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Francesc Xavier Molero Richard

Institutions of which they are part

Main researcher
Physiology and Pathophysiology of the Digestive Tract
Vall Hebron Institut de Recerca

Francesc Xavier Molero Richard

Institutions of which they are part

Main researcher
Physiology and Pathophysiology of the Digestive Tract
Vall Hebron Institut de Recerca

Research lines

Pathophysiology and treatment of pancreatic disorders.

The focus of our research is to study the series of pathophysiologic events leading to acute and chronic pancreatitis and, eventually, pancreatic cancer. We aim to take advantage of knowledge gained at our basic research program to design therapeutic strategies intended to prevent or ameliorate human pancreatic disorders. In rodent models of acute and chronic pancreatitis we examine pancreatic regeneration, fibrogenesis, acino-ductal trandiferentiation, stellate cell activation, epithelial-to-mesenchymal transition and cancer development. In human pancreatitis we investigate environmental and genetic determinants (with special focus at CFTR dysfunction) and new treatment modalities for acute and chronic pancreatitis.

IP: Francesc Xavier Molero Richard

Projects

New tool based on Artificial Intelligence and Biomarkers for early non-invasive diagnosis of Pancreatic Cancer - AI-Early PanC

IP: Francesc Xavier Molero Richard
Collaborators: Santiago Pérez Hoyos, Joaquin Balsells Valls
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 293321
Reference: CPP2022- 009592
Duration: 01/10/2023 - 30/09/2026

Ministerio de Ciencia

CFTR down regulation enhances pancreatic carcinogenesis and promotes cancer invasion and metastasis

IP: Francesc Xavier Molero Richard
Collaborators: Raquel Ibañez Ferrer
Funding agency: Cystic Fibrosis Foundation
Funding: 300565.29
Reference: CFTR_CFF_RESEARCH GRANTS - FALL 2021
Duration: 01/05/2022 - 30/04/2024

Contribución de la disfunción de CFTR al desarrollo y agresividad del cáncer de páncreas. Estimulación del crecimiento tumoral y metástasis por células estrelladas carentes de CFTR.

IP: Francesc Xavier Molero Richard
Collaborators: Laura Campderros Traver, Eva Polverino
Funding agency: Instituto de Salud Carlos III
Funding: 147620
Reference: PI22/00887
Duration: 01/01/2023 - 31/12/2025

Fisiologia i fisiopatologia digestiva

IP: Fco Javier Santos Vicente
Collaborators: Maria Vicario Perez, Beatriz Lobo Alvarez, Fernando Azpiroz Vidaur, Natalia Borruel Sainz, Francesc Xavier Molero Richard, Francesc Casellas Jordá, Carmen Alonso Cotoner, Carolina Malagelada Prats, Jorge Serra Pueyo, Ana Maria Gonzalez Castro, Ariadna Aguilar Cayuelas, Elba Exposito Fernandez, Laura Campderros Traver, Blanca Grases Pintó, Virginia Robles Alonso, Adoración Nieto Ruiz, Claudia Barber Caselles, Elena Céspedes Martínez, Danila Guagnozzi, Ronald Benjamin Llerena Castro, Francisca Yañez Araya, Consuelo Cammarota
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00766
Duration: 01/01/2022 - 31/12/2024

Related news

Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

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