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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Conesa Milian

Laura Conesa Milian

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Luisa Maria Martinez Sánchez

Luisa Maria Martinez Sánchez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Carmen Sanchez  Valcarcel

Maria del Carmen Sanchez Valcarcel

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mireia Benito Jimenez

Mireia Benito Jimenez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Conesa Milian

Laura Conesa Milian

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Luisa Maria Martinez Sánchez

Luisa Maria Martinez Sánchez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Carmen Sanchez  Valcarcel

Maria del Carmen Sanchez Valcarcel

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mireia Benito Jimenez

Mireia Benito Jimenez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies.

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, Eddie Pradas Gracia, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Jordi Riera Heredia, Marta Montpeyó Garcia-Moreno, Daniela Samaniego Toro, Laura Castillo Ribelles, Daniela Samaniego Toro
Funding agency: Instituto de Salud Carlos III
Funding: 245932.5
Reference: PI20/00728
Duration: 01/01/2021 - 30/06/2025

Microperimetry and serum biomarkers for identifying type 2 diabetic patients with cognitive impairment. A cross-sectional and prospective study.

IP: Olga Simó Servat
Collaborators: Ana Boixadera Espax, Marina Giralt Arnaiz, Cristina Udina Argilaga
Funding agency: Instituto de Salud Carlos III
Funding: 82280
Reference: PI20/01703
Duration: 01/01/2021 - 30/06/2025

MIMIC-KeY - A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES.

IP: Ibane Abasolo Olaortua
Collaborators: Joaquin Seras Franzoso, Guillem Pintos Morell, Zamira Vanessa Diaz Riascos, Simon Schwartz Navarro, Julia German Cortes, Angels Alcina Mila
Funding agency: EUROPEAN COMMISSION
Funding: 457250
Reference: MIMIC-KEY_H2020-FETPROACT-2020
Duration: 01/06/2021 - 31/05/2025

EVERETT: Engineered mesenchymal stromal cell Extracellular Vesicles for immunomodulatory biotherapy and Enzyme REplacemenT Therapy

IP: Ibane Abasolo Olaortua
Collaborators: -
Funding agency: Agence Nationale de la Recherche
Funding: 0.01
Reference: EVERETT_ANR-BIOPNSE2020
Duration: 01/11/2022 - 31/10/2025

Publications

Electronic health records (EHRs) in clinical research and platform trials: application of the innovative EHR-based methods developed by EU-PEARL.

PMID: 38000766
Journal: JOURNAL OF BIOMEDICAL INFORMATICS
Year: 2023
Reference: J Biomed Inform. 2023 Nov 22:104553. doi: 10.1016/j.jbi.2023.104553.
Impact factor:
Publication type: Paper in international publication
Authors: Amasi-Hartoonian, Nare; Ammour, Nadir; Begum, Amina; Blanco, Albert; Brown, Mollie; Comas, Immaculada; Conesa, Laura; Couvert, Camille; Diaz-Troyano, Noelia; Didden, Eva-Maria et al.
DOI: 10.1016/j.jbi.2023.104553

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability: Insights from McArdle disease.

PMID: 38030066
Journal:
Year: 2023
Reference: J Sport Health Sci. 2023 Nov 27:S2095-2546(23)00115-1. doi: 10.1016/j.jshs.2023.11.006.
Impact factor:
Publication type: Paper in international publication
Authors: Alejo, Lidia B; Barranco-Gil, David; Bestard, Oriol; Bustos, Asuncion; Castellote-Belles, Laura; Couzi, Lionel; Fernandez-Ruiz, Mario; Ferrer-Costa, Roser; Kaminski, Hannah; Lucia, Alejandro et al.
DOI: 10.1016/j.jshs.2023.11.006

Postoperative complications after pancreatoduodenectomy for malignancy: results from the Recurrence After Whipple's (RAW) study.

PMID: 38036696
Journal: BJS Open
Year: 2023
Reference: BJS Open. 2023 Nov 1;7(6):zrad106. doi: 10.1093/bjsopen/zrad106.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Sarrieh, Bilal A; Alejo, Lidia B; Alhaboob, Nassir; Aroori, Somaiah; Ausania, Fabio; Bari, Hassaan; Barranco-Gil, David; Bhogal, Ricky H; Bustos, Asuncion; Castellote-Belles, Laura et al.
DOI: 10.1093/bjsopen/zrad106

Prevalence and Risk Factors of MASLD and Liver Fibrosis amongst the Penitentiary Population in Catalonia: The PRISONAFLD Study.

PMID: 38068330
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Nov 24;12(23):7276. doi: 10.3390/jcm12237276.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Guerrero, Rafael A; Jimenez-Masip, Alba; Marco, Andres; Munoz-Martinez, Sergio; On Behalf Of The Prisonafld Study Group Collaborators; Pericas, Juan M; Rivera-Esteban, Jesus et al.
DOI: 10.3390/jcm12237276

Blog

News

Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.