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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Team

Maria Sellés Altés

Maria Sellés Altés

Research technician
Neurodegenerative Diseases
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Montse Perez Fernandez

Montse Perez Fernandez

Research technician
Neurodegenerative Diseases
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Montserrat Solé Piñol

Montserrat Solé Piñol

Postdoctoral researcher
Neurodegenerative Diseases
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Pablo Castillo Sánchez

Pablo Castillo Sánchez

Predoctoral researcher
Neurodegenerative Diseases
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Paola Monterosso

Paola Monterosso

Research technician
Neurodegenerative Diseases
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Pol Rodríguez Carreras

Pol Rodríguez Carreras

Predoctoral researcher
Neurodegenerative Diseases
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Maria Sellés Altés

Maria Sellés Altés

Research technician
Neurodegenerative Diseases
Read more
Montse Perez Fernandez

Montse Perez Fernandez

Research technician
Neurodegenerative Diseases
Read more
Montserrat Solé Piñol

Montserrat Solé Piñol

Postdoctoral researcher
Neurodegenerative Diseases
Read more
Pablo Castillo Sánchez

Pablo Castillo Sánchez

Predoctoral researcher
Neurodegenerative Diseases
Read more
Paola Monterosso

Paola Monterosso

Research technician
Neurodegenerative Diseases
Read more
Pol Rodríguez Carreras

Pol Rodríguez Carreras

Predoctoral researcher
Neurodegenerative Diseases
Read more

Projects

The brain-body axis in Parkinson's disease for biomarker and therapeutic development (BRAIN-BODY-PD)

IP: Ariadna Laguna Tuset
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 199998.14
Reference: CNS2023-145555
Duration: 01/04/2024 - 31/03/2026

Ministerio de Ciencia

Red de Investigación MitoNED: (Dis)función mitocondrial en enfermedades neurodegenerativas

IP: Miquel Vila Bover
Collaborators: -
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 0.01
Reference: RED2022-134786-T
Duration: 01/06/2023 - 31/05/2025

Ministerio de Ciencia

New nanotechnological therapy for Parkinson ?s disease: nose to brain delivery of GBA-polymer nanoconjugates

IP: Marta Martínez Vicente
Collaborators: Pablo Castillo Sánchez, Laia Perez Lasarte
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 73383.97
Reference: AGAUR/FI/2023/CASTILLO
Duration: 01/06/2023 - 31/05/2026

Peripheral synucleinopathy: pathogenicity and modulation of propagation

IP: Ariadna Laguna Tuset
Collaborators: -
Funding agency: Parkinson's Foundation
Funding: 54466.62
Reference: PARKINSON.F_IMPACT2022
Duration: 01/07/2022 - 31/07/2025

Blog

News

This VHIR initiative promotes well-being, empathy and community participation in Barcelona neighbourhoods through an intergenerational model

PAIR is an intergenerational initiative with people affected by Parkinson's disease and adolescents.

The nomination recognises the work she has led together with Dr. Núria Peñuelas and Dr. Miquel Vila, on the generation of new preclinical models to study Parkinson's disease.

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study