On July 29, 2003, a scientific collaboration agreement was signed in order to regulate scientific cooperation in biomedical research and in health and life sciences, the training of research staff and the publication of publications, among the different organisms.

The signatory entities were: the Vall d'Hebron University Hospital, the Vall d'Hebron Research Institute, the Blood and Tissue Bank, the Autonomous University of Barcelona, ​​the Institute of Diagnostic Imaging and the Institut Català Foundation of Pharmacology.

Five years later, on June 12, 2014, the IIS received its first reaccreditation and, on May 1, 2015, a research collaboration agreement was signed in relation to the Research Institute Sanitària IIS IR-HUVH, in order to formalize the integration of the Vall d'Hebron Institute of Oncology (VHIO).

On March 21, 2018, ISCiii and the Ministry authorized the integration of VHIO into the IIS IR-HUVH.

In October 2018, the Collaboration Agreement was signed that implements the creation of the Governing Board of the Health Research Institute Accredited by the IIS IR-HUVH.

In January 2019, the first meeting of the Governing Council was held, and in April 2019, the first meeting of the Internal Scientific Council was held.

On August 5, 2019, the IIS received a second re-accreditation.

The IIS IR-HUVH constantly seeks to expand the boundaries of scientific knowledge in the field of medicine to contribute to improving the care and quality of life of patients through the development of research activities in priority research fields and lines, which meet the highest international quality standards in collaboration with the institutions that make up IIS IR-HUVH.

The IIS IR-HUVH aspires to become the reference medical research campus in southern Europe thanks to the high quality of the research activities carried out there, its translational orientation, the impact of the results obtained, involvement in the main national and international networks and consortia, as well as high standards in the training of researchers.