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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Team

Camille Guillard Sirieix

Camille Guillard Sirieix

Research technician
Neurodegenerative Diseases
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David Ramos Vicente

David Ramos Vicente

Postdoctoral researcher
Neurodegenerative Diseases
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Gerard Roch Alba

Gerard Roch Alba

Research technician
Neurodegenerative Diseases
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Helena Xicoy Cortada

Helena Xicoy Cortada

Postdoctoral researcher
Neurodegenerative Diseases
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Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
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Joan Compte Barrón

Joan Compte Barrón

Predoctoral researcher
Neurodegenerative Diseases
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Camille Guillard Sirieix

Camille Guillard Sirieix

Research technician
Neurodegenerative Diseases
Read more
David Ramos Vicente

David Ramos Vicente

Postdoctoral researcher
Neurodegenerative Diseases
Read more
Gerard Roch Alba

Gerard Roch Alba

Research technician
Neurodegenerative Diseases
Read more
Helena Xicoy Cortada

Helena Xicoy Cortada

Postdoctoral researcher
Neurodegenerative Diseases
Read more
Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
Read more
Joan Compte Barrón

Joan Compte Barrón

Predoctoral researcher
Neurodegenerative Diseases
Read more

Projects

Sex-based modulation of neuromelanin-linked Parkinson’s disease pathology

IP: Miquel Vila Bover
Collaborators: Camille Guillard Sirieix
Funding agency: Michael J. Fox Foundation
Funding: 163538.22
Reference: SEX_NEUROMELANINE_MJFF2020
Duration: 01/02/2021 - 31/12/2024

NIPARK Neuromelamina como diana terapéutica en la enfermedad de Parkinson y envejecimiento cerebral: abordaje por neuroimagen y estimulación cerebral

IP: Miquel Vila Bover
Collaborators: Alba Nicolau Vera, Thais Cuadros Arasa, Marta González Sepúlveda
Funding agency: Instituto de Salud Carlos III
Funding: 249984.79
Reference: AC20/00121
Duration: 01/01/2021 - 31/12/2024

Mecanismos moleculares de neurodegeneración ligada a la neuromelanina en la enfermedad de Parkinson y envejecimiento cerebral

IP: Miquel Vila Bover
Collaborators: Thais Cuadros Arasa, Helena Xicoy Cortada, Marta González Sepúlveda, Annabelle Parent
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 332750
Reference: PID2020-116339RB-I00
Duration: 01/09/2021 - 31/08/2024

Ministerio de Ciencia

The brain-body axis in Parkinson’s disease patients: from pathophysiology to biomarkers and therapeutic approaches

IP: Ariadna Laguna Tuset
Collaborators: Maria Victoria Gonzalez Martinez, Miquel Vila Bover, Marina Lorente Picón, Helena Xicoy Cortada, Daniela Samaniego Toro, Sara Belmonte Calderon
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI21/01603
Duration: 01/01/2022 - 31/12/2024

Publications

Fulminant myocarditis following SARS-CoV-2 mRNA vaccination rescued with venoarterial ECMO: A report of two cases.

PMID: 37075138
Journal: PERFUSION-UK
Year: 2023
Reference: Perfusion. 2023 Apr 19:2676591231170480. doi: 10.1177/02676591231170480.
Impact factor:
Publication type: Paper in international publication
Authors: Argudo, Eduard; Barrabes, Jose A; Bonilla, Camilo; Chiscano, Luis; De la Iglesia, Ana; Diaz, Maria Angeles; Ferreira-Gonzalez, Ignacio; Ferrer, Ricard; Font, Marta; Gabaldon, Alejandra et al.
DOI: 10.1177/02676591231170480

CHIR99021 causes inactivation of Tyrosine Hydroxylase and depletion of dopamine in rat brain striatum.

PMID: 37844866
Journal: NEUROPHARMACOLOGY
Year: 2023
Reference: Neuropharmacology. 2023 Oct 14:109759. doi: 10.1016/j.neuropharm.2023.109759.
Impact factor:
Publication type: Paper in international publication
Authors: Benlloch, Luis E; Carcel, Paula; Cedena Romero, Maria Teresa; Crucitti, Davide; De Miguel Sanchez, Carlos; Del Orbe Barreto, Rafael Andres; Diaz Varela, Nicolas A; Diaz-Beya, Marina; Diez-Campelo, Maria; Fernandez-Gonzalez, Pol et al.
DOI: 10.1016/j.neuropharm.2023.109759

Indeterminate pulmonary nodules in non-rhabdomyosarcoma soft tissue sarcoma: A study of the European paediatric Soft Tissue Sarcoma Study Group.

PMID: 37846799
Journal: CANCER
Year: 2023
Reference: Cancer. 2023 Oct 17. doi: 10.1002/cncr.35061.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Gianni; Bouhamama, Amine; Brennan, Bernadette; Brisse, Herve J; Cardoen, Liesbeth; Coma, Ana; Coppadoro, Beatrice; Di Paolo, Pier Luigi; Fayard, Cindy; Fernandez-Gonzalez, Pol et al.
DOI: 10.1002/cncr.35061

De senectute and the art of medicine: how old is too old for ECMO in cardiogenic shock?

PMID: 37922009
Journal: INTENSIVE CARE MEDICINE
Year: 2023
Reference: Intensive Care Med. 2023 Nov 3. doi: 10.1007/s00134-023-07251-0.
Impact factor:
Publication type: Editorail in international publication
Authors: Ambale-Venkatesh, Bharath; Belohlavek, Jan; Bluemke, David A; Fujii, Tomoki; Gomes, Antoinette S; Hundley, W Gregory; Jung, Christian; Lima, Joao A C; Noda, Chikara; Redhueil, Alban et al.
DOI: 10.1007/s00134-023-07251-0

Blog

News

Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.

This initiative is part of a pioneering study that seeks to assess how the relationship between different age groups can influence the quality of life and mental health of patients.

Dr. Miquel Vila, head of the Neurodegenerative Diseases research group at VHIR, is the co-chair of the local organising committee. And Dr. Ariadna Laguna, principal investigator of the same group, is a scientific ambassador.

Job offers

Clinical Researcher - Neurodegenerative Diseases Group
Start date:
03/04/2023
End date:
17/04/2023
Document: Download
Licensed Research Technician - Neurodegenerative Diseases Research Group
Start date:
16/12/2022
End date:
30/12/2022
Document: Download
Predoctoral Researcher
Start date:
10/11/2022
End date:
25/11/2022
Document: Download

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study