Musculoskeletal Tissue Engineering

Our research group is a multidisciplinary team with clinical researchers from Orthopedic Surgery and Traumatology Service dedicated to preclinical translational research and members with different backgrounds in the field of biomedicine, biochemistry, biotechnology and biology from the Laboratory for the Development of Cell Therapies from the Banc de Sang i Teixits. The mission of this group is to develop cell and tissue-based therapies in the field of regenerative medicine. They are focused in design, conduct and transform preclinical efforts into clinical trials mainly in bone regeneration that could be used in different indications. The team holds a high degree of knowledge and translational experience thanks to several years working in the field and have also established successful collaboration with partners from different fields.

Team

Nayana Joshi Jubert

Main researcher
Musculoskeletal Tissue Engineering
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Raquel Cabrera Perez

Predoctoral researcher
Musculoskeletal Tissue Engineering
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Roberto Vélez Villa

Head of group
Musculoskeletal Tissue Engineering
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Nayana Joshi Jubert

Main researcher
Musculoskeletal Tissue Engineering
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Raquel Cabrera Perez

Predoctoral researcher
Musculoskeletal Tissue Engineering
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Roberto Vélez Villa

Head of group
Musculoskeletal Tissue Engineering
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Projects

Traslación de un producto alogénico de ingeniería tisular para el tratamiento de lesiones focales del cartílago articular.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Anna Server Salvà, Juan Minguell Moñart, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 105270
Reference: PI22/01906
Duration: 01/01/2023 - 31/12/2025

SHARESPACE: Embodied Social Experiences in Hybrid Shared Spaces

IP: Anna Server Salvà
Collaborators: Francisco Javier Medel Rebollo, Arantxa Ibarz Casas, Jana Quesada Garcia
Funding agency: EUROPEAN COMMISSION
Funding: 144620
Reference: SHARESPACE_HE-CL4_22-HUMAN01
Duration: 01/01/2023 - 31/12/2025

RICORS TERAV - Teràpies avançades

IP: Joan García López
Collaborators: Sergi Querol Giner, Joaquim Vives Armengol, Luciano Rodríguez Gómez, Francesc Rudilla Salvador, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol, Joaquim Vives Armengol
Funding agency: Instituto de Salud Carlos III
Funding: 338472.2
Reference: RD21/0017/0022
Duration: 01/01/2022 - 31/12/2024

TRASLACIÓN DE UN PRODUCTO DE INGENIERÍA TISULAR ALOGÉNICO CON MSC DE GELATINA DE WHARTON PARA EL TRATAMIENTO DE LA OSTEONECROSIS EN PACIENTES ONCOLÓGICOS PEDIÁTRICOS.

IP: Joaquim Vives Armengol
Collaborators: Roberto Vélez Villa, Nayana Joshi Jubert, Lluis Martorell Cedres, Maria Cristina Díaz de Heredia Rubio, Màrius Aguirre Canyadell, Irene Portas Torres, Raquel Cabrera Perez
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI19/01788
Duration: 01/01/2020 - 30/06/2024

Publications

A management model in blood, tissue and cell establishments to ensure rapid and sustainable patient access to advanced therapy medicinal products in Europe.

PMID: 37737767
Journal: CYTOTHERAPY
Year: 2023
Reference: Cytotherapy. 2023 Sep 5:S1465-3249(23)01015-0. doi: 10.1016/j.jcyt.2023.08.001.
Impact factor:
Publication type: Review in international publication
Authors: Akker, Emile van den; Baudoux, Etienne; De Vos, John; Delgadillo, Joaquin; Gardiner, Nicola; Kerkela, Erja; Lechanteur, Chantal; Vives, Joaquim; Waters, Allison et al.
DOI: 10.1016/j.jcyt.2023.08.001

Human Wharton's jelly-derived mesenchymal stromal cells promote bone formation in immunodeficient mice when administered into a bone microenvironment.

PMID: 37950242
Journal: Journal of Translational Medicine
Year: 2023
Reference: J Transl Med. 2023 Nov 10;21(1):802. doi: 10.1186/s12967-023-04672-9.
Impact factor:
Publication type: Paper in international publication
Authors: Arance, Ana M; Batlle-Morera, Laura; Beltramone, Silvia; Billan, Salem; Bratland, Ase; Cabrera-Perez, Raquel; Ge, Joy; Gonzalez, Rene; Grange, Florent; Grob, Jean-Jacques et al.
DOI: 10.1186/s12967-023-04672-9

A systematic review of potential biomarkers for bacterial burden and treatment efficacy assessment in TB platform-based clinical trials.

PMID: 37956107
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2023
Reference: J Infect Dis. 2023 Nov 13:jiad482. doi: 10.1093/infdis/jiad482.
Impact factor:
Publication type: Paper in international publication
Authors: Alagna, Riccardo; Batlle-Morera, Laura; Beltramone, Silvia; Cabrera-Perez, Raquel; Cirillo, Daniella; Espinosa-Pereiro, Juan; Gonzalez-Moreno, Jesus; Heinrich, Norbert; Rafols-Mitjans, Alexis; Roig-Molina, Angela et al.
DOI: 10.1093/infdis/jiad482

Multiligament knee injuries. Ten years' experience at a public university, level I Trauma Center.

PMID: 38147073
Journal: European journal of orthopaedic surgery & traumatology
Year: 2023
Reference: Eur J Orthop Surg Traumatol. 2023 Dec 26. doi: 10.1007/s00590-023-03807-4.
Impact factor:
Publication type: Paper in international publication
Authors: Andres-Peiro, Jose Vicente; Blasco-Casado, Ferran; Castellet-Feliu, Enric; Garcia-Albo, Enrique; Joshi-Jubert, Nayana; Minguell-Monyart, Joan; Pijoan, Bueno Joan; Portas-Torres, Irene; Pujol, Oriol; Reverte-Vinaixa, Maria Mercedes et al.
DOI: 10.1007/s00590-023-03807-4

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial.

PMID: 34989778
Journal: JAMA Oncology
Year: 2022
Reference: JAMA Oncol. 2022 Mar 1;8(3):345-353. doi: 10.1001/jamaoncol.2021.6628.
Impact factor: 31.777
Publication type: Paper in international publication
Authors: Betournay, Marysa; Cheng, Edward Y; Doung, Yee-Cheen; Ferguson, Peter C; Giglio, Victoria; Hayden, James; Heels-Ansdell, Diane; Khan, Shah Alam; Sampath Kumar, Venkatesan; McKay, Paula et al.
DOI: 10.1001/jamaoncol.2021.6628

Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit.

PMID: 35739187
Journal: Communications Biology
Year: 2022
Reference: Commun Biol. 2022 Jun 23;5(1):620. doi: 10.1038/s42003-022-03568-6.
Impact factor: 6.268
Publication type: Paper in international publication
Authors: Molina-Granada, David; Gonzalez-Vioque, Emiliano; Dibley, Marris G; Cabrera-Perez, Raquel; Vallbona-Garcia, Antoni; Torres-Torronteras, Javier; Sazanov, Leonid A; Ryan, Michael T; Camara, Yolanda; Marti, Ramon et al.
DOI: 10.1038/s42003-022-03568-6

Compliance in Non-Clinical Development of Cell-, Gene-, and Tissue-Based Medicines: Good Practice for Better Therapies.

PMID: 35830540
Journal: Stem Cells Translational Medicine
Year: 2022
Reference: Stem Cells Transl Med. 2022 Jul 13. pii: 6643345. doi: 10.1093/stcltm/szac046.
Impact factor: 6.94
Publication type: Paper in international publication
Authors: Vives, Joaquim, Sanchez-Pernaute, Rosario, Torrents, Silvia, Lopez-Navas, Luis et al.
DOI: 10.1093/stcltm/szac046

The Quality Management Ecosystem in Cell Therapy in Catalonia (Spain): An Opportunity for Integrating Standards and Streamlining Quality Compliance.

PMID: 35805196
Journal: Cells
Year: 2022
Reference: Cells. 2022 Jul 5;11(13). pii: cells11132112. doi: 10.3390/cells11132112.
Impact factor: 6.6
Publication type: Paper in international publication
Authors: Soria, Maria Gloria, McGrath, Eoin, Magri, Mara, Vives, Joaquim et al.
DOI: 10.3390/cells11132112

Clinical effects of intrathecal administration of expanded Wharton jelly mesenchymal stromal cells in patients with chronic complete spinal cord injury: a randomized controlled study.

PMID: 32981857
Journal: CYTOTHERAPY
Year: 2021
Reference: Cytotherapy. 2021 Feb;23(2):146-156. doi: 10.1016/j.jcyt.2020.08.008. Epub 2020 Sep 25.
Impact factor: 5.414
Publication type: Paper in international publication
Authors: Albu, Sergiu, Kumru, Hatice, Coll, Ruth, Vives, Joaquim, Valles, Margarita, Benito-Penalva, Jesus, Rodriguez, Luciano, Codinach, Margarita, Hernandez, Joaquim, Navarro, Xavier et al.
DOI: 10.1016/j.jcyt.2020.08.008

Towards the standardization of methods of tissue processing for the isolation of mesenchymal stromal cells for clinical use.

PMID: 33994662
Journal: CYTOTECHNOLOGY
Year: 2021
Reference: Cytotechnology. 2021 May 10;73(3):1-10. doi: 10.1007/s10616-021-00474-3.
Impact factor: 2.058
Publication type: Paper in international publication
Authors: Garcia-Munoz, Elisabeth, Vives, Joaquim et al.
DOI: 10.1007/s10616-021-00474-3

Use of Multipotent Mesenchymal Stromal Cells, Fibrin, and Scaffolds in the Production of Clinical Grade Bone Tissue Engineering Products.

PMID: 32705544
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2021
Reference: Methods Mol Biol. 2021;2286:251-261. doi: 10.1007/7651_2020_280.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vives, Joaquim, Rodriguez, Luciano, Coca, Maria Isabel, Reales, Laura, Cabrera-Perez, Raquel, Martorell, Lluis et al.
DOI: 10.1007/7651_2020_280

Reconstruction of infected post-traumatic bone defects of the distal femur with the Compress() implant. Preliminary results of a staged non-biological strategy.

PMID: 33066985
Journal: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Year: 2021
Reference: Injury. 2021 Mar;52(3):606-615. doi: 10.1016/j.injury.2020.10.016. Epub 2020 Oct 6.
Impact factor: 2.586
Publication type: Paper in international publication
Authors: Corona, Pablo S, Altayo, Marta, Amat, Carles, Vicente, Matias, Velez, Roberto et al.
DOI: 10.1016/j.injury.2020.10.016

Core Decompression Combined with Implantation of Autologous Bone Marrow Concentrate with Tricalcium Phosphate Does Not Prevent Radiographic Progression in Early Stage Osteonecrosis of the Hip.

PMID: 32489535
Journal: Clinics in orthopedic surgery
Year: 2020
Reference: Clin Orthop Surg. 2020 Jun;12(2):151-157. doi: 10.4055/cios19033. Epub 2020 May 6.
Impact factor: 0
Publication type: Paper in international publication
Authors: Hernandez, Alejandro, Nunez, Jorge H, Sallent, Andrea, Gargallo-Margarit, Albert, Gallardo-Calero, Irene, Barro, Victor et al.
DOI: 10.4055/cios19033

A Case Series of X-Linked Deafness-2 with Sensorineural Hearing Loss, Stapes Fixation, and Perilymphatic Gusher: MR Imaging and Clinical Features of Hypothalamic Malformations.

PMID: 32409310
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2020
Reference: AJNR Am J Neuroradiol. 2020 Jun;41(6):1087-1093. doi: 10.3174/ajnr.A6541. Epub 2020 May 14.
Impact factor: 3.381
Publication type: Paper in international publication
Authors: Prat Matifoll, J-A, Wilson, M, Goetti, R, Birman, C, Bennett, B, Peadon, E, Prats-Uribe, A, Prelog, K et al.
DOI: 10.3174/ajnr.A6541

First-in-human PeriCord cardiac bioimplant: Scalability and GMP manufacturing of an allogeneic engineered tissue graft.

PMID: 32304998
Journal: EBioMedicine
Year: 2020
Reference: EBioMedicine. 2020 Apr;54:102729. doi: 10.1016/j.ebiom.2020.102729. Epub 2020 Apr 15.
Impact factor: 5.736
Publication type: Paper in international publication
Authors: Coca, Maria Isabel, Reales, Laura, Camara-Rosell, Maria Luisa, Cediel, German, Coll, Ruth, Farre, Ramon, Navajas, Daniel, Vilarrodona, Anna, Garcia-Lopez, Joan, Munoz-Guijosa, Christian et al.
DOI: 10.1016/j.ebiom.2020.102729

Cord blood-derived platelet concentrates as starting material for new therapeutic blood components prepared in a public cord blood bank: from product development to clinical application.

PMID: 32281925
Journal: Blood Transfusion
Year: 2020
Reference: Blood Transfus. 2020 May;18(3):208-216. doi: 10.2450/2020.0305-19. Epub 2020 Apr 3.
Impact factor: 3.662
Publication type: Paper in international publication
Authors: Samarkanova, Dinara, Rodriguez, Luciano, Vives, Joaquim, Coll, Ruth, Tahull, Elisabet, Azqueta, Carmen, Valdivia, Elena, Codinach, Margarita, Farssac, Elisenda, Gaitan, Jesus et al.
DOI: 10.2450/2020.0305-19

Vascularized Periosteal Flaps Accelerate Osteointegration and Revascularization of Allografts in Rats.

PMID: 30810538
Journal: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Year: 2019
Reference: Clin Orthop Relat Res. 2019 Apr;477(4):741-755. doi: 10.1097/CORR.0000000000000400.
Impact factor: 4.154
Publication type: Paper in international publication
Authors: Gallardo-Calero, Irene, Barrera-Ochoa, Sergi, Manzanares, Maria Cristina, Sallent, Andrea, Vicente, Matias, Lopez-Fernandez, Alba, De Albert, Matias, Aguirre, Marius, Soldado, Francisco, Velez, Roberto et al.
DOI: 10.1097/CORR.0000000000000400

Extracellular vesicles: squeezing every drop of regenerative potential of umbilical cord blood.

PMID: 30831143
Journal: METABOLISM-CLINICAL AND EXPERIMENTAL
Year: 2019
Reference: Metabolism. 2019 Jun;95:102-104. doi: 10.1016/j.metabol.2019.02.006. Epub 2019 Mar 1.
Impact factor: 6.513
Publication type: Paper in international publication
Authors: Roura, Santiago, Vives, Joaquim et al.
DOI: 10.1016/j.metabol.2019.02.006

Causes and Frequencies of Reoperations After Endoprosthetic Reconstructions for Extremity Tumor Surgery: A Systematic Review.

PMID: 30801278
Journal: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
Year: 2019
Reference: Clin Orthop Relat Res. 2019 Apr;477(4):894-902. doi: 10.1097/CORR.0000000000000630.
Impact factor: 4.154
Publication type: Review in international publication
Authors: Thornley, Patrick, Vicente, Matias, MacDonald, Austin, Evaniew, Nathan, Ghert, Michelle, Velez, Roberto et al.
DOI: 10.1097/CORR.0000000000000630

Levels of IL-17F and IL-33 correlate with HLA-DR activation in clinical-grade human bone marrow-derived multipotent mesenchymal stromal cell expansion cultures.

PMID: 30447901
Journal: CYTOTHERAPY
Year: 2019
Reference: Cytotherapy. 2019 Jan;21(1):32-40. doi: 10.1016/j.jcyt.2018.09.009. Epub 2018 Nov 15.
Impact factor: 4.297
Publication type: Paper in international publication
Authors: Oliver-Vila, Irene, Garcia-Lopez, Joan, Vives, Joaquim, Blanco, Margarita, Codinach, Margarita, Vivas, Daniel, Torrents-Zapata, Silvia, Grau-Vorster, Marta, Rodriguez, Luciano et al.
DOI: 10.1016/j.jcyt.2018.09.009

Derivation of Multipotent Mesenchymal Stromal Cells from Ovine Bone Marrow.

PMID: 29512111
Journal: Current protocols in stem cell biology
Year: 2018
Reference: Curr Protoc Stem Cell Biol. 2018 Feb 28;44:2B.9.1-2B.9.22. doi: 10.1002/cpsc.43.
Impact factor: 0
Publication type: Paper in international publication
Authors: Vives, Joaquim, Vivas, Daniel, Caminal, Marta, Oliver-Vila, Irene et al.
DOI: 10.1002/cpsc.43

Optimisation of a potency assay for the assessment of immunomodulative potential of clinical grade multipotent mesenchymal stromal cells.

PMID: 29322348
Journal: CYTOTECHNOLOGY
Year: 2018
Reference: Cytotechnology. 2018 Feb;70(1):31-44. doi: 10.1007/s10616-017-0186-0. Epub 2018 Jan 10.
Impact factor: 1.461
Publication type: Paper in international publication
Authors: Vives, Joaquim, Oliver-Vila, Irene, Ramirez-Moncayo, Carmen, Grau-Vorster, Marta, Marin-Gallen, Silvia, Caminal, Marta et al.
DOI: 10.1007/s10616-017-0186-0

Blog

News

Vall d'Hebron hosts a meeting of Sharespace, a European virtual reality Project

The creation of hybrid digital-human interaction spaces between avatars and people offers new opportunities for personalized medicine