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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Team

Monder Abu-Suboh Abadia

Monder Abu-Suboh Abadia

Physiology and Pathophysiology of the Digestive Tract
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Barber Caselles, Claudia

Barber Caselles, Claudia

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Erika Zodda

Erika Zodda

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Lastiri González, Ernesto Alejand

Lastiri González, Ernesto Alejand

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Luis Gerardo Alcala Gonzalez

Luis Gerardo Alcala Gonzalez

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Marín Garcia, Antonio

Marín Garcia, Antonio

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Monder Abu-Suboh Abadia

Monder Abu-Suboh Abadia

Physiology and Pathophysiology of the Digestive Tract
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Barber Caselles, Claudia

Barber Caselles, Claudia

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Erika Zodda

Erika Zodda

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Lastiri González, Ernesto Alejand

Lastiri González, Ernesto Alejand

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Luis Gerardo Alcala Gonzalez

Luis Gerardo Alcala Gonzalez

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Marín Garcia, Antonio

Marín Garcia, Antonio

Predoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Research lines

Pathophysiology and treatment of pancreatic disorders.

The focus of our research is to study the series of pathophysiologic events leading to acute and chronic pancreatitis and, eventually, pancreatic cancer. We aim to take advantage of knowledge gained at our basic research program to design therapeutic strategies intended to prevent or ameliorate human pancreatic disorders. In rodent models of acute and chronic pancreatitis we examine pancreatic regeneration, fibrogenesis, acino-ductal trandiferentiation, stellate cell activation, epithelial-to-mesenchymal transition and cancer development. In human pancreatitis we investigate environmental and genetic determinants (with special focus at CFTR dysfunction) and new treatment modalities for acute and chronic pancreatitis.

IP: Pathophysiology and treatment of pancreatic disorders.

Translational mucosal immunology

Mucosal surfaces of the gastrointestinal, bronchopulmonary, and genitourinary tracts constitute the most prominent site of interaction between the host and the external habitat and a real hub where microbes and the host bi-directionally communicate through mechanisms that engage the activation of the immune and nervous systems. Barrier mechanisms have evolved early in evolution, and consist of a number of anatomical and functional elements distributed across the tissue layers, which tightly interact to maintain homeostasis. The mucosal immune system develops fundamental defensive and homeostatic duties at mucosal sites through activation of innate and adaptive immunity and the development of tolerogenic responses against harmless antigens. Immune responses also include the resolution of inflammation to avoid tissue damage after antigen penetration. However, uncontrolled immune activity is associated with mucosal barrier failure and organ dysfunction, which characterize most organic and functional disorders. The major goal of the Translational Mucosal Immunology lab is to further identify the role of specific immune cells (mast cells, eosinophils and B cells) as major players in the control of mucosal barrier mechanisms in health and disease. Our approach to translational research in digestive diseases involves the development of preclinical and clinical studies aimed at identifying biomarkers of gastrointestinal dysfunction and gut health.

IP: Translational mucosal immunology

Projects

Fisiologia i fisiopatologia digestiva

IP: Fco Javier Santos Vicente
Collaborators: Beatriz Lobo Alvarez, Fisiologia i fisiopatologia digestiva, Merce Albert Bayo, Natalia Borruel Sainz, Francesc Casellas Jordá, Carmen Alonso Cotoner, Carolina Malagelada Prats, Jorge Serra Pueyo, Ana Maria Gonzalez Castro, Ariadna Aguilar Cayuelas, Elba Exposito Fernandez, Laura Campderros Traver, Blanca Grases Pintó, Virginia Robles Alonso, Adoración Nieto Ruiz, Claudia Barber Caselles, Elena Céspedes Martínez, Danila Guagnozzi, Ronald Benjamin Llerena Castro, Consuelo Cammarota
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00766
Duration: 01/01/2022 - 30/06/2025

NEUROGASTRO - Neurofisiología y neurofisiopatología digestiva

IP: NEUROGASTRO - Neurofisiología y neurofisiopatología digestiva
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 108900
Reference: PID2021-122295OB-I00
Duration: 01/09/2022 - 31/08/2026

Ministerio de Ciencia

RETVISION: Del diagnóstico genético molecular a las terapias avanzadas para tratar las enfermedades degenerativas de la retina.

IP: José García Arumí
Collaborators: María Antolín Mate, Anna Duarri Piqué, Helena Isla Magrané, Claudia Garcia-Arumí Fusté, Miguel Angel Zapata Victori, Laura Natalia Distefano, Maddalen Zufiaurre Seijo
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI22/01747
Duration: 01/01/2023 - 31/12/2025

Desarrollo de programas telemáticos de intervención psicológica para el tratamiento de los trastornos funcionales digestivos.l

IP: Jorge Serra Pueyo
Collaborators: Ariadna Aguilar Cayuelas, Anna Beneria González, Claudia Barber Caselles
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI22/00618
Duration: 01/01/2023 - 31/12/2025

Publications

RhoA downregulation in the murine intestinal epithelium results in chronic Wnt activation and increased tumorigenesis.

PMID: 38523777
Journal: iScience
Year: 2024
Reference: iScience. 2024 Mar 1;27(4):109400. doi: 10.1016/j.isci.2024.109400. eCollection 2024 Apr 19.
Impact factor:
Publication type: Paper in international publication
Authors: Anguita, Estefania; Arango, Diego; Bea, Laia; Bilic, Josipa; Brotons, Bruno; Carton-Garcia, Fernando; Dopeso, Higinio; Farre, Ricard; Hernandez-Losa, Javier; Jing, Li et al.
DOI: 10.1016/j.isci.2024.109400

Microbiome Composition Recovery after Liver Transplantation Correlates with Initial Liver Disease Severity and Antibiotics Treatment.

PMID: 38556088
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2024
Reference: Am J Transplant. 2024 Mar 29:S1600-6135(24)00248-X. doi: 10.1016/j.ajt.2024.03.038.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Canalda Baltrons, Aleix; Dopazo, Cristina; Manichanh, Chaysavanh; Pons, Marc; Soler, Zaida; Vega-Abellaneda, Sara; Xie, Zixuan; Yanez, Francisca et al.
DOI: 10.1016/j.ajt.2024.03.038

OTULIN Haploinsufficiency Causes Hyperinflammatory Responses to Infectious and Non-Infectious Triggers.

PMID: 38578307
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2024
Reference: J Clin Immunol. 2024 Apr 5;44(4):95. doi: 10.1007/s10875-024-01700-1.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Antolin, Maria; Batlle-Maso, Laura; Colobran, Roger; Dieli-Crimi, Romina; Marques-Soares, Joana et al.
DOI: 10.1007/s10875-024-01700-1

ASOCIACION ESPANOLA DE NEUROGASTROENTEROLOGIA Y MOTILIDAD (ASENEM) UPDATED REVIEW ON THE MANAGEMENT OF FUNCTIONAL ABDOMINAL PAIN.

PMID: 38677507
Journal: Gastroenterologia y Hepatologia
Year: 2024
Reference: Gastroenterol Hepatol. 2024 Apr 25:S0210-5705(24)00145-6. doi: 10.1016/j.gastrohep.2024.02.005.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Ariadna; Barba, Elizabeth; de Los Rios, Constanza Ciriza; Falcon, Blanca Serrano; Martinez, Vicente; Pravia, Laura Garcia; Serra, Jordi et al.
DOI: 10.1016/j.gastrohep.2024.02.005

Differences between childhood- and adulthood-onset eosinophilic esophagitis: An analysis from the EoE connect registry.

PMID: 36280437
Journal: DIGESTIVE AND LIVER DISEASE
Year: 2023
Reference: Dig Liver Dis. 2023 Mar;55(3):350-359. doi: 10.1016/j.dld.2022.09.020. Epub 2022 Oct 22.
Impact factor:
Publication type: Paper in international publication
Authors: Alcedo, Javier; Arias, Angel; Barrio, Jesus; Betore-Glaria, Maria Elena; Blas-Jhon, Leonardo; Carrion, Silvia; Casabona-Frances, Sergio; Dainese, Raffaella; Feo-Ortega, Sara; Fernandez-Fernandez, Sonia et al.
DOI: 10.1016/j.dld.2022.09.020

Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers.

PMID: 36314901
Journal: United European Gastroenterology Journal
Year: 2023
Reference: United European Gastroenterol J. 2023 Feb;11(1):31-41. doi: 10.1002/ueg2.12329. Epub 2022 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: Ericson, Ann-Charlott; Gerdin, Linda; Gonzalez-Castro, Ana M; Keita, Asa V; Persborn, Mats; Santos, Javier; Soderholm, Johan D; Vicario, Maria; Walter, Susanna A et al.
DOI: 10.1002/ueg2.12329

Abdomino-phrenic dyssynergia: a narrative review.

PMID: 36191283
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2023
Reference: Am J Gastroenterol. 2023 Jan 1;118(1):41-45. doi: 10.14309/ajg.0000000000002044. Epub 2022 Sep 30.
Impact factor:
Publication type: Review in international publication
Authors: Azpiroz, Fernando; Barba, Elizabeth; Damianos, John A; Tomar, Sanjeevani K et al.
DOI: 10.14309/ajg.0000000000002044

Visible abdominal distension in functional gut disorders: Objective evaluation.

PMID: 36153798
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Feb;35(2):e14466. doi: 10.1111/nmo.14466. Epub 2022 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Barba, Elizabeth; Burri, Emanuel; Quiroga, Sergio et al.
DOI: 10.1111/nmo.14466

Efficacy and Safety of a Novel Therapeutic of Natural Origin (NTN) in Adult Patients with Lactose Intolerance: A Multicenter, Randomized, Crossover, Double-Blind, Placebo-Controlled Study.

PMID: 36076786
Journal: Foods
Year: 2022
Reference: Foods. 2022 Aug 26;11(17). pii: foods11172600. doi: 10.3390/foods11172600.
Impact factor:
Publication type: Paper in international publication
Authors: Pop, Corina; Santos, Javier; Sporea, Ioan; Tiuca, Nicoleta; Tudor, Nicolae et al.
DOI: 10.3390/foods11172600

Bacillus clausii for Gastrointestinal Disorders: A Narrative Literature Review.

PMID: 36018495
Journal: ADVANCES IN THERAPY
Year: 2022
Reference: Adv Ther. 2022 Nov;39(11):4854-4874. doi: 10.1007/s12325-022-02285-0. Epub 2022 Aug 26.
Impact factor:
Publication type: Review in international publication
Authors: Abreu Y Abreu, Ana Teresa; Acosta-Rodriguez-Bueno, Carlos Patricio; Guarner, Francisco; Guno, Mary Jean V; Pehlivanoglu, Ender; Perez, Marcos 3rd et al.
DOI: 10.1007/s12325-022-02285-0

Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn's Disease Patients on Ustekinumab.

PMID: 35956133
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Aug 3;11(15). pii: jcm11154518. doi: 10.3390/jcm11154518.
Impact factor:
Publication type: Paper in international publication
Authors: Amo, Victor Manuel; Arguelles-Arias, Federico; Arroyo, Maite; Barreiro-de Acosta, Manuel; Baston-Rey, Iria; Bermejo, Fernando; Bosca-Watts, Marta Maia; Busquets, David; Cabello, Mercedes; Camo-Monterde, Patricia et al.
DOI: 10.3390/jcm11154518

Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy (MNGIE) Patient Receiving Liver Transplant.

PMID: 35955927
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Aug 8;23(15). pii: ijms23158792. doi: 10.3390/ijms23158792.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Boschetti, Elisa; Caporali, Leonardo; Carelli, Valerio; Cenacchi, Giovanna; Costa, Roberta; D'Angelo, Roberto; De Giorgio, Roberto; Dotti, Maria Teresa; Malagelada, Carolina et al.
DOI: 10.3390/ijms23158792

Present and Future Therapeutic Approaches to Barrier Dysfunction.

PMID: 34778332
Journal: Frontiers in Nutrition
Year: 2021
Reference: Front Nutr. 2021 Oct 28;8:718093. doi: 10.3389/fnut.2021.718093. eCollection 2021.
Impact factor:
Publication type: Review in international publication
Authors: Abril-Gil, Mar; Albert-Bayo, Merce; Alonso-Cotoner, Carmen; Exposito, Elba; Fortea, Marina; Ganda Mall, John-Peter; Gonzalez-Castro, Ana Maria; Guagnozzi, Danila; Henao-Paez, Alejandro; Lobo, Beatriz et al.
DOI: 10.3389/fnut.2021.718093

United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia.

PMID: 34586707
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2021
Reference: Neurogastroenterol Motil. 2021 Sep;33(9):e14238. doi: 10.1111/nmo.14238.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Barbara, Giovanni; Bor, Serhat; Coffin, Benoit; Corsetti, Maura; De Schepper, Heiko; Dickman, Ram; Drug, Vasile; Dumitrascu, Dan; Enck, Paul et al.
DOI: 10.1111/nmo.14238

Integrating Dietary Data into Microbiome Studies: A Step Forward for Nutri-Metaomics.

PMID: 34578856
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Aug 27;13(9). pii: nu13092978. doi: 10.3390/nu13092978.
Impact factor:
Publication type: Paper in international publication
Authors: Manichanh, Chaysavanh; Oliero, Manon; Oyarzun, Inigo; Serrano-Gomez, Gerard; Soler, Zaida; Xie, Zixuan; Yanez, Francisca et al.
DOI: 10.3390/nu13092978

Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis.

PMID: 34567350
Journal: World Allergy Organization Journal
Year: 2021
Reference: World Allergy Organ J. 2021 Sep 11;14(9):100585. doi: 10.1016/j.waojou.2021.100585. eCollection 2021 Sep.
Impact factor:
Publication type: Letter or abstract
Authors: Doulaptsi, Maria; Farre, Ricard; Fokkens, Wytske; Hellings, Peter W; Martens, Katleen; Prokopakis, Emmanuel; Steelant, Brecht; Vicario, Maria; Wils, Tine et al.
DOI: 10.1016/j.waojou.2021.100585

Duodenal acidification induces gastric relaxation and alters epithelial barrier function by a mast cell independent mechanism.

PMID: 33060783
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Oct 15;10(1):17448. doi: 10.1038/s41598-020-74491-1.
Impact factor:
Publication type: Paper in international publication
Authors: Accarie, Alison; Beeckmans, Dorien; Boeckxstaens, Guy; Cocca, Silvia; De Hertogh, Gert; Farre, Ricard; Matteoli, Gianluca; Rodewald, Hans-Reimer; Tack, Jan; Toth, Joran et al.
DOI: 10.1038/s41598-020-74491-1

Publisher Correction: Unraveling the effects of the gut microbiota composition and function on horse endurance physiology.

PMID: 32968096
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Sep 23;10(1):15880. doi: 10.1038/s41598-020-69895-y.
Impact factor:
Publication type: Letter or abstract
Authors: Barrey, Eric; Clark, Allison; Esquerre, Diane; Helbling, Jean-Christophe; Le Moyec, Laurence; Mach, Nuria; Moisan, Marie-Pierre; Philippe, Catherine; Plancade, Sandra; Robert, Celine et al.
DOI: 10.1038/s41598-020-69895-y

Correction of Dyssynergic Defecation, but not Fiber Supplementation, Reduces Symptoms of Functional Dyspepsia in Patients With Constipation in a Randomized Trial.

PMID: 31811952
Journal: Clinical Gastroenterology and Hepatology
Year: 2020
Reference: Clin Gastroenterol Hepatol. 2020 Oct;18(11):2463-2470.e1. doi: 10.1016/j.cgh.2019.11.048. Epub 2019 Dec 4.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Bendezu, Alvaro; Huaman, Jose-Walter; Mego, Marianela; Monrroy, Hugo; Samino, Sara; Saperas, Esteban et al.
DOI: 10.1016/j.cgh.2019.11.048

Responses to the Letter to the Editor by Brusciano et al.

PMID: 32856764
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2020
Reference: Neurogastroenterol Motil. 2020 Sep;32(9):e13981. doi: 10.1111/nmo.13981.
Impact factor:
Publication type: Letter or abstract
Authors: Azpiroz, Fernando; Chiarioni, Giuseppe; Ducrotte, Philippe; Gourcerol, Guillaume; Hungin, Amrit Pali S; Layer, Peter; Mendive, Juan-Manuel; Pfeifer, Johann; Pohl, Daniel; Rogler, Gerhard et al.
DOI: 10.1111/nmo.13981

Altered host-gut microbes symbiosis in severely malnourished anorexia nervosa (AN) patients undergoing enteral nutrition: An explicative factor of functional intestinal disorders?

PMID: 30527539
Journal: CLINICAL NUTRITION
Year: 2019
Reference: Clin Nutr. 2019 Oct;38(5):2304-2310. doi: 10.1016/j.clnu.2018.10.004. Epub 2018 Oct 9.
Impact factor:
Publication type: Paper in international publication
Authors: Cournede, Nicole; Dore, Joel; Hanachi, Mouna; Levenez, Florence; Manichanh, Chaysavanh; Melchior, Jean-Claude; Pascal, Victoria; Schoenenberger, Andreu et al.
DOI: 10.1016/j.clnu.2018.10.004

Enteric neuron density correlates with clinical features of severe gut dysmotility.

PMID: 31545923
Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Year: 2019
Reference: Am J Physiol Gastrointest Liver Physiol. 2019 Dec 1;317(6):G793-G801. doi: 10.1152/ajpgi.00199.2019. Epub 2019 Sep 23.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Bianco, Francesca; Bonora, Elena; Boschetti, Elisa; Clavenzani, Paolo; Cogliandro, Rosanna F; De Giorgio, Roberto; Giancola, Fiorella; Gori, Alessandra et al.
DOI: 10.1152/ajpgi.00199.2019

Editorial: Next-Generation Probiotics: From Commensal Bacteria to Novel Drugs and Food Supplements.

PMID: 31507575
Journal: Frontiers in Microbiology
Year: 2019
Reference: Front Microbiol. 2019 Aug 27;10:1973. doi: 10.3389/fmicb.2019.01973. eCollection 2019.
Impact factor:
Publication type: Editorail in international publication
Authors: Guarner, Francisco; Langella, Philippe; Martin, Rebeca et al.
DOI: 10.3389/fmicb.2019.01973

Abdominal distension after eating lettuce: The role of intestinal gas evaluated in vitro and by abdominal CT imaging.

PMID: 31402544
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2019
Reference: Neurogastroenterol Motil. 2019 Dec;31(12):e13703. doi: 10.1111/nmo.13703. Epub 2019 Aug 11.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Azpiroz, Fernando; Barba, Elizabeth; Burri, Emanuel; Guarner, Francisco; Margolles, Abelardo; Monclus, Eva; Navazo, Isabel; Sanchez, Borja et al.
DOI: 10.1111/nmo.13703

Probiotics in irritable bowel syndrome: Where are we?

PMID: 30460770
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Dec;30(12):e13513. doi: 10.1111/nmo.13513.
Impact factor:
Publication type: Review in national publication
Authors: Azpiroz, Fernando; Barbara, Giovanni; Cremon, Cesare et al.
DOI: 10.1111/nmo.13513

Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations.

PMID: 30442290
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Year: 2018
Reference: J Am Coll Cardiol. 2018 Nov 13;72(20):2471-2481. doi: 10.1016/j.jacc.2018.08.2181.
Impact factor:
Publication type: Paper in international publication
Authors: Akhtar, Mohammed; Akhtar, Mohammed; Alonso-Pulpon, Luis; Asselbergs, Folkert; Asselbergs, Folkert; Baas, Annette; Barriales, Roberto; Barriales-Villa, Roberto; Barton, Paul J; Barton, Paul J et al.
DOI: 10.1016/j.jacc.2018.08.2181

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

PMID: 30421956
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2018
Reference: Rev Esp Enferm Dig. 2018 Dec;110(12):806-824. doi: 10.17235/reed.2018.5941/2018.
Impact factor:
Publication type: Paper in international publication
Authors: Burgos, Rosa; Casellas, Francesc; Ciriza de Los Rios, Constanza; Garcia Manzanares, Alvaro; Lema Marques, Beatriz; Marcos, Ascension; Polanco, Isabel; Puy Portillo, Maria; Santos, Javier; Vazquez Alferez, Maria Del Carmen et al.
DOI: 10.17235/reed.2018.5941/2018

[Diet and microbiota. Impact on health].

PMID: 30351154
Journal: Nutricion Hospitalaria
Year: 2018
Reference: Nutr Hosp. 2018 Sep 7;35(Spec No6):11-15.
Impact factor:
Publication type: Paper in national publication
Authors: Alvarez-Calatayud, Guillermo; Guarner, Francisco; Marcos, Ascension; Requena, Teresa et al.
DOI: 10.20960/nh.2280

Functional dyspepsia.

PMID: 29099093
Journal: Nature Reviews Disease Primers
Year: 2017
Reference: Nat Rev Dis Primers. 2017 Nov 3;3:17081. doi: 10.1038/nrdp.2017.81.
Impact factor:
Publication type: Review in international publication
Authors: Azpiroz, Fernando; Boeckxstaens, Guy; Elsenbruch, Sigrid; Enck, Paul; Feinle-Bisset, Christine; Holtmann, Gerald; Lackner, Jeffrey M; Ronkainen, Jukka; Schemann, Michael; Stengel, Andreas et al.
DOI: 10.1038/nrdp.2017.81

miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome.

PMID: 29089619
Journal: Scientific Reports
Year: 2017
Reference: Sci Rep. 2017 Oct 31;7(1):14680. doi: 10.1038/s41598-017-13982-0.
Impact factor:
Publication type: Paper in international publication
Authors: Agreus, Lars; Andreasson, Anna; Assadi, Ghazaleh; Becker, Philip P; Bermejo, Justo Lorenzo; Boeckxstaens, Guy; Braun, Alexander; Burwinkel, Barbara; D'Amato, Mauro; Dlugosz, Aldona et al.
DOI: 10.1038/s41598-017-13982-0

Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study.

PMID: 29026603
Journal: United European Gastroenterology Journal
Year: 2017
Reference: United European Gastroenterol J. 2017 Oct;5(6):887-897. doi: 10.1177/2050640617691690. Epub 2017 Jan 29.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Azpiroz, Fernando; de Torres, Ines; Fortea, Marina; Gonzalez-Castro, Ana M; Guagnozzi, Danila; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pardo-Camacho, Cristina et al.
DOI: 10.1177/2050640617691690

Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice.

PMID: 29026591
Journal: United European Gastroenterology Journal
Year: 2017
Reference: United European Gastroenterol J. 2017 Oct;5(6):773-788. doi: 10.1177/2050640617731968. Epub 2017 Sep 28.
Impact factor:
Publication type: Review in national publication
Authors: Andresen, Viola; Azpiroz, Fernando; Barbara, Giovanni; Corsetti, Maura; Emmanuel, Anton; Hungin, A Pali S; Layer, Peter; Mearin, Fermin; Moayyedi, Paul; Stanghellini, Vincenzo et al.
DOI: 10.1177/2050640617731968

Mechanism-Oriented Therapy of Irritable Bowel Syndrome.

PMID: 27138605
Journal: ADVANCES IN THERAPY
Year: 2016
Reference: Adv Ther. 2016 Jun;33(6):877-93. doi: 10.1007/s12325-016-0336-3. Epub 2016 Apr 30.
Impact factor:
Publication type: Review in international publication
Authors: Malagelada, Carolina; Malagelada, Juan R et al.
DOI: 10.1007/s12325-016-0336-3

Gastroduodenal Disorders.

PMID: 27147122
Journal: GASTROENTEROLOGY
Year: 2016
Reference: Gastroenterology. 2016 May;150(6):1380-92. doi: 10.1053/j.gastro.2016.02.011.
Impact factor:
Publication type: Review in international publication
Authors: Chan, Francis K L; Hasler, William L; Malagelada, Juan R; Stanghellini, Vincenzo; Suzuki, Hidekazu; Tack, Jan; Talley, Nicholas J et al.
DOI: 10.1053/j.gastro.2016.02.011

Current concepts on microscopic colitis: evidence-based statements and recommendations of the Spanish Microscopic Colitis Group.

PMID: 26597122
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2016
Reference: Aliment Pharmacol Ther. 2016 Feb;43(3):400-26. doi: 10.1111/apt.13477. Epub 2015 Nov 24.
Impact factor:
Publication type: Review in international publication
Authors: Arguedas, Y; Beltran, B; Busquets, D; Casanova, M J; Fernandez, J M; Fernandez-Banares, F; Fernandez-Salazar, L; Garcia-Planella, E; Gisbert, J P; Guagnozzi, D et al.
DOI: 10.1111/apt.13477

Extraction of esophageal foreign body with burrowing technique.

PMID: 26965741
Journal: GASTROINTESTINAL ENDOSCOPY
Year: 2016
Reference: Gastrointest Endosc. 2016 Jul;84(1):174. doi: 10.1016/j.gie.2016.02.037. Epub 2016 Mar 7.
Impact factor:
Publication type: Letter or abstract
Authors: Abu-Suboh Abadia, Monder; Armengol Miro, Jordi; Armengol Miro, Josep Ramon; Dot Bach, Joan; Masachs Peracaula, Miquel et al.
DOI: 10.1016/j.gie.2016.02.037

Digestive Symptoms in Healthy People and Subjects With Irritable Bowel Syndrome: Validation of Symptom Frequency Questionnaire.

PMID: 25014236
Journal: J CLIN GASTROENTEROL
Year: 2015
Reference: J Clin Gastroenterol. 2015 Aug;49(7):e64-70. doi: 10.1097/MCG.0000000000000178.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Donazzolo, Yves; Gendre, David; Guarner, Francisco; Guyonnet, Denis; Tanguy, Jerome et al.
DOI: 10.1097/MCG.0000000000000178

Benefit on health-related quality of life of adherence to gluten-free diet in adult patients with celiac disease.

PMID: 25824917
Journal: REV ESP ENFERM DIG
Year: 2015
Reference: Rev Esp Enferm Dig. 2015 Apr;107(4):196-201.
Impact factor:
Publication type: Paper in international publication
Authors: Casellas, Francisco; Duenas, Carmen; Fernandez-Banares, Fernando; Lopez-Vivancos, Josefa; Lucendo, Alfredo J; Molina-Infante, Javier; Rodrigo, Luis; Rosinach, Merce; Vivas, Santiago et al.
DOI:

Immunogenicity of hepatitis B vaccine in patients with inflammatory bowel disease and the benefits of revaccination.

PMID: 25160690
Journal: J GASTROEN HEPATOL
Year: 2015
Reference: J Gastroenterol Hepatol. 2015 Jan;30(1):92-8. doi: 10.1111/jgh.12712.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel-Sainz, Natalia; Campins-Marti, Magda; Casellas-Jorda, Francesc; Cossio-Gil, Yolima; Martinez-Gomez, Xavier; Rodrigo-Pendas, Jose Angel; Rodriguez-Frias, Francisco et al.
DOI: 10.1111/jgh.12712

Executive summary of the GESIDA/National AIDS Plan Consensus Document on antiretroviral therapy in adults infected by the human immunodeficiency virus (updated January 2015).

PMID: 26021186
Journal: ENFERM INFEC MICR CL
Year: 2015
Reference: Enferm Infecc Microbiol Clin. 2015 Oct;33(8):544-56. doi: 10.1016/j.eimc.2015.03.017. Epub 2015 May 26.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirrebengoa, Koldo; Aguirrebengoa, Koldo; Aldeguer, Jose Lopez; Aldeguer, Jose Lopez; Arribas, Jose Ramon; Arribas, Jose Ramon; Berenguer, Juan; Berenguer, Juan; Blanco, Jose Ramon; Blanco, Jose Ramon et al.
DOI: 10.1016/j.eimc.2015.03.017

Coping with common gastrointestinal symptoms in the community: a global perspective on heartburn, constipation, bloating, and abdominal pain/discomfort May 2013.

PMID: 25000344
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2014
Reference: J Clin Gastroenterol. 2014 Aug;48(7):567-78. doi: 10.1097/MCG.0000000000000141.
Impact factor:
Publication type: Paper in international publication
Authors: Abbas, Zaigham; Besancon, Luc; Eliakim, Abraham; Emmanuel, Anton; Goh, Khean-Lee; Guarner, Francisco; Horn, John; Hungin, Pali; Hunt, Richard; Johanson, John et al.
DOI: 10.1097/MCG.0000000000000141

From basic to applied research: lessons from the human microbiome projects.

PMID: 25291122
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2014
Reference: J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S3-4. doi: 10.1097/MCG.0000000000000242.
Impact factor:
Publication type: Paper in international publication
Authors: Guarner, Francisco; Robles-Alonso, Virginia et al.
DOI: 10.1097/MCG.0000000000000242

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.

PMID: 24997787
Journal: NATURE BIOTECHNOLOGY
Year: 2014
Reference: Nat Biotechnol. 2014 Aug;32(8):822-8. doi: 10.1038/nbt.2939. Epub 2014 Jul 6.
Impact factor:
Publication type: Paper in international publication
Authors: Almeida, Mathieu; Almeida, Mathieu; Antolin, Maria; Artiguenave, Francois; Arumugam, Manimozhiyan; Arumugam, Manimozhiyan; Batto, Jean-Michel; Batto, Jean-Michel; Blom, Nikolaj; Blom, Nikolaj et al.
DOI: 10.1038/nbt.2939

An integrated catalog of reference genes in the human gut microbiome.

PMID: 24997786
Journal: NATURE BIOTECHNOLOGY
Year: 2014
Reference: Nat Biotechnol. 2014 Aug;32(8):834-41. doi: 10.1038/nbt.2942. Epub 2014 Jul 6.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Aama, Jumana Yousuf; Antolin, Maria; Artiguenave, Francois; Arumugam, Manimozhiyan; Batto, Jean-Michel; Blottiere, Herve; Bork, Peer; Borruel, Natalia; Brechot, Christian; Bruls, Thomas et al.
DOI: 10.1038/nbt.2942

Vaccination of patients with inflammatory bowel disease. Practical recommendations.

PMID: 23659508
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2013
Reference: Rev Esp Enferm Dig. 2013 Feb;105(2):93-102.
Impact factor:
Publication type: Paper in national publication
Authors: Borruel, N; Campins, M; Cossio, Y; Martinez, X et al.
DOI:

Mechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention.

PMID: 23607758
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2013
Reference: Neurogastroenterol Motil. 2013 Jun;25(6):e389-94. doi: 10.1111/nmo.12128. Epub 2013 Apr 22.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, A; Azpiroz, F; Barba, E; Burri, E; Lahoya, E M; Malagelada, C; Malagelada, J-R; Navazo, I; Quiroga, S et al.
DOI: 10.1111/nmo.12128

Dietary lipids and functional gastrointestinal disorders.

PMID: 23567355
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2013
Reference: Am J Gastroenterol. 2013 May;108(5):737-47. doi: 10.1038/ajg.2013.76. Epub 2013 Apr 9.
Impact factor:
Publication type: Review in international publication
Authors: Azpiroz, Fernando; Feinle-Bisset, Christine et al.
DOI: 10.1038/ajg.2013.76

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology.

PMID: 23202796
Journal: Gut Microbes
Year: 2013
Reference: Gut Microbes. 2013 Jan-Feb;4(1):17-27. doi: 10.4161/gmic.22973. Epub 2012 Nov 30.
Impact factor:
Publication type: Letter or abstract
Authors: Bercik, Premysl; Dinan, Ted G; Foster, Jane A; Guarner, Francisco; Hecht, Gail; Heyman, Melvin B; Ringel, Yehuda; Saulnier, Delphine M; Shulman, Robert J; Verdu, Elena F et al.
DOI: 10.4161/gmic.22973

Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1{alpha} in acinar cell homeostasis.

PMID: 21948943
Journal: GUT
Year: 2012
Reference: Gut. 2012 Aug;61(8):1187-96. doi: 10.1136/gutjnl-2011-300360. Epub 2011 Sep 23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/gutjnl-2011-300360

Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey.

PMID: 23021167
Journal: GASTROINTESTINAL ENDOSCOPY
Year: 2012
Reference: Gastrointest Endosc. 2012 Dec;76(6):1133-41. doi: 10.1016/j.gie.2012.08.001. Epub 2012 Sep 26.
Impact factor:
Publication type: Paper in international publication
Authors: Abadia, Monder Abu-Suboh; Alvarez, Alberto; Aparicio, Jose R; Armengol-Miro, Jose R; Barturen, Angel; Casi, Maria A; de la Morena, Felipe; De la Serna, Carlos; Fernandez-Urien, Ignacio; Garcia-Cano, Jesus et al.
DOI: 10.1016/j.gie.2012.08.001

Guidelines for the use and interpretation of assays for monitoring autophagy.

PMID: 22966490
Journal: Autophagy
Year: 2012
Reference: Autophagy. 2012 Apr;8(4):445-544.
Impact factor:
Publication type: Review in international publication
Authors: ; Abdalla, Fabio C; Abeliovich, Hagai; Abraham, Robert T; Acevedo-Arozena, Abraham; Adeli, Khosrow; Agholme, Lotta; Agnello, Maria; Agostinis, Patrizia; Aguirre-Ghiso, Julio A et al.
DOI:

The gut microbiota in IBD.

PMID: 22907164
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2012
Reference: Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):599-608. doi: 10.1038/nrgastro.2012.152. Epub 2012 Aug 21.
Impact factor:
Publication type: Review in international publication
Authors: Borruel, Natalia; Casellas, Francesc; Guarner, Francisco; Manichanh, Chaysavanh et al.
DOI: 10.1038/nrgastro.2012.152

Assessment of the protective effects of oral tocotrienols in arginine chronic-like pancreatitis.

PMID: 21852363
Journal: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Year: 2011
Reference: Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G846-55. Epub 2011 Aug 18.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.1152/ajpgi.00485.2010

Meal size can be decreased in obese subjects through pharmacological acceleration of gastric emptying (The OBERYTH trial).

PMID: 20938444
Journal: INTERNATIONAL JOURNAL OF OBESITY
Year: 2011
Reference: Int J Obes (Lond). 2011 Jun;35(6):829-37. doi: 10.1038/ijo.2010.210. Epub 2010 Oct 12.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/ijo.2010.210

Diseases of the digestive tract: is prevention possible and feasible?

PMID: 21734393
Journal: DIGESTIVE DISEASES
Year: 2011
Reference: Dig Dis. 2011;29(2):255-63. Epub 2011 Jul 5.
Impact factor:
Publication type: Paper in international publication
Authors: Malagelada, Juan-R et al.
DOI: 10.1159/000323931

Probiotic and prebiotic claims in Europe: seeking a clear roadmap.

PMID: 21736772
Journal: BRITISH JOURNAL OF NUTRITION
Year: 2011
Reference: Br J Nutr. 2011 Dec;106(11):1765-7. Epub 2011 Jun 21.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1017/S0007114511002248

Contribution of nurses to the quality of care in management of inflammatory bowel disease: A synthesis of the evidence.

PMID: 21122570
Journal: Journal of Crohns & Colitis
Year: 2010
Reference: J Crohns Colitis. 2010 Dec;4(6):611-22. Epub 2010 Sep 17.
Impact factor:
Publication type: Review in international publication
Authors: Blasco, Antonio J; Casellas, Francisco; Garcia, Valle; Hernandez-Sampelayo, Paloma; Lazaro, Pablo; Marin, Laura; Oltra, Lorena; Parody, Elizabeth; Seoane, Montserrat; Torrejon, Antonio et al.
DOI: 10.1016/j.crohns.2010.08.009

Cutoff values of the Inflammatory Bowel Disease Questionnaire to predict a normal health related quality of life.

PMID: 21122573
Journal: Journal of Crohns & Colitis
Year: 2010
Reference: J Crohns Colitis. 2010 Dec;4(6):637-41. Epub 2010 Aug 2.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, N; Casellas, F; Castells, I; Guarner, F; Huaman, Jw; Masachs, M; Pelaez, A; Torrejon, A; Varela, E et al.
DOI: 10.1016/j.crohns.2010.07.006

[Recommendations for diagnosis, staging and treatment of pancreatic cancer (Part I). Grupo Espanol de Consenso en Cancer de Pancreas]

PMID: 20346471
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 May 15;134(14):643-55. Epub 2010 Mar 26.
Impact factor:
Publication type: Editorial in national publication
Authors: Alvarez, Emilio; Arguello, Lidia; Barranco, Luis; Bombi, Josep Antoni; Cardenas, Andres; Conill, Carlos; Cuatrecasas, Miriam; De Juan, Carmen; de Madaria, Enrique; del Pino Florez, M et al.
DOI: 10.1016/j.medcli.2009.12.014

Validation of the Spanish version of a questionnaire to measure quality of care through the eyes of patients with inflammatory bowel disease (QUOTE-IBD).

PMID: 19918968
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2010
Reference: Inflamm Bowel Dis. 2010 Jun;16(6):982-92.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, Natalia; Casellas, Francesc; Castells, Isabel; Malagelada, Juan Ramon; Masachs, Miquel; Torrejon, Antonio et al.
DOI: 10.1002/ibd.21156

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

PMID: 19585519
Journal: JOURNAL OF PATHOLOGY
Year: 2009
Reference: J Pathol. 2009 Oct;219(2):205-13.
Impact factor:
Publication type: Paper in international publication
Authors: Barbacid, Mariano; Bosch, Almudena; Gonzalez, Ana; Guerra, Carmen; Hernandez-Munoz, Inmaculada; Iglesias, Mar; Lobato, Tania; Martinez-Romero, Carles; Molero, Xavier; Real, Francisco X et al.
DOI: 10.1002/path.2585

Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.

PMID: 19326463
Journal: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Year: 2009
Reference: Environ Mol Mutagen. 2009 Jun;50(5):421-30.
Impact factor:
Publication type: Paper in international publication
Authors: Carrato, Alfredo; Crous-Bou, Marta; Guarner, Luisa; Jariod, Manel; Lopez, Tomas; Malats, Nuria; Morales, Eva; Porta, Miquel; Real, Francisco X; Rifa, Juli et al.
DOI: 10.1002/em.20483

Risk factors for recurrence of acute gastrointestinal bleeding from angiodysplasia.

PMID: 19512936
Journal: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Year: 2009
Reference: Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1333-9.
Impact factor:
Publication type: Paper in international publication
Authors: Abu-Suboh, Monder; Armengol, Jose Ramon; Bayarri, Carolina; Dot, Joan; Lobo, Beatriz; Malagelada, Juan R; Saperas, Esteve; Videla, Sebastian et al.
DOI: 10.1097/MEG.0b013e32830e491c

Infliximab maintenance therapy is associated with decreases in direct resource use in patients with luminal or fistulizing Crohn's disease.

PMID: 19448569
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2009
Reference: J Clin Gastroenterol. 2009 Nov-Dec;43(10):950-6.
Impact factor:
Publication type: Paper in international publication
Authors: Calvet, Xavier; Casado, Miguel A; Casellas, Francesc; Castro, Luisa; Castro, Manuel; Ginard, Daniel; Gisbert, Javier P; Gomez-Camacho, Federico; Martinez-Montiel, Pilar; Morales, Jose M et al.
DOI: 10.1097/MCG.0b013e3181986917

Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon.

PMID: 18691825
Journal: PSYCHONEUROENDOCRINOLOGY
Year: 2008
Reference: Psychoneuroendocrinology. 2008 Oct;33(9):1248-56. doi: 10.1016/j.psyneuen.2008.07.002. Epub 2008 Aug 8.
Impact factor: 4.422
Publication type: Paper in international publication
Authors: Vicario, Maria, Alonso, Carmen, Perdue, Mary H, Guilarte, Mar, Yates, Derrick, Santos, Javier et al.
DOI: 10.1016/j.psyneuen.2008.07.002

Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation.

PMID: 18455999
Journal: GASTROENTEROLOGY
Year: 2008
Reference: Gastroenterology. 2008 Jul;135(1):163-172.e1. doi: 10.1053/j.gastro.2008.03.036. Epub 2008 Mar 22.
Impact factor: 11.673
Publication type: Paper in international publication
Authors: Alonso, Carmen, Guilarte, Mar, Vicario, Maria, Ramos, Laura, Ramadan, Ziad, Antolin, Maria, Martinez, Cristina, Rezzi, Serge, Saperas, Esteban, Kochhar, Sunil et al.
DOI: 10.1053/j.gastro.2008.03.036

Thesis

La respuesta humoral y las interacciones neuro-inmunológicas en la mucosa intestinal como contribuyentes en la patofisiología del Síndrome del Intestino Irritable con predominio de diarrea

PhD student: Cristina Pardo Camacho
Director/s: Fco Javier Santos Vicente, Maria Vicario Perez
University: Universidad Autònoma de Barcelona
Year: 2020

Blog

News

A new diagnostic algorithm has been created to guide professionals in cases of persistent vomiting for more than four weeks.

Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.