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Pharmacokinetic Nanoparticles

The group of design and pharmacodynamics of nanoparticles at the Vall d’Hebron Research Institute focuses on the synthesis, characterization, and applications of engineered inorganic nanoparticles in the field of medicine. By mastering the inorganic core (size, structure, and shape) and understanding and controlling the linking of molecules to the nanoparticle surface, we engineer nanoparticles that can interact with biological systems in a specific way. We also put particular emphasis on safety, feasibility, scale-up, applicability, and other aspects of nanoparticle design.

Our group is led by Prof. Víctor Puntes, who holds an ICREA Research Professorship. Since a great part of our work demands highly multidisciplinary expertise, we maintain several strong collaborations with biologists, immunologists, oncologists, physicists, environmentalists, and more, from all over Europe, China and the US. The work of the group has resulted in several patents and the creation of several spin-offs such as Nanotargeting and Applied nanoparticles.

Projects

Antioxidant and antiinflammatory therapy for the treatment of preeclampsia

IP: Victor Franco Puntes
Collaborators: Joana Ramis Garcia
Funding agency: Generalitat de Catalunya - Departament de Salut
Funding: 89693.23
Reference: SLT017/20/000182
Duration: 14/07/2021 - 31/12/2024

Terapia basada en células madre asistida con nanopartículas de Ce02: un enfoque nanofarmacéutico innovador para tratar enfermedades degenerativas de la retina.

IP: Anna Duarri Piqué
Collaborators: José García Arumí, Jordi Rosell Aluja, Victor Franco Puntes, Helena Isla Magrané, Joana Ramis Garcia
Funding agency: Instituto de Salud Carlos III
Funding: 174845
Reference: AC19/00080
Duration: 01/01/2020 - 30/06/2024

NEW ANTIOXIDANT STRATEGIES FOR THE MULTIMODAL TREATMENT OF PREECLAMPSIA (AFRODITA)

IP: Elena Carreras Moratonas
Collaborators: Itziar Garcia Ruiz, Erika Bonacina, Joana Ramis Garcia
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI20/00606
Duration: 01/01/2021 - 30/06/2025

Publications

Nanoceria as Safe Contrast Agents for X-ray CT Imaging.

PMID: 37570527
Journal: Nanomaterials
Year: 2023
Reference: Nanomaterials (Basel). 2023 Jul 29;13(15):2208. doi: 10.3390/nano13152208.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bastus, Neus G; Boullosa, Ana Maria; Camara, Juan Antonio; Casals, Eudald; Garcia, Ana; Gusta, Muriel F; Mondragon, Laura; Puntes, Victor; Schwartz, Simo Jr et al.
DOI: 10.3390/nano13152208

Recovering What Matters: High Protein Recovery after Endotoxin Removal from LPS-Contaminated Formulations Using Novel Anti-Lipid A Antibody Microparticle Conjugates.

PMID: 37762274
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Sep 12;24(18):13971. doi: 10.3390/ijms241813971.
Impact factor:
Publication type: Paper in international publication
Authors: Bastus, Neus G; Casonato Melo, Cristiane; Duschl, Albert; Fauerbach, Jonathan A; Fux, Alexandra C; Gessner, Isabel; Himly, Martin; Puntes, Victor; Puntes, Victor; Schlahsa, Laura et al.
DOI: 10.3390/ijms241813971

Sculpting Windows onto AuAg Hollow Cubic Nanocrystals.

PMID: 37764620
Journal: Nanomaterials
Year: 2023
Reference: Nanomaterials (Basel). 2023 Sep 19;13(18):2590. doi: 10.3390/nano13182590.
Impact factor:
Publication type: Paper in international publication
Authors: Bastus, Neus G; Patarroyo, Javier; Puntes, Victor; Puntes, Victor et al.
DOI: 10.3390/nano13182590

Facet-engineered TiO(2) drives photocatalytic activity and stability of supported noble metal clusters during H(2) evolution.

PMID: 37789037
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Oct 3;14(1):6165. doi: 10.1038/s41467-023-41976-2.
Impact factor:
Publication type: Paper in international publication
Authors: Bastus, Neus G; Cazorla, Claudio; Chen, Yufen; Llorca, Jordi; Oliveras, Jana; Puntes, Victor F; Puntes, Victor F; Soler, Lluis; Soler, Lluis et al.
DOI: 10.1038/s41467-023-41976-2