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Stroke Research

The search for quality and innovation has always been an inherent part of the activity of the Stroke Research Group and represents the common thread that leads us to excellence and continuous improvement.

In recent years, the Stroke Research Group has established itself as a leader in the management, recruitment and international coordination of multicenter clinical trials, as well as in the development of patents for new thrombectomy devices and the creation of new technological solutions and digital platforms to improve the diagnosis, treatment and follow-up of stroke patients. Robust strategic alliances have also been consolidated with public and private entities that ensure the viability and scalability of the research projects initiated in our group.

The Stroke Research Group is made up of a transversal and multidisciplinary team that shares a common idea: to contribute from its area of knowledge to the care and management of stroke through the effective transfer of knowledge and the complementarity of the processes of clinical research.

Team

Cristina Losada Gimenez

Cristina Losada Gimenez

Research technician
Stroke research
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David Cano Zafra

David Cano Zafra

Research technician
Stroke research
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David Hernandez Morales

David Hernandez Morales

Research technician
Stroke research
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David Rodriguez Luna

David Rodriguez Luna

Main researcher
Stroke research
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Estefania Montiel

Estefania Montiel

Main researcher
Stroke research
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Ester Sanchez Gavilan

Ester Sanchez Gavilan

Research technician
Stroke research
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Cristina Losada Gimenez

Cristina Losada Gimenez

Research technician
Stroke research
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David Cano Zafra

David Cano Zafra

Research technician
Stroke research
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David Hernandez Morales

David Hernandez Morales

Research technician
Stroke research
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David Rodriguez Luna

David Rodriguez Luna

Main researcher
Stroke research
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Estefania Montiel

Estefania Montiel

Main researcher
Stroke research
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Ester Sanchez Gavilan

Ester Sanchez Gavilan

Research technician
Stroke research
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Projects

Development and validation of an artificial intelligence model for the prehospital management of patients with a suspected acute ischemic stroke

IP: Marc Ribó Jacobi
Collaborators: Alvaro Garcia Tornel Garcia Camba, Judit Álvarez González
Funding agency: Instituto de Salud Carlos III
Funding: 180000
Reference: JR22/00046
Duration: 01/01/2023 - 31/12/2026

HARMONICS. Harmonization and Implementation of High Value Stroke Care

IP: Carlos Molina Cateriano
Collaborators: Maria Baladas Orti, Ester Sanchez Gavilan, Cristina Guirao Martinez, Estefania Montiel, Marina Jimenez Iglesias, Lidia Garcia Guillamón, Federica Rizzo, Marta Aurora Rubiera Del Fueyo, David Rodriguez Luna, Manuel Requena Ruiz, Marta Olive Gadea, Alvaro Garcia Tornel Garcia Camba, Marc Rodrigo Gisbert
Funding agency: EUROPEAN COMMISSION
Funding: 468090
Reference: HARMONICS_EIT-HEALTH-BP2022
Duration: 01/01/2022 - 31/12/2024

Clinical trial to evaluate the administration of ApTOLL in ambulances and the neuroprotective effect in stroke patients. RACETOLL

IP: Marc Ribó Jacobi
Collaborators: Marta Aurora Rubiera Del Fueyo, Carlos Molina Cateriano, Federica Rizzo
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 437334
Reference: CPP2021-008378
Duration: 01/03/2022 - 28/02/2025

Ministerio de Ciencia

Caracterización de la DIScapacidad y la COgnición en sujetos con Esclerosis múltiple a partir de secuencias de Resonancia magnética convencional (DISCOvER).

IP: Deborah Pareto Onghena
Collaborators: Ingrid Galán Cartaña, Herena Eixarch Ahufinger, M Jesus Arevalo Navines, Andrea De Barros Figueredo, Neus Mongay Ochoa, Giorgio Colangelo
Funding agency: Instituto de Salud Carlos III
Funding: 87120
Reference: PI22/01709
Duration: 01/01/2023 - 31/12/2025

Publications

Editorial: Understanding PFO-associated stroke.

PMID: 37693757
Journal: Frontiers in Neurology
Year: 2023
Reference: Front Neurol. 2023 Aug 24;14:1274123. doi: 10.3389/fneur.2023.1274123. eCollection 2023.
Impact factor:
Publication type: Editorail in international publication
Authors: Karapanayiotides, Theodoros; Lioutas, Vasileios-Arsenios; Mitsias, Panayiotis; Montalescot, Gilles; Rubiera, Marta et al.
DOI: 10.3389/fneur.2023.1274123

Partial (SAVE) versus Complete (Solumbra) Stent Retriever Retraction Technique for Mechanical Thrombectomy: A Randomized In Vitro Study.

PMID: 37709355
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2023
Reference: AJNR Am J Neuroradiol. 2023 Sep 14. doi: 10.3174/ajnr.A7996.
Impact factor:
Publication type: Paper in international publication
Authors: Canals, Pere; Jablonska, Magda; Li, Jiahui; Li, Jiahui; Ortega, Santiago; Ribo, Marc; Ribo, Marc; Tiberi, Riccardo; Tomasello, Alejandro; Tomasello, Alejandro et al.
DOI: 10.3174/ajnr.A7996

Underlying Causes of TIA and Minor Ischemic Stroke and Risk of Major Vascular Events.

PMID: 37782494
Journal: JAMA Neurology
Year: 2023
Reference: JAMA Neurol. 2023 Oct 2. doi: 10.1001/jamaneurol.2023.3344.
Impact factor:
Publication type: Paper in international publication
Authors: Abboud, Halim; Albers, Gregory W; Amarenco, Pierre; Amarenco, Pierre; Ameriso, Sebastian; Anticoli, Sabrina; Arauz, Antonio; Arenillas, J F; Audebert, Henrich; Awada, Adnan et al.
DOI: 10.1001/jamaneurol.2023.3344

Evaluation of effectiveness and safety of the CorPath GRX robotic system in endovascular embolization procedures of cerebral aneurysms.

PMID: 37793795
Journal: Journal of NeuroInterventional Surgery
Year: 2023
Reference: J Neurointerv Surg. 2023 Oct 4:jnis-2023-020161. doi: 10.1136/jnis-2023-020161.
Impact factor:
Publication type: Paper in international publication
Authors: Blanc, Raphael; Cancelliere, Nicole M; Clarencon, Frederic; Costalat, Vincent; De Villiers, Laetitia; Galvan Fernandez, Jorge; Gascou, Gregory; Gralla, Jan; Hernandez, David; Hernandez, David et al.
DOI: 10.1136/jnis-2023-020161

Patient-reported outcome measures after thrombectomy in patients with acute stroke: fine-tuning the modified Rankin Scale.

PMID: 35508380
Journal: Journal of NeuroInterventional Surgery
Year: 2022
Reference: J Neurointerv Surg. 2022 May 4. pii: neurintsurg-2022-018840. doi: 10.1136/neurintsurg-2022-018840.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Cano, David, Montiel, Estefania, Baladas, Maria, Sanchez-Gavilan, Esther, Paredes, Carolina, Rubiera, Marta, Requena, Manuel, Muchada, Marian, Olive Gadea, Marta, Garcia-Tornel, Alvaro et al.
DOI: 10.1136/neurintsurg-2022-018840

Combined technique as first approach in mechanical thrombectomy: Efficacy and safety of REACT catheter combined with stent retriever.

PMID: 35491662
Journal: INTERVENTIONAL NEURORADIOLOGY
Year: 2022
Reference: Interv Neuroradiol. 2022 May 2:15910199221095798. doi: 10.1177/15910199221095798.
Impact factor: 1.61
Publication type: Paper in international publication
Authors: Requena, Manuel, Pinana, Carlos, Olive-Gadea, Marta, Hernandez, David, Boned, Sandra, De Dios, Marta, Rodrigo, Marc, Rivera, Eila, Muchada, Marian, Cuevas, Jose Luis et al.
DOI: 10.1177/15910199221095798

Trackability of distal access catheters: an in vitro quantitative evaluation of navigation strategies.

PMID: 35450927
Journal: Journal of NeuroInterventional Surgery
Year: 2022
Reference: J Neurointerv Surg. 2022 Apr 21. pii: neurintsurg-2022-018889. doi: 10.1136/neurintsurg-2022-018889.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Castano, Oscar, Ribo, Marc, Kallmes, David F, Engel, Elisabeth, Galve, Inaki, Tiberi, Riccardo, Li, Jiahui, Tomasello, Alejandro, Requena, Manuel, Canals, Pere et al.
DOI: 10.1136/neurintsurg-2022-018889

Clinical Results of the Advanced Neurovascular Access Catheter System Combined With a Stent Retriever in Acute Ischemic Stroke (SOLONDA).

PMID: 35360928
Journal: STROKE
Year: 2022
Reference: Stroke. 2022 Jul;53(7):2211-2219. doi: 10.1161/STROKEAHA.121.037577. Epub 2022 Apr 1.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Requena, Manuel, Ribo, Marc, Zamarro, Joaquin, Vega, Pedro, Blasco, Jordi, Gonzalez, Eva Maria, Del Mar Freijo, Maria, Mendez Cendon, Jose Carlos, de Miquel, Maria Angeles, Hernandez, David et al.
DOI: 10.1161/STROKEAHA.121.037577

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.

PMID: 33801197
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Mar 2;10(5). pii: jcm10050989. doi: 10.3390/jcm10050989.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Marazuela, Paula, Bonaterra-Pastra, Anna, Faura, Julia, Penalba, Anna, Pizarro, Jesus, Pancorbo, Olalla, Rodriguez-Luna, David, Vert, Carla, Rovira, Alex, Pujadas, Francesc et al.
DOI: 10.3390/jcm10050989

Ischemic Core Overestimation on Computed Tomography Perfusion.

PMID: 33682453
Journal: STROKE
Year: 2021
Reference: Stroke. 2021 May;52(5):1751-1760. doi: 10.1161/STROKEAHA.120.031800. Epub 2021 Mar 8.
Impact factor: 7.914
Publication type: Paper in international publication
Authors: Garcia-Tornel, Alvaro, Campos, Daniel, Rubiera, Marta, Boned, Sandra, Olive-Gadea, Marta, Requena, Manuel, Ciolli, Ludovico, Muchada, Marian, Pagola, Jorge, Deck, Matias et al.
DOI: 10.1161/STROKEAHA.120.031800

Corrigendum to 'Screening of Embolic Sources by Point-of-Care Ultrasound in the Acute Phase of Ischemic Stroke' [Ultrasound in Med. & Biol. 46 (2020) 2173-2180].

PMID: 33589352
Journal: ULTRASOUND IN MEDICINE AND BIOLOGY
Year: 2021
Reference: Ultrasound Med Biol. 2021 May;47(5):1428. doi: 10.1016/j.ultrasmedbio.2021.01.021. Epub 2021 Feb 12.
Impact factor: 2.998
Publication type: Letter or abstract
Authors: Juega, Jesus, Pagola, Jorge, Gonzalez-Alujas, Teresa, Rodriguez-Luna, David, Rubiera, Marta, Rodriguez-Villatoro, Noelia, Garcia-Tornel, Alvaro, Requena, Manuel, Deck, Matias, Sero, Laia et al.
DOI: 10.1016/j.ultrasmedbio.2021.01.021

Comparison of Plasma Lipoprotein Composition and Function in Cerebral Amyloid Angiopathy and Alzheimer's Disease.

PMID: 33445800
Journal: Biomedicines
Year: 2021
Reference: Biomedicines. 2021 Jan 12;9(1). pii: biomedicines9010072. doi: 10.3390/biomedicines9010072.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Vera, Rocio, Lebrato-Hernandez, Lucia, Arenillas, Juan F, Perez-Sanchez, Soledad, Montaner, Joan, Sanchez-Quesada, Jose Luis, Hernandez-Guillamon, Mar, Cardona Portela, Pere, Martinez-Zabaleta, Maite, Tur, Silvia et al.
DOI: 10.3390/biomedicines9010072

[Cavernous sinus syndrome secondary to thrombophlebitis due to Streptococcus intermedius complicated with vasculitis of the internal carotid artery and brain abscesses].

PMID: 31845752
Journal: REVISTA DE NEUROLOGIA
Year: 2020
Reference: Rev Neurol. 2020 Jan 1;70(1):19-22. doi: 10.33588/rn.7001.2019376.
Impact factor: 0.562
Publication type: Letter or abstract
Authors: Rubiera, M, Vert, C, Muchada, M, Deck, M, Anguizola-Tamayo, D A, Ballve-Martin, A, Campos-Fernandez, D, Morais-Dias, M, Garcia-Tornel, A et al.
DOI: 10.33588/rn.7001.2019376

Circulating Aquaporin-4 as a biomarker of early neurological improvement in stroke patients: a pilot study.

PMID: 31672489
Journal: NEUROSCIENCE LETTERS
Year: 2020
Reference: Neurosci Lett. 2020 Jan 1;714:134580. doi: 10.1016/j.neulet.2019.134580. Epub 2019 Oct 28.
Impact factor: 2.274
Publication type: Paper in international publication
Authors: Ramiro, Laura, Simats, Alba, Penalba, Anna, Garcia-Tornel, Alvaro, Rovira, Alex, Mancha, Fernando, Bustamante, Alejandro, Montaner, Joan et al.
DOI: 10.1016/j.neulet.2019.134580

Blog

News

UMBRELLA, a consortium of over 20 public and private partners, kicks off this week with the aim of revolutionising the entire stroke care pathway in Europe by adopting a holistic approach that covers stroke diagnosis, prevention and care.

The Consortium will create a platform to facilitate a personalised management for stroke patients, enabling a more efficient personalized monitoring and patient follow up.

Funding is key to bringing the neuroprotective drug ApTOLL to market and providing a new therapeutic option for the patients.