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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Team

Aurora Fernandez Polo

Aurora Fernandez Polo

Senior researcher
Infection and immunity in pediatric patients
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Laura Lopez Seguer

Laura Lopez Seguer

Research technician
Infection and immunity in pediatric patients
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Sonia Rodriguez Tello

Sonia Rodriguez Tello

Research technician
Infection and immunity in pediatric patients
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Miriam Gonzalez Amores

Miriam Gonzalez Amores

Research technician
Infection and immunity in pediatric patients
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Rello Saltor, Victoria

Rello Saltor, Victoria

Research technician
Infection and immunity in pediatric patients
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Sonia Galindo Maycas

Sonia Galindo Maycas

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Aurora Fernandez Polo

Aurora Fernandez Polo

Senior researcher
Infection and immunity in pediatric patients
Read more
Laura Lopez Seguer

Laura Lopez Seguer

Research technician
Infection and immunity in pediatric patients
Read more
Sonia Rodriguez Tello

Sonia Rodriguez Tello

Research technician
Infection and immunity in pediatric patients
Read more
Miriam Gonzalez Amores

Miriam Gonzalez Amores

Research technician
Infection and immunity in pediatric patients
Read more
Rello Saltor, Victoria

Rello Saltor, Victoria

Research technician
Infection and immunity in pediatric patients
Read more
Sonia Galindo Maycas

Sonia Galindo Maycas

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Projects

Integrating genome and transcriptome profiling for the identification of novel genetic basis of primary immunodeficiencies.

IP: Roger Colobran Oriol
Collaborators: Aina Aguiló Cucurull, Andrea Martín Nalda, Laura Batlle Masó
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI20/00761
Duration: 01/01/2021 - 30/06/2025

SARS-CoV-2 and other respiratory viruses in childhood: different approaches to define predictive models for their diagnosis and epidemiological evolution

IP: Antoni Soriano Arandes
Collaborators: Jorgina Vila Soler, Joan Balcells Ramirez, Núria Worner Tomasa, Cristina Andrés Vergés
Funding agency: Fundació La Marató de TV3
Funding: 161075
Reference: 202134
Duration: 23/09/2021 - 22/09/2024

Caracterización de Neisseria meningitidis tras la introducción de la vacuna frente al serogrupo B e identificación de factores predisponentes para la enfermedad meningocócica invasiva

IP: Juan Jose Gonzalez Lopez
Collaborators: Manuel Hernández González, Jose Angel Rodrigo Pendás, Maria Belén Viñado Perez, Aina Aguiló Cucurull, Alba Mir Cros, Albert Moreno Mingorance, Andrea Martín Nalda, Nuria Serre Delcor, Josep Roca Grande, Laura Batlle Masó
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI21/00132
Duration: 01/01/2022 - 30/06/2026

RBDCOV: RBD Dimer recombinant protein vaccine against SARSCoV2

IP: Pere Soler Palacín
Collaborators: Miriam Gonzalez Amores, Tamara Del Rio Higueras, Ariadna Martín Balcells, Amaia Latasa Arrazubi, Noemí Giménez Sanz, Olga Sánchez- Maroto Carrizo, Maria Soraya Badia Ventura
Funding agency: EUROPEAN COMMISSION
Funding: 475000
Reference: RBDCOV_HE-HLTH-CORONA2021
Duration: 01/12/2021 - 31/05/2025

Publications

Treosulfan-based conditioning regimen in pediatric hematopoietic stem cell transplantation: A retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC).

PMID: 37595686
Journal: Transplantation and cellular therapy
Year: 2023
Reference: Transplant Cell Ther. 2023 Aug 16:S2666-6367(23)01473-2. doi: 10.1016/j.jtct.2023.08.016.
Impact factor:
Publication type: Paper in international publication
Authors: Belendez, Cristina; Benitez, Isabel; Bueno, David; de Heredia, Cristina Diaz; Echecopar, Carlos; Estival, Pablo; Fuentes, Carolina; Fuster, Jose Luis; Galan, Victor; Margarit, Adriana et al.
DOI: 10.1016/j.jtct.2023.08.016

Characterization and real-live results of nebulized voriconazole: A single-center observational study.

PMID: 37612182
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia H
Year: 2023
Reference: Farm Hosp. 2023 Aug 21:S1130-6343(23)00102-2. doi: 10.1016/j.farma.2023.07.010.
Impact factor:
Publication type: Paper in national publication
Authors: Campanario, Sonia Terradas; Herrero, David Campany; Larrosa-Garcia, Maria; Parra, Alba Pau; Polo, Aurora Fernandez; Ramirez, Carme Canete et al.
DOI: 10.1016/j.farma.2023.07.010

A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors.

PMID: 37723198
Journal: Communications Biology
Year: 2023
Reference: Commun Biol. 2023 Sep 18;6(1):949. doi: 10.1038/s42003-023-05320-0.
Impact factor:
Publication type: Paper in international publication
Authors: Berlanga, Pablo; Cairo, Stefano; Calvo, Julien; Casanova, Michela; Chastagner, Pascal; Cherkaoui, Sarah; Daudigeos-Dubus, Estelle; Delattre, Olivier; Dessen, Philippe; Droit, Robin et al.
DOI: 10.1038/s42003-023-05320-0

Bartonella henselae neuroretinitis: a case report.

PMID: 37164827
Journal: Anales de pediatria
Year: 2023
Reference: An Pediatr (Engl Ed). 2023 May 8:S2341-2879(23)00097-2. doi: 10.1016/j.anpede.2023.04.006.
Impact factor:
Publication type: Paper in international publication
Authors: Martin Begue, Nieves; Melendo Perez, Susana; Mirabet Mas, Julia; Morell Daniel, Mariona et al.
DOI: 10.1016/j.anpede.2023.04.006

Common Variable Immunodeficiency and Neurodevelopmental Delay Due to a 13Mb Deletion on Chromosome 4 Including the NFKB1 Gene: A Case Report.

PMID: 35784294
Journal: Frontiers in Immunology
Year: 2022
Reference: Front Immunol. 2022 Jun 17;13:897975. doi: 10.3389/fimmu.2022.897975. eCollection 2022.
Impact factor: 7.561
Publication type: Letter or abstract
Authors: Valenzuela, Irene; Franco-Jarava, Clara; Colobran, Roger; Batlle-Maso, Laura; Castells, Neus; Dieli-Crimi, Romina; Martinez-Gallo, Monica; Garcia-Prat, Marina; Riviere, Jacques G; Soler-Palacin, Pere et al.
DOI: 10.3389/fimmu.2022.897975

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.

PMID: 35708626
Journal: JOURNAL OF EXPERIMENTAL MEDICINE
Year: 2022
Reference: J Exp Med. 2022 Aug 1;219(8). pii: 213287. doi: 10.1084/jem.20220131. Epub 2022 Jun 16.
Impact factor: 14.307
Publication type: Paper in international publication
Authors: El Baghdadi, Jamila, Bohlen, Jonathan, Liu, Zhiyong, Moncada-Velez, Marcela, Kendir-Demirkol, Yasemin, Jing, Huie, Bizien, Lucy, Marchal, Astrid, Abolhassani, Hassan, Delafontaine, Selket et al.
DOI: 10.1084/jem.20220131

The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.

PMID: 35043109
Journal:
Year: 2022
Reference: Res Sq. 2022 Jan 14. doi: 10.21203/rs.3.rs-1225906/v1.
Impact factor: 0
Publication type: Letter or abstract
Authors: Riviere, Jacques G, Garcia-Prat, Marina, Parra-Martinez, Alba, Soler-Palacin, Pere et al.
DOI: 10.21203/rs.3.rs-1225906/v1

Impact of JAK Inhibitors in Pediatric Patients with STAT1 Gain of Function (GOF) Mutations-10 Children and Review of the Literature.

PMID: 35486339
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Clin Immunol. 2022 Apr 29. pii: 10.1007/s10875-022-01257-x. doi: 10.1007/s10875-022-01257-x.
Impact factor: 8.317
Publication type: Paper in international publication
Authors: Martin-Nalda, Andrea, Alsina, Laia, Neth, Olaf, Olbrich, Peter, Martinez Pomar, Natalia, Lopez-Corbeto, Mireia, Garcia-Garcia, Ana, Kanderova, Veronika, Deya-Martinez, Angela, Riviere, Jaques G et al.
DOI: 10.1007/s10875-022-01257-x

Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down Syndrome.

PMID: 34089457
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2021
Reference: J Clin Immunol. 2021 Oct;41(7):1457-1462. doi: 10.1007/s10875-021-01078-4. Epub 2021 Jun 5.
Impact factor: 8.317
Publication type: Paper in international publication
Authors: Riviere, Jacques G, Malle, Louise, Bastard, Paul, Martin-Nalda, Andrea, Carpenter, Taya, Bush, Douglas, Patel, Roosheel, Colobran, Roger, Soler-Palacin, Pere, Casanova, Jean-Laurent et al.
DOI: 10.1007/s10875-021-01078-4

[SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance].

PMID: 33775582
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Jan 27. pii: S1695-4033(21)00012-6. doi: 10.1016/j.anpedi.2021.01.006.
Impact factor: 1.5
Publication type: Letter whit IF
Authors: Bassets-Bosch, Alba, Raya-Munoz, Judith, Worner-Tomasa, Nuria, Melendo-Perez, Susana, Gonzalez-Peris, Sebastia et al.
DOI: 10.1016/j.anpedi.2021.01.006

Prescription quality of prolonged antibiotherapy in pediatrics. Impact of ASP program interventions.

PMID: 32229130
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2021
Reference: Enferm Infecc Microbiol Clin. 2021 Mar;39(3):134-138. doi: 10.1016/j.eimc.2020.02.015. Epub 2020 Mar 27.
Impact factor: 1.731
Publication type: Paper in national publication
Authors: Melendo, Susana, Fernandez-Polo, Aurora, Castellnou Asens, Ivette, Mendoza-Palomar, Natalia, Barnes-Mayolas, Meritxell, Soler-Palacin, Pere, Soler Palacin, Pere, Melendo Perez, Susana, Mendoza Palomar, Natalia, Nieves Larrosa Escartin, M et al.
DOI: 10.1016/j.eimc.2020.02.015

Failure of Viral-Specific T Cells Administered in Pre-transplant Settings in Children with Inborn Errors of Immunity.

PMID: 33462728
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2021
Reference: J Clin Immunol. 2021 May;41(4):748-755. doi: 10.1007/s10875-020-00961-w. Epub 2021 Jan 18.
Impact factor: 8.317
Publication type: Paper in international publication
Authors: Alonso, Laura, Mendez-Echevarria, Ana, Rudilla, Francesc, Mozo, Yasmina, Soler-Palacin, Pere, Sisinni, Luisa, Bueno, David, Riviere, Jacques, de Paz, Raquel, Sanchez-Zapardiel, Elena et al.
DOI: 10.1007/s10875-020-00961-w

Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score.

PMID: 31887391
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Allergy Clin Immunol. 2020 May;145(5):1452-1463. doi: 10.1016/j.jaci.2019.12.896. Epub 2019 Dec 27.
Impact factor: 10.228
Publication type: Paper in international publication
Authors: Tesch, Victoria Katharina, Abolhassani, Hassan, Shadur, Bella, Zobel, Joachim, Mareika, Yuliya, Sharapova, Svetlana, Karakoc-Aydiner, Elif, Riviere, Jacques G, Garcia-Prat, Marina, Moes, Nicolette et al.
DOI: 10.1016/j.jaci.2019.12.896

Low-dose liposomal amphotericin B for antifungal prophylaxis in paediatric allogeneic haematopoietic stem cell transplantation.

PMID: 32335674
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2020
Reference: J Antimicrob Chemother. 2020 Aug 1;75(8):2264-2271. doi: 10.1093/jac/dkaa149.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: Mendoza-Palomar, Natalia, Soques, Elena, Benitez-Carabante, Maria Isabel, Gonzalez-Amores, Miriam, Fernandez-Polo, Aurora, Renedo, Berta, Martin, Maria Teresa, Soler-Palacin, Pere, Diaz-de-Heredia, Cristina et al.
DOI: 10.1093/jac/dkaa149

Health-Related Quality of Life and Multidimensional Fatigue Scale in Children with Primary Immunodeficiencies.

PMID: 32291562
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Clin Immunol. 2020 May;40(4):602-609. doi: 10.1007/s10875-020-00775-w. Epub 2020 Apr 15.
Impact factor: 6.78
Publication type: Paper in international publication
Authors: Ridao-Manonellas, Saida, Fabregas-Bofill, Anna, Nunez-Rueda, Gloria, Gonzalez-Amores, Miriam, Garcia-Prat, Marina, Lopez-Seguer, Laura, Riviere, Jacques G, Martin-Nalda, Andrea, Mendoza-Palomar, Natalia, Melendo-Perez, Susana et al.
DOI: 10.1007/s10875-020-00775-w

The IL2RG R328X nonsense mutation allows partial STAT5 phosphorylation and defines a critical region involved in leaky-SCID phenotype.

PMID: 31799703
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2020
Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19.
Impact factor: 3.532
Publication type: Paper in international publication
Authors: Alonso, Laura, Riviere, Jacques G, Soler-Palacin, Pere, Colobran, Roger, Sayos, Joan, Martinez-Gallo, Monica, Franco-Jarava, Clara, Ossowski, Stephan, Drechsel, Oliver, Magallon-Lorenz, Miriam et al.
DOI: 10.1111/cei.13405

Blog

News

On European Antibiotic Awareness Day, we highlight the importance of using these medications responsibly and finding innovative solutions to combat this issue.

This appointment is an international recognition of VHIR's immunodeficiency research.

So far, 240 volunteers have been recruited within all the centres set to join adolescents’ clinical trial (named HH3) to test the efficacy, tolerability, and safety of the BIMERVAX® COVID-19 vaccine in adolescents aged 12 to 17.