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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

Whole-genome sequencing reveals host factors underlying critical COVID-19.

PMID: 35255492
Journal: NATURE
Year: 2022
Reference: Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7.
Impact factor: 49.962
Publication type: Paper in international publication
Authors: Tsinaslanidis, George; Birkinshaw, Isobel; Carter, Joseph; Howard, Kate; Ingham, Joanne; Joy, Rosie; Pearson, Harriet; Roche, Samantha; Scott, Zoe; Bancroft, Hollie et al.
DOI: 10.1038/s41586-022-04576-6

Impact of vaccinating pregnant women against pertussis on hospitalizations of children under one year of age in a tertiary hospital in Catalonia.

PMID: 35752569
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2022
Reference: Enferm Infecc Microbiol Clin (Engl Ed). 2022 Jun 22. pii: S2529-993X(22)00132-0. doi: 10.1016/j.eimce.2022.06.002.
Impact factor: 1.731
Publication type: Paper in international publication
Authors: Ruiz-Botia, Irene; Riera-Bosch, M Teresa; Rodriguez-Losada, Olalla; Soler-Palacin, Pere; Melendo, Susana; Moraga-Llop, Fernando; Balcells-Ramirez, Joan; Otero-Romero, Susana; Armadans-Gil, Lluis et al.
DOI: 10.1016/j.eimce.2022.06.002

Comparison of pneumonia features in children caused by SARS-CoV-2 and other viral respiratory pathogens.

PMID: 35754093
Journal: PEDIATRIC PULMONOLOGY
Year: 2022
Reference: Pediatr Pulmonol. 2022 Jun 26. doi: 10.1002/ppul.26042.
Impact factor: 3.039
Publication type: Paper in international publication
Authors: Mesa, Juan Miguel; Dominguez-Rodriguez, Sara; Moraleda, Cinta; Tagarro, Alfredo; Rodriguez, Maria Jose; Galan, Juan Carlos; Barrios, Ana; Del Valle-Perez, Rut; Ballesteros, Alvaro; Calvo, Cristina et al.
DOI: 10.1002/ppul.26042

Headache and Vomiting in an 8-Year-Old Girl.

PMID: 35766460
Journal: CLINICAL PEDIATRICS
Year: 2022
Reference: Clin Pediatr (Phila). 2022 Jun 29:99228221106429. doi: 10.1177/00099228221106429.
Impact factor: 1.168
Publication type: Paper in international publication
Authors: Erika, Arno; Alfons, Macaya; Ignacio, Delgado-Alvarez; Ana, Felipe-Rucian; Jorgina, Vila; Duna, Casadesus-Cabral et al.
DOI: 10.1177/00099228221106429

Influenza-Associated Disseminated Aspergillosis in a 9-Year-Old Girl Requiring ECMO Support.

PMID: 34575764
Journal: Journal of Fungi
Year: 2021
Reference: J Fungi (Basel). 2021 Sep 5;7(9). pii: jof7090726. doi: 10.3390/jof7090726.
Impact factor: 5.816
Publication type: Letter or abstract
Authors: Velasco-Nuno, Monica, Mendoza-Palomar, Natalia, Melendo-Perez, Susana, Balcells, Joan, Izquierdo-Blasco, Jaume, Martin-Gomez, Maria Teresa, Soler-Palacin, Pere, Riviere, Jacques G et al.
DOI: 10.3390/jof7090726

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

PMID: 34413140
Journal: Science Immunology
Year: 2021
Reference: Sci Immunol. 2021 Aug 19;6(62). pii: 6/62/eabl4348. doi: 10.1126/sciimmunol.abl4348.
Impact factor: 17.727
Publication type: Paper in international publication
Authors: Morelle, Guillaume, Asano, Takaki, Boisson, Bertrand, Onodi, Fanny, Shahrooei, Mohammad, Darazam, Ilad Alavi, Olyaei, Nasrin Alipour, Mansouri, Davood, Hatipoglu, Nevin, Palabiyik, Figen et al.
DOI: 10.1126/sciimmunol.abl4348

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

PMID: 34413139
Journal: Science Immunology
Year: 2021
Reference: Sci Immunol. 2021 Aug 19;6(62). pii: 6/62/eabl4340. doi: 10.1126/sciimmunol.abl4340.
Impact factor: 17.727
Publication type: Paper in international publication
Authors: Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jeremie, Philippot, Quentin, Manry, Jeremy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina et al.
DOI: 10.1126/sciimmunol.abl4340

Newborn Screening for SCID. Experience in Spain (Catalonia).

PMID: 34294672
Journal: International journal of neonatal screening
Year: 2021
Reference: Int J Neonatal Screen. 2021 Jul 20;7(3). pii: ijns7030046. doi: 10.3390/ijns7030046.
Impact factor: 0
Publication type: Paper in international publication
Authors: Argudo-Ramirez, Ana, Martin-Nalda, Andrea, Gonzalez de Aledo-Castillo, Jose Manuel, Lopez-Galera, Rosa, Marin-Soria, Jose Luis, Pajares-Garcia, Sonia, Martinez-Gallo, Monica, Garcia-Prat, Marina, Colobran, Roger, Riviere, Jacques G et al.
DOI: 10.3390/ijns7030046

Blog

News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.