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Rheumatology

The Rheumatology Research Group (GRR) is focused on translational research in immunity-mediated inflammatory diseases (IMIDA), mainly in the area of rheumatology. The GRR is a multidisciplinary group made up of clinical specialists, biologists, bioinformaticians and laboratory technicians. The different research lines of the GRR emphasize the use of high-performance technologies for the study at the cellular and molecular level of the immununopathology of IMIDA, mainly chronic inflammatory arthritis and autoimmune systemic diseases.

At the clinical level, we have developed lines of research in very diverse areas of rheumatology, including chronic inflammatory arthritis (rheumatoid arthritis, spondyloarthropathies), systemic autoimmune diseases (lupus, myositis, Sjögren's syndrome), the study of musculoskeletal imaging, pediatric rheumatology (juvenile idiopathic arthritis, autoimmune systemic diseases, autoinflammatory syndromes), central sensitization syndromes and the study of bone metabolism. One of the main objectives of the GRR is the coordination of basic and clinical research to accelerate the transfer of knowledge to clinical practice and thus improve the quality of life of patients.

Team

Mireia Barcelo Bru

Mireia Barcelo Bru

Predoctoral researcher
Rheumatology
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Mireia Lopez Corbeto

Mireia Lopez Corbeto

Main researcher
Rheumatology
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Sara Marsal Barril

Sara Marsal Barril

Main researcher
Rheumatology
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M Alba Erra Duran

M Alba Erra Duran

Postdoctoral researcher
Rheumatology
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Ramón Sanmartín Sentañes

Ramón Sanmartín Sentañes

Main researcher
Rheumatology
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Andrea Pluma Sanjurjo

Andrea Pluma Sanjurjo

Predoctoral researcher
Rheumatology
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Mireia Barcelo Bru

Mireia Barcelo Bru

Predoctoral researcher
Rheumatology
Read more
Mireia Lopez Corbeto

Mireia Lopez Corbeto

Main researcher
Rheumatology
Read more
Sara Marsal Barril

Sara Marsal Barril

Main researcher
Rheumatology
Read more
M Alba Erra Duran

M Alba Erra Duran

Postdoctoral researcher
Rheumatology
Read more
Ramón Sanmartín Sentañes

Ramón Sanmartín Sentañes

Main researcher
Rheumatology
Read more
Andrea Pluma Sanjurjo

Andrea Pluma Sanjurjo

Predoctoral researcher
Rheumatology
Read more

Projects

Caracterización por single cell RNA-seq de las células T patogénicas en la artritis idiopática juvenil oliogarticular, estudio de aplicabilidad translacional.

IP: Mireia Lopez Corbeto
Collaborators: -
Funding agency: Sociedad Española de Reumatología Pediátrica SERP
Funding: 8000
Reference: SERPE/REUMAPED/2022/LOPEZ
Duration: 30/12/2022 - 29/12/2024

Valorización de una terapia antígeno-específica para el tratamiento disruptivo de la diabetes tipo 1; esclerosis múltiple, miastenia gravis, enfermedad celíaca y artritis reumatoide.

IP: Carmen Espejo Ruiz
Collaborators: Sara Marsal Barril, Herena Eixarch Ahufinger, Helena Borrell Paños, Maria America Lopez Lasanta
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 217313.9
Reference: CPP2021-008475
Duration: 10/02/2022 - 09/02/2025

Ministerio de Ciencia

Estratificación de la severidad de la fatiga en el síndrome de COVID persistente: nuevas estrategias terapéuticas

IP: José Alegre Martin
Collaborators: PATRICIA LAUNOIS OBREGÓN, Ramón Sanmartín Sentañes
Funding agency: Fundación Invest. Médica Mutua Madrileña
Funding: 109998
Reference: MUTUA_MADRILEÑA/2022/ALEGRE
Duration: 20/07/2022 - 19/07/2025

Caracterización de las células patogénicas del músculo y piel de pacientes con Dermatomiositis y Síndrome Antisintetasa y estudio de aplicabilidad traslacional.

IP: Ernesto Trallero Araguas
Collaborators: Albert Selva O'Callaghan, Raul Tortosa Mendez, Albert Gil Vila, Gloria Aparicio Español, Adria Aterido Ballonga, Hugo Fernando Avalos Bogado
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI22/00708
Duration: 01/01/2023 - 31/12/2025

Publications

Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery.

PMID: 37744357
Journal: Frontiers in Immunology
Year: 2023
Reference: Front Immunol. 2023 Sep 7;14:1253121. doi: 10.3389/fimmu.2023.1253121. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre-Martin, Jose; Alegre-Martin, Jose; Almirall, Miriam; Blanco-Suarez, Manuel; Caceres, Oscar; Castro-Marrero, Jesus; Domingo, Joan Carles; Gonzalez-Castro, Ana Maria; Gonzalez-Castro, Ana Maria; Jurek, Joanna et al.
DOI: 10.3389/fimmu.2023.1253121

HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.

PMID: 37768647
Journal: Journal of Crohns & Colitis
Year: 2023
Reference: J Crohns Colitis. 2023 Sep 28:jjad165. doi: 10.1093/ecco-jcc/jjad165.
Impact factor:
Publication type: Paper in international publication
Authors: Almer, Sven; Bonfiglio, Ferdinando; Bresso, Francesca; Bujanda, Luis; Camargo Tavares, Leticia; Chen, Ye; Colombel, Jean-Frederic; D'Amato, Mauro; Escudero-Hernandez, Celia; Esteve, Maria et al.
DOI: 10.1093/ecco-jcc/jjad165

Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity.

PMID: 37801035
Journal: FASEB JOURNAL
Year: 2023
Reference: FASEB J. 2023 Nov;37(11):e23220. doi: 10.1096/fj.202300077R.
Impact factor:
Publication type: Paper in international publication
Authors: Albillos, Agustin; Alter, David N; Asselta, Rosanna; Banales, Jesus M; Brewer, Jo; Bujanda, Luis; Buti, Maria; Buti, Maria; Conway, Joseph; de Cid, Rafael et al.
DOI: 10.1096/fj.202300077R

Unsupervised cluster analysis reveals distinct subtypes of ME/CFS patients based on peak oxygen consumption and SF-36 scores.

PMID: 37802746
Journal: CLINICAL THERAPEUTICS
Year: 2023
Reference: Clin Ther. 2023 Oct 4:S0149-2918(23)00352-1. doi: 10.1016/j.clinthera.2023.09.007.
Impact factor:
Publication type: Paper in international publication
Authors: Alegre, Jose; Alegre, Jose; Casas-Roma, Jordi; Lacasa, Marcos; Launois, Patricia; Launois, Patricia; Prados, Ferran et al.
DOI: 10.1016/j.clinthera.2023.09.007

Identifying mindfulness and acceptance as mediators between negative affect, functional disability and emotional distress in patients with fibromyalgia.

PMID: 34796836
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2022
Reference: Clin Exp Rheumatol. 2022 Jun;40(6):1102-1111. doi: 10.55563/clinexprheumatol/uzzejn. Epub 2021 Nov 18.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Maurel, Sara; Saez-Francas, Naia; Calvo, Natalia; Alegre-Martin, Jose; Castro-Marrero, Jesus et al.
DOI:

Trajectories in early rheumatoid arthritis related fatigue over 10 years: results from the ESPOIR cohort.

PMID: 34596027
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2022
Reference: Clin Exp Rheumatol. 2022 Jul;40(7):1361-1367. doi: 10.55563/clinexprheumatol/kk1ndf. Epub 2021 Sep 21.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Marsal, Sara; Olive, Alejandro; Fautrel, Bruno; Guillemin, Francis; Combe, Bernard; Rodriguez-Muguruza, Samantha; Valero, Oliver; Lukas, Cedric et al.
DOI: 10.55563/clinexprheumatol/kk1ndf

Radiography-based triage for COVID-19 in the Emergency Department in a Spanish cohort of patients.

PMID: 35702721
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Engl Ed). 2022 May 27;158(10):466-471. doi: 10.1016/j.medcle.2021.05.021. Epub 2022 Jun 9.
Impact factor: 1.725
Publication type: Paper in international publication
Authors: Domingo-Baldrich, Eva, Michelena, Xabier, Meza, Beatriz, Garcia-Vives, Eloi, Gil-Vila, Albert, Sarrapio-Lorenzo, Javier, Romero-Ruperto, Sheila, Sanpedro-Jimenez, Francesc, Arranz-Betegon, Maria, Fernandez-Codina, Andreu et al.
DOI: 10.1016/j.medcle.2021.05.021

Radiography-based triage for COVID-19 in the Emergency Department in a Spanish cohort of patients.

PMID: 34256936
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 May 27;158(10):466-471. doi: 10.1016/j.medcli.2021.05.013. Epub 2021 Jun 16.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Sempere-Gonzalez, Abiu, Llaneras-Artigues, Jordi, Pinal-Fernandez, Iago, Canas-Ruano, Esperanza, Orozco-Galvez, Olimpia, Domingo-Baldrich, Eva, Michelena, Xabier, Meza, Beatriz, Garcia-Vives, Eloi, Gil-Vila, Albert et al.
DOI: 10.1016/j.medcli.2021.05.013

Blog

News

The head of the Rheumatology Service at Vall d'Hebron University Hospital and of the Rheumatology research group at VHIR is a highly accomplished rheumatologist with a distinguished career in the field.

It is the first international multi-centre clinical trial to analyse the safety and effect of this treatment for an autoimmune disease.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.