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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Noelia Díaz Troyano

Noelia Díaz Troyano

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Pablo Gabriel Medina

Pablo Gabriel Medina

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Pilar Bonet Palomares

Pilar Bonet Palomares

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Raquel  Barquin Del Pino

Raquel Barquin Del Pino

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Rosanna Paciucci Barzanti

Rosanna Paciucci Barzanti

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Yolanda Villena Ortiz

Yolanda Villena Ortiz

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Noelia Díaz Troyano

Noelia Díaz Troyano

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Pablo Gabriel Medina

Pablo Gabriel Medina

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Pilar Bonet Palomares

Pilar Bonet Palomares

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Raquel  Barquin Del Pino

Raquel Barquin Del Pino

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Rosanna Paciucci Barzanti

Rosanna Paciucci Barzanti

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Yolanda Villena Ortiz

Yolanda Villena Ortiz

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

Role of sarcopenia in the evolution of morbidly obese patients who undergo bariatric surgery. Study of cohorts and mechanisms involved.

IP: Andreea Ciudin Mihai
Collaborators: Oscar González López, Fiorella Ximena Palmas Candia, Marina Giralt Arnaiz, Marta Comas Martínez, Rosa Burgos Peláez, Irene Hernández Hernández, Enzamaría Fidilio Meli, Efráin Santiago Cordero Vázquez, Cristina Gamez Cenzano
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI20/01086
Duration: 01/01/2021 - 31/12/2024

Role of Apolipoprotein A-Ib in the idiopathic nephrotic syndrome

IP: Concepció Jacobs Cachá
Collaborators: -
Funding agency: Fundació La Marató de TV3
Funding: 199966.31
Reference: 202017/10
Duration: 30/03/2021 - 31/12/2024

MIMIC-KeY - A KEY TO THE RATIONAL DESIGN OF EXTRACELLULAR VESICLES-MIMICKING NANOPARTICLES.

IP: Ibane Abasolo Olaortua
Collaborators: Joaquin Seras Franzoso, Guillem Pintos Morell, Zamira Vanessa Diaz Riascos, Simon Schwartz Navarro
Funding agency: EUROPEAN COMMISSION
Funding: 457250
Reference: MIMIC-KEY_H2020-FETPROACT-2020
Duration: 01/06/2021 - 31/05/2025

EVERETT: Engineered mesenchymal stromal cell Extracellular Vesicles for immunomodulatory biotherapy and Enzyme REplacemenT Therapy

IP: Ibane Abasolo Olaortua
Collaborators: -
Funding agency: Agence Nationale de la Recherche
Funding: 0.01
Reference: EVERETT_ANR-BIOPNSE2020
Duration: 01/11/2022 - 31/10/2025

Publications

A new era for Advances in Laboratory Medicine.

PMID: 38075176
Journal: Advances in Laboratory Medicine
Year: 2023
Reference: Adv Lab Med. 2023 Sep 13;4(3):203-204. doi: 10.1515/almed-2023-0116. eCollection 2023 Sep.
Impact factor:
Publication type: Editorail in international publication
Authors: Arribas, Ignacio; Fernandez-Calle, Pilar; Ferrer-Costa, Roser; Gonzalez, Alvaro; Jimenez, Wladimiro et al.
DOI: 10.1515/almed-2023-0116

[Not Available].

PMID: 38075162
Journal: Advances in Laboratory Medicine
Year: 2023
Reference: Adv Lab Med. 2023 Sep 8;4(3):205-206. doi: 10.1515/almed-2023-0113. eCollection 2023 Sep.
Impact factor:
Publication type: Editorial in national publication
Authors: Arribas, Ignacio; Fernandez-Calle, Pilar; Ferrer-Costa, Roser; Gonzalez, Alvaro; Jimenez, Wladimiro et al.
DOI: 10.1515/almed-2023-0113

Community-based screening enhances hepatitis B virus linkage to care among West African migrants in Spain.

PMID: 38097770
Journal: Communications medicine
Year: 2023
Reference: Commun Med (Lond). 2023 Dec 14;3(1):182. doi: 10.1038/s43856-023-00420-8.
Impact factor:
Publication type: Paper in international publication
Authors: Araujo, Silvia G; Buti, Maria; Fernandez, Emma; Forns, Xavier; Lazarus, Jeffrey V; Lens, Sabela; MacKinnon, Marina; Martro, Elisa; Nomah, Daniel K; Nunez, Carmen Lopez et al.
DOI: 10.1038/s43856-023-00420-8

Assessing the rate of non-linkage to care and identifying barriers in individuals living with hepatitis B. Results of the LINK-B study.

PMID: 38111084
Journal: LIVER INTERNATIONAL
Year: 2023
Reference: Liver Int. 2023 Dec 18. doi: 10.1111/liv.15814.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Buti, Maria; Esteban, Rafael; Feliu-Prius, Anna; Palom, Adriana; Rando, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruiz-Cobo, Juan C; Vargas-Accarino, Elena et al.
DOI: 10.1111/liv.15814

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.