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Ophtalmology

The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.

We have a research program for the development of new therapeutic strategies based on:

  • Cell therapies
  • Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
  • Biological matrices
  • Gene therapy
  • Animal models
  • Retinal cell models based on stem cell-derived organoids.

In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.

Team

Sara Martin Nalda

Sara Martin Nalda

Ophtalmology
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Valero Dominguez, Daniel

Valero Dominguez, Daniel

Ophtalmology
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Ares Borras, Barbara

Ares Borras, Barbara

Postdoctoral researcher
Ophtalmology
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Gil Loyo, Alba

Gil Loyo, Alba

Research technician
Ophtalmology
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Maddalen Zufiaurre Seijo

Maddalen Zufiaurre Seijo

Research technician
Ophtalmology
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Pere Marc Almagro Muriana

Pere Marc Almagro Muriana

Research technician
Ophtalmology
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Sara Martin Nalda

Sara Martin Nalda

Ophtalmology
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Valero Dominguez, Daniel

Valero Dominguez, Daniel

Ophtalmology
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Ares Borras, Barbara

Ares Borras, Barbara

Postdoctoral researcher
Ophtalmology
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Gil Loyo, Alba

Gil Loyo, Alba

Research technician
Ophtalmology
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Maddalen Zufiaurre Seijo

Maddalen Zufiaurre Seijo

Research technician
Ophtalmology
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Pere Marc Almagro Muriana

Pere Marc Almagro Muriana

Research technician
Ophtalmology
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Projects

Retinal and cognitive dysfunction in type 2 diabetes: unraveling the common pathways and identification of patients at risk of dementia

IP: Rafael Simó Canonge
Collaborators: Marina Jimenez Iglesias, Cristina Hernández Pascual, Jaume Rigo Quera, Julia Vazquez de Sebastian, Queralt Martin Saladich, Helena Brosa Morros, Alejandro López Targa, Patricia Bogdanov Baruj, Gianluca Fatti , Randa Falah , Andreea Ciudin Mihai, Ferran Casals Riera
Funding agency: EUROPEAN COMMISSION
Funding: 950410
Reference: RECOGNISED_H2020SC1BHC2019
Duration: 01/01/2020 - 31/12/2024

Terapia basada en células madre asistida con nanopartículas de Ce02: un enfoque nanofarmacéutico innovador para tratar enfermedades degenerativas de la retina.

IP: Anna Duarri Piqué
Collaborators: José García Arumí, Jordi Rosell Aluja, Victor Franco Puntes, Helena Isla Magrané, Joana Ramis Garcia
Funding agency: Instituto de Salud Carlos III
Funding: 174845
Reference: AC19/00080
Duration: 01/01/2020 - 30/06/2024

Publications

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: Primary results from the phase 3 MARIPOSA-2 study.

PMID: 37879444
Journal: ANNALS OF ONCOLOGY
Year: 2023
Reference: Ann Oncol. 2023 Oct 17:S0923-7534(23)04281-3. doi: 10.1016/j.annonc.2023.10.117.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Azuma, K; Baneras, Jordi; Barala, P; Bauml, J M; Bearz, A; Boixadera, Anna; Bourla, A B; Califano, R; Campelo, R G et al.
DOI: 10.1016/j.annonc.2023.10.117

Macular Neovascularization type influence on anti-VEGF intravitreal therapy outcomes in Age-related Macular Degeneration.

PMID: 37924946
Journal: Ophthalmology. Retina
Year: 2023
Reference: Ophthalmol Retina. 2023 Nov 2:S2468-6530(23)00573-0. doi: 10.1016/j.oret.2023.10.022.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Maximino; Alforja, Socorro; Arruabarrena, Carolina; Bardia, Aditya; Barthelmes, Daniel; Bellet-Ezquerra, Meritxell; Bernal-Morales, Carolina; Bond, John W; Boni, Valentina; Broc-Iturralde, Laura et al.
DOI: 10.1016/j.oret.2023.10.022

[Not Available].

PMID: 37923065
Journal: Actas dermo-sifiliograficas
Year: 2023
Reference: Actas Dermosifiliogr. 2023 Nov 1:S0001-7310(23)00866-9. doi: 10.1016/j.ad.2023.10.032.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes Lopez-Veiga, Maximino Jose; Abraldes, Maximino; Aldazabal-Echeveste, Maialen; Alforja, Socorro; Alforja, Socorro; Alonso, Elena; Arias-Barquet, Lluis; Arruabarrena, Carolina; Arruabarrena, Carolina; Ascaso Puyuelo, Francisco Javier et al.
DOI: 10.1016/j.ad.2023.10.032

Angioid streaks and obstructive sleep apnea syndrome: are they related?

PMID: 32301031
Journal: Sleep and Breathing
Year: 2021
Reference: Sleep Breath. 2021 Mar;25(1):163-169. doi: 10.1007/s11325-020-02019-y. Epub 2020 Apr 16.
Impact factor: 2.816
Publication type: Paper in international publication
Authors: Catala-Mora, Jaume, Anton, Alfonso, Perez-Hoyos, Santiago, Carceller, Amadeu, Aparicio, Gloria, Castany-Aregall, Marta, Grau, Nuria et al.
DOI: 10.1007/s11325-020-02019-y

Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration.

PMID: 33738324
Journal: Molecular Therapy-Methods & Clinical Development
Year: 2021
Reference: Mol Ther Methods Clin Dev. 2021 Feb 10;20:688-702. doi: 10.1016/j.omtm.2021.02.006. eCollection 2021 Mar 12.
Impact factor: 6.698
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose, Veiga, Anna, Zapata, Miguel Angel, Salas, Anna, Duarri, Anna, Fontrodona, Laura, Ramirez, Diana Mora, Badia, Anna, Isla-Magrane, Helena, Ferreira-de-Souza, Barbara et al.
DOI: 10.1016/j.omtm.2021.02.006

Role of intraretinal and subretinal fluid on clinical and anatomical outcomes in patients with neovascular age-related macular degeneration treated with bimonthly, treat-and-extend and as-needed ranibizumab in the In-Eye study.

PMID: 33720541
Journal: ACTA OPHTHALMOLOGICA
Year: 2021
Reference: Acta Ophthalmol. 2021 Dec;99(8):861-870. doi: 10.1111/aos.14786. Epub 2021 Mar 15.
Impact factor: 3.761
Publication type: Paper in international publication
Authors: Galvez, Maria Isabel Lopez, Saenz-de-Viteri, Manuel, Recalde, Sergio, Fernandez-Robredo, Patricia, Lopez Galvez, Maria Isabel, Arias Barquet, Lluis, Figueroa, Marta S, Garcia-Arumi, Jose, Garcia-Layana, Alfredo, Figueroa, Marta S et al.
DOI: 10.1111/aos.14786

Uveitic macular edema response to intravitreal dexamethasone implant is independent of optical coherence tomography findings.

PMID: 33184677
Journal: INTERNATIONAL OPHTHALMOLOGY
Year: 2021
Reference: Int Ophthalmol. 2021 Mar;41(3):787-796. doi: 10.1007/s10792-020-01631-x. Epub 2020 Nov 12.
Impact factor: 2.031
Publication type: Paper in international publication
Authors: Moll-Udina, Aina, Figueras-Roca, Marc, Oliveres, Joan, Sala-Puigdollers, Anna, Esquinas, Cristina, Alba-Linero, Carmen, Llorenc, Victor, Adan, Alfredo et al.
DOI: 10.1007/s10792-020-01631-x

Inter-Ocular Asymmetry in Anterior Corneal Aberrations Using Placido Disk-Based Topography.

PMID: 32546953
Journal: Clinical ophthalmology (Auckland, N.Z.)
Year: 2020
Reference: Clin Ophthalmol. 2020 May 27;14:1451-1457. doi: 10.2147/OPTH.S255086. eCollection 2020.
Impact factor: 0
Publication type: Paper in international publication
Authors: Alzaben, Zeyad, Gammoh, Yazan, Freixas, Marta, Zaben, Ahmad, Zapata, Miguel A, Koff, Dana N et al.
DOI: 10.2147/OPTH.S255086

Retinal Vasculitis Secondary to Durvalumab.

PMID: 32508622
Journal: Case reports in ophthalmology
Year: 2020
Reference: Case Rep Ophthalmol. 2020 May 5;11(2):161-166. doi: 10.1159/000507609. eCollection 2020 May-Aug.
Impact factor: 0
Publication type: Letter or abstract
Authors: R Andrade, Antonio, Moll-Udina, Aina, Cilveti, Esther, Subira, Olaia, Disfetano, Laura, Garcia-Arumi, Jose, Martin, Ruth et al.
DOI: 10.1159/000507609

The Usefulness of Serum Biomarkers in the Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial.

PMID: 32344735
Journal: Journal of Clinical Medicine
Year: 2020
Reference: J Clin Med. 2020 Apr 24;9(4). pii: jcm9041233. doi: 10.3390/jcm9041233.
Impact factor: 3.303
Publication type: Paper in international publication
Authors: Egan, Catherine, Hernandez, Cristina, Porta, Massimo, Bandello, Francesco, Grauslund, Jakob, Harding, Simon P, Aldington, Stephen J, Gibson, Jonathan, Lang, Gabriele E, Lattanzio, Rosangela et al.
DOI: 10.3390/jcm9041233

Untitled Reply

PMID: 32349099
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2020
Reference: Retina. 2020 Aug;40(8):e38-e39. doi: 10.1097/IAE.0000000000002832.
Impact factor: 3.649
Publication type: Letter or abstract
Authors: Copete, Sergio, Pastor-Idoate, Salvador, Garcia-Arumi, Josep, Zapata, Miguel A et al.
DOI: 10.1097/IAE.0000000000002832

Predictive capacity of baseline hyperreflective dots on the intravitreal dexamethasone implant (Ozurdex(R)) outcomes in diabetic macular edema: a multicenter study.

PMID: 31451909
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2019
Reference: Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2381-2390. doi: 10.1007/s00417-019-04446-4. Epub 2019 Aug 26.
Impact factor: 2.25
Publication type: Paper in international publication
Authors: Fonollosa, Alejandro, Zarranz-Ventura, Javier, Valverde, Alicia, Becerra, Erika, Bernal-Morales, Carolina, Pastor-Idoate, Salvador, Zapata, Miguel Angel et al.
DOI: 10.1007/s00417-019-04446-4

Guidelines for the Management of Retinal Vein Occlusion by the European Society of Retina Specialists (EURETINA).

PMID: 31412332
Journal: OPHTHALMOLOGICA
Year: 2019
Reference: Ophthalmologica. 2019;242(3):123-162. doi: 10.1159/000502041. Epub 2019 Aug 14.
Impact factor: 1.781
Publication type: Paper in international publication
Authors: Schmidt-Erfurth, Ursula, Garcia-Arumi, Jose, Gerendas, Bianca S, Midena, Edoardo, Sivaprasad, Sobha, Tadayoni, Ramin, Wolf, Sebastian, Loewenstein, Anat et al.
DOI: 10.1159/000502041

Comparative study of penetrating keratoplasty and vitreoretinal surgery with Eckardt temporary keratoprosthesis in ocular trauma versus non-trauma patients.

PMID: 31363832
Journal: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Year: 2019
Reference: Graefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2547-2558. doi: 10.1007/s00417-019-04420-0. Epub 2019 Jul 30.
Impact factor: 2.25
Publication type: Paper in international publication
Authors: Bove Alvarez, Maria, Arumi, Claudia Garcia, Distefano, Laura, Guell, Jose Luis, Gris, Oscar, Mateo, Carlos, Corcostegui, Borja, Garcia-Arumi, Jose et al.
DOI: 10.1007/s00417-019-04420-0

Comparison of Anatomical and Visual Outcomes between Idiopathic and Myopic Macular Holes Using the Internal Limiting Membrane or Inverted Internal Limiting Membrane Flap Technique.

PMID: 31205783
Journal: Journal of Ophthalmology
Year: 2019
Reference: J Ophthalmol. 2019 May 7;2019:6723824. doi: 10.1155/2019/6723824. eCollection 2019.
Impact factor: 1.58
Publication type: Paper in international publication
Authors: Peralta Iturburu, Federico, Garcia-Arumi, Claudia, Bove Alvarez, Maria, Garcia-Arumi, Jose et al.
DOI: 10.1155/2019/6723824

Efficacy of immunomodulatory therapy with interferon-beta or glatiramer acetate on multiple sclerosis-associated uveitis.

PMID: 28188020
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2017
Reference: Arch Soc Esp Oftalmol. 2017 Jun;92(6):273-279. doi: 10.1016/j.oftal.2016.11.018. Epub 2017 Feb 8.
Impact factor: 0
Publication type: Paper in national publication
Authors: Velazquez-Villoria, D, Macia-Badia, C, Segura-Garcia, A, Pastor Idoate, S, Arcos-Algaba, G, Velez-Escola, L, Garcia-Arumi, J et al.
DOI: 10.1016/j.oftal.2016.11.018

Telemedicine for a General Screening of Retinal Disease Using Nonmydriatic Fundus Cameras in Optometry Centers: Three-Year Results.

PMID: 27228051
Journal: Telemedicine and e-Health
Year: 2017
Reference: Telemed J E Health. 2017 Jan;23(1):30-36. doi: 10.1089/tmj.2016.0020. Epub 2016 May 26.
Impact factor: 2.031
Publication type: Paper in international publication
Authors: Zapata, Miguel A, Arcos, Gabriel, Fonollosa, Alex, Abraldes, Maximino, Olenik, Andrea, Gutierrez, Estanislao, Garcia-Arumi, Jose et al.
DOI: 10.1089/tmj.2016.0020

A review of current management of vitreomacular traction and macular hole.

PMID: 25821592
Journal: Journal of Ophthalmology
Year: 2015
Reference: J Ophthalmol. 2015;2015:809640. doi: 10.1155/2015/809640. Epub 2015 Mar 3.
Impact factor: 1.425
Publication type: Paper in international publication
Authors: Garcia-Layana, Alfredo, Garcia-Arumi, Jose, Ruiz-Moreno, Jose M, Arias-Barquet, Lluis, Cabrera-Lopez, Francisco, Figueroa, Marta S et al.
DOI: 10.1155/2015/809640

Effect of Intravitreal Injection of Dexamethasone 0.7 mg (Ozurdex(R)) on Intraocular Pressure in Patients with Macular Edema.

PMID: 26394206
Journal: OPHTHALMIC RESEARCH
Year: 2015
Reference: Ophthalmic Res. 2015;54(3):143-9. doi: 10.1159/000438759. Epub 2015 Sep 23.
Impact factor: 1.422
Publication type: Paper in international publication
Authors: Mazzarella, Stefania, Mateo, Carlos, Freixes, Silvia, Bures-Jelstrup, Anniken, Rios, Jose, Navarro, Rafael, Garcia-Arumi, Jose, Corcostegui, Borja, Arrondo, Elena et al.
DOI: 10.1159/000438759

Management of Vision-Threatening Complications of Vasoproliferative Tumors of the Retina.

PMID: 26065358
Journal: OPHTHALMIC RESEARCH
Year: 2015
Reference: Ophthalmic Res. 2015;54(1):34-40. doi: 10.1159/000430955. Epub 2015 Jun 6.
Impact factor: 1.422
Publication type: Paper in international publication
Authors: Garcia-Arumi, Jose, Distefano, Laura N, Fonollosa, Alex, Quijano, Claudia, Corcostegui, Borja et al.
DOI: 10.1159/000430955

RETINAL SENSITIVITY AND CHOROIDAL THICKNESS IN HIGH MYOPIA.

PMID: 25478863
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2015
Reference: Retina. 2015 Mar;35(3):398-406. doi: 10.1097/IAE.0000000000000367.
Impact factor: 3.243
Publication type: Paper in international publication
Authors: Zaben, Ahmad, Zapata, Miguel A, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0000000000000367

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives.

PMID: 24183659
Journal: TRENDS ENDOCRIN MET
Year: 2014
Reference: Trends Endocrinol Metab. 2014 Jan;25(1):23-33. doi: 10.1016/j.tem.2013.09.005. Epub 2013 Nov 1.
Impact factor: 8.868
Publication type: Paper in international publication
Authors: Simo, Rafael, Hernandez, Cristina, Bandello, F, Burks, D, Cunha-Vaz, J, Egan, C, Garcia-Arumi, J, Gibson, J, Harding, S, Karadeniz, S et al.
DOI: 10.1016/j.tem.2013.09.005

Photodynamic therapy for symptomatic subretinal fluid related to choroidal nevus.

PMID: 22366902
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2012
Reference: Retina. 2012 May;32(5):936-41. doi: 10.1097/IAE.0b013e318232c366.
Impact factor: 2.812
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1097/IAE.0b013e318232c366

Pars plana vitrectomy alone with diffuse illumination and vitreous dissection to manage primary retinal detachment with unseen breaks.

PMID: 19822846
Journal: ARCHIVES OF OPHTHALMOLOGY
Year: 2009
Reference: Arch Ophthalmol. 2009 Oct;127(10):1297-304.
Impact factor: 3.242
Publication type: Paper in international publication
Authors: Martinez-Castillo, Vicente, Boixadera, Anna, Garcia-Arumi, Jose et al.
DOI: 10.1001/archophthalmol.2009.254

Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy.

PMID: 19823802
Journal: DIABETOLOGIA
Year: 2009
Reference: Diabetologia. 2009 Dec;52(12):2633-41.
Impact factor: 6.418
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1007/s00125-009-1548-8

Blog

News

On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.

Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project. 

Job offers

Study Coordinator - Ophtalmology Unit
Start date:
07/12/2022
End date:
21/12/2022
Document: Download
Postdoc Researcher - Ophthalmology Research Group
Start date:
21/11/2022
End date:
15/12/2022
Document: Download
Ophthalmologist for Clinical Trials - Ophthalmology Research Group.
Start date:
15/11/2022
End date:
29/11/2022
Document: Download