About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches.
IP: Alvaro Cobo Calvo Collaborators: - Funding agency: Fondation ARSEP Funding: 20000 Reference: MULTI-MOGAD/ARSEP/2022 Duration: 15/12/2022 - 14/01/2024
IP: Xavier Montalban Gairín Collaborators: Ana Isabel Guerrero Perez, Carlos Nos Llopis, Sunny Malhotra Sareen, José Ant. Graells Salvador, Jaume Sastre Garriga, Jordi Rio Izquierdo, Ingrid Galán Cartaña, Rosalia Horno Ocaña, Manuel Comabella Lopez, Andrea Serrano Mascarós, Margarida Capell Maymo, Samuel Sánchez Pous, Elisenda Anglada Clofent, Montserrat Aroca Alsina, SGR-Cat 2021: Neuroimmunologia Clínica, Sergio Cabello, Carmen Tur Gomez, Gabriel Ig Camiña Rodríguez, Herena Eixarch Ahufinger, Carme Santoyo Medina, Oriol Nualart Mundo, Mar Tintore Subirana, M Jesus Arevalo Navines, Edwin Roger Meza Murillo, Augusto Cesar Sao Aviles, Miguel Angel Robles Sanchez, Dunia Muñoz Valdivielso, Carmen Espejo Ruiz, Marta Rodríguez Barranco, Gaizka Loyola Sanmillan, Mireia Resina Salles, Angela Vidal Jordana, Lucía Gutiérrez Ruiz, Ana Zabalza de Torres, Sergio Vergara Ruiz, Javier Villacieros Álvarez, Rafael Garcia Merida, Maria Arantza Dema Etxezarreta, Luciana Midaglia Fernandez, Alvaro Cobo Calvo, Neus Mongay Ochoa, Joaquin Castillo Justribo, Milagros Fraga Pereira, Breogan Rodriguez Acevedo, SGR-Cat 2021: Neuroimmunologia Clínica, Mireia Castillo Juarez, Rucsanda Pinteac, Nicolás Miguel Fissolo Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00782 Duration: 01/01/2022 - 30/06/2025
IP: Manuel Comabella Lopez Collaborators: Ana Zabalza de Torres, Miriam Izquierdo Sans Funding agency: Instituto de Salud Carlos III Funding: 65000 Reference: CM22/00237 Duration: 10/03/2023 - 09/03/2025
IP: Mar Tintore Subirana Collaborators: Miriam Izquierdo Sans, Andreu Vilaseca Jolonch Funding agency: Instituto de Salud Carlos III Funding: 65000 Reference: CM22/00247 Duration: 01/03/2023 - 28/02/2025
PMID: 37447866 Journal: SENSORS Year: 2023 Reference: Sensors (Basel). 2023 Jun 29;23(13):6017. doi: 10.3390/s23136017. Impact factor: Publication type: Paper in international publication Authors: Bailon, Raquel; Buron, Mathias Due; Comi, Giancarlo; Costa, Gloria Dalla; Cummins, Nicholas; Dobson, Richard J B; Garcia, Esther; Guerrero, Ana Isabel; Hotopf, Matthew; Kontaxis, Spyridon et al. DOI: 10.3390/s23136017
PMID: 37468284 Journal: NEUROLOGY Year: 2023 Reference: Neurology. 2023 Jul 19:10.1212/WNL.0000000000207664. doi: 10.1212/WNL.0000000000207664. Impact factor: Publication type: Paper in international publication Authors: Alvarez, Javier Villacieros; Arrambide, Georgina; Auger, Cristina; Carbonell-Mirabent, Pere; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Galan, Ingrid; Midaglia, Luciana Soledad; Mongay, Neus et al. DOI: 10.1212/WNL.0000000000207664
PMID: 37490262 Journal: Clinical & Translational Oncology Year: 2023 Reference: Clin Transl Oncol. 2023 Jul 25. doi: 10.1007/s12094-023-03262-x. Impact factor: Publication type: Paper in international publication Authors: Cobo, Manuel; Conde, Esther; Corral, Jesus; de Castro, Javier; Felip, Enriqueta; Garrido, Pilar; Gil-Moncayo, Francisco; Isla, Dolores; Majem, Margarita; Mezquita, Laura et al. DOI: 10.1007/s12094-023-03262-x
PMID: 37485841 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2023 Reference: Eur J Neurol. 2023 Jul 24. doi: 10.1111/ene.15988. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Bravo, G; Hauser, S L; Laguillo, G; Miguela, A; Montalban, X; Puig-Casadevall, M; Quiroga Varela, A; Ramio-Torrenta, Ll; Robles-Cedeno, R; Sanchez, L et al. DOI: 10.1111/ene.15988
PMID: 35158476 Journal: Multiple Sclerosis and Related Disorders Year: 2022 Reference: Mult Scler Relat Disord. 2022 Jan;57:103385. doi: 10.1016/j.msard.2021.103385. Epub 2021 Nov 9. Impact factor: 4.339 Publication type: Paper in international publication Authors: Hupperts, Raymond; Langdon, Dawn; Solari, Alessandra; Piehl, Fredrik; Lechner-Scott, Jeannette; Montalban, Xavier; Selmaj, Krzysztof; Valis, Martin; Rejdak, Konrad; Havrdova, Eva K et al. DOI: 10.1016/j.msard.2021.103385
PMID: 35747540 Journal: Neurology. Clinical practice Year: 2022 Reference: Neurol Clin Pract. 2022 Jun;12(3):263-269. doi: 10.1212/CPJ.0000000000001149. Impact factor: 0 Publication type: Paper in international publication Authors: Cohen, Jeffrey A; Weinshenker, Brian G; Rovira, Alex; Reich, Daniel S; Mowry, Ellen M; Makhani, Naila; Lublin, Fred D; Gaitan, Maria I; Cross, Anne H; Brownlee, Wallace et al. DOI: 10.1212/CPJ.0000000000001149
PMID: 35749034 Journal: Translational Stroke Research Year: 2022 Reference: Transl Stroke Res. 2022 Jun 24. pii: 10.1007/s12975-022-01054-z. doi: 10.1007/s12975-022-01054-z. Impact factor: 6.829 Publication type: Letter or abstract Authors: Tomasello, Alejandro; Ribo, Marc; Gil, Alberto; Li, Jiahui; Esteves, Marielle; Coscojuela, Pilar; de Dios, Marta; Pinana, Carlos; Requena, Manuel; Gramegna, Laura Ludovica et al. DOI: 10.1007/s12975-022-01054-z
PMID: 35760106 Journal: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION Year: 2022 Reference: Arch Phys Med Rehabil. 2022 Jun 24. pii: S0003-9993(22)00478-6. doi: 10.1016/j.apmr.2022.06.001. Impact factor: 3.966 Publication type: Paper in international publication Authors: Coote, Susan; Santoyo-Medina, Carme; Jonsdottir, Johanna; Kos, Daphne; Nedeljkovic, Una; Yazgan, Yonca Zenginler; Kalron, Alon; Novotna, Klara; Tacchino, Andrea; Pedulla, Ludovico et al. DOI: 10.1016/j.apmr.2022.06.001
PMID: 33327838 Journal: Multiple Sclerosis Journal Year: 2021 Reference: Mult Scler. 2021 Aug;27(9):1455-1457. doi: 10.1177/1352458520980141. Epub 2020 Dec 17. Impact factor: 6.312 Publication type: Paper in international publication Authors: Comabella, Manuel, Deutschmann, Claudia, Midaglia, Luciana, Schierack, Peter, Martinez, Julia, Roggenbuck, Dirk, Montalban, Xavier et al. DOI: 10.1177/1352458520980141
PMID: 34338742 Journal: JAMA Neurology Year: 2021 Reference: JAMA Neurol. 2021 Sep 1;78(9):1099-1107. doi: 10.1001/jamaneurol.2021.2385. Impact factor: 18.302 Publication type: Paper in international publication Authors: Requena, Manuel, Olive-Gadea, Marta, Muchada, Marian, Hernandez, David, Rubiera, Marta, Boned, Sandra, Pinana, Carlos, Deck, Matias, Garcia-Tornel, Alvaro, Diaz-Silva, Humberto et al. DOI: 10.1001/jamaneurol.2021.2385
PMID: 34293826 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2021 Reference: Eur J Neurol. 2021 Dec;28(12):4124-4134. doi: 10.1111/ene.15030. Epub 2021 Aug 5. Impact factor: 6.089 Publication type: Paper in international publication Authors: Cardenas-Robledo, Simon, Otero-Romero, Susana, Passarell-Bacardit, Maria Angels, Carbonell-Mirabent, Pere, Sastre-Garriga, Jaume, Montalban, Xavier, Tintore, Mar et al. DOI: 10.1111/ene.15030
PMID: 34273945 Journal: JOURNAL OF HEADACHE AND PAIN Year: 2021 Reference: J Headache Pain. 2021 Jul 17;22(1):75. doi: 10.1186/s10194-021-01289-5. Impact factor: 7.277 Publication type: Paper in international publication Authors: Torres-Ferrus, Marta, Pareto, Deborah, Gallardo, Victor J, Cuberas-Borros, Gemma, Alpuente, Alicia, Caronna, Edoardo, Vila-Ballo, Adria, Lorenzo-Bosquet, Carles, Castell-Conesa, Joan, Rovira, Alex et al. DOI: 10.1186/s10194-021-01289-5
PMID: 32772807 Journal: Multiple Sclerosis Journal Year: 2020 Reference: Mult Scler. 2020 Sep;26(10):1163-1171. doi: 10.1177/1352458520948231. Epub 2020 Aug 10. Impact factor: 5.412 Publication type: Paper in international publication Authors: Moss, Brandon P, Mahajan, Kedar R, Bermel, Robert A, Hellisz, Kelsey, Hua, Le H, Hudec, Timothy, Husak, Scott, McGinley, Marisa P, Ontaneda, Daniel, Wang, Zhini et al. DOI: 10.1177/1352458520948231
PMID: 31221001 Journal: Multiple Sclerosis Journal Year: 2020 Reference: Mult Scler. 2020 Aug;26(9):1074-1082. doi: 10.1177/1352458519851428. Epub 2019 Jun 21. Impact factor: 5.412 Publication type: Paper in international publication Authors: Peroni, Silvia, Sorosina, Melissa, Malhotra, Sunny, Clarelli, Ferdinando, Osiceanu, Ana Maria, Ferre, Laura, Roostaei, Tina, Rio, Jordi, Midaglia, Luciana, Villar, Luisa Maria et al. DOI: 10.1177/1352458519851428
PMID: 32715174 Journal: Journal of vascular surgery cases and innovative techniques Year: 2020 Reference: J Vasc Surg Cases Innov Tech. 2020 May 11;6(3):374-380. doi: 10.1016/j.jvscit.2020.04.006. eCollection 2020 Sep. Impact factor: 0 Publication type: Paper in international publication Authors: Lopez, Orlando, Pinana, Carlos, Gramegna, Laura Ludovica, Rodriguez, Jose, Hernandez, David, Tomasello, Alejandro et al. DOI: 10.1016/j.jvscit.2020.04.006
PMID: 32700311 Journal: REVISTA DE NEUROLOGIA Year: 2020 Reference: Rev Neurol. 2020 Aug 16;71(4):151-158. doi: 10.33588/rn.7104.2020095. Impact factor: 0.562 Publication type: Review in national publication Authors: Cardenas-Robledo, S, Otero-Romero, S, Montalban, X, Tintore, M et al. DOI: 10.33588/rn.7104.2020095
PMID: 30834955 Journal: NEURORADIOLOGY Year: 2019 Reference: Neuroradiology. 2019 Jun;61(6):667-674. doi: 10.1007/s00234-019-02191-3. Epub 2019 Mar 5. Impact factor: 2.504 Publication type: Paper in international publication Authors: Pareto, Deborah, Sastre-Garriga, Jaume, Alberich, Manel, Auger, Cristina, Tintore, Mar, Montalban, Xavier, Rovira, Alex et al. DOI: 10.1007/s00234-019-02191-3
PMID: 30555005 Journal: NeuroImage-Clinical Year: 2019 Reference: Neuroimage Clin. 2019;21:101638. doi: 10.1016/j.nicl.2018.101638. Epub 2018 Dec 10. Impact factor: 3.943 Publication type: Paper in international publication Authors: Valverde, Sergi, Salem, Mostafa, Cabezas, Mariano, Pareto, Deborah, Vilanova, Joan C, Ramio-Torrenta, Lluis, Rovira, Alex, Salvi, Joaquim, Oliver, Arnau, Llado, Xavier et al. DOI: 10.1016/j.nicl.2018.101638
PMID: 30824557 Journal: NEUROLOGY Year: 2019 Reference: Neurology. 2019 Mar 26;92(13):e1507-e1516. doi: 10.1212/WNL.0000000000007178. Epub 2019 Mar 1. Impact factor: 8.689 Publication type: Paper in international publication Authors: Comabella, Manuel, Nos, Carlos, Arevalo, Maria Jesus, Vidal-Jordana, Angela, Castillo, Joaquin, Rodriguez, Breogan, Midaglia, Luciana, Mulero, Patricia, Mitjana, Raquel, Auger, Cristina et al. DOI: 10.1212/WNL.0000000000007178
PMID: 30776698 Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY Year: 2019 Reference: Seizure. 2019 Mar;66:31-35. doi: 10.1016/j.seizure.2019.02.004. Epub 2019 Feb 8. Impact factor: 2.765 Publication type: Paper in international publication Authors: Toledo, Manuel, Sarria, Silvana, Abraira, Laura, Gramegna, Laura Ludovica, Quintana, Manuel, Santamarina, Estevo, Salas-Puig, Javier, Rovira, Alex et al. DOI: 10.1016/j.seizure.2019.02.004
PMID: 29462277 Journal: BRAIN Year: 2018 Reference: Brain. 2018 Apr 1;141(4):1075-1084. doi: 10.1093/brain/awy006. Impact factor: 10.84 Publication type: Paper in international publication Authors: Castillo, Joaquin, Vidal-Jordana, Angela, Galan, Ingrid, Nos, Carlos, Mitjana, Raquel, Mulero, Patricia, de Barros, Andrea, Rodriguez-Acevedo, Breogan, Midaglia, Luciana, Sastre-Garriga, Jaume et al. DOI: 10.1093/brain/awy006
PMID: 29452342 Journal: BRAIN Year: 2018 Reference: Brain. 2018 Apr 1;141(4):1085-1093. doi: 10.1093/brain/awy021. Impact factor: 10.84 Publication type: Paper in international publication Authors: Tintore, Mar, Sanchez, Alex, Montalban, Xavier, Comabella, Manuel, Rio, Jordi, Deisenhammer, Florian, Hegen, Harald, Quintana, Ester, Matute-Blanch, Clara, Villar, Luisa M et al. DOI: 10.1093/brain/awy021
PMID: 29400912 Journal: JOURNAL OF NEUROIMAGING Year: 2018 Reference: J Neuroimaging. 2018 May;28(3):313-319. doi: 10.1111/jon.12500. Epub 2018 Feb 5. Impact factor: 1.953 Publication type: Paper in international publication Authors: Rovira, Alex, Renom, Marta, Pareto, Deborah, Sastre-Garriga, Jaume, Alonso, Juli, Galan, Ingrid, Arevalo, Maria Jesus, Montalban, Xavier et al. DOI: 10.1111/jon.12500
PMID: 29177546 Journal: JOURNAL OF NEUROLOGY Year: 2018 Reference: J Neurol. 2018 Jan;265(1):32. doi: 10.1007/s00415-017-8679-5. Impact factor: 3.783 Publication type: Letter or abstract Authors: Alenda, Raquel, Costa-Frossard, Lucienne, Alvarez-Lafuente, Roberto, Espejo, Carmen, Rodriguez-Martin, Eulalia, Sainz de la Maza, Susana, Villarrubia, Noelia, Rio, Jordi, Dominguez-Mozo, Maria I, Alvarez-Cermeno, Jose C et al. DOI: 10.1007/s00415-017-8679-5
PMID: 27884876 Journal: AMERICAN JOURNAL OF NEURORADIOLOGY Year: 2017 Reference: AJNR Am J Neuroradiol. 2017 Feb;38(2):250-256. doi: 10.3174/ajnr.A4999. Epub 2016 Nov 24. Impact factor: 3.55 Publication type: Paper in international publication Authors: Vidal-Jordana, A, Pareto, D, Sastre-Garriga, J, Auger, C, Ciampi, E, Montalban, X, Rovira, A et al. DOI: 10.3174/ajnr.A4999
PMID: 28116817 Journal: NEUROGASTROENTEROLOGY AND MOTILITY Year: 2017 Reference: Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13031. Epub 2017 Jan 23. Impact factor: 3.617 Publication type: Paper in international publication Authors: Pribic, T, Kilpatrick, L, Ciccantelli, B, Malagelada, C, Accarino, A, Rovira, A, Pareto, D, Mayer, E, Azpiroz, F et al. DOI: 10.1111/nmo.13031
PMID: 25778697 Journal: Multiple Sclerosis Journal Year: 2015 Reference: Mult Scler. 2015 Dec;21(14):1802-10. doi: 10.1177/1352458515575338. Epub 2015 Mar 16. Impact factor: 4.822 Publication type: Paper in international publication Authors: Simon, Eva, Castillo, Joaquin, Palavra, Filipe, Mitjana, Raquel, Auger, Cristina, Rovira, Alex, Montalban, Xavier, Vidal-Jordana, Angela, Galan, Ingrid, Nos, Carlos et al. DOI: 10.1177/1352458515575338
PMID: 26185778 Journal: Neurology: Neuroimmunology & Neuroinflammation Year: 2015 Reference: Neurol Neuroimmunol Neuroinflamm. 2015 Jul 2;2(4):e132. doi: 10.1212/NXI.0000000000000132. eCollection 2015 Aug. Impact factor: Publication type: Letter or abstract Authors: Perez-Miralles, Francisco Carlos, Sastre-Garriga, Jaume, Vidal-Jordana, Angela, Rio, Jordi, Auger, Cristina, Pareto, Deborah, Tintore, Mar, Rovira, Alex, Montalban, Xavier et al. DOI: 10.1212/NXI.0000000000000132
PMID: 26204085 Journal: REVISTA DE NEUROLOGIA Year: 2015 Reference: Rev Neurol. 2015 Aug 16;61(4):145-52. Impact factor: 0.83 Publication type: Clinical guide Authors: Rio, Jordi, Gobartt, Ana L, Ramio-Torrenta, Ll, Munteis-Olivas, E, Perez-Trullen, J M, Bujanda-Alegria, M, Solar-Sanchez, D M, Menendez-Gonzalez, M, Marey-Lopez, J, Llaneza-Gonzalez, M A et al. DOI:
PMID: 26445728 Journal: Neurology: Neuroimmunology & Neuroinflammation Year: 2015 Reference: Neurol Neuroimmunol Neuroinflamm. 2015 Sep 24;2(5):e154. eCollection 2015 Oct. Impact factor: Publication type: Letter or abstract Authors: Bustamante, Marta F, Morcillo-Suarez, Carlos, Malhotra, Sunny, Rio, Jordi, Leyva, Laura, Fernandez, Oscar, Zettl, Uwe K, Killestein, Joep, Brassat, David, Garcia-Merino, Juan Antonio et al. DOI: 10.1212/NXI.0000000000000154
In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.
Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.
The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.
Simoa HD1 equipment
We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.
