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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

Management of Hospitalized Respiratory Syncytial Virus Bronchiolitis in the Pediatric Ward in Spain: Assessing the Impact of a New Clinical Practice Protocol.

PMID: 34936054
Journal: PEDIATRIC DRUGS
Year: 2022
Reference: Paediatr Drugs. 2022 Jan;24(1):63-71. doi: 10.1007/s40272-021-00488-6. Epub 2021 Dec 22.
Impact factor:
Publication type: Paper in international publication
Authors: Andres, Cristina; Anton, Andres; Barcelo, Irene; Lera, Esther; Martinez, Laia; Peremiquel-Trillas, Paula; Rodrigo, Carlos; Rodrigo-Pendas, Jose Angel; Vila, Jorgina et al.
DOI: 10.1007/s40272-021-00488-6

International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome.

PMID: 34033842
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Allergy Clin Immunol. 2022 Jan;149(1):410-421.e7. doi: 10.1016/j.jaci.2021.04.036. Epub 2021 May 24.
Impact factor:
Publication type: Paper in international publication
Authors: Abolhassani, Hassan; Aghamohammadi, Asghar; Bayer, Diana K; Bleesing, Jacob J; Bonfim, Carmem; Carpenter, Benjamin; Dara, Jasmeen; Dimitrova, Dimana; Duffner, Ulrich; Dvorak, Christopher C et al.
DOI: 10.1016/j.jaci.2021.04.036

Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.

PMID: 33991581
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2022
Reference: J Allergy Clin Immunol. 2022 Jan;149(1):369-378. doi: 10.1016/j.jaci.2021.04.033. Epub 2021 May 12.
Impact factor:
Publication type: Paper in international publication
Authors: Aeschlimann, Florence A; Bader-Meunier, Brigitte; Bakhtiar, Shahrzad; Bal, Sevgi Kostel; Bock, Christoph; Boztug, Kaan; Briggs, Tracy A; Brogan, Paul; Burns, Siobhan; Caorsi, Roberta et al.
DOI: 10.1016/j.jaci.2021.04.033

Children living with HIV in Europe: do migrants have worse treatment outcomes?

PMID: 34596323
Journal: HIV MEDICINE
Year: 2022
Reference: HIV Med. 2022 Feb;23(2):186-196. doi: 10.1111/hiv.13177. Epub 2021 Oct 1.
Impact factor:
Publication type: Paper in international publication
Authors: Abou-Rayyah, M; Aebi-Popp, K; Ait Benali, Fazia; Ait Si Selmi, Lamya; Alfayate, Santiago; Allodi, Alessandra; Alvarez, Cristina; Anagnostopoulos, A; Anastasio, Elisa; Angel Roa, Miguel et al.
DOI: 10.1111/hiv.13177

Overview of STING-associated vasculopathy with onset in infancy (SAVI) among 21 patients.

PMID: 33217613
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2021
Reference: J Allergy Clin Immunol Pract. 2021 Feb;9(2):803-818.e11. doi: 10.1016/j.jaip.2020.11.007. Epub 2020 Nov 18.
Impact factor:
Publication type: Paper in international publication
Authors: Bader-Meunier, Brigitte; Barnabei, Laura; Belot, Alexandre; Berteloot, Laureline; Blanche, Stephane; Bondet, Vincent; Bresson, Violaine; Breton, Sylvain; Brocq, Olivier; Chan, Damien et al.
DOI: 10.1016/j.jaip.2020.11.007

Severe COVID-19 during pregnancy and the subsequent premature delivery.

PMID: 33039313
Journal: Pediatrics and Neonatology
Year: 2021
Reference: Pediatr Neonatol. 2021 Jan;62(1):113-114. doi: 10.1016/j.pedneo.2020.09.005. Epub 2020 Sep 19.
Impact factor:
Publication type: Paper in international publication
Authors: Camba-Longueira, Fatima; Castillo-Salinas, Felix; Fernandez-Garcia, Cristina; Frick, Marie Antoinette; Hernandez-Perez, Susana; Montaner-Ramon, Alicia; Ribes-Bautista, Carmen et al.
DOI: 10.1016/j.pedneo.2020.09.005

Antifungal stewardship in a tertiary care paediatric hospital: the PROAFUNGI study.

PMID: 33482749
Journal: BMC INFECTIOUS DISEASES
Year: 2021
Reference: BMC Infect Dis. 2021 Jan 22;21(1):100. doi: 10.1186/s12879-021-05774-9.
Impact factor:
Publication type: Paper in international publication
Authors: Fernandez-Polo, Aurora; Garcia-Palop, Beatriz; Martin, Maria Teresa; Melendo, Susana; Mendoza-Palomar, Natalia; Renedo-Miro, Berta; Soler-Palacin, Pere et al.
DOI: 10.1186/s12879-021-05774-9

Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19).

PMID: 33482757
Journal: BMC Pregnancy and Childbirth
Year: 2021
Reference: BMC Pregnancy Childbirth. 2021 Jan 22;21(1):78. doi: 10.1186/s12884-021-03572-4.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Anton, Andres; Arevalo, Silvia; Barranco, Francisco Jose; Camba, Fatima; Camba, Fatima; Carbonell, Melchor; Carbonell, Melchor; Carreras, Elena; Carreras, Elena et al.
DOI: 10.1186/s12884-021-03572-4

Health-Related Quality of Life and Multidimensional Fatigue Scale in Children with Primary Immunodeficiencies.

PMID: 32291562
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Clin Immunol. 2020 May;40(4):602-609. doi: 10.1007/s10875-020-00775-w. Epub 2020 Apr 15.
Impact factor: 6.78
Publication type: Paper in international publication
Authors: Ridao-Manonellas, Saida, Fabregas-Bofill, Anna, Nunez-Rueda, Gloria, Gonzalez-Amores, Miriam, Garcia-Prat, Marina, Lopez-Seguer, Laura, Riviere, Jacques G, Martin-Nalda, Andrea, Mendoza-Palomar, Natalia, Melendo-Perez, Susana et al.
DOI: 10.1007/s10875-020-00775-w

The IL2RG R328X nonsense mutation allows partial STAT5 phosphorylation and defines a critical region involved in leaky-SCID phenotype.

PMID: 31799703
Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Year: 2020
Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19.
Impact factor: 3.532
Publication type: Paper in international publication
Authors: Alonso, Laura, Riviere, Jacques G, Soler-Palacin, Pere, Colobran, Roger, Sayos, Joan, Martinez-Gallo, Monica, Franco-Jarava, Clara, Ossowski, Stephan, Drechsel, Oliver, Magallon-Lorenz, Miriam et al.
DOI: 10.1111/cei.13405

Uncovering Low-Level Maternal Gonosomal Mosaicism in X-Linked Agammaglobulinemia: Implications for Genetic Counseling.

PMID: 32117230
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Feb 12;11:46. doi: 10.3389/fimmu.2020.00046. eCollection 2020.
Impact factor: 5.085
Publication type: Paper in international publication
Authors: Riviere, Jacques G, Franco-Jarava, Clara, Martinez-Gallo, Monica, Aguilo-Cucurull, Aina, Blasco-Perez, Laura, Paramonov, Ida, Antolin, Maria, Martin-Nalda, Andrea, Soler-Palacin, Pere, Colobran, Roger et al.
DOI: 10.3389/fimmu.2020.00046

FHLdb: A Comprehensive Database on the Molecular Basis of Familial Hemophagocytic Lymphohistiocytosis.

PMID: 32076423
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Jan 31;11:107. doi: 10.3389/fimmu.2020.00107. eCollection 2020.
Impact factor: 5.085
Publication type: Paper in international publication
Authors: Vinas-Gimenez, Laura, Padilla, Natalia, Batlle-Maso, Laura, Casals, Ferran, Riviere, Jacques G, Martinez-Gallo, Monica, de la Cruz, Xavier, Colobran, Roger et al.
DOI: 10.3389/fimmu.2020.00107

Blog

News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.