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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Alba Estela García Fernández

Alba Estela García Fernández

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Albert Blanco Grau

Albert Blanco Grau

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Andrea  Arias  Garcia

Andrea Arias Garcia

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Clara Carnicer Cáceres

Clara Carnicer Cáceres

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Daniel Bravo Nieto

Daniel Bravo Nieto

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Alba Estela García Fernández

Alba Estela García Fernández

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Albert Blanco Grau

Albert Blanco Grau

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Andrea  Arias  Garcia

Andrea Arias Garcia

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Clara Carnicer Cáceres

Clara Carnicer Cáceres

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Concepció Jacobs Cachá

Concepció Jacobs Cachá

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Daniel Bravo Nieto

Daniel Bravo Nieto

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more

Projects

Malalties neurodegeneratives

IP: Miquel Vila Bover
Collaborators: Jorge Hernández Vara, Joan Compte Barrón, Marta Martínez Vicente, Jordi Bove Badell, Eddie Pradas Gracia, Maria Camprodon Gomez, Camille Guillard Sirieix, Marina Lorente Picón, Laura Castillo Ribelles, Oriol de Fabregues-Boixar Nebot, Javier Hoyo Pérez, Ariadna Laguna Tuset, Thais Cuadros Arasa, Jordi Riera Heredia, David Ramos Vicente, Marta Montpeyó Garcia-Moreno, Helena Xicoy Cortada, Alba Nicolau Vera, Marta González Sepúlveda, Joana Margalida Cladera Sastre, Annabelle Parent, Daniela Samaniego Toro
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00784
Duration: 01/01/2022 - 31/12/2024

New nanotechnological therapy for Parkinson's disease: nose-to-brain delivery of GBA-polymer nanoconjugates (NANOGBAtoBRAIN)

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Eddie Pradas Gracia, Laura Castillo Ribelles, Clara Carnicer Cáceres, David Moreno Martinez, Jordi Riera Heredia, Marta Montpeyó Garcia-Moreno, Pablo Castillo Sánchez
Funding agency: Fundació "La Caixa"
Funding: 249950
Reference: HR22-00602
Duration: 01/11/2022 - 31/10/2025

(HEPAST) - Estrategias de terapia genica para controlar la infeccion por los virus de la Hepatitis B y Delta basada en el estudio de las cuasiespecies virales por secuenciación masiva

IP: Francisco Rodríguez Frias
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 157300
Reference: PID2021-126447OB-I00
Duration: 01/09/2022 - 01/09/2025

Ministerio de Ciencia

Estudio de quasispecies por metagenómica en neuropatías asociadas a virus por secuenciación masiva de nueva generación.

IP: Josep Quer Sivila
Collaborators: Sergi Colomer Castell, Lluís Viladomiu Catà, Damir Garcia Cehic, Maria Piñana Moro, Pablo Gabriel Medina, Arnau Llauradó Gayete, Carolina Campos Martinez, Alejandra Gonzalez Sánchez
Funding agency: Instituto de Salud Carlos III
Funding: 292820
Reference: PI22/00258
Duration: 01/01/2023 - 31/12/2025

Publications

The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients.

PMID: 37183562
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2023
Reference: Eur J Neurol. 2023 May 14. doi: 10.1111/ene.15866.
Impact factor:
Publication type: Paper in international publication
Authors: Chuquisana, Omar; Comabella, Manuel; Ferrer, Roser; Fissolo, Nicolas; Gil-Varea, Elia; Giralt, Marina; Lunemann, Jan D; Malhotra, Sunny; Midaglia, Luciana; Montalban, Xavier et al.
DOI: 10.1111/ene.15866

Aluminum blood concentration in adult patients: effect of multichamber-bag versus hospital-compounded parenteral nutrition.

PMID: 37073757
Journal: Nutricion Hospitalaria
Year: 2023
Reference: Nutr Hosp. 2023 Apr 11. doi: 10.20960/nh.04436.
Impact factor:
Publication type: Paper in international publication
Authors: Albertos, Raquel; Barquin, Raquel; Berlana, David; Cea, Cristina; Lopez-Hellin, Juan; Montoro-Ronsano, J Bruno; Pau-Parra, Alba; Zabalegui, Alba et al.
DOI: 10.20960/nh.04436

Anaphylaxis.

PMID: 37833106
Journal: MEDICINA CLINICA
Year: 2023
Reference: Med Clin (Barc). 2023 Oct 11:S0025-7753(23)00552-3. doi: 10.1016/j.medcli.2023.08.010.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Andrade, Fernanda; Cardona, Victoria; Duran-Lara, Esteban F; Galvan-Blasco, Paula; Gil-Serrano, Johana; Lobos G, Olga; Rafael, Diana; Vijayakumar, Sekar et al.
DOI: 10.1016/j.medcli.2023.08.010

Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions.

PMID: 37870976
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2023
Reference: N Engl J Med. 2023 Oct 21. doi: 10.1056/NEJMoa2306441.
Impact factor:
Publication type: Paper in international publication
Authors: Agrawal, Trishala; Bhattacharya, Archan; Blanco, Ana; Boyer, Michael; Cheng, Susanna; Cho, Byoung Chul; Cruz, Xavier de la; Diez, Orland; Felip, Enriqueta; Feliubadalo, Lidia et al.
DOI: 10.1056/NEJMoa2306441

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.