About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.
PMID: 35238758 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2022 Reference: Clin Exp Rheumatol. 2022 May;40 Suppl 134(5):71-80. doi: 10.55563/clinexprheumatol/qq9qup. Epub 2022 Mar 1. Impact factor: 4.473 Publication type: Review in international publication Authors: Monti, Sara, Nalli, Cecilia, Schleinitz, Nicolas, Tincani, Angela, Della Torre, Emanuel, Alexander, Tobias, Montecucco, Carlomaurizio, Martinez-Valle, Fernando, van Laar, Jan A M, Iaccarino, Luca et al. DOI:
PMID: 34115832 Journal: RHEUMATOLOGY Year: 2022 Reference: Rheumatology (Oxford). 2022 Mar 2;61(3):1053-1061. doi: 10.1093/rheumatology/keab475. Impact factor: 7.58 Publication type: Paper in international publication Authors: Pardos-Gea, Jose, Marques-Soares, Joana R, Bujan, Segundo, Ordi-Ros, Jose, Alijotas-Reig, Jaume et al. DOI: 10.1093/rheumatology/keab475
PMID: 35229657 Journal: ANTIOXIDANTS & REDOX SIGNALING Year: 2022 Reference: Antioxid Redox Signal. 2022 Apr;36(10-12):729-739. doi: 10.1089/ars.2022.0018. Impact factor: 8.401 Publication type: Paper in international publication Authors: Castro-Marrero, Jesus, Domingo, Joan Carles, Cordobilla, Begona, Ferrer, Roser, Giralt, Marina, Sanmartin-Sentanes, Ramon, Alegre-Martin, Jose et al. DOI: 10.1089/ars.2022.0018
PMID: 35234202 Journal: CLINICAL NUCLEAR MEDICINE Year: 2022 Reference: Clin Nucl Med. 2022 May 1;47(5):387-393. doi: 10.1097/RLU.0000000000004097. Impact factor: 7.794 Publication type: Paper in international publication Authors: Navales-Mateu, Ignacio, Mestre-Torres, Jaume, Martinez-Valle, Fernando, Gabaldon, Alejandra, Simo-Perdigo, Marc, Salcedo-Allende, M Teresa, Solans-Laque, Roser et al. DOI: 10.1097/RLU.0000000000004097
PMID: 34161227 Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Year: 2021 Reference: Clin Exp Rheumatol. 2021 May-Jun;39 Suppl 130(3):170-173. Epub 2021 Jun 21. Impact factor: 4.473 Publication type: Paper in international publication Authors: Blanco, Francisco, Perez, Carolina, Olive, Alex, Olive, Alex, Corominas, Hector, Martinez-Taboada, Victor, Gonzalez, Isidoro, Erra, Alba, Lopez-Lasanta, Maria, Sanchez, Simon et al. DOI:
PMID: 33316070 Journal: RHEUMATOLOGY Year: 2021 Reference: Rheumatology (Oxford). 2021 Jun 18;60(6):2946-2957. doi: 10.1093/rheumatology/keaa748. Impact factor: 7.58 Publication type: Paper in international publication Authors: Pasoto, Sandra G, Valim, Valeria, Siso-Almirall, Antoni, Mariette, Xavier, Carreira, Patricia, Ramos-Casals, Manuel, Brito-Zeron, P, Morcillo, C, Brito-Zeron, P, Flores-Chavez, A et al. DOI: 10.1093/rheumatology/keaa748
PMID: 34136127 Journal: Clinical and Translational Allergy Year: 2021 Reference: Clin Transl Allergy. 2021 Jun 9;11(4):e12014. doi: 10.1002/clt2.12014. eCollection 2021 Jun. Impact factor: 5.871 Publication type: Review in international publication Authors: Casale, Tomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M, Chkhartishvili, Ekaterine, Chu, Derek K, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Del Giacco, Stefano, Carreiro-Martins, Pedro et al. DOI: 10.1002/clt2.12014
PMID: 34142390 Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY Year: 2021 Reference: Pediatr Allergy Immunol. 2021 Nov;32(8):1730-1742. doi: 10.1111/pai.13578. Epub 2021 Jul 21. Impact factor: 6.377 Publication type: Paper in international publication Authors: Tanno, Luciana Kase, Clark, Evangeline, Mamodaly, Myriam, Cardona, Victoria, Ebisawa, Motohiro, Asontegui, Ignacio, Sanchez-Borges, Mario, Santos, Alexandra F, Fiocchi, Alessandro, Worm, Margitta et al. DOI: 10.1111/pai.13578
PMID: 32351168 Journal: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY Year: 2020 Reference: Scand J Rheumatol. 2020 Jul;49(4):259-266. doi: 10.1080/03009742.2020.1726449. Epub 2020 Apr 30. Impact factor: 3.025 Publication type: Paper in international publication Authors: Rodriguez-Muguruza, S, Combe, B, Guillemin, F, Fautrel, B, Olive, A, Marsal, S, Valero, O, Rincheval, N, Lukas, C et al. DOI: 10.1080/03009742.2020.1726449
PMID: 32329119 Journal: LIVER INTERNATIONAL Year: 2020 Reference: Liver Int. 2020 Aug;40(8):1906-1916. doi: 10.1111/liv.14489. Epub 2020 Jun 3. Impact factor: 5.175 Publication type: Paper in international publication Authors: Riveiro-Barciela, Mar, Barreira-Diaz, Ana, Vidal-Gonzalez, Judit, Munoz-Couselo, Eva, Martinez-Valle, Fernando, Viladomiu, Lluis, Minguez, Beatriz, Ortiz-Velez, Carolina, Castells, Lluis, Esteban, Rafael et al. DOI: 10.1111/liv.14489
PMID: 32295620 Journal: ARTHRITIS RESEARCH & THERAPY Year: 2020 Reference: Arthritis Res Ther. 2020 Apr 15;22(1):82. doi: 10.1186/s13075-020-02168-1. Impact factor: 4.103 Publication type: Paper in international publication Authors: Calvo-Alen, Jaime, Sellas, Agustin, Rodriguez, Fernando Jose, Bermudez, Alberto, Romero, Manuel, Riesco, Manuel, Cobeta, Juan Carlos, Medina, Fermin, Garcia, M Luz, Urruticoechea, Ana et al. DOI: 10.1186/s13075-020-02168-1
PMID: 32291908 Journal: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Year: 2020 Reference: J Cell Mol Med. 2020 May;24(10):5865-5877. doi: 10.1111/jcmm.15260. Epub 2020 Apr 14. Impact factor: 4.486 Publication type: Paper in international publication Authors: Cheema, Amanpreet K, Sarria, Leonor, Bekheit, Mina, Collado, Fanny, Almenar-Perez, Eloy, Martin-Martinez, Eva, Alegre, Jose, Klimas, Nancy G, Oltra, Elisa, Nathanson, Lubov et al. DOI: 10.1111/jcmm.15260
PMID: 31320135 Journal: MEDICINA CLINICA Year: 2019 Reference: Med Clin (Barc). 2019 Dec 27;153(12):446-453. doi: 10.1016/j.medcli.2019.02.026. Epub 2019 Jul 16. Impact factor: 1.277 Publication type: Paper in national publication Authors: Mestre-Torres, Jaume, Garrido-Clua, Miriam, Lalueza-Broto, Pilar, Sanclemente-Boli, Teresa, Ponce-Ruiz, Sandra, Alvarez-Lorenzo, Consuelo, Zuriguel-Perez, Esperanza, Tapia-Melenchon, Raquel, Ramentol-Sintas, Marc, Villar-Casares, Maria Del Mar et al. DOI: 10.1016/j.medcli.2019.02.026
PMID: 31312201 Journal: Frontiers in Immunology Year: 2019 Reference: Front Immunol. 2019 Jul 2;10:1459. doi: 10.3389/fimmu.2019.01459. eCollection 2019. Impact factor: 4.716 Publication type: Paper in international publication Authors: Aterido, Adria, Canete, Juan D, Tornero, Jesus, Blanco, Francisco, Fernandez-Gutierrez, Benjamin, Perez, Carolina, Alperi-Lopez, Mercedes, Olive, Alex, Corominas, Hector, Martinez-Taboada, Victor et al. DOI: 10.3389/fimmu.2019.01459
PMID: 31308545 Journal: NATURE GENETICS Year: 2019 Reference: Nat Genet. 2019 Aug;51(8):1207-1214. doi: 10.1038/s41588-019-0439-2. Epub 2019 Jul 15. Impact factor: 25.455 Publication type: Paper in international publication Authors: Huckins, Laura M, Gaspar, Helena A, Bryois, Julien, Hinney, Anke, Leppa, Virpi M, Mattheisen, Manuel, Medland, Sarah E, Ripke, Stephan, Yao, Shuyang, Giusti-Rodriguez, Paola et al. DOI: 10.1038/s41588-019-0439-2
PMID: 31278138 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2019 Reference: Ann Rheum Dis. 2019 Oct;78(10):1405-1411. doi: 10.1136/annrheumdis-2018-214472. Epub 2019 Jul 5. Impact factor: 14.299 Publication type: Paper in international publication Authors: Ter Haar, Nienke M, Frenkel, Joost, Papa, Riccardo, Brogan, Paul A, Kone-Paut, Isabelle, Modesto, Consuelo, Hofer, Michael, Iagaru, Nicolae, Fingerhutova, Sarka, Insalaco, Antonella et al. DOI: 10.1136/annrheumdis-2018-214472
PMID: 29635517 Journal: RHEUMATOLOGY Year: 2018 Reference: Rheumatology. 2018 Jul 1;57(7):1299-304. doi: 10.1093/rheumatology/key090. Impact factor: 5.245 Publication type: Paper in international publication Authors: Votta, Bart J, Wang, Lin, Rose, Carlos D, Foley, Kevin P, Anton, Jordi, Bader-Meunier, Brigitte, Brissaud, Philippe, Chedeville, Gaelle, Cimaz, Rolando, Fernandez-Martin, Jorge et al. DOI: 10.1093/rheumatology/key090
PMID: 29602570 Journal: OPHTHALMOLOGY Year: 2018 Reference: Ophthalmology. 2018 Sep;125(9):1444-1451. doi: 10.1016/j.ophtha.2018.02.020. Epub 2018 Mar 27. Impact factor: 7.479 Publication type: Paper in international publication Authors: Pato, Esperanza, Aurrecoechea, Elena, Caracuel, Miguel A, Gamero, Fernando, Minguez, Enrique, Carrasco-Cubero, Carmen, Olive, Alejandro, Vazquez, Julio, Ruiz-Moreno, Oscar, Manero, Javier et al. DOI: 10.1016/j.ophtha.2018.02.020
PMID: 29183646 Journal: Journal of Cardiology Year: 2018 Reference: J Cardiol. 2018 May;71(5):505-512. doi: 10.1016/j.jjcc.2017.10.019. Epub 2017 Nov 26. Impact factor: 2.918 Publication type: Paper in international publication Authors: Perez-Rodon, Jordi, Galve, Enrique, Perez-Bocanegra, Carmen, Soriano-Sanchez, Teresa, Recio-Iglesias, Jesus, Domingo-Baldrich, Eva, Alzola-Guevara, Mila, Ferreira-Gonzalez, Ignacio, Marsal, Josep Ramon, Ribera-Sole, Aida et al. DOI: 10.1016/j.jjcc.2017.10.019
PMID: 29572561 Journal: ANNALS OF HEMATOLOGY Year: 2018 Reference: Ann Hematol. 2018 Aug;97(8):1349-1356. doi: 10.1007/s00277-018-3302-0. Epub 2018 Mar 23. Impact factor: 2.845 Publication type: Paper in international publication Authors: Montoro, Julia, Gallur, Laura, Merchan, Brayan, Molero, Antonieta, Roldan, Elisa, Martinez-Valle, Ferran, Villacampa, Guillermo, Navarrete, Mayda, Ortega, Margarita, Castellvi, Josep et al. DOI: 10.1007/s00277-018-3302-0
PMID: 28570224 Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY Year: 2017 Reference: J Investig Allergol Clin Immunol. 2017 Jun;27(3):185-187. doi: 10.18176/jiaci.0150. Impact factor: 3.094 Publication type: Paper in international publication Authors: Basagana, M, Luengo, O, Labrador, M, Garriga, T, Mattsson, L, Lidholm, J, Cardona, V et al. DOI: 10.18176/jiaci.0150
PMID: 28496564 Journal: World Allergy Organization Journal Year: 2017 Reference: World Allergy Organ J. 2017 May 4;10(1):15. doi: 10.1186/s40413-017-0148-1. eCollection 2017. Impact factor: 0 Publication type: Review in national publication Authors: Sanchez-Borges, Mario, Cardona, Victoria, Worm, Margitta, Lockey, Richard F, Sheikh, Aziz, Greenberger, Paul A, Ansotegui, Ignacio J, Ebisawa, Motohiro, El-Gamal, Yehia, Fineman, Stanley et al. DOI: 10.1186/s40413-017-0148-1
PMID: 28475762 Journal: HUMAN MOLECULAR GENETICS Year: 2017 Reference: Hum Mol Genet. 2017 Jul 15;26(14):2803-2811. doi: 10.1093/hmg/ddx177. Impact factor: 5.34 Publication type: Paper in international publication Authors: Julia, Antonio, Absher, Devin, Lopez-Lasanta, Maria, Palau, Nuria, Pluma, Andrea, Jones, Lindsay Waite, Glossop, John R, Farrell, William E, Myers, Richard M, Marsal, Sara et al. DOI: 10.1093/hmg/ddx177
PMID: 28450313 Journal: ANNALS OF THE RHEUMATIC DISEASES Year: 2017 Reference: Ann Rheum Dis. 2017 Sep;76(9):1575-1582. doi: 10.1136/annrheumdis-2016-210882. Epub 2017 Apr 27. Impact factor: 12.811 Publication type: Paper in international publication Authors: Ordi-Ros, Josep, Saez-Comet, Luis, Perez-Conesa, Mercedes, Vidal, Xavier, Mitjavila, Francesca, Castro Salomo, Antoni, Cuquet Pedragosa, Jordi, Ortiz-Santamaria, Vera, Mauri Plana, Montserrat, Cortes-Hernandez, Josefina et al. DOI: 10.1136/annrheumdis-2016-210882
PMID: 27091480 Journal: IMMUNOLOGY LETTERS Year: 2016 Reference: Immunol Lett. 2016 Jun;174:19-22. doi: 10.1016/j.imlet.2016.04.011. Epub 2016 Apr 14. Impact factor: 2.483 Publication type: Paper in international publication Authors: Franco-Jarava, Clara, Colobran, Roger, Mestre-Torres, Jaume, Vargas, Victor, Pujol-Borrell, Ricardo, Hernandez-Gonzalez, Manuel et al. DOI: 10.1016/j.imlet.2016.04.011
PMID: 26096669 Journal: NEUROLOGIA Year: 2016 Reference: Neurologia. 2016 May;31(4):231-238. doi: 10.1016/j.nrl.2015.05.002. Epub 2015 Jun 19. Impact factor: 1.79 Publication type: Paper in international publication Authors: Saez-Francas, N, Marti Andres, G, Ramirez, N, de Fabregues, O, Alvarez-Sabin, J, Hernandez-Vara, J, Casas, M et al. DOI: 10.1016/j.nrl.2015.05.002
PMID: 25978920 Journal: MEDICAL CLINICS OF NORTH AMERICA Year: 2016 Reference: Med Clin (Barc). 2016 Jan 1;146(1):8-15. doi: 10.1016/j.medcli.2015.02.026. Epub 2015 May 12. Impact factor: 2.333 Publication type: Paper in national publication Authors: Vergara-Gomez, Merce, Simeon-Aznar, Carmen Pilar, Fonollosa-Pla, Vicente, Jove-Buxeda, Esther, Oliva-Morera, Juan, Tolosa-Vilella, Carles, Amengual-Guedan, Maria Jose, Mari-Alfonso, Begona et al. DOI: 10.1016/j.medcli.2015.02.026
PMID: 26944419 Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Year: 2016 Reference: Eur J Clin Pharmacol. 2016 Jun;72(6):755-64. doi: 10.1007/s00228-016-2032-2. Epub 2016 Mar 5. Impact factor: 2.71 Publication type: Paper in international publication Authors: Vidal, Xavier, Agusti, Antonia, Vallano, Antoni, Formiga, Francesc, Moyano, Antonio Fernandez, Garcia, Juana, Lopez-Soto, Alfonso, Ramirez-Duque, Nieves, Torres, Olga H, Barbe, Jose et al. DOI: 10.1007/s00228-016-2032-2
PMID: 26081942 Journal: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING Year: 2015 Reference: Eur J Nucl Med Mol Imaging. 2015 Oct;42(11):1778-1779. doi: 10.1007/s00259-015-3108-4. Epub 2015 Jun 17. Impact factor: 5.383 Publication type: Paper in international publication Authors: Martinez-Valle, Fernando, Gironella, Mercedes, Riveiro-Barciela, Mar, Lorenzo-Bosquet, Carles et al. DOI: 10.1007/s00259-015-3108-4
PMID: 25806935 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2015 Reference: N Engl J Med. 2015 Mar 26;372(13):1273-4. doi: 10.1056/NEJMc1500688#SA1. Impact factor: 55.873 Publication type: Letter whit IF Authors: Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Labrador-Horrillo, Moises et al. DOI: 10.1056/NEJMc1500688#SA1
PMID: 25666515 Journal: Internal and Emergency Medicine Year: 2015 Reference: Intern Emerg Med. 2015 Apr;10(3):345-50. doi: 10.1007/s11739-015-1205-9. Epub 2015 Feb 10. Impact factor: 2.624 Publication type: Paper in international publication Authors: Bova, Maria, Guilarte, Mar, Sala-Cunill, Anna, Borrelli, Paolo, Rizzelli, Grazia Maria Luisa, Zanichelli, Andrea et al. DOI: 10.1007/s11739-015-1205-9
PMID: 25240785 Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Year: 2015 Reference: J Allergy Clin Immunol. 2015 Apr;135(4):1031-43.e6. doi: 10.1016/j.jaci.2014.07.057. Epub 2014 Sep 18. Impact factor: 11.476 Publication type: Paper in international publication Authors: Cumin, Frederic, Sala-Cunill, Anna, Bjorkqvist, Jenny, Senter, Riccardo, Guilarte, Mar, Cardona, Victoria, Labrador, Moises, Nickel, Katrin F, Butler, Lynn, Luengo, Olga et al. DOI: 10.1016/j.jaci.2014.07.057
PMID: 24906908 Journal: SEMIN ARTHRITIS RHEU Year: 2014 Reference: Semin Arthritis Rheum. 2014 Oct;44(2):234-40. doi: 10.1016/j.semarthrit.2014.05.004. Epub 2014 May 9. Impact factor: 3.629 Publication type: Paper in international publication Authors: Pinal-Fernandez, Iago, Selva-O'Callaghan, Albert, Martinez-Gomez, Xavier, Rodrigo-Pendas, Jose, Perez-Lopez, Jordi, Vilardell-Tarres, Miquel, Fernandez-Codina, Andreu et al. DOI: 10.1016/j.semarthrit.2014.05.004
PMID: 24412907 Journal: CLIN IMMUNOL Year: 2014 Reference: Clin Immunol. 2014 Feb;150(2):143-8. doi: 10.1016/j.clim.2013.11.013. Epub 2013 Dec 4. Impact factor: 3.992 Publication type: Paper in international publication Authors: Colobran, Roger, Lois, Sergio, de la Cruz, Xavier, Pujol-Borrell, Ricardo, Hernandez-Gonzalez, Manuel, Guilarte, Mar et al. DOI: 10.1016/j.clim.2013.11.013
PMID: 24582949 Journal: PAIN Year: 2014 Reference: Pain. 2014 Jun;155(6):1102-9. doi: 10.1016/j.pain.2014.02.016. Epub 2014 Feb 26. Impact factor: 5.836 Publication type: Paper in international publication Authors: Docampo, Elisa, Escaramis, Georgia, Gratacos, Monica, Villatoro, Sergi, Puig, Anna, Kogevinas, Manolis, Carbonell, Jordi, Rivera, Javier, Vidal, Javier, Alegre, Jose et al. DOI: 10.1016/j.pain.2014.02.016
PMID: 24826505 Journal: Applied neuropsychology. Adult Year: 2014 Reference: Appl Neuropsychol Adult. 2014;21(2):120-7. doi: 10.1080/09084282.2013.771264. Epub 2013 Aug 13. Impact factor: 0.275 Publication type: Paper in international publication Authors: Santamarina-Perez, Pilar, Eiroa-Orosa, Francisco Jose, Rodriguez-Urrutia, Amanda, Qureshi, Adil, Alegre, Jose et al. DOI: 10.1080/09084282.2013.771264
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PMID: 19627609 Journal: BMC MUSCULOSKELETAL DISORDERS Year: 2009 Reference: BMC Musculoskelet Disord. 2009 Jul 23;10:91. Impact factor: 1.987 Publication type: Paper in international publication Authors: Gomez-Reino, Juan J, Perez-Pampin, Eva, Barcelo, Mireia, Navarro-Compan, Victoria, Navarro-Sarabia, Federico, Ruiz-Montesinos, Dolores, Hernandez, Blanca, Marsal, Sara et al. DOI: 10.1186/1471-2474-10-91
The new technology allows more sensitive detection of scleroderma patients' autoantibodies, which are related to the severity and progression of the disease.
Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.
It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.
