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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Laura Conesa Milian

Laura Conesa Milian

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Luisa Maria Martinez Sánchez

Luisa Maria Martinez Sánchez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Carmen Sanchez  Valcarcel

Maria del Carmen Sanchez Valcarcel

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mireia Benito Jimenez

Mireia Benito Jimenez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mª Pilar Felipe Fernandez

Mª Pilar Felipe Fernandez

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mª Teresa Gené Juyent

Mª Teresa Gené Juyent

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Conesa Milian

Laura Conesa Milian

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Luisa Maria Martinez Sánchez

Luisa Maria Martinez Sánchez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria del Carmen Sanchez  Valcarcel

Maria del Carmen Sanchez Valcarcel

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mireia Benito Jimenez

Mireia Benito Jimenez

Research assistant
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mª Pilar Felipe Fernandez

Mª Pilar Felipe Fernandez

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Mª Teresa Gené Juyent

Mª Teresa Gené Juyent

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

Vehiculización de proteínas terapéuticas mediante vesículas extracelulares para el tratamiento de enfermedades huérfanas

IP: Ibane Abasolo Olaortua
Collaborators: Diego Baranda Martínez-Abasca, Miriam Izquierdo Sans
Funding agency: Ministerio de Educación, Cultura y Deporte
Funding: 59223.42
Reference: FPU20/04210
Duration: 01/12/2021 - 31/03/2025

Mejora del tratamiento de las enfermedades de depósito lisosomal mediante vehículos nanométricos optimizados

IP: Ibane Abasolo Olaortua
Collaborators: Marc Miquel Moltó Abad, Miriam Izquierdo Sans
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 90306.55
Reference: SLT017/20/000181
Duration: 05/07/2021 - 31/12/2024

Demencia mixta por Alzheimer y enfermedad cerebrovascular: un estudio clínico y experimental.

IP: Maria Pilar Delgado Martínez
Collaborators: Francesc Pujadas Navinés, Olga Maisterra Santos, Laura Castillo Ribelles, Carles Lorenzo Bosquet, Antonio Palasi Franco, Maria Belén Gutiérrez Iglesias, Jesús Pizarro Gonzálvez, Diana Liebana Gutierrez
Funding agency: Instituto de Salud Carlos III
Funding: 134310
Reference: PI19/00217
Duration: 01/01/2020 - 30/06/2024

The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies.

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies an, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Jordi Riera Heredia, Marta Montpeyó Garcia-Moreno, Daniela Samaniego Toro, Laura Castillo Ribelles, Daniela Samaniego Toro
Funding agency: Instituto de Salud Carlos III
Funding: 245932.5
Reference: PI20/00728
Duration: 01/01/2021 - 30/06/2025

Publications

Electronic health records (EHRs) in clinical research and platform trials: application of the innovative EHR-based methods developed by EU-PEARL.

PMID: 38000766
Journal: JOURNAL OF BIOMEDICAL INFORMATICS
Year: 2023
Reference: J Biomed Inform. 2023 Nov 22:104553. doi: 10.1016/j.jbi.2023.104553.
Impact factor:
Publication type: Paper in international publication
Authors: Amasi-Hartoonian, Nare; Ammour, Nadir; Begum, Amina; Blanco, Albert; Brown, Mollie; Comas, Immaculada; Conesa, Laura; Couvert, Camille; Diaz-Troyano, Noelia; Didden, Eva-Maria et al.
DOI: 10.1016/j.jbi.2023.104553

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability: Insights from McArdle disease.

PMID: 38030066
Journal:
Year: 2023
Reference: J Sport Health Sci. 2023 Nov 27:S2095-2546(23)00115-1. doi: 10.1016/j.jshs.2023.11.006.
Impact factor:
Publication type: Paper in international publication
Authors: Alejo, Lidia B; Barranco-Gil, David; Bestard, Oriol; Bustos, Asuncion; Castellote-Belles, Laura; Couzi, Lionel; Fernandez-Ruiz, Mario; Ferrer-Costa, Roser; Kaminski, Hannah; Lucia, Alejandro et al.
DOI: 10.1016/j.jshs.2023.11.006

Postoperative complications after pancreatoduodenectomy for malignancy: results from the Recurrence After Whipple's (RAW) study.

PMID: 38036696
Journal: BJS Open
Year: 2023
Reference: BJS Open. 2023 Nov 1;7(6):zrad106. doi: 10.1093/bjsopen/zrad106.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Sarrieh, Bilal A; Alejo, Lidia B; Alhaboob, Nassir; Aroori, Somaiah; Ausania, Fabio; Bari, Hassaan; Barranco-Gil, David; Bhogal, Ricky H; Bustos, Asuncion; Castellote-Belles, Laura et al.
DOI: 10.1093/bjsopen/zrad106

Prevalence and Risk Factors of MASLD and Liver Fibrosis amongst the Penitentiary Population in Catalonia: The PRISONAFLD Study.

PMID: 38068330
Journal: Journal of Clinical Medicine
Year: 2023
Reference: J Clin Med. 2023 Nov 24;12(23):7276. doi: 10.3390/jcm12237276.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Guerrero, Rafael A; Jimenez-Masip, Alba; Marco, Andres; Munoz-Martinez, Sergio; On Behalf Of The Prisonafld Study Group Collaborators; Pericas, Juan M; Rivera-Esteban, Jesus et al.
DOI: 10.3390/jcm12237276

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.