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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Diana Fernandes de Rafael

Diana Fernandes de Rafael

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Fernanda Raquel Da Silva Andrade

Fernanda Raquel Da Silva Andrade

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Pilar Reimundo Diaz-Fierros

Maria del Pilar Reimundo Diaz-Fierros

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Diego Baranda Martínez-Abasca

Diego Baranda Martínez-Abasca

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Marc Miquel Moltó Abad

Marc Miquel Moltó Abad

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Angels Alcina Mila

Angels Alcina Mila

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Diana Fernandes de Rafael

Diana Fernandes de Rafael

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Fernanda Raquel Da Silva Andrade

Fernanda Raquel Da Silva Andrade

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Maria del Pilar Reimundo Diaz-Fierros

Maria del Pilar Reimundo Diaz-Fierros

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Diego Baranda Martínez-Abasca

Diego Baranda Martínez-Abasca

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Marc Miquel Moltó Abad

Marc Miquel Moltó Abad

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Angels Alcina Mila

Angels Alcina Mila

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Research lines

Disseny, síntesi i caracterització de nanosistemes terapèutics biodegradables

IP: Fernanda Raquel Da Silva Andrade

Estudi de les bases moleculars i cel·lulars del càncer

IP: Joaquin Seras Franzoso

Estudi i Millora del procés de fecundació in vitro

IP: Maria del Pilar Reimundo Diaz-Fierros

Obtenció i us de vesícules extracel·lulars com vehicles per proteïnes i biomolècules

IP: Ibane Abasolo Olaortua

Projects

TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas

IP: Begoña Benito Villabriga
Collaborators: Carmen Escudero Iriarte, Laia Ventura i Expósito, Susana Otero Romero, Ibane Abasolo Olaortua, Ignacio Ferreira González, José Antonio Barrabés Riu, Carlos Nos Llopis, Pablo Velasco Puyó, Jose Fernando Rodríguez Palomares, María Rosario Pérez- Torres Lobato, Sunny Malhotra Sareen, Belen Perez Dueñas, Jaume Sastre Garriga, Joan López Hellin, Antonia Sambola Ayala, Jordi Rio Izquierdo, Nuria Rivas Gandara, Jordi Perez Rodon, Aroa Soriano Fernández, Manuel Comabella Lopez, Antonio Rodríguez Sinovas, Gisela Teixido Tura, Antonia Pijuan Domenech, Roser Ferrer Costa, Joaquin Seras Franzoso, Carmen Tur Gomez, Maria Cristina Díaz de Heredia Rubio, Laia Yañez Bisbe, Julia German Cortes, Maria Jose Pérez García, Miguel Segura Ginard, Diego Baranda Martínez-Abasca, Cristina Auger Acosta, Neus Bellera Gotarda, Herena Eixarch Ahufinger, M Mar Mañu Pereira, Deborah Pareto Onghena, Lorena Valero Arrese, Aitor Uribarri Gonzalez, Jordi Bañeras Rius, Alex Rovira Cañellas, Mar Tintore Subirana, Bruno García del Blanco, Maria Teresa Salcedo Allende, Marisol Ruiz Meana, Ana Belén Méndez Fernández, Xavier Montalban Gairín, Simon Schwartz Navarro, Anna Llort Sales, Carmen Espejo Ruiz, Raquel Hladun Alvaro, Angels Alcina Mila, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Ana Zabalza de Torres, TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas, Marc Miquel Moltó Abad, Javier Inserte Igual, Luciana Midaglia Fernandez, Elizabeth Pando Rau, Gabriela Guillén Burrieza, Ana Laura Cazurro Gutierrez, David Gómez Andrés, Alvaro Cobo Calvo, Alvaro Calabuig Goena, Joaquin Castillo Justribo, Lydia Dux-Santoy Hurtado, Lucas Moreno Martín-Retortillo, TACTIC: Explorando soluciones a los retos de salud mediante ciencia disruptiva, terapias avanzadas y medicina de sistemas, Josep Roma Castanyer, Laura Dos Subirá, Nicolás Miguel Fissolo, Maria Nazarena Pizzi, Tian Tian, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael, Andrea Guala
Funding agency: Instituto de Salud Carlos III
Funding: 2494527.53
Reference: FORT23/00034
Duration: 01/01/2024 - 31/12/2027

Efecto de la reposición de hierro sobre el remodelado ventricular después de la oclusi´pon coronaria transitoria en un modelo animal de ferropenia inducida por dieta

IP: José Antonio Barrabés Riu
Collaborators: Ignacio Ferreira González, David Aluja Gonzalez, Sara Delgado Tomás, Laura Castellote Bellés, Javier Inserte Igual
Funding agency: -Sociedad Española de Cardiologia
Funding: 15000
Reference: SEC/FEC-INV-BAS 23/11
Duration: 26/10/2023 - 31/12/2027

Impact of stem-related tumor extracellular vesicles subsets in TNBC progression.

IP: Joaquin Seras Franzoso
Collaborators: Maria Fidel Lledò, Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 119567
Reference: FI23/00223
Duration: 15/01/2024 - 14/01/2028

Funciones Alternativas de la Sex Hormone-Binding Globulin: Mecanismos Moleculares y Papel en Fisiología y Fisiopatología

IP: David Martinez Selva
Collaborators: Maria Teresa Salcedo Allende, Lorena Ramos Pérez, Pablo Gabriel Medina, Pilar Costa Forner
Funding agency: Instituto de Salud Carlos III
Funding: 190000
Reference: PI23/00544
Duration: 01/01/2024 - 31/12/2026

Publications

The Nanotechnology-Based Approaches against Kirsten Rat Sarcoma-Mutated Cancers.

PMID: 37376135
Journal: Pharmaceutics
Year: 2023
Reference: Pharmaceutics. 2023 Jun 8;15(6):1686. doi: 10.3390/pharmaceutics15061686.
Impact factor:
Publication type: Review in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; Baranda-Martinez-Abascal, Diego; Carcavilla, Pilar; Diaz-Riascos, Zamira Vanessa; German-Cortes, Julia; Molto-Abad, Marc; Montero, Sara; Rafael, Diana; Seras-Franzoso, Joaquin et al.
DOI: 10.3390/pharmaceutics15061686

Correction to: implementation of second-tier tests in newborn screening for the detection of vitamin B12 related acquired and genetic disorders: results on 258,637 newborns.

PMID: 37443087
Journal: Orphanet Journal of Rare Diseases
Year: 2023
Reference: Orphanet J Rare Dis. 2023 Jul 13;18(1):188. doi: 10.1186/s13023-023-02793-4.
Impact factor:
Publication type: Letter or abstract
Authors: Argudo, Ana; Arranz, Jose Antonio; Artuch, Rafael; Carnicer, Clara; de Aledo-Castillo, Jose Manuel Gonzalez; de Los Santos, Mariela Mercedes; Fernandez, Rosa; Garcia-Cazorla, Angeles; Garcia-Villoria, Judit; Garcia-Volpe, Camila et al.
DOI: 10.1186/s13023-023-02793-4

Mid-trimester uterine artery Doppler for aspirin discontinuation in pregnancies at high risk for preterm pre-eclampsia: Post-hoc analysis of StopPRE trial.

PMID: 37555464
Journal: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Year: 2023
Reference: BJOG. 2023 Aug 9. doi: 10.1111/1471-0528.17631.
Impact factor:
Publication type: Paper in international publication
Authors: Alsius, Merce; Bonacina, Erika; Caamina, Sara; Carreras, Elena; Castillo-Ribelles, Laura; de Mingo, Laura; Diaz, Sonia; Garcia, Esperanza; Garcia-Manau, Pablo; Lopez, Monica et al.
DOI: 10.1111/1471-0528.17631

Comparison of Extracellular Vesicle Isolation Methods for miRNA Sequencing.

PMID: 37569568
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Jul 29;24(15):12183. doi: 10.3390/ijms241512183.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, Marta; Borras, Francesc E; Burgui, Idoia; Camos, Silvia; Corrales, Irene; Costafreda, Maria Isabel; Domingo, Esteban; Esteban, Juan Ignacio; Llorens-Revull, Meritxell; Martinez-Gonzalez, Brenda et al.
DOI: 10.3390/ijms241512183

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.