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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Eirini Kyriakopoulou

Eirini Kyriakopoulou

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gerard Fischer Albiol

Gerard Fischer Albiol

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Giacomoluciano Vitelli

Giacomoluciano Vitelli

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gisela Espriu Aguado

Gisela Espriu Aguado

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Eirini Kyriakopoulou

Eirini Kyriakopoulou

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Gerard Fischer Albiol

Gerard Fischer Albiol

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Giacomoluciano Vitelli

Giacomoluciano Vitelli

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Gisela Espriu Aguado

Gisela Espriu Aguado

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more

Projects

Nanoclustered Affimers for Targeted KRAS Ablation in Pancreatic Ductal Adenocarcinoma

IP: Joaquin Seras Franzoso
Collaborators: Diana Fernandes de Rafael
Funding agency: Asociación Cáncer de Páncreas
Funding: 50000
Reference: ACANPAN/PROJECTES/2023/SERAS
Duration: 05/12/2023 - 04/12/2025

RED NACIONAL DE LABORATORIOS DE FUNCION RENAL

IP: Francesc Moreso Mateos
Collaborators: Gema Ariceta Iraola, Joan López Hellin
Funding agency: Instituto de Salud Carlos III
Funding: 42900
Reference: PMP22/00119
Duration: 01/01/2023 - 31/12/2025

Optimización del test de deposición ex vivo de C5b9 para monitorizar la actividad y la respuesta al tratamiento en SHUa y otras glomerulopatías complejas

IP: Concepció Jacobs Cachá
Collaborators: Manuel Hernández González, Natalia Ramos Terrades, Joana Sellarés Roig, Carmen Llorens Cebriá, Mercedes López González, Janire Perurena Prieto
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/JACOBS
Duration: 23/12/2023 - 22/12/2025

MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small Cell Lung Cancer

IP: -
Collaborators: Joaquin Seras Franzoso, MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C, MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C, MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C, MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C, MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C, MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small C
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 333099
Reference: CPP2022-009780
Duration: 01/07/2023 - 30/06/2026

Ministerio de Ciencia
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News

The study results show that the local presence of IL-1β promotes the development of myeloid cells with an immunosuppressive function.

The grants promote new therapeutic strategies and diagnostic tools in highly complex tumors such as glioblastoma, triple-negative breast cancer, and endometrial cancer.

The project aims to improve prevention, diagnosis, and treatment through computational biomedicine, innovative therapies, and the transfer of knowledge into clinical practice.