el pronóstico funcional

PhD student: David Rodriguez Luna
Director/s: José Alvarez Sabin, Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2012

Trombosis de la arteria basilar. Tolerancia isquémica, respuesta a la sonotronolisis potenciada y transformación hemorrágica postratamiento

PhD student: Jorge Pagola Pérez Blanca
Director/s: José Alvarez Sabin, Marc Ribó Jacobi, Carlos Molina Cateriano
University: Universidad Autònoma de Barcelona
Year: 2010

Factores predictores de Reoclusion arterial tras tratamiento fibrionolitico en pacientes con ictus isquemico agudo

PhD student: Marta Aurora Rubiera Del Fueyo
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2006

influencia de los inhibidores endógenos de la fibrinólisis sobre el tratamiento trombolítico del ictus con t-pa

PhD student: Marc Ribó Jacobi
Director/s:
University: Universidad Autònoma de Barcelona
Year: 2004

Blog

News

UMBRELLA, a consortium of over 20 public and private partners, kicks off this week with the aim of revolutionising the entire stroke care pathway in Europe by adopting a holistic approach that covers stroke diagnosis, prevention and care.

The Consortium will create a platform to facilitate a personalised management for stroke patients, enabling a more efficient personalized monitoring and patient follow up.

Funding is key to bringing the neuroprotective drug ApTOLL to market and providing a new therapeutic option for the patients.