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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Belen Garcia Prats

Belen Garcia Prats

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Clara Ramírez Serra

Clara Ramírez Serra

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Julia German Cortes

Julia German Cortes

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura García Latorre

Laura García Latorre

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Marina Giralt Arnaiz

Marina Giralt Arnaiz

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Sandra Mancilla Zamora

Sandra Mancilla Zamora

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Belen Garcia Prats

Belen Garcia Prats

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Clara Ramírez Serra

Clara Ramírez Serra

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Julia German Cortes

Julia German Cortes

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Laura García Latorre

Laura García Latorre

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Marina Giralt Arnaiz

Marina Giralt Arnaiz

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Sandra Mancilla Zamora

Sandra Mancilla Zamora

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more

Projects

Antimicrobianos nebulizados en receptores de trasplante pulmonar

IP: Ibai Los Arcos Bertiz
Collaborators: M Teresa Martin Gomez, Yolanda Villena Ortiz, Javier Gomis Rodriguez, Joan Gavaldà Santapau, Judith Sacanell Lacasa, Marta Zapata Ortega, Leire Sanchez Corujo
Funding agency: Instituto de Salud Carlos III
Funding: 37500
Reference: PI23/01467
Duration: 01/01/2024 - 31/12/2026

Nanoclustered Affimers for Targeted KRAS Ablation in Pancreatic Ductal Adenocarcinoma

IP: Joaquin Seras Franzoso
Collaborators: Diana Fernandes de Rafael
Funding agency: Asociación Cáncer de Páncreas
Funding: 50000
Reference: ACANPAN/PROJECTES/2023/SERAS
Duration: 05/12/2023 - 04/12/2025

Optimización del test de deposición ex vivo de C5b9 para monitorizar la actividad y la respuesta al tratamiento en SHUa y otras glomerulopatías complejas

IP: Concepció Jacobs Cachá
Collaborators: Manuel Hernández González, Natalia Ramos Terrades, Joana Sellarés Roig, Carmen Llorens Cebriá, Janire Perurena Prieto
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/JACOBS
Duration: 23/12/2023 - 22/12/2025

RED NACIONAL DE LABORATORIOS DE FUNCION RENAL

IP: Francesc Moreso Mateos
Collaborators: Gema Ariceta Iraola, Joan López Hellin
Funding agency: Instituto de Salud Carlos III
Funding: 42900
Reference: PMP22/00119
Duration: 01/01/2023 - 31/12/2025

Publications

Nanoceria as Safe Contrast Agents for X-ray CT Imaging.

PMID: 37570527
Journal: Nanomaterials
Year: 2023
Reference: Nanomaterials (Basel). 2023 Jul 29;13(15):2208. doi: 10.3390/nano13152208.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bastus, Neus G; Boullosa, Ana Maria; Camara, Juan Antonio; Casals, Eudald; Garcia, Ana; Gusta, Muriel F; Mondragon, Laura; Puntes, Victor; Schwartz, Simo Jr et al.
DOI: 10.3390/nano13152208

Transfusion-transmission of hepatitis E virus through red blood cell transfusion but not through platelet concentrates: A case report from Spain.

PMID: 37593971
Journal: TRANSFUSION
Year: 2023
Reference: Transfusion. 2023 Aug 18. doi: 10.1111/trf.17498.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez Arguelles, Marta Elena; Garcia-Gala, Jose Maria; Mata, Pablo; Munoz, Maria Del Carmen; Ojea, Ana Maria; Quer Sivila, Josep; Rando Segura, Ariadna; Rodriguez, Mercedes; Rodriguez-Frias, Francisco; Seco, Carolina et al.
DOI: 10.1111/trf.17498

Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA </= 6.

PMID: 37626646
Journal: Biomedicines
Year: 2023
Reference: Biomedicines. 2023 Jul 30;11(8):2149. doi: 10.3390/biomedicines11082149.
Impact factor:
Publication type: Paper in international publication
Authors: Baldira, Jaume; Chiscano, Luis; Comas, Inma; Cortes, Alejandro; Ferrer, Ricard; Ferrer-Costa, Roser; Gonzalez-Lopez, Juan Jose; Larrosa, Maria Nieves; Ruiz-Rodriguez, Juan Carlos; Ruiz-Sanmartin, Adolfo et al.
DOI: 10.3390/biomedicines11082149

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).

PMID: 37696147
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2023
Reference: Eur J Obstet Gynecol Reprod Biol. 2023 Aug 23;289:203-207. doi: 10.1016/j.ejogrb.2023.08.376.
Impact factor:
Publication type: Paper in international publication
Authors: Beneitez, D; Beneitez, D; Bergamo, S; Carbonell, M; Carbonell, M; Carreras, E; Carreras, E; Castillo, F; Castillo, F; Cespedes, M C et al.
DOI: 10.1016/j.ejogrb.2023.08.376

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.