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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Team

Annabelle Parent

Annabelle Parent

Research technician
Neurodegenerative Diseases
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Gerard Roch Alba

Gerard Roch Alba

Predoctoral researcher
Neurodegenerative Diseases
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Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
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Joana Margalida Cladera  Sastre

Joana Margalida Cladera Sastre

Research technician
Neurodegenerative Diseases
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Johanna Andrea Folleco Eraso

Johanna Andrea Folleco Eraso

Predoctoral researcher
Neurodegenerative Diseases
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Jorge Hernández Vara

Jorge Hernández Vara

Main researcher
Neurodegenerative Diseases
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Annabelle Parent

Annabelle Parent

Research technician
Neurodegenerative Diseases
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Gerard Roch Alba

Gerard Roch Alba

Predoctoral researcher
Neurodegenerative Diseases
Read more
Javier Hoyo Pérez

Javier Hoyo Pérez

Administration and Management
Neurodegenerative Diseases
Read more
Joana Margalida Cladera  Sastre

Joana Margalida Cladera Sastre

Research technician
Neurodegenerative Diseases
Read more
Johanna Andrea Folleco Eraso

Johanna Andrea Folleco Eraso

Predoctoral researcher
Neurodegenerative Diseases
Read more
Jorge Hernández Vara

Jorge Hernández Vara

Main researcher
Neurodegenerative Diseases
Read more

Projects

New nanotechnological therapy for Parkinson's disease: nose-to-brain delivery of GBA-polymer nanoconjugates (NANOGBAtoBRAIN)

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Eddie Pradas Gracia, Laura Castillo Ribelles, Clara Carnicer Cáceres, David Moreno Martinez, Pablo Castillo Sánchez
Funding agency: Fundació "La Caixa"
Funding: 249950
Reference: HR22-00602
Duration: 01/11/2022 - 31/10/2025

DECISION ON OPTIMAL COMBINATORIAL THERAPIES IN IMIDS USING SYSTEMS APPROACHES (DOCTIS)

IP: Sara Marsal Barril
Collaborators: Antonio Julia Cano, Javier Hoyo Pérez, Elena Granell Pallares, Adria Aterido Ballonga, Montse Sender Beleta, Nuria Palau Balaña, Edgar Nuñez Gallardo, Raul Tortosa Mendez, M Alba ERRA DURAN
Funding agency: EUROPEAN COMMISSION
Funding: 1079085
Reference: DOCTIS_H2020_SC1-BHC2019
Duration: 01/01/2020 - 31/12/2025

The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies and therapies.

IP: Marta Martínez Vicente
Collaborators: José Antonio Arranz Amo, Jorge Hernández Vara, Eddie Pradas Gracia, Guillem Pintos Morell, Clara Carnicer Cáceres, Carles Lorenzo Bosquet, David Moreno Martinez, Daniela Samaniego Toro, Laura Castillo Ribelles, The Vall d’Hebron Iniciative for Parkinson associated to GBA (VHIP-GBA): from biospecimen collection to translational studies an
Funding agency: Instituto de Salud Carlos III
Funding: 245932.5
Reference: PI20/00728
Duration: 01/01/2021 - 30/06/2025

Characterization of the CD8 T cell response in Parkinson’s disease for the development of preventive and therapeutic strategies that halt the progression of the disease: SARS-Cov-2-induced long term-hyposmia as a possible prodromal stage

IP: Jordi Bove Badell
Collaborators: Miquel Vila Bover, Alejandro Ferré Masó, Oriol de Fabregues-Boixar Nebot, Carles Lorenzo Bosquet, Antonio Palasi Franco, Maria Sellés Altés
Funding agency: Instituto de Salud Carlos III
Funding: 165770
Reference: PI21/01358
Duration: 01/01/2022 - 30/06/2026

Blog

News

This VHIR initiative promotes well-being, empathy and community participation in Barcelona neighbourhoods through an intergenerational model

PAIR is an intergenerational initiative with people affected by Parkinson's disease and adolescents.

The nomination recognises the work she has led together with Dr. Núria Peñuelas and Dr. Miquel Vila, on the generation of new preclinical models to study Parkinson's disease.

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study