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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Team

Monder Abu-Suboh Abadia

Monder Abu-Suboh Abadia

Physiology and Pathophysiology of the Digestive Tract
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Barber Caselles, Claudia

Barber Caselles, Claudia

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Erika Zodda

Erika Zodda

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Lastiri González, Ernesto Alejand

Lastiri González, Ernesto Alejand

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Laura Hui Perez Guerrero

Laura Hui Perez Guerrero

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Luis Gerardo Alcala Gonzalez

Luis Gerardo Alcala Gonzalez

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Monder Abu-Suboh Abadia

Monder Abu-Suboh Abadia

Physiology and Pathophysiology of the Digestive Tract
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Barber Caselles, Claudia

Barber Caselles, Claudia

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Erika Zodda

Erika Zodda

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Lastiri González, Ernesto Alejand

Lastiri González, Ernesto Alejand

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Laura Hui Perez Guerrero

Laura Hui Perez Guerrero

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Luis Gerardo Alcala Gonzalez

Luis Gerardo Alcala Gonzalez

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Research lines

Pathophysiology and treatment of pancreatic disorders.

The focus of our research is to study the series of pathophysiologic events leading to acute and chronic pancreatitis and, eventually, pancreatic cancer. We aim to take advantage of knowledge gained at our basic research program to design therapeutic strategies intended to prevent or ameliorate human pancreatic disorders. In rodent models of acute and chronic pancreatitis we examine pancreatic regeneration, fibrogenesis, acino-ductal trandiferentiation, stellate cell activation, epithelial-to-mesenchymal transition and cancer development. In human pancreatitis we investigate environmental and genetic determinants (with special focus at CFTR dysfunction) and new treatment modalities for acute and chronic pancreatitis.

IP: Pathophysiology and treatment of pancreatic disorders.

Translational mucosal immunology

Mucosal surfaces of the gastrointestinal, bronchopulmonary, and genitourinary tracts constitute the most prominent site of interaction between the host and the external habitat and a real hub where microbes and the host bi-directionally communicate through mechanisms that engage the activation of the immune and nervous systems. Barrier mechanisms have evolved early in evolution, and consist of a number of anatomical and functional elements distributed across the tissue layers, which tightly interact to maintain homeostasis. The mucosal immune system develops fundamental defensive and homeostatic duties at mucosal sites through activation of innate and adaptive immunity and the development of tolerogenic responses against harmless antigens. Immune responses also include the resolution of inflammation to avoid tissue damage after antigen penetration. However, uncontrolled immune activity is associated with mucosal barrier failure and organ dysfunction, which characterize most organic and functional disorders. The major goal of the Translational Mucosal Immunology lab is to further identify the role of specific immune cells (mast cells, eosinophils and B cells) as major players in the control of mucosal barrier mechanisms in health and disease. Our approach to translational research in digestive diseases involves the development of preclinical and clinical studies aimed at identifying biomarkers of gastrointestinal dysfunction and gut health.

IP: Translational mucosal immunology

Projects

Fisiologia i fisiopatologia digestiva

IP: Fco Javier Santos Vicente
Collaborators: Beatriz Lobo Alvarez, Fernando Azpiroz Vidaur, Merce Albert Bayo, Natalia Borruel Sainz, Francesc Casellas Jordá, Carmen Alonso Cotoner, Carolina Malagelada Prats, Jorge Serra Pueyo, Ana Maria Gonzalez Castro, Ariadna Aguilar Cayuelas, Elba Exposito Fernandez, Laura Campderros Traver, Blanca Grases Pintó, Virginia Robles Alonso, Adoración Nieto Ruiz, Claudia Barber Caselles, Elena Céspedes Martínez, Danila Guagnozzi, Ronald Benjamin Llerena Castro, Francisca Yañez Araya, Consuelo Cammarota
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00766
Duration: 01/01/2022 - 30/06/2025

El déficit de CFTR facilita la carcinogénesis pancreática y potencia el crecimiento, la agresividad tumoral y las metástasis

IP: Chaysavanh Manichanh
Collaborators: Laura Campderros Traver, Judit Álvarez González
Funding agency: Instituto de Salud Carlos III
Funding: 95000
Reference: CD22/00177
Duration: 01/03/2023 - 28/02/2025

NEUROGASTRO - Neurofisiología y neurofisiopatología digestiva

IP: Fernando Azpiroz Vidaur
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 108900
Reference: PID2021-122295OB-I00
Duration: 01/09/2022 - 01/09/2026

Ministerio de Ciencia

RETVISION: Del diagnóstico genético molecular a las terapias avanzadas para tratar las enfermedades degenerativas de la retina.

IP: José García Arumí
Collaborators: María Antolín Mate, Anna Duarri Piqué, Helena Isla Magrané, Claudia Garcia-Arumí Fusté, Miguel Angel Zapata Victori, Laura Natalia Distefano, Maddalen Zufiaurre Seijo
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI22/01747
Duration: 01/01/2023 - 31/12/2025

Publications

Prevalence and description of disorders of gut-brain interaction in Spain according to the results of the Rome Foundation Global Epidemiology Study.

PMID: 37010843
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Jun;35(6):e14582. doi: 10.1111/nmo.14582. Epub 2023 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Aso, Maria C; Bangdiwala, Shrikant I; Bujanda, Luis; Flores-Arriaga, Joel; Izagirre, Arantzazu; Lanas, Angel; Lobo, Beatriz; Palsson, Olafur S; Sanchez-Pla, Alex et al.
DOI: 10.1111/nmo.14582

Face-to-face interviews versus Internet surveys: Comparison of two data collection methods in the Rome foundation global epidemiology study: Implications for population-based research.

PMID: 37018412
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Jun;35(6):e14583. doi: 10.1111/nmo.14583. Epub 2023 Apr 5.
Impact factor:
Publication type: Paper in international publication
Authors: Adibi, Payman; Andresen, Viola; Archampong, Timothy; Bangdiwala, Shrikant I; Benninga, Marc A; Bonaz, Bruno; Bor, Serhat; Buyruk, Murat; Choi, Suck Chei; Corazziari, Enrico S et al.
DOI: 10.1111/nmo.14583

Severe and refractory gastrointestinal toxicity due to immune checkpoint inhibitors: clinical experience in a tertiary referral hospital.

PMID: 37170542
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2023
Reference: Rev Esp Enferm Dig. 2023 May 12. doi: 10.17235/reed.2023.9436/2022.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, Natalia; Borruel, Natalia; Casellas, Francesc; Casellas, Francesc; Cespedes Martinez, Elena; Herrera-De Guise, Claudia; Herrera-De Guise, Claudia; Mayorga, Luis; Robles Alonso, Virginia; Robles Alonso, Virginia et al.
DOI: 10.17235/reed.2023.9436/2022

Conditioning by a Previous Experience Impairs the Rewarding Value of a Comfort Meal.

PMID: 37242129
Journal: Nutrients
Year: 2023
Reference: Nutrients. 2023 May 9;15(10):2247. doi: 10.3390/nu15102247.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Livovsky, Dan M; Nieto, Adoracion et al.
DOI: 10.3390/nu15102247

Quantitative GC-TCD Measurements of Major Flatus Components: A Preliminary Analysis of the Diet Effect.

PMID: 35161583
Journal: SENSORS
Year: 2022
Reference: Sensors (Basel). 2022 Jan 22;22(3). pii: s22030838. doi: 10.3390/s22030838.
Impact factor: 3.576
Publication type: Paper in international publication
Authors: Freire, Rafael; Mego, Marianela; Oliveira, Luciana Fontes; Mas, Silvia; Azpiroz, Fernando; Marco, Santiago; Pardo, Antonio et al.
DOI: 10.3390/s22030838

Anti-Inflammatory Effect of an O-2-Substituted (1-3)-beta-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model.

PMID: 35163449
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Jan 28;23(3). pii: ijms23031527. doi: 10.3390/ijms23031527.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Notararigo, Sara; Varela, Encarnacion; Otal, Anna; Antolin, Maria; Guarner, Francisco; Lopez, Paloma et al.
DOI: 10.3390/ijms23031527

Colonic bacterial diversity and dysbiosis in active microscopic colitis as compared to chronic diarrhoea and healthy controls: effect of polyethylene glycol after bowel lavage for colonoscopy.

PMID: 35764931
Journal: BMC GASTROENTEROLOGY
Year: 2022
Reference: BMC Gastroenterol. 2022 Jun 28;22(1):320. doi: 10.1186/s12876-022-02392-w.
Impact factor: 3.067
Publication type: Paper in international publication
Authors: Batista, Lissette; Robles, Virginia; Manichanh, Chaysavanh; Ruiz, Laura; Pinsach, Ferran; Guarner, Francisco; Fernandez-Banares, Fernando; Guagnozzi, Danila et al.
DOI: 10.1186/s12876-022-02392-w

Nutritional challenges in patients with gastroparesis.

PMID: 35838300
Journal: CURRENT OPINION IN CLINICAL NUTRITION AND METABOLI
Year: 2022
Reference: Curr Opin Clin Nutr Metab Care. 2022 Jul 16. pii: 00075197-990000000-00020. doi: 10.1097/MCO.0000000000000856.
Impact factor: 4.294
Publication type: Paper in international publication
Authors: Aguilar, Ariadna, Serra, Jordi, Malagelada, Carolina et al.
DOI: 10.1097/MCO.0000000000000856

Present and Future Therapeutic Approaches to Barrier Dysfunction.

PMID: 34778332
Journal: Frontiers in Nutrition
Year: 2021
Reference: Front Nutr. 2021 Oct 28;8:718093. doi: 10.3389/fnut.2021.718093. eCollection 2021.
Impact factor: 6.576
Publication type: Review in international publication
Authors: Fortea, Marina, Albert-Bayo, Merce, Abril-Gil, Mar, Ganda Mall, John-Peter, Serra-Ruiz, Xavier, Henao-Paez, Alejandro, Exposito, Elba, Gonzalez-Castro, Ana Maria, Guagnozzi, Danila, Lobo, Beatriz et al.
DOI: 10.3389/fnut.2021.718093

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia.

PMID: 34586707
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2021
Reference: Neurogastroenterol Motil. 2021 Sep;33(9):e14238. doi: 10.1111/nmo.14238.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Wauters, Lucas, Dickman, Ram, Drug, Vasile, Mulak, Agata, Serra, Jordi, Smet, Annemieke, Stengel, Andreas, Storonova, Olga, Storr, Martin, Tornblom, Hans et al.
DOI: 10.1111/nmo.14238

Integrating Dietary Data into Microbiome Studies: A Step Forward for Nutri-Metaomics.

PMID: 34578856
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Aug 27;13(9). pii: nu13092978. doi: 10.3390/nu13092978.
Impact factor: 5.719
Publication type: Paper in international publication
Authors: Serrano-Gomez, Gerard, Manichanh, Chaysavanh, Oyarzun, Inigo, Xie, Zixuan, Oliero, Manon, Soler, Zaida, Yanez, Francisca et al.
DOI: 10.3390/nu13092978

Differential Effects of Western and Mediterranean-Type Diets on Gut Microbiota: A Metagenomics and Metabolomics Approach.

PMID: 34444797
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Jul 30;13(8). pii: nu13082638. doi: 10.3390/nu13082638.
Impact factor: 5.719
Publication type: Paper in international publication
Authors: Barber, Claudia, Mego, Marianela, Sabater, Carlos, Vallejo, Fernando, Bendezu, Rogger Alvaro, Masihy, Marcela, Guarner, Francisco, Espin, Juan Carlos, Margolles, Abelardo, Azpiroz, Fernando et al.
DOI: 10.3390/nu13082638

Responses to the Letter to the Editor by Brusciano et al.

PMID: 32856764
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2020
Reference: Neurogastroenterol Motil. 2020 Sep;32(9):e13981. doi: 10.1111/nmo.13981.
Impact factor: 2.946
Publication type: Letter or abstract
Authors: Whorwell, Peter, Serra, Jordi, Pohl, Daniel, Azpiroz, Fernando, Chiarioni, Giuseppe, Ducrotte, Philippe, Gourcerol, Guillaume, Hungin, Amrit Pali S, Layer, Peter, Mendive, Juan-Manuel et al.
DOI: 10.1111/nmo.13981

Consensus document on the management preferences of patients with ulcerative colitis: points to consider and recommendations.

PMID: 32804838
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2020
Reference: Eur J Gastroenterol Hepatol. 2020 Dec;32(12):1514-1522. doi: 10.1097/MEG.0000000000001885.
Impact factor: 2.251
Publication type: Paper in international publication
Authors: Casellas, Francesc, Guinard Vicens, Daniel, Garcia-Lopez, Santiago, Gonzalez-Lama, Yago, Arguelles-Arias, Federico, Barreiro-de Acosta, Manuel, Marin Sanchez, Laura, Mendive, Juan Manuel, Saldana, Roberto, Cabez, Ana et al.
DOI: 10.1097/MEG.0000000000001885

Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

PMID: 32740086
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2020
Reference: Am J Gastroenterol. 2020 Dec;115(12):2047-2059. doi: 10.14309/ajg.0000000000000789.
Impact factor: 10.171
Publication type: Paper in international publication
Authors: Guilarte, Mar, Vicario, Maria, Martinez, Cristina, de Torres, Ines, Lobo, Beatriz, Pigrau, Marc, Gonzalez-Castro, Ana, Rodino-Janeiro, Bruno K, Salvo-Romero, Eloisa, Fortea, Marina et al.
DOI: 10.14309/ajg.0000000000000789

A Global, Prospective, Observational Study Measuring Disease Burden and Suffering in Patients with Ulcerative Colitis Using the Pictorial Representation of Illness and Self-Measure Tool.

PMID: 32722760
Journal: Journal of Crohns & Colitis
Year: 2020
Reference: J Crohns Colitis. 2020 Jul 29. pii: 5877457. doi: 10.1093/ecco-jcc/jjaa159.
Impact factor: 8.658
Publication type: Paper in international publication
Authors: Ghosh, Subrata, Sensky, Tom, Casellas, Francesc, Rioux, Louis-Charles, Ahmad, Tariq, Marquez, Juan R, Vanasek, Tomas, Gubonina, Irina, Sezgin, Orhan, Ardizzone, Sandro et al.
DOI: 10.1093/ecco-jcc/jjaa159

Altered host-gut microbes symbiosis in severely malnourished anorexia nervosa (AN) patients undergoing enteral nutrition: An explicative factor of functional intestinal disorders?

PMID: 30527539
Journal: CLINICAL NUTRITION
Year: 2019
Reference: Clin Nutr. 2019 Oct;38(5):2304-2310. doi: 10.1016/j.clnu.2018.10.004. Epub 2018 Oct 9.
Impact factor: 6.402
Publication type: Paper in international publication
Authors: Levenez, Florence, Cournede, Nicole, Dore, Joel, Melchior, Jean-Claude, Pascal, Victoria, Schoenenberger, Andreu, Manichanh, Chaysavanh, Hanachi, Mouna et al.
DOI: 10.1016/j.clnu.2018.10.004

Enteric neuron density correlates with clinical features of severe gut dysmotility.

PMID: 31545923
Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Year: 2019
Reference: Am J Physiol Gastrointest Liver Physiol. 2019 Dec 1;317(6):G793-G801. doi: 10.1152/ajpgi.00199.2019. Epub 2019 Sep 23.
Impact factor: 3.729
Publication type: Paper in international publication
Authors: Boschetti, Elisa, Malagelada, Carolina, Accarino, Anna, Malagelada, Juan R, Cogliandro, Rosanna F, Gori, Alessandra, Bonora, Elena, Giancola, Fiorella, Bianco, Francesca, Tugnoli, Vitaliano et al.
DOI: 10.1152/ajpgi.00199.2019

Editorial: Next-Generation Probiotics: From Commensal Bacteria to Novel Drugs and Food Supplements.

PMID: 31507575
Journal: Frontiers in Microbiology
Year: 2019
Reference: Front Microbiol. 2019 Aug 27;10:1973. doi: 10.3389/fmicb.2019.01973. eCollection 2019.
Impact factor: 4.259
Publication type: Editorail in international publication
Authors: Langella, Philippe, Guarner, Francisco, Martin, Rebeca et al.
DOI: 10.3389/fmicb.2019.01973

Abdominal distension after eating lettuce: The role of intestinal gas evaluated in vitro and by abdominal CT imaging.

PMID: 31402544
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2019
Reference: Neurogastroenterol Motil. 2019 Dec;31(12):e13703. doi: 10.1111/nmo.13703. Epub 2019 Aug 11.
Impact factor: 3.803
Publication type: Paper in international publication
Authors: Monclus, Eva, Navazo, Isabel, Guarner, Francisco, Margolles, Abelardo, Azpiroz, Fernando, Accarino, Anna, Burri, Emanuel, Sanchez, Borja, Barba, Elizabeth et al.
DOI: 10.1111/nmo.13703

Primary Ventricular Fibrillation in the Primary Percutaneous Coronary Intervention ST-Segment Elevation Myocardial Infarction Era (from the "Codi IAM" Multicenter Registry).

PMID: 29960663
Journal: AMERICAN JOURNAL OF CARDIOLOGY
Year: 2018
Reference: Am J Cardiol. 2018 Aug 15;122(4):529-536. doi: 10.1016/j.amjcard.2018.04.054. Epub 2018 Jun 27.
Impact factor:
Publication type: Paper in international publication
Authors: Bayes-Genis, Antoni; Carrillo, Xavier; Faixedas, Maria Teresa; Fernandez-Nofrerias, Eduard; Ferrer, Marc; Garcia-Garcia, Cosme; Jimenez, Javier; Labata, Carlos; Lupon, Josep; Mauri, Josepa et al.
DOI: 10.1016/j.amjcard.2018.04.054

Comparison between small bowel manometric patterns and full-thickness biopsy histopathology in severe intestinal dysmotility.

PMID: 28941004
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Mar;30(3). doi: 10.1111/nmo.13219. Epub 2017 Sep 22.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Malagelada, C, Karunaratne, T B, Accarino, A, Cogliandro, R F, Landolfi, S, Gori, A, Boschetti, E, Malagelada, J R, Stanghellini, V, Azpiroz, F et al.
DOI: 10.1111/nmo.13219

[Rumination syndrome: Diagnostic and therapeutic difficulties of a not so uncommon disorder].

PMID: 28460821
Journal: ANALES DE PEDIATRIA
Year: 2018
Reference: An Pediatr (Barc). 2018 Feb;88(2):100-105. doi: 10.1016/j.anpedi.2017.03.011. Epub 2017 Apr 29.
Impact factor: 1.14
Publication type: Paper in national publication
Authors: Segarra Canton, Oscar, Azpiroz Vidaur, Fernando, Gimenez Casado, Aida, Lopez Linan, Maria Jose, Barba Orozco, Elisabeth, Accarino Garaventa, Anna, Alvarez Beltran, Marina et al.
DOI: 10.1016/j.anpedi.2017.03.011

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

PMID: 30525861
Journal: Nutricion Hospitalaria
Year: 2018
Reference: Nutr Hosp. 2018 Dec 3;35(6):1450-1466.
Impact factor: 0.747
Publication type: Paper in international publication
Authors: Casellas, Francesc, Burgos, Rosa, Marcos, Ascension, Santos, Javier, Ciriza-de-Los-Rios, Constanza, Garcia-Manzanares, Alvaro, Polanco, Isabel, Puy-Portillo, Maria, Villarino, Antonio, Lema-Marques, Beatriz et al.
DOI:

Functional dyspepsia.

PMID: 29099093
Journal: Nature Reviews Disease Primers
Year: 2017
Reference: Nat Rev Dis Primers. 2017 Nov 3;3:17081. doi: 10.1038/nrdp.2017.81.
Impact factor: 6.389
Publication type: Review in international publication
Authors: Azpiroz, Fernando, Enck, Paul, Feinle-Bisset, Christine, Holtmann, Gerald, Lackner, Jeffrey M, Ronkainen, Jukka, Schemann, Michael, Stengel, Andreas, Tack, Jan, Zipfel, Stephan et al.
DOI: 10.1038/nrdp.2017.81

Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice.

PMID: 29026591
Journal: United European Gastroenterology Journal
Year: 2017
Reference: United European Gastroenterol J. 2017 Oct;5(6):773-788. doi: 10.1177/2050640617731968. Epub 2017 Sep 28.
Impact factor: 3.673
Publication type: Review in national publication
Authors: Moayyedi, Paul, Mearin, Fermin, Azpiroz, Fernando, Andresen, Viola, Barbara, Giovanni, Corsetti, Maura, Emmanuel, Anton, Hungin, A Pali S, Layer, Peter, Stanghellini, Vincenzo et al.
DOI: 10.1177/2050640617731968

Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study.

PMID: 29026603
Journal: United European Gastroenterology Journal
Year: 2017
Reference: United European Gastroenterol J. 2017 Oct;5(6):887-897. doi: 10.1177/2050640617691690. Epub 2017 Jan 29.
Impact factor: 3.673
Publication type: Paper in international publication
Authors: Azpiroz, Fernando, Santos, Javier, Vicario, Maria, Guagnozzi, Danila, Pardo-Camacho, Cristina, Salvo-Romero, Eloisa, Lobo, Beatriz, Ramos, Laura, Martinez, Cristina, Guilarte, Mar et al.
DOI: 10.1177/2050640617691690

Towards standards for human fecal sample processing in metagenomic studies.

PMID: 28967887
Journal: NATURE BIOTECHNOLOGY
Year: 2017
Reference: Nat Biotechnol. 2017 Nov;35(11):1069-1076. doi: 10.1038/nbt.3960. Epub 2017 Oct 2.
Impact factor: 41.667
Publication type: Paper in international publication
Authors: Costea, Paul I, Zeller, Georg, Sunagawa, Shinichi, Pelletier, Eric, Alberti, Adriana, Levenez, Florence, Tramontano, Melanie, Driessen, Marja, Hercog, Rajna, Jung, Ferris-Elias et al.
DOI: 10.1038/nbt.3960

Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function.

PMID: 26481311
Journal: FASEB JOURNAL
Year: 2016
Reference: FASEB J. 2016 Feb;30(2):544-54. doi: 10.1096/fj.15-272773. Epub 2015 Oct 19.
Impact factor: 5.043
Publication type: Paper in international publication
Authors: Fernandez-Calotti, Paula, Casulleras, Olga, Antolin, Maria, Guarner, Francisco, Pastor-Anglada, Marcal et al.
DOI: 10.1096/fj.15-272773

An exploratory study comparing psychological profiles and its congruence with clinical performance among patients with functional or motility digestive disorders.

PMID: 25921480
Journal: Journal of health psychology
Year: 2016
Reference: J Health Psychol. 2016 Nov;21(11):2590-2599. doi: 10.1177/1359105315581069. Epub 2016 Jul 9.
Impact factor:
Publication type: Letter or abstract
Authors: Azpiroz, Fernando, Parramon, Gemma, Santamarina-Perez, Pilar, Accarino, Anna, Rodriguez-Urrutia, Amanda, Eiroa-Orosa, Francisco Jose et al.
DOI: 10.1177/1359105315581069

Iron Deficiency in the Absence of Anemia Impairs the Perception of Health-Related Quality of Life of Patients with Inflammatory Bowel Disease.

PMID: 27057682
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2016
Reference: Inflamm Bowel Dis. 2016 Jun;22(6):1450-5. doi: 10.1097/MIB.0000000000000768.
Impact factor: 4.358
Publication type: Paper in international publication
Authors: Herrera-deGuise, Claudia, Casellas, Francesc, Robles, Virginia, Navarro, Ester, Borruel, Natalia et al.
DOI: 10.1097/MIB.0000000000000768

Impact of endoscopic ultrasonography (EUS) and EUS-guided fine-needle aspiration on the management of pancreatic cystic lesions.

PMID: 27286570
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2016
Reference: Eur J Gastroenterol Hepatol. 2016 Sep;28(9):1094-9. doi: 10.1097/MEG.0000000000000678.
Impact factor: 2.093
Publication type: Paper in international publication
Authors: Fernandez-Esparrach, Gloria, Boadas, Jaume, Busquets, Juli, Fernandez-Cruz, Laureano, Ferrer, Joana, Vaquero, Eva C, Molero, Xavier, Navarro, Salvador, Sanchez-Cabus, Santiago, Araujo, Isis K et al.
DOI: 10.1097/MEG.0000000000000678

Digestive Symptoms in Healthy People and Subjects With Irritable Bowel Syndrome: Validation of Symptom Frequency Questionnaire.

PMID: 25014236
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2015
Reference: J Clin Gastroenterol. 2015 Aug;49(7):e64-70. doi: 10.1097/MCG.0000000000000178.
Impact factor: 3.186
Publication type: Paper in international publication
Authors: Azpiroz, Fernando, Guyonnet, Denis, Donazzolo, Yves, Gendre, David, Tanguy, Jerome, Guarner, Francisco et al.
DOI: 10.1097/MCG.0000000000000178

Benefit on health-related quality of life of adherence to gluten-free diet in adult patients with celiac disease.

PMID: 25824917
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2015
Reference: Rev Esp Enferm Dig. 2015 Apr;107(4):196-201.
Impact factor: 1.414
Publication type: Paper in international publication
Authors: Vivas, Santiago, Rosinach, Merce, Duenas, Carmen, Lopez-Vivancos, Josefa, Molina-Infante, Javier, Fernandez-Banares, Fernando, Lucendo, Alfredo J, Rodrigo, Luis, Casellas, Francisco et al.
DOI:

Immunogenicity of hepatitis B vaccine in patients with inflammatory bowel disease and the benefits of revaccination.

PMID: 25160690
Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Year: 2015
Reference: J Gastroenterol Hepatol. 2015 Jan;30(1):92-8. doi: 10.1111/jgh.12712.
Impact factor: 3.504
Publication type: Paper in international publication
Authors: Cossio-Gil, Yolima, Martinez-Gomez, Xavier, Campins-Marti, Magda, Rodrigo-Pendas, Jose Angel, Borruel-Sainz, Natalia, Rodriguez-Frias, Francisco, Casellas-Jorda, Francesc et al.
DOI: 10.1111/jgh.12712

Predictive value of early restoration of quality of life in Crohn's disease patients receiving antitumor necrosis factor agents.

PMID: 25302652
Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Year: 2015
Reference: J Gastroenterol Hepatol. 2015 Feb;30(2):286-91. doi: 10.1111/jgh.12803.
Impact factor: 3.504
Publication type: Paper in international publication
Authors: Herrera-deGuise, Claudia, Casellas, Francesc, Robles, Virginia, Navarro, Ester, Borruel, Natalia et al.
DOI: 10.1111/jgh.12803

Vitamin E and vitamin E acetate absorption from self-assembly systems under pancreas insufficiency conditions.

PMID: 24801842
Journal: CHIMIA
Year: 2014
Reference: Chimia (Aarau). 2014;68(3):129-34. doi: 10.2533/chimia.2014.129.
Impact factor: 1.091
Publication type: Clinical Trials
Authors: Nagy, Kornel, Lobo, Beatriz, Courtet-Compondu, Marie-Claude, Braga-Lagache, Sophie, Ramos, Laura, Puig-Divi, Valenti, Azpiroz, Fernando, Malagelada, Juan Ramon, Beaumont, Maurice, Moulin, Julie et al.
DOI: 10.2533/chimia.2014.129

Decade in review-gut microbiota: The gut microbiota era marches on.

PMID: 25201043
Journal: NAT REV GASTRO HEPAT
Year: 2014
Reference: Nat Rev Gastroenterol Hepatol. 2014 Nov;11(11):647-9. doi: 10.1038/nrgastro.2014.156. Epub 2014 Sep 9.
Impact factor: 10.807
Publication type: Paper in international publication
Authors: Guarner, Francisco et al.
DOI: 10.1038/nrgastro.2014.156

Structure And Functions Of The Gut Microbiome.

PMID: 25022563
Journal: Endocrine, Metabolic & Immune Disorders - Drug Targets
Year: 2014
Reference: Endocr Metab Immune Disord Drug Targets. 2014;14(4):290-9.
Impact factor: 0
Publication type: Review in international publication
Authors: Panda, Suchita, Guarner, Francisco, Manichanh, Chaysavanh et al.
DOI: 10.2174/1871530314666140714120744

Coping with common gastrointestinal symptoms in the community: a global perspective on heartburn, constipation, bloating, and abdominal pain/discomfort May 2013.

PMID: 25000344
Journal: J CLIN GASTROENTEROL
Year: 2014
Reference: J Clin Gastroenterol. 2014 Aug;48(7):567-78. doi: 10.1097/MCG.0000000000000141.
Impact factor: 3.186
Publication type: Paper in international publication
Authors: Krabshuis, Justus, Hunt, Richard, Quigley, Eamonn, Abbas, Zaigham, Eliakim, Abraham, Emmanuel, Anton, Goh, Khean-Lee, Guarner, Francisco, Katelaris, Peter, Smout, Andre et al.
DOI: 10.1097/MCG.0000000000000141

Metagenomic species profiling using universal phylogenetic marker genes.

PMID: 24141494
Journal: NATURE METHODS
Year: 2013
Reference: Nat Methods. 2013 Dec;10(12):1196-9. doi: 10.1038/nmeth.2693. Epub 2013 Oct 20.
Impact factor: 23.565
Publication type: Paper in international publication
Authors: Mende, Daniel R, Zeller, Georg, Izquierdo-Carrasco, Fernando, Berger, Simon A, Kultima, Jens Roat, Coelho, Luis Pedro, Arumugam, Manimozhiyan, Tap, Julien, Nielsen, Henrik Bjorn, Sunagawa, Shinichi et al.
DOI: 10.1038/nmeth.2693

Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis.

PMID: 23725320
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2013
Reference: Aliment Pharmacol Ther. 2013 Jul;38(2):151-61. doi: 10.1111/apt.12365. Epub 2013 Jun 3.
Impact factor: 4.548
Publication type: Paper in international publication
Authors: Varela, E, Manichanh, C, Gallart, M, Torrejon, A, Borruel, N, Casellas, F, Guarner, F, Antolin, M et al.
DOI: 10.1111/apt.12365

Vaccination of patients with inflammatory bowel disease. Practical recommendations.

PMID: 23659508
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2013
Reference: Rev Esp Enferm Dig. 2013 Feb;105(2):93-102.
Impact factor: 1.652
Publication type: Paper in national publication
Authors: Campins, M, Cossio, Y, Martinez, X, Borruel, N et al.
DOI:

Mechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention.

PMID: 23607758
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2013
Reference: Neurogastroenterol Motil. 2013 Jun;25(6):e389-94. doi: 10.1111/nmo.12128. Epub 2013 Apr 22.
Impact factor: 2.935
Publication type: Paper in international publication
Authors: Barba, E, Quiroga, S, Accarino, A, Lahoya, E M, Malagelada, C, Malagelada, J-R, Azpiroz, F, Navazo, I, Burri, E et al.
DOI: 10.1111/nmo.12128

Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1{alpha} in acinar cell homeostasis.

PMID: 21948943
Journal: GUT
Year: 2012
Reference: Gut. 2012 Aug;61(8):1187-96. doi: 10.1136/gutjnl-2011-300360. Epub 2011 Sep 23.
Impact factor: 10.111
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1136/gutjnl-2011-300360

Guidelines for the use and interpretation of assays for monitoring autophagy.

PMID: 22966490
Journal: Autophagy
Year: 2012
Reference: Autophagy. 2012 Apr;8(4):445-544.
Impact factor: 7.453
Publication type: Review in international publication
Authors: Bai, Xue-Yuan, Albin, Roger L, Alegre-Abarrategui, Javier, Aleo, Maria Francesca, Alirezaei, Mehrdad, Almasan, Alexandru, Almonte-Becerril, Maylin, Amano, Atsuo, Amaravadi, Ravi, Amarnath, Shoba et al.
DOI:

The gut microbiota in IBD.

PMID: 22907164
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2012
Reference: Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):599-608. doi: 10.1038/nrgastro.2012.152. Epub 2012 Aug 21.
Impact factor: 8.102
Publication type: Review in international publication
Authors: Manichanh, Chaysavanh, Borruel, Natalia, Casellas, Francesc, Guarner, Francisco et al.
DOI: 10.1038/nrgastro.2012.152

Storage conditions of intestinal microbiota matter in metagenomic analysis.

PMID: 22846661
Journal: BMC MICROBIOLOGY
Year: 2012
Reference: BMC Microbiol. 2012 Jul 30;12:158. doi: 10.1186/1471-2180-12-158.
Impact factor: 3.044
Publication type: Paper in international publication
Authors: Cardona, Silvia, Eck, Anat, Cassellas, Montserrat, Gallart, Milagros, Alastrue, Carmen, Dore, Joel, Azpiroz, Fernando, Roca, Joaquim, Guarner, Francisco, Manichanh, Chaysavanh et al.
DOI: 10.1186/1471-2180-12-158

Assessment of the protective effects of oral tocotrienols in arginine chronic-like pancreatitis.

PMID: 21852363
Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Year: 2011
Reference: Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G846-55. Epub 2011 Aug 18.
Impact factor: 3.522
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1152/ajpgi.00485.2010

Meal size can be decreased in obese subjects through pharmacological acceleration of gastric emptying (The OBERYTH trial).

PMID: 20938444
Journal: INTERNATIONAL JOURNAL OF OBESITY
Year: 2011
Reference: Int J Obes (Lond). 2011 Jun;35(6):829-37. doi: 10.1038/ijo.2010.210. Epub 2010 Oct 12.
Impact factor: 5.125
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/ijo.2010.210

Diseases of the digestive tract: is prevention possible and feasible?

PMID: 21734393
Journal: DIGESTIVE DISEASES
Year: 2011
Reference: Dig Dis. 2011;29(2):255-63. Epub 2011 Jul 5.
Impact factor: 1
Publication type: Paper in international publication
Authors: Malagelada, Juan-R et al.
DOI: 10.1159/000323931

Probiotic and prebiotic claims in Europe: seeking a clear roadmap.

PMID: 21736772
Journal: BRITISH JOURNAL OF NUTRITION
Year: 2011
Reference: Br J Nutr. 2011 Dec;106(11):1765-7. Epub 2011 Jun 21.
Impact factor: 3.072
Publication type: Letter or abstract
Authors: , , , , , , , , , et al.
DOI: 10.1017/S0007114511002248

The dysfunctional gut.

PMID: 20582743
Journal: Curr Gastroenterol Rep
Year: 2010
Reference: Curr Gastroenterol Rep. 2010 Aug;12(4):242-8.
Impact factor:
Publication type: Letter or abstract
Authors: Malagelada, Carolina, Malagelada, Juan-R et al.
DOI: 10.1007/s11894-010-0119-y

Crohn s disease, feeling well or healthy?

PMID: 21142381
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2010
Reference: Rev Esp Enferm Dig. 2010 Nov;102(11):621-623.
Impact factor: 0.994
Publication type: Editorial in national publication
Authors: et al.
DOI:

Cutoff values of the Inflammatory Bowel Disease Questionnaire to predict a normal health related quality of life.

PMID: 21122573
Journal: Journal of Crohns & Colitis
Year: 2010
Reference: J Crohns Colitis. 2010 Dec;4(6):637-41. Epub 2010 Aug 2.
Impact factor: 1.729
Publication type: Paper in international publication
Authors: Pelaez, A, Torrejon, A, Castells, I, Masachs, M, Varela, E, Guarner, F, Borruel, N, Casellas, F, Huaman, Jw et al.
DOI: 10.1016/j.crohns.2010.07.006

Contribution of nurses to the quality of care in management of inflammatory bowel disease: A synthesis of the evidence.

PMID: 21122570
Journal: Journal of Crohns & Colitis
Year: 2010
Reference: J Crohns Colitis. 2010 Dec;4(6):611-22. Epub 2010 Sep 17.
Impact factor: 1.729
Publication type: Review in international publication
Authors: Hernandez-Sampelayo, Paloma, Seoane, Montserrat, Oltra, Lorena, Marin, Laura, Torrejon, Antonio, Vera, Maria Isabel, Garcia, Valle, Lazaro, Pablo, Parody, Elizabeth, Blasco, Antonio J et al.
DOI: 10.1016/j.crohns.2010.08.009

[Probiotics and the digestive system. Current evidence]

PMID: 19524118
Journal: Gastroenterol Hepatol
Year: 2009
Reference: Gastroenterol Hepatol. 2009 May;32 Suppl 1:1-14.
Impact factor:
Publication type: Letter or abstract
Authors: Mearin, Fermin, Guarner, Francisco, Verdu, Elena et al.
DOI: 10.1016/S0210-5705(09)71003-9

Intestinal motor activity, endoluminal motion and transit.

PMID: 19614865
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2009
Reference: Neurogastroenterol Motil. 2009 Dec;21(12):1264-e119.
Impact factor: 3.48
Publication type: Paper in international publication
Authors: de Iorio, F, Malagelada, C, Azpiroz, F, Maluenda, M, Violanti, C, Igual, L, Vitria, J, Malagelada, J-R et al.
DOI: 10.1111/j.1365-2982.2009.01363.x

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

PMID: 19585519
Journal: JOURNAL OF PATHOLOGY
Year: 2009
Reference: J Pathol. 2009 Oct;219(2):205-13.
Impact factor: 5.121
Publication type: Paper in international publication
Authors: Martinez-Romero, Carles, Rooman, Ilse, Skoudy, Anouchka, Guerra, Carmen, Molero, Xavier, Gonzalez, Ana, Iglesias, Mar, Lobato, Tania, Bosch, Almudena, Barbacid, Mariano et al.
DOI: 10.1002/path.2585

Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia.

PMID: 19512936
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2009
Reference: Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1333-9.
Impact factor: 2.08
Publication type: Paper in international publication
Authors: Saperas, Esteve, Videla, Sebastian, Bayarri, Carolina, Lobo, Beatriz, Abu-Suboh, Monder, Armengol, Jose Ramon, Malagelada, Juan R, Dot, Joan et al.
DOI: 10.1097/MEG.0b013e32830e491c

Thesis

La respuesta humoral y las interacciones neuro-inmunológicas en la mucosa intestinal como contribuyentes en la patofisiología del Síndrome del Intestino Irritable con predominio de diarrea

PhD student: Cristina Pardo Camacho
Director/s: Fco Javier Santos Vicente, Maria Vicario Perez
University: Universidad Autònoma de Barcelona
Year: 2020

Blog

News

Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.