About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models.
Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to:
IP: Miquel Vila Bover Collaborators: Gerard Roch Alba, Miriam Izquierdo Sans Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 99260 Reference: PRE2021-098300 Duration: 01/07/2022 - 30/06/2026
IP: Miquel Vila Bover Collaborators: Jorge Hernández Vara, Joan Compte Barrón, Marta Martínez Vicente, Jordi Bove Badell, Eddie Pradas Gracia, Maria Camprodon Gomez, Marina Lorente Picón, Laura Castillo Ribelles, Oriol de Fabregues-Boixar Nebot, Javier Hoyo Pérez, Ariadna Laguna Tuset, Malalties neurodegeneratives , Jordi Riera Heredia, Malalties neurodegeneratives , Helena Xicoy Cortada, Alba Nicolau Vera, Marta González Sepúlveda, Joana Margalida Cladera Sastre, Annabelle Parent, Daniela Samaniego Toro, Daniela Samaniego Toro Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00784 Duration: 01/01/2022 - 30/06/2025
IP: Ariadna Laguna Tuset Collaborators: Miriam Izquierdo Sans, Laia Perez Lasarte Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 236350 Reference: RYC2021-032947-I Duration: 01/01/2023 - 31/12/2027
IP: Marta Martínez Vicente Collaborators: José Antonio Arranz Amo, Eddie Pradas Gracia, Laura Castillo Ribelles, Clara Carnicer Cáceres, David Moreno Martinez, Jordi Riera Heredia, New nanotechnological therapy for Parkinson's disease: nose-to-brain delivery of GBA-polymer nanoconjugates (NANOGBAtoBRAIN), Pablo Castillo Sánchez Funding agency: Fundació "La Caixa" Funding: 249950 Reference: HR22-00602 Duration: 01/11/2022 - 31/10/2025
PMID: 39097479 Journal: Year: 2024 Reference: Med Intensiva (Engl Ed). 2024 Aug 2:S2173-5727(24)00175-9. doi: 10.1016/j.medine.2024.06.021. Impact factor: Publication type: Paper in international publication Authors: Argudo, Eduard; Barrabes, Jose A; Buera, Irene; Chiscano-Camon, Luis; Ferreira-Gonzalez, Ignacio; Ferrer, Ricard; Gallart, Elisabet; Garcia Del Blanco, Bruno; Llaneras, Jordi; Martinez-Martinez, Maria et al. DOI: 10.1016/j.medine.2024.06.021
PMID: 39211340 Journal: Frontiers in Medicine Year: 2024 Reference: Front Med (Lausanne). 2024 Aug 15;11:1431791. doi: 10.3389/fmed.2024.1431791. eCollection 2024. Impact factor: Publication type: Paper in international publication Authors: Bajana, Ivan; Bastidas, Juliana; Chiscano-Camon, Luis; Ferrer, Ricard; Franco-Jarava, Clara; Gonzalez, Juan Jose; Larrosa, Nieves; Lopez-Martinez, Rocio; Nuvials-Casals, Xavier; Riera, Jordi et al. DOI: 10.3389/fmed.2024.1431791
PMID: 39394193 Journal: Nature Communications Year: 2024 Reference: Nat Commun. 2024 Oct 11;15(1):8819. doi: 10.1038/s41467-024-53168-7. Impact factor: Publication type: Paper in international publication Authors: Arthaud, Sebastien; Bortolozzi, Analia; Carballo-Carbajal, Iria; Compte, Joan; Cuadros, Thais; Fort, Patrice; Gimenez-Llort, Lydia; Gonzalez-Sepulveda, Marta; Guillard-Sirieix, Camille; Laguna, Ariadna et al. DOI: 10.1038/s41467-024-53168-7
PMID: 39448669 Journal: npj Parkinsons Disease Year: 2024 Reference: NPJ Parkinsons Dis. 2024 Oct 24;10(1):198. doi: 10.1038/s41531-024-00820-0. Impact factor: Publication type: Paper in international publication Authors: Avenali, Micol; Barlow, Carrolee; Brockmann, Kathrin; France, Nicholas P; Hernandez-Vara, Jorge; Laguna, Ariadna; Lerche, Stefanie; Martinez-Vicente, Marta; Samaniego, Daniela; Sankaranarayanan, Sethu et al. DOI: 10.1038/s41531-024-00820-0
PMID: 36902552 Journal: Journal of Clinical Medicine Year: 2023 Reference: J Clin Med. 2023 Feb 22;12(5):1765. doi: 10.3390/jcm12051765. Impact factor: Publication type: Review in international publication Authors: Arens, Jutta; Dabrowski, Marek; Duinmeijer, Wytze C; Fresiello, Libera; Halfwerk, Frank R; Obreja, Valentina; Puslecki, Mateusz; Riera, Jordi; Riera, Jordi; Swol, Justyna et al. DOI: 10.3390/jcm12051765
PMID: 37328754 Journal: RESPIRATORY RESEARCH Year: 2023 Reference: Respir Res. 2023 Jun 17;24(1):159. doi: 10.1186/s12931-023-02462-x. Impact factor: Publication type: Paper in international publication Authors: Anon, Jose M; Barbe, Ferran; Barbera, Carmen; Belmonte, Thalia; Benitez, Ivan D; Bermejo-Martin, Jesus F; Bustamante-Munguira, Elena; Caballero, Jesus; Carbonell, Nieves; Ceccato, Adrian et al. DOI: 10.1186/s12931-023-02462-x
PMID: 37356622 Journal: JOURNAL OF MOLECULAR DIAGNOSTICS Year: 2023 Reference: J Mol Diagn. 2023 Jun 23:S1525-1578(23)00134-4. doi: 10.1016/j.jmoldx.2023.06.006. Impact factor: Publication type: Paper in international publication Authors: Antolin, Maria; Blasco-Perez, Laura; Camprodon-Gomez, Maria; Garcia-Arumi, Elena; Iranzo-Nuez, Leticia; Lopez-Ortega, Ricard; Martinez-Cruz, Desiree; Tenes, Anna; Tizzano, Eduardo F et al. DOI: 10.1016/j.jmoldx.2023.06.006
PMID: 37507573 Journal: INTENSIVE CARE MEDICINE Year: 2023 Reference: Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07161-1. Impact factor: Publication type: Paper in international publication Authors: Adell-Serrano, Berta; Agrifoglio, Alexander; Aguilar Cabello, Maria; Aguilera, Luciano; Alcaraz-Serrano, Victoria; Aldecoa, Cesar; Alegre, Cynthia; Alvarez Ruiz, Antonjo; Alvarez, Sergio; Amaya-Villar, Rosario et al. DOI: 10.1007/s00134-023-07161-1
PMID: 34957949 Journal: Journal of Parkinsons Disease Year: 2022 Reference: J Parkinsons Dis. 2022;12(3):935-955. doi: 10.3233/JPD-213004. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarez Sauco, Maria; Avila Rivera, Maria A; Blazquez Estrada, Marta; Borrue, Carmen; Caballol, Nuria; Cabo, Iria; Canfield, Hector et al. DOI: 10.3233/JPD-213004
PMID: 35285474 Journal: BRAIN Year: 2022 Reference: Brain. 2022 Apr 29;145(3):1001-1017. doi: 10.1093/brain/awab374. Impact factor: Publication type: Paper in international publication Authors: Arotcarena, Marie-Laure; Bezard, Erwan; Bourdenx, Mathieu; Camus, Sandrine; Dehay, Benjamin; Dovero, Sandra; Estrada, Cristina; Garcia-Carrillo, Nuria; Herrero, Maria Trinidad; Meissner, Wassilios G et al. DOI: 10.1093/brain/awab374
PMID: 35263007 Journal: AGING CELL Year: 2022 Reference: Aging Cell. 2022 Apr;21(4):e13583. doi: 10.1111/acel.13583. Epub 2022 Mar 9. Impact factor: Publication type: Paper in international publication Authors: Alibakhshi, Esmaeil; Aparicio, Pilar; Aris, Cecilia; Castellanos, Juan; Guma, Anna; Irazoki, Andrea; Lores, Luis; Martinez-Vicente, Marta; Palacin, Manuel; Rubio-Valera, Maria et al. DOI: 10.1111/acel.13583
PMID: 35210396 Journal: Translational Psychiatry Year: 2022 Reference: Transl Psychiatry. 2022 Feb 24;12(1):79. doi: 10.1038/s41398-022-01842-z. Impact factor: Publication type: Paper in international publication Authors: Alarcon-Aris, Diana; Artigas, Francesc; Bortolozzi, Analia; Campa, Leticia; Casal, Carme; Coppola-Segovia, Valentin; Miquel-Rio, Lluis; Montefeltro, Andres; Pavia-Collado, Ruben; Paz, Veronica et al. DOI: 10.1038/s41398-022-01842-z
PMID: 34281918 Journal: BMJ Open Year: 2021 Reference: BMJ Open. 2021 Jul 19;11(7):e045272. doi: 10.1136/bmjopen-2020-045272. Impact factor: Publication type: Paper in international publication Authors: Adarmes-Gomez, Astrid; Alonso, M feminine Gema; Alonso, Ruben; Alvarez, Ignacio; Alvarez, Maria; Alvarez, Ramiro; Avila, Maria Asuncion; Balaguer, Ernest; Bayes-Rusinol, Angels; Blanco, Esther et al. DOI: 10.1136/bmjopen-2020-045272
PMID: 34209166 Journal: Journal of Personalized Medicine Year: 2021 Reference: J Pers Med. 2021 Jun 30;11(7). pii: jpm11070626. doi: 10.3390/jpm11070626. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alonso, Gemma; Alonso, Ruben; Alvarez Sauco, Maria; Ardura, Jessica; Avila Rivera, Maria A; Blazquez, Marta; Borrue, Carmen; Caballol, Nuria; Cabo, Iria et al. DOI: 10.3390/jpm11070626
PMID: 34094501 Journal: Parkinsons Disease Year: 2021 Reference: Parkinsons Dis. 2021 May 13;2021:8871549. doi: 10.1155/2021/8871549. eCollection 2021. Impact factor: Publication type: Paper in international publication Authors: Aguilar, M; Alonso Losada, M G; Alvarez Sauco, M; Avila Rivera, M A; Blazquez Estrada, M; Borrue, C; Caballol, N; Cabo, I; Carrillo Padilla, F; Catalan, M J et al. DOI: 10.1155/2021/8871549
PMID: 33986284 Journal: npj Parkinsons Disease Year: 2021 Reference: NPJ Parkinsons Dis. 2021 May 13;7(1):40. doi: 10.1038/s41531-021-00184-9. Impact factor: Publication type: Paper in international publication Authors: Amigo, Nuria; Fernandez, Manel; Gaig, Carles; Iranzo, Alex; Laguna, Ariadna; Santamaria, Joan; Serradell, Monica; Tolosa, Eduardo; Vila, Miquel; Vilas, Dolores et al. DOI: 10.1038/s41531-021-00184-9
PMID: 32517777 Journal: Molecular Neurodegeneration Year: 2020 Reference: Mol Neurodegener. 2020 Jun 9;15(1):35. doi: 10.1186/s13024-020-00382-8. Impact factor: Publication type: Paper in international publication Authors: Galea, Elena; Ganfornina, Maria Dolores; Garcia-Barrera, Tamara; Gomez-Ariza, Jose Luis; Gonzalez-Arias, Candela; Gutierrez, Antonia; Hudry, Eloise; Kara, Eleanna; Larramona-Arcas, Raquel; Martinez-Vicente, Marta et al. DOI: 10.1186/s13024-020-00382-8
PMID: 32426502 Journal: Science Advances Year: 2020 Reference: Sci Adv. 2020 May 13;6(20):eaaz9165. doi: 10.1126/sciadv.aaz9165. eCollection 2020 May. Impact factor: Publication type: Paper in international publication Authors: Arotcarena, M-L; Aubert, P; Bezard, E; Bohic, S; Bourdenx, M; Camus, S; Damas, I Trigo; Dehay, B; Derkinderen, P; Doudnikoff, E et al. DOI: 10.1126/sciadv.aaz9165
PMID: 32380543 Journal: BRAIN Year: 2020 Reference: Brain. 2020 May 1;143(5):1462-1475. doi: 10.1093/brain/awaa096. Impact factor: Publication type: Paper in international publication Authors: Arotcarena, Marie-Laure; Aubert, Philippe; Bezard, Erwan; Bourdenx, Mathieu; Camus, Sandrine; Damas, Ines Trigo; Dehay, Benjamin; Derkinderen, Pascal; Dovero, Sandra; El-Agnaf, Omar M A et al. DOI: 10.1093/brain/awaa096
PMID: 32354491 Journal: CIRUGIA ESPANOLA Year: 2020 Reference: Cir Esp. 2020 Nov;98(9):507-509. doi: 10.1016/j.ciresp.2020.04.011. Epub 2020 Apr 18. Impact factor: Publication type: Paper in national publication Authors: Garcia Alamino, Josep M; Lopez Cano, Manuel; Pereira, Jose Antonio; Rodrigues Goncalves, Victor; Rossello-Jimenez, Daniel; Saludes Serra, Judit et al. DOI: 10.1016/j.ciresp.2020.04.011
PMID: 30846695 Journal: Nature Communications Year: 2019 Reference: Nat Commun. 2019 Mar 7;10(1):973. doi: 10.1038/s41467-019-08858-y. Impact factor: 11.878 Publication type: Paper in international publication Authors: Gonzalez-Sepulveda, Marta, Penuelas, Nuria, Torra, Albert, Rodriguez-Galvan, Beatriz, Ballabio, Andrea, Hasegawa, Takafumi, Bortolozzi, Analia, Gelpi, Ellen, Vila, Miquel, Parent, Annabelle et al. DOI: 10.1038/s41467-019-08858-y
PMID: 30744042 Journal: Cells Year: 2019 Reference: Cells. 2019 Feb 8;8(2). pii: cells8020135. doi: 10.3390/cells8020135. Impact factor: 5.656 Publication type: Review in national publication Authors: Albert-Bayo, Merce, Paracuellos, Irene, Gonzalez-Castro, Ana M, Rodriguez-Urrutia, Amanda, Rodriguez-Lagunas, Maria J, Alonso-Cotoner, Carmen, Santos, Javier, Vicario, Maria et al. DOI: 10.3390/cells8020135
PMID: 30415891 Journal: EBioMedicine Year: 2019 Reference: EBioMedicine. 2019 Jan;39:497-509. doi: 10.1016/j.ebiom.2018.10.071. Epub 2018 Nov 8. Impact factor: 6.68 Publication type: Paper in international publication Authors: Gosalbes, Maria Jose, Compte, Joan, Moriano-Gutierrez, Silvia, Valles, Yvonne, Jimenez-Hernandez, Nuria, Pons, Xavier, Artacho, Alejandro, Francino, M Pilar et al. DOI: 10.1016/j.ebiom.2018.10.071
PMID: 29464030 Journal: Oncotarget Year: 2018 Reference: Oncotarget. 2017 Dec 19;9(5):5736-5751. doi: 10.18632/oncotarget.23422. eCollection 2018 Jan 19. Impact factor: Publication type: Paper in international publication Authors: Alcaraz, Estefania; Cuadros, Thais; de Torres, Ines; Itarte, Emilio; Meseguer, Anna; Morote, Juan; Pinna, Lorenzo A; Plana, Maria; Ramon Y Cajal, Santiago; Ruzzene, Maria et al. DOI: 10.18632/oncotarget.23422
PMID: 29429047 Journal: MOLECULAR NEUROBIOLOGY Year: 2018 Reference: Mol Neurobiol. 2018 Sep;55(9):7533-7552. doi: 10.1007/s12035-018-0881-7. Epub 2018 Feb 10. Impact factor: Publication type: Paper in international publication Authors: Berkowitz, Laura; Calatayud, Carles; Caldwell, Guy A; Caldwell, Kim A; Carballo-Carbajal, Iria; Consiglio, Antonella; Dalfo, Esther; Ezquerra, Mario; Fernandez-Carasa, Irene; Fernandez-Santiago, Ruben et al. DOI: 10.1007/s12035-018-0881-7
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PMID: 21619488 Journal: ANTIOXIDANTS & REDOX SIGNALING Year: 2012 Reference: Antioxid Redox Signal. 2012 May 1;16(9):883-95. Epub 2011 Jul 18. Impact factor: Publication type: Review in international publication Authors: ; ; et al. DOI: 10.1089/ars.2011.4074
PMID: 22355801 Journal: J AUST CERAM SOC Year: 2012 Reference: Cold Spring Harb Perspect Med. 2012 Feb;2(2):a009332. Impact factor: Publication type: Letter or abstract Authors: Perier, Celine; Vila, Miquel et al. DOI: 10.1101/cshperspect.a009332
PMID: 21835138 Journal: JOURNAL OF HEPATOLOGY Year: 2012 Reference: J Hepatol. 2012 Jan;56(1):109-14. Epub 2011 Aug 9. Impact factor: Publication type: Paper in international publication Authors: ; ; ; ; ; et al. DOI: 10.1016/j.jhep.2011.06.026
The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.
Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.
