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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Team

Cándido Muñoz Muñoz

Cándido Muñoz Muñoz

Predoctoral researcher
Systemic Diseases
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Carmen Pilar Simeón i Aznar

Carmen Pilar Simeón i Aznar

Main researcher
Systemic Diseases
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David Gurwitz

David Gurwitz

Senior researcher
Systemic Diseases
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David Moreno Martinez

David Moreno Martinez

Systemic Diseases
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Fernando Martínez Valle

Fernando Martínez Valle

Systemic Diseases
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Jaume Alijotas Reig

Jaume Alijotas Reig

Head of group
Systemic Diseases
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Cándido Muñoz Muñoz

Cándido Muñoz Muñoz

Predoctoral researcher
Systemic Diseases
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Carmen Pilar Simeón i Aznar

Carmen Pilar Simeón i Aznar

Main researcher
Systemic Diseases
Read more
David Gurwitz

David Gurwitz

Senior researcher
Systemic Diseases
Read more
David Moreno Martinez

David Moreno Martinez

Systemic Diseases
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Fernando Martínez Valle

Fernando Martínez Valle

Systemic Diseases
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Jaume Alijotas Reig

Jaume Alijotas Reig

Head of group
Systemic Diseases
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Research lines

IgG4 Related Disease: Clinical and Immunological studies

IgG4 Related Disease (IgG4RD) is a new fibroinflammatory disorder, described in 2009, and characterized by the presence of a lymphoplasmacytic infiltrate, storiform fibrosis and pylephlebitis. A Spanish Register of that disease is currently being established, the coordinator member of our institution being one of our researchers. This collaborative study encompasses 16 centers around Spain and has allowed us to describe one of the most important series of patients in the world. A program of a PhD fellowship is currently active, along with a clinical trial due to start very soon. On the other hand, studies on the immunologic mechanism of the disease and a radiologic evaluation with PET-SCAN is also expected to be carried out in the near future.

IP: -

Immunobiology and immunopathology of recurrent pregnancy loses and spontaneous loses.

Around 2-3% of reproductive-age couples suffer recurrent pregnancy loses. Almost 18% of couples that wish to have children suffer infertility problems. Simultaneously, 2-3% of all pregnant women are diagnosed with spontaneous loses. The expression of HLA molecules, specially type G, the degree of trophoblastic apoptosis, the outsourcing of new neoantigens such as phospholipids, the balance between Th1/Th2/Th3 cytokines, the type and quantity of CD4+CD25+Foxp3+ lymphocytes, the kind and the activity of uterine NK cells (uNK) cells, the presence or absence of blocking antibodies, and other mechanisms play different roles in the achievement of the so-called "tolerant microenvironment" needed to develop a normal pregnancy. Therefore, both autoimmune and alloimmune mechanisms are important. We aim at studying which isolated, and specially associated, anomalies can be identified as risk markers to be able to evaluate possible treatments.

IP: Jaume Alijotas Reig

Immunologic lesional mechanisms in late adverse reactions against bioimplants.

The late clinical manifestations that arise when bioimplants are applied seem to have an immunologic basis. We are studying both the histological characteristics and the lesional mechanisms of the most frequently used implants. We try to analyze the role that bacteria may have in the induction and/or maintenance of these reactions and the possible correlation between particular HLA haplotypes and the adverse effects.

IP: Jaume Alijotas Reig

Immunological basis and new therapeutic options in severe preeclampsia.

Three to five percent of pregnancies are complicated by preeclampsia (PE). PE is a multisystemic-related endothelial dysfunction disorder characterized by hypertension, proteinuria and renal injury. Despite considerable research, its etiology and pathophysiology still remains unclear. Different theories involving many pathways including thrombophilia, immunologic changes, circulating angiogenic /antiangiogenic factors and increased oxidative stress have been related to its pathogenesis. The role played by antiphospholipid antibodies (aPL) is a matter of discussion in PE.  Biological evidence of endothelial dysfunction related to PE/FGR has been shown by modified plasma markers including fibronectin, von Willebrand factor and ICAM-1 in a similar manner to that which occurs in aPL-related obstetric complications. We are searching now the role played by different aPL and cofactor antibodies, as well as its relationship with angiogenic /antiangiogenic factors and microparticle number in severe PE.

IP: Jaume Alijotas Reig, Elisa Llurba Olivé, Anna Suy Franch

Publications

Immunoglobulins in systemic sclerosis management. A large multicenter experience.

PMID: 37708984
Journal: AUTOIMMUNITY REVIEWS
Year: 2023
Reference: Autoimmun Rev. 2023 Sep 12:103441. doi: 10.1016/j.autrev.2023.103441.
Impact factor:
Publication type: Review in international publication
Authors: Alegre-Sancho, J J; Atienza-Mateo, B; Blanco, R; Bonilla, G; Carreira, P E; Casafont-Sole, I; Castellvi, I; De la Puente, C; Galisteo, C; Garcia-Vicuna, R et al.
DOI: 10.1016/j.autrev.2023.103441

Serum amyloid A as a potential biomarker for disease activity in chronic spontaneous urticaria.

PMID: 37716523
Journal: The journal of allergy and clinical immunology. In practice
Year: 2023
Reference: J Allergy Clin Immunol Pract. 2023 Sep 14:S2213-2198(23)01012-7. doi: 10.1016/j.jaip.2023.09.004.
Impact factor:
Publication type: Paper in international publication
Authors: Baeza, Maria Luisa; Carvallo, Alvaro; Donado, Carmen Diaz; Ferrer, Marta; Ferrer, Marta; Guilarte, Mar; Herrera-Lasso, Valeria; Labrador-Horrillo, Moises; Labrador-Horrillo, Moises; Rodriguez-Garijo, Nuria et al.
DOI: 10.1016/j.jaip.2023.09.004

Could it be hereditary angioedema?-Perspectives from different medical specialties.

PMID: 37746796
Journal: Clinical and Translational Allergy
Year: 2023
Reference: Clin Transl Allergy. 2023 Sep;13(9):e12297. doi: 10.1002/clt2.12297.
Impact factor:
Publication type: Review in international publication
Authors: Magerl, Markus; Mormile, Ilaria; Sala-Cunill, Anna; Spadaro, Giuseppe; Trainotti, Susanne; Weber-Chrysochoou, Christina et al.
DOI: 10.1002/clt2.12297

Anti-nuclear valosin-containing protein-like autoantibody is associated with calcinosis and higher risk of cancer in systemic sclerosis.

PMID: 37769243
Journal: RHEUMATOLOGY
Year: 2023
Reference: Rheumatology (Oxford). 2023 Sep 28:kead520. doi: 10.1093/rheumatology/kead520.
Impact factor:
Publication type: Paper in international publication
Authors: Callejas-Moraga, Eduardo Luis; Callejas-Moraga, Eduardo Luis; Colobran, Roger; Colobran, Roger; Del-Castillo, Alfredo Guillen-; Del-Castillo, Alfredo Guillen-; Perurena-Prieto, Janire; Sanz-Martinez, Maria Teresa; Selva-O'Callaghan, Albert; Selva-O'Callaghan, Albert et al.
DOI: 10.1093/rheumatology/kead520

Gastrointestinal Involvement in Dermatomyositis.

PMID: 35626355
Journal: Diagnostics
Year: 2022
Reference: Diagnostics (Basel). 2022 May 11;12(5). pii: diagnostics12051200. doi: 10.3390/diagnostics12051200.
Impact factor: 3.706
Publication type: Review in international publication
Authors: Matas-Garcia, Ana, Milisenda, Jose C, Espinosa, Gerard, Cuatrecasas, Miriam, Selva-O'Callaghan, Albert, Grau, Josep Maria, Prieto-Gonzalez, Sergio et al.
DOI: 10.3390/diagnostics12051200

Increase of Circulating Monocyte-Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage.

PMID: 35628558
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 May 20;23(10). pii: ijms23105748. doi: 10.3390/ijms23105748.
Impact factor: 5.924
Publication type: Paper in international publication
Authors: Mariscal, Anais, Zamora, Carlos, Diaz-Torne, Cesar, Ortiz, M Angels, Agustin, Juan Jose de, Reina, Delia, Estrada, Paula, Moya, Patricia, Corominas, Hector, Vidal, Silvia et al.
DOI: 10.3390/ijms23105748

Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis.

PMID: 35576644
Journal: EBioMedicine
Year: 2022
Reference: EBioMedicine. 2022 Jun;80:104053. doi: 10.1016/j.ebiom.2022.104053. Epub 2022 May 13.
Impact factor: 8.143
Publication type: Paper in international publication
Authors: Julia, Antonio, Gomez, Antonio, Lopez-Lasanta, Maria, Blanco, Francisco, Erra, Alba, Fernandez-Nebro, Antonio, Mas, Antonio Juan, Perez-Garcia, Carolina, Vivar, Ma Luz Garcia, Sanchez-Fernandez, Simon et al.
DOI: 10.1016/j.ebiom.2022.104053

Comparison of rhinitis treatments using MASK-air(R) data and considering the Minimal Important Difference.

PMID: 35567393
Journal: ALLERGY
Year: 2022
Reference: Allergy. 2022 May 14. doi: 10.1111/all.15371.
Impact factor: 13.146
Publication type: Paper in international publication
Authors: Bedbrook, Anna, Sousa-Pinto, Bernardo, Schunemann, Holger J, Sa-Sousa, Ana, Vieira, Rafael Jose, Amaral, Rita, Anto, Josep M, Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim et al.
DOI: 10.1111/all.15371

Role of MUC1 rs4072037 polymorphism and serum KL-6 levels in patients with antisynthetase syndrome.

PMID: 34799647
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Nov 19;11(1):22574. doi: 10.1038/s41598-021-01992-y.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Remuzgo-Martinez, Sara, Atienza-Mateo, Belen, Ocejo-Vinyals, J Gonzalo, Genre, Fernanda, Pulito-Cueto, Veronica, Mora-Cuesta, Victor M, Iturbe-Fernandez, David, Lera-Gomez, Leticia, Perez-Fernandez, Raquel, Prieto-Pena, Diana et al.
DOI: 10.1038/s41598-021-01992-y

Identifying mindfulness and acceptance as mediators between negative affect, functional disability and emotional distress in patients with fibromyalgia.

PMID: 34796836
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2021
Reference: Clin Exp Rheumatol. 2021 Nov 18. pii: 17661.
Impact factor: 4.473
Publication type: Paper in international publication
Authors: Castro-Marrero, Jesus, Alegre-Martin, Jose, Calvo, Natalia, Maurel, Sara, Saez-Francas, Naia et al.
DOI:

When the usual doses are not enough.

PMID: 34774452
Journal: Reumatologia clinica
Year: 2021
Reference: Reumatol Clin (Engl Ed). 2021 Nov 10. pii: S2173-5743(21)00189-1. doi: 10.1016/j.reumae.2021.05.001.
Impact factor: 0
Publication type: Letter or abstract
Authors: Macias Reyes, Maria Jose, Pluma Sanjurjo, Andrea, Marsal Barril, Sara, Grados Canovas, Maria Dolors et al.
DOI: 10.1016/j.reumae.2021.05.001

Off-Label Use of Rituximab in Patients with Different Types of Nephropathies in a Tertiary Hospital: A Retrospective Study.

PMID: 34768461
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Oct 26;10(21). pii: jcm10214941. doi: 10.3390/jcm10214941.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Sans-Pola, Carla, Agusti, Antonia, Bosch, Josep Angel, Agraz, Irene, Alerany, Carmen, Danes, Immaculada et al.
DOI: 10.3390/jcm10214941

Aligning the Good Practice MASK With the Objectives of the European Innovation Partnership on Active and Healthy Ageing.

PMID: 32009320
Journal: Allergy Asthma & Immunology Research
Year: 2020
Reference: Allergy Asthma Immunol Res. 2020 Mar;12(2):238-258. doi: 10.4168/aair.2020.12.2.238.
Impact factor: 4.157
Publication type: Review in international publication
Authors: Bousquet, J, Farrell, J, Illario, M, Cardona Dahl, Victòria, ARIA-MASK study group et al.
DOI: 10.4168/aair.2020.12.2.238

A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020.

PMID: 32180890
Journal: World Allergy Organization Journal
Year: 2020
Reference: World Allergy Organ J. 2020 Mar 7;13(2):100091. doi: 10.1016/j.waojou.2019.100091. eCollection 2020 Feb.
Impact factor: 3.506
Publication type: Paper in international publication
Authors: Martin, Bryan, Luengo, Olga, Caraballo, Luis, Passalacqua, Giovanni, Poulsen, Lars K, Savi, Eleonora, Zuberbier, Torsten, Villa, Elisa, Oppenheimer, John, Asero, Riccardo et al.
DOI: 10.1016/j.waojou.2019.100091

Toxicities from immunotherapy: From clinical trials to real-world clinical practice.

PMID: 32868034
Journal: MEDICINA CLINICA
Year: 2020
Reference: Med Clin (Barc). 2020 Dec 24;155(12):541-547. doi: 10.1016/j.medcli.2020.06.057. Epub 2020 Aug 28.
Impact factor: 1.635
Publication type: Review in national publication
Authors: Trallero-Araguas, Ernesto, Martinez-Valle, Fernando, Roca-Herrera, Maria, Zamora, Ester, Barreira-Diaz, Ana, Munoz-Couselo, Eva, Riveiro-Barciela, Mar et al.
DOI: 10.1016/j.medcli.2020.06.057

Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjogren's syndrome.

PMID: 31873754
Journal: RHEUMATOLOGY
Year: 2020
Reference: Rheumatology (Oxford). 2020 Sep 1;59(9):2350-2359. doi: 10.1093/rheumatology/kez578.
Impact factor: 5.606
Publication type: Paper in international publication
Authors: Sanchez-Guerrero, Jorge, Brito-Zeron, Pilar, Acar-Denizli, Nihan, Ng, Wan-Fai, Bootsma, Hendrika, Nakamura, Hideki, Giacomelli, Roberto, Devauchelle-Pensec, Valerie, Hofauer, Benedikt, Bombardieri, Michele et al.
DOI: 10.1093/rheumatology/kez578

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study.

PMID: 30442823
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2019
Reference: J Rheumatol. 2019 Mar;46(3):279-284. doi: 10.3899/jrheum.180355. Epub 2018 Nov 15.
Impact factor: 3.634
Publication type: Paper in international publication
Authors: Mosca, Marta, Bauhammer, Jutta, Miehle, Nikolaus, Parisi, Simone, Cavagna, Lorenzo, Codullo, Veronica, Montecucco, Carlomaurizio, Lopez-Longo, Francisco Javier, Martinez-Barrio, Julia, Nieto-Gonzalez, Juan Carlos et al.
DOI: 10.3899/jrheum.180355

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry.

PMID: 30535994
Journal: CLINICAL RHEUMATOLOGY
Year: 2019
Reference: Clin Rheumatol. 2019 Apr;38(4):1117-1124. doi: 10.1007/s10067-018-4390-x. Epub 2018 Dec 7.
Impact factor: 2.293
Publication type: Paper in international publication
Authors: Chamorro, A J, Todoli-Parra, Jose A, Rodriguez-Carballeira, Monica, Espinosa-Garriga, Gerard, Colunga-Arguelles, Dolores, Ortego-Centeno, Norberto, Trapiella-Martinez, Luis, Rodero-Roldan, Maria M, Pla-Salas, Xavier, Perales-Fraile, Isabel et al.
DOI: 10.1007/s10067-018-4390-x

Therapeutic strategy according to the differing patient response profiles to omalizumab in chronic spontaneous urticaria.

PMID: 30222111
Journal: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Investig Allergol Clin Immunol. 2019;29(5):338-348. doi: 10.18176/jiaci.0323. Epub 2018 Sep 17.
Impact factor: 3.802
Publication type: Review in international publication
Authors: Ferrer Puga, M, Silvestre Salvador, F J, Sastre, J, Ortiz de Frutos, J, Miquel Miquel, F J, Gimenez Arnau, A M, Valero Santiago, A, Bartra Tomas, J, Jauregui Presa, I, Labrador-Horrillo, M et al.
DOI: 10.18176/jiaci.0323

ARIA Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology.

PMID: 30273709
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2019
Reference: J Allergy Clin Immunol. 2019 Mar;143(3):864-879. doi: 10.1016/j.jaci.2018.08.049. Epub 2018 Sep 29.
Impact factor: 14.11
Publication type: Paper in international publication
Authors: Okubo, Ken, Bousquet, Jean, Hellings, Peter W, Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J, Anto, Josep M, Bachert, Claus, Bateman, Eric D et al.
DOI: 10.1016/j.jaci.2018.08.049

Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe-the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review.

PMID: 30181183
Journal: BMJ Open
Year: 2018
Reference: BMJ Open. 2018 Sep 4;8(9):e020817. doi: 10.1136/bmjopen-2017-020817.
Impact factor: 2.413
Publication type: Paper in international publication
Authors: Lorusso, Lorenzo, Estevez-Lopez, Fernando, Castro-Marrero, Jesus, Wang, Xia, Bakken, Inger Johanne, Ivanovs, Andrejs, Nacul, Luis, Sepulveda, Nuno, Strand, Elin B, Pheby, Derek et al.
DOI: 10.1136/bmjopen-2017-020817

Severe, life-threatening phenotype of primary Sjogren's syndrome: clinical characterisation and outcomes in 1580 patients (GEAS-SS Registry).

PMID: 30156546
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2018
Reference: Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):121-129. Epub 2018 Aug 14.
Impact factor: 3.201
Publication type: Paper in international publication
Authors: Flores-Chavez, Alejandra, Kostov, Belchin, Solans, Roser, Fraile, Guadalupe, Maure, Brenda, Feijoo-Masso, Carlos, Rascon, Francisco-Javier, Perez-Alvarez, Roberto, Zamora-Pasadas, Monica, Garcia-Perez, Alicia et al.
DOI:

How immunological profile drives clinical phenotype of primary Sjogren's syndrome at diagnosis: analysis of 10,500 patients (Sjogren Big Data Project).

PMID: 30156539
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2018
Reference: Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):102-112. Epub 2018 Aug 14.
Impact factor: 3.201
Publication type: Paper in international publication
Authors: Nakamura, Takashi, Gottenberg, Jacques-Eric, Danda, Debashish, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, Gabriela, Armagan, Berkan, Kruize, Aike A, Kwok, Seung-Ki, Kvarnstrom, Marika et al.
DOI:

Classification and management of adult inflammatory myopathies.

PMID: 30129477
Journal: LANCET NEUROLOGY
Year: 2018
Reference: Lancet Neurol. 2018 Sep;17(9):816-828. doi: 10.1016/S1474-4422(18)30254-0.
Impact factor: 27.138
Publication type: Review in international publication
Authors: Mammen, Andrew L, Grau-Junyent, Josep Maria, Milisenda, Jose Cesar, Selva-O'Callaghan, Albert, Pinal-Fernandez, Iago, Trallero-Araguas, Ernesto et al.
DOI: 10.1016/S1474-4422(18)30254-0

Immunotherapy in allergic rhinitis and lower airway outcomes.

PMID: 27439141
Journal: ALLERGY
Year: 2017
Reference: Allergy. 2017 Jan;72(1):35-42. doi: 10.1111/all.12989. Epub 2016 Aug 15.
Impact factor: 6.335
Publication type: Paper in international publication
Authors: Luengo, Olga, Cardona, Victoria, Labrador, Moises et al.
DOI: 10.1111/all.12989

Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial.

PMID: 27269294
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2017
Reference: Ann Rheum Dis. 2017 Jan;76(1):196-202. doi: 10.1136/annrheumdis-2015-208918. Epub 2016 Jun 7.
Impact factor: 12.384
Publication type: Paper in international publication
Authors: Diaz-Gonzalez, Federico, DelaRosa, Olga, Alvaro-Gracia, Jose M, Jover, Juan A, Garcia-Vicuna, Rosario, Carreno, Luis, Alonso, Alberto, Marsal, Sara, Blanco, Francisco, Martinez-Taboada, Victor M et al.
DOI: 10.1136/annrheumdis-2015-208918

Should tumour necrosis factor antagonist safety information be applied from patients with rheumatoid arthritis to psoriasis? Rates of serious adverse events in the prospective rheumatoid arthritis BIOBADASER and psoriasis BIOBADADERM cohorts.

PMID: 27258623
Journal: BRITISH JOURNAL OF DERMATOLOGY
Year: 2017
Reference: Br J Dermatol. 2017 Mar;176(3):643-649. doi: 10.1111/bjd.14776. Epub 2016 Oct 3.
Impact factor: 4.317
Publication type: Paper in international publication
Authors: Rivera, Raquel, Garcia-Doval, I, Hernandez, M V, Vanaclocha, F, Sellas, A, de la Cueva, P, Montero, D, Rodriguez, Basilio, Erausquin, Celia, Rua, Inigo et al.
DOI: 10.1111/bjd.14776

[Characteristics of potentially inappropriate prescribing of drugs in elderly polypathological patients].

PMID: 27486035
Journal: Gaceta Sanitaria
Year: 2017
Reference: Gac Sanit. 2017 Jul - Aug;31(4):327-331. doi: 10.1016/j.gaceta.2016.06.013. Epub 2016 Jul 30.
Impact factor: 1.509
Publication type: Paper in national publication
Authors: Lopez-Soto, Alfonso, Torres, Olga H, San-Jose, Antonio, Formiga, Francesc, Vidal, Xavier, Garcia, Juana, Rivas-Cobas, Paula Carlota, Ramirez-Duque, Nieves, Gomez Hernandez, Mercedes, Agusti, Antonia et al.
DOI: 10.1016/j.gaceta.2016.06.013

[Hiccups as an onset form of aortic dissection].

PMID: 27143531
Journal: MEDICINA CLINICA
Year: 2016
Reference: Med Clin (Barc). 2016 Aug 5;147(3):e13. doi: 10.1016/j.medcli.2016.03.014. Epub 2016 Apr 30.
Impact factor: 1.267
Publication type: Letter or abstract
Authors: Callejas-Moraga, Eduardo L, Mestre-Torres, Jaume, Riveiro-Barciela, Mar et al.
DOI: 10.1016/j.medcli.2016.03.014

Effects of rituximab in connective tissue disorders related interstitial lung disease.

PMID: 27749242
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2016
Reference: Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):181-185. Epub 2016 Oct 14.
Impact factor: 2.495
Publication type: Paper in international publication
Authors: Matucci-Cerinic, Marco, Allanore, Yannick, Distler, Oliver, Riccieri, Valeria, Maurer, Britta, Lepri, Gemma, Avouac, Jerome, Airo, Paolo, Anguita Santos, Francisco, Bellando-Randone, Silvia et al.
DOI:

Clinical manifestations and long-term outcome of anti-Jo1 antisynthetase patients in a large cohort of Spanish patients from the GEAS-IIM group.

PMID: 27139168
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2016
Reference: Semin Arthritis Rheum. 2016 Oct;46(2):225-231. doi: 10.1016/j.semarthrit.2016.03.011. Epub 2016 Mar 30.
Impact factor: 3.946
Publication type: Paper in international publication
Authors: Trallero-Araguas, Ernesto, Grau-Junyent, Josep Maria, Labirua-Iturburu, Anne, Garcia-Hernandez, Francisco Jose, Monteagudo-Jimenez, Manuel, Fraile-Rodriguez, Guadalupe, Les-Bujanda, Inigo, Rodriguez-Carballeira, Monica, Saez-Comet, Luis, Selva-O'Callaghan, Albert et al.
DOI: 10.1016/j.semarthrit.2016.03.011

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project.

PMID: 27895895
Journal: Clinical and Translational Allergy
Year: 2016
Reference: Clin Transl Allergy. 2016 Nov 23;6:41. doi: 10.1186/s13601-016-0131-x. eCollection 2016.
Impact factor: 0
Publication type: Review in international publication
Authors: Casale, T, Calderon, M A, Demoly, P, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, E F, Kuna, P et al.
DOI: 10.1186/s13601-016-0131-x

[Statins and autoimmunity].

PMID: 25662717
Journal: MEDICINA CLINICA
Year: 2015
Reference: Med Clin (Barc). 2015 Nov 6;145(9):399-403. doi: 10.1016/j.medcli.2014.11.017. Epub 2015 Feb 7.
Impact factor: 1.417
Publication type: Review in national publication
Authors: Lima Ruiz, Joan, Marin Sanchez, Ana, Alvarado Cardenas, Marcelo et al.
DOI: 10.1016/j.medcli.2014.11.017

[Association with IgG3 deficiency in chronic autoimmune neutropenia in adults: case report and literatura review].

PMID: 25865610
Journal: MEDICINA CLINICA
Year: 2015
Reference: Med Clin (Barc). 2015 Dec 21;145(12):553-4. doi: 10.1016/j.medcli.2015.03.002. Epub 2015 Apr 9.
Impact factor: 1.417
Publication type: Review in national publication
Authors: Artaza Minano, Gonzalo, Sanjose, Antonio, Pardos-Gea, Jose et al.
DOI: 10.1016/j.medcli.2015.03.002

Cardiac manifestations other than valvulopathy in antiphospholipid syndrome: long-time echocardiography follow-up study.

PMID: 24131635
Journal: International Journal of Rheumatic Diseases
Year: 2015
Reference: Int J Rheum Dis. 2015 Jan;18(1):76-83. doi: 10.1111/1756-185X.12191. Epub 2013 Oct 17.
Impact factor: 1.65
Publication type: Paper in international publication
Authors: Ordi-Ros, Jose, Vilardell, Miguel, Avegliano, Gonzalo, Pardos-Gea, Jose, Evangelista, Arturo et al.
DOI: 10.1111/1756-185X.12191

The Impact of Fatigue and Fibromyalgia on Sexual Dysfunction in Women with Chronic Fatigue Syndrome.

PMID: 24274008
Journal: JOURNAL OF SEX & MARITAL THERAPY
Year: 2015
Reference: J Sex Marital Ther. 2015;41(1):1-10. doi: 10.1080/0092623X.2013.864370. Epub 2014 Mar 11.
Impact factor: 1.782
Publication type: Paper in international publication
Authors: Blazquez, Alicia, Ruiz, Eva, Aliste, Luisa, Garcia-Quintana, Ana, Alegre, Jose et al.
DOI: 10.1080/0092623X.2013.864370

[Lanthanum carbonate abdominal foreign bodies].

PMID: 24480287
Journal: MED CLIN-BARCELONA
Year: 2014
Reference: Med Clin (Barc). 2014 May 6;142(9):426. doi: 10.1016/j.medcli.2013.10.010. Epub 2014 Jan 28.
Impact factor: 1.252
Publication type: Letter or abstract
Authors: Pinal Fernandez, Iago, Moris Felgueroso, Maria, Trallero Araguas, Ernesto et al.
DOI: 10.1016/j.medcli.2013.10.010

[Biologic therapy in idiopathic inflammatory myopathy].

PMID: 24393419
Journal: MED CLIN-BARCELONA
Year: 2014
Reference: Med Clin (Barc). 2014 Sep 15;143(6):275-80. doi: 10.1016/j.medcli.2013.11.009. Epub 2014 Jan 3.
Impact factor: 1.252
Publication type: Review in national publication
Authors: Selva-O'Callaghan, Albert, Ramos Casals, Manel, Grau Junyent, Josep M et al.
DOI: 10.1016/j.medcli.2013.11.009

Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies.

PMID: 24812289
Journal: ANN RHEUM DIS
Year: 2014
Reference: Ann Rheum Dis. 2014 Sep;73(9):1750-2. doi: 10.1136/annrheumdis-2014-205440. Epub 2014 May 7.
Impact factor: 9.27
Publication type: Letter or abstract
Authors: Radstake, T, Jani, M, Massey, J, Wedderburn, L R, Vencovsky, J, Danko, K, Lundberg, I E, Padyukov, L, Selva-O'Callaghan, A, Griffiths, C E et al.
DOI: 10.1136/annrheumdis-2014-205440

A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.

PMID: 25082827
Journal: HUM MOL GENET
Year: 2014
Reference: Hum Mol Genet. 2014 Dec 20;23(25):6927-34. doi: 10.1093/hmg/ddu398. Epub 2014 Jul 31.
Impact factor: 6.677
Publication type: Paper in international publication
Authors: Garcia-Planella, Esther, Aguas, Mariam, Munoz, Fernando, Esteve, Maria, Mendoza, Juan L, Vera, Maribel, Marquez, Lucia, Tortosa, Raul, Lopez-Lasanta, Maria, Alonso, Arnald et al.
DOI: 10.1093/hmg/ddu398

Association of thromboxane A1 synthase (TBXAS1) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs.

PMID: 23763970
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2013
Reference: J Allergy Clin Immunol. 2013 Oct;132(4):989-91. doi: 10.1016/j.jaci.2013.04.045. Epub 2013 Jun 12.
Impact factor: 12.047
Publication type: Letter whit IF
Authors: Vidal, Carmen, Porras-Hurtado, Liliana, Cruz, Raquel, Quiralte, Joaquin, Cardona, Victoria, Colas, Carlos, Castillo, Luisa F, Marcos, Carmen, Soto, Teresa, Lopez-Abad, Raquel et al.
DOI: 10.1016/j.jaci.2013.04.045

Allergology in Europe, the blueprint.

PMID: 24053537
Journal: ALLERGY
Year: 2013
Reference: Allergy. 2013 Oct;68(10):1211-8. doi: 10.1111/all.12225. Epub 2013 Sep 21.
Impact factor: 5.883
Publication type: Paper in international publication
Authors: de Monchy, J G, Demoly, P, Akdis, C A, Cardona, V, Papadopoulos, N G, Schmid-Grendelmeier, P, Gayraud, J et al.
DOI: 10.1111/all.12225

Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review.

PMID: 22753383
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2013
Reference: Ann Rheum Dis. 2013 May;72(5):678-85. doi: 10.1136/annrheumdis-2011-201268. Epub 2012 Jun 29.
Impact factor: 9.111
Publication type: Review in international publication
Authors: Ioseliani, Maka, Nielsen, Susan, Martini, Alberto, Ruperto, Nicolino, Gattorno, Marco, Frenkel, Joost, Kondi, Anuela, De Cunto, Carmen, Espada, Graciela, Russo, Ricardo et al.
DOI: 10.1136/annrheumdis-2011-201268

GStream: improving SNP and CNV coverage on genome-wide association studies.

PMID: 23844243
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Jul 3;8(7):e68822. doi: 10.1371/journal.pone.0068822. Print 2013.
Impact factor: 3.73
Publication type: Paper in international publication
Authors: Alonso, Arnald, Marsal, Sara, Tortosa, Raul, Canela-Xandri, Oriol, Julia, Antonio et al.
DOI: 10.1371/journal.pone.0068822

Autoimmune/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade.

PMID: 22952322
Journal: LUPUS
Year: 2012
Reference: Lupus. 2012;21(12):1326-34. Epub 2012 Sep 5.
Impact factor: 2.337
Publication type: Paper in international publication
Authors: Alijotas-Reig, J, Garcia-Gimenez, V, Llurba, E, Vilardell-Tarres, M, , et al.
DOI: 10.1177/0961203312458838

Screening for the presence of FMR1 premutation alleles in a Spanish population with fibromyalgia.

PMID: 22903700
Journal: CLINICAL RHEUMATOLOGY
Year: 2012
Reference: Clin Rheumatol. 2012 Nov;31(11):1611-5. doi: 10.1007/s10067-012-2052-y. Epub 2012 Aug 18.
Impact factor: 1.996
Publication type: Paper in international publication
Authors: Naudo, Montserrat, Martorell, Loreto, Tondo, Mireia, Garcia-Fructuoso, Ferran, Genoves, Jordi, Poo, Pilar, Gamez, Josep, Alegre, Cayetano et al.
DOI: 10.1007/s10067-012-2052-y

Unveiling Case-Control Relationships in Designing a Simple and Powerful Method for Detecting Gene-Gene Interactions.

PMID: 22886951
Journal: GENETIC EPIDEMIOLOGY
Year: 2012
Reference: Genet Epidemiol. 2012 Nov;36(7):710-6. doi: 10.1002/gepi.21665. Epub 2012 Aug 7.
Impact factor: 3.441
Publication type: Paper in international publication
Authors: Julia, Antonio, Gelpi, Josep Lluis, Marsal, Sara, Canela-Xandri, Oriol et al.
DOI: 10.1002/gepi.21665

Co-factor-enhanced food allergy.

PMID: 22845005
Journal: ALLERGY
Year: 2012
Reference: Allergy. 2012 Oct;67(10):1316-8. doi: 10.1111/j.1398-9995.2012.02877.x.. Epub 2012 Jul 30.
Impact factor: 6.271
Publication type: Paper in international publication
Authors: Sala-Cunill, A, Cardona, V, Luengo, O, Garriga, T, Labrador-Horrillo, M, Guilarte, M, Soto, L, Izquierdo, A et al.
DOI: 10.1111/j.1398-9995.2012.02877.x.

The PTPN22*R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population.

PMID: 21923648
Journal: International Journal of Immunogenetics
Year: 2011
Reference: Int J Immunogenet. 2011 Dec;38(6):529-31. doi: 10.1111/j.1744-313X.2011.01038.x. Epub 2011 Sep 19.
Impact factor: 1.62
Publication type: Paper in international publication
Authors: , , , et al.
DOI: 10.1111/j.1744-313X.2011.01038.x

Effect of mycophenolate sodium in scleroderma-related interstitial lung disease.

PMID: 21881859
Journal: CLINICAL RHEUMATOLOGY
Year: 2011
Reference: Clin Rheumatol. 2011 Nov;30(11):1393-8. Epub 2011 Sep 1.
Impact factor: 1.687
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1007/s10067-011-1823-1

Length of illness does not predict cognitive dysfunction in chronic fatigue syndrome.

PMID: 21846221
Journal: APPLIED NEUROPSYCHOLOGY
Year: 2011
Reference: Appl Neuropsychol. 2011 Jul;18(3):216-22.
Impact factor: 0.714
Publication type: Paper in international publication
Authors: Santamarina-Perez, Pilar, Moreno-Mayos, Aurea, Alegre, Jose, Saez, Naia, Jacas, Carlos, Freniche, Veronica, Eiroa-Orosa, Francisco Jose et al.
DOI: 10.1080/09084282.2011.595448

Generalised delayed desquamative exanthema after intradermal testing with betalactam antibiotics.

PMID: 21470241
Journal: ALLERGY
Year: 2011
Reference: Allergy. 2011 May;66(5):702-3. doi: 10.1111/j.1398-9995.2010.02495.x. Epub 2010 Oct 26.
Impact factor: 6.297
Publication type: Editorail in international publication
Authors: Sala Cunill, A, Labrador-Horrillo, M, Guilarte, M, Luengo, O, Cardona, V et al.
DOI: 10.1111/j.1398-9995.2010.02495.x

Implication of human endogenous retroviruses in the development of autoimmune diseases.

PMID: 20635879
Journal: INTERNATIONAL REVIEWS OF IMMUNOLOGY
Year: 2010
Reference: Int Rev Immunol. 2010 Aug;29(4):351-70.
Impact factor: 2.641
Publication type: Review in international publication
Authors: Balada, Eva, Vilardell-Tarres, Miquel, Ordi-Ros, Josep et al.
DOI: 10.3109/08830185.2010.485333

The patient has the diagnosis.

PMID: 20971367
Journal: LANCET
Year: 2010
Reference: Lancet. 2010 Oct 23;376(9750):1436.
Impact factor: 30.758
Publication type: Editorail in international publication
Authors: Jubany, Li, Selva-O'Callaghan, A, Perez-Vega, C, Grau-Junyent, Jm, Hernandez-Losa, J, Vilardell-Tarres, M et al.
DOI: 10.1016/S0140-6736(10)61049-5

[Alcoholic patient with abdominal pain and vomits]

PMID: 19576597
Journal: MEDICINA CLINICA
Year: 2010
Reference: Med Clin (Barc). 2010 Mar 6;134(6):285. Epub 2009 Jul 2.
Impact factor: 1.231
Publication type: Letter or abstract
Authors: Navarro i Mercade, Jordi, Labirua Iturburu, Ane, Solans Laque, Roser et al.
DOI: 10.1016/j.medcli.2009.04.037

Malignancy and myositis: novel autoantibodies and new insights.

PMID: 20827204
Journal: CURRENT OPINION IN RHEUMATOLOGY
Year: 2010
Reference: Curr Opin Rheumatol. 2010 Nov;22(6):627-32.
Impact factor: 4.6
Publication type: Review in international publication
Authors: Selva-O'Callaghan, Albert, Trallero-Araguas, Ernesto, Grau-Junyent, Josep M, Labrador-Horrillo, Moises et al.
DOI: 10.1097/BOR.0b013e32833f1075

Randomized clinical trial of the effectiveness of a home-based intervention in patients with heart failure: the IC-DOM study.

PMID: 19401125
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2009
Reference: Rev Esp Cardiol. 2009 Apr;62(4):400-8.
Impact factor: 2.88
Publication type: Paper in national publication
Authors: Brotons, Carlos, Falces, Carles, Alegre, Jose, Ballarin, Elena, Casanovas, Jordi, Cata, Teresa, Martinez, Mireia, Moral, Irene, Ortiz, Jacint, Perez, Eulalia et al.
DOI:

[Search for information on the Internet by patients with chronic autoimmune diseases in different Spanish populations]

PMID: 19376539
Journal: MEDICINA CLINICA
Year: 2009
Reference: Med Clin (Barc). 2009 Oct 3;133(12):467-71.
Impact factor: 1.258
Publication type: Review or editorial in national publication
Authors: Ortego Centeno, Norberto, Barnosi Marin, Ana Celia, Simeon Aznar, Carmen Pilar, Ortego Jurado, Miguel et al.
DOI: 10.1016/j.medcli.2008.12.028

Generalized muscle pseudo-hypertrophy and stiffness associated with the myotilin Ser55Phe mutation: a novel myotilinopathy phenotype?

PMID: 19027924
Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES
Year: 2009
Reference: J Neurol Sci. 2009 Feb 15;277(1-2):167-71.
Impact factor: 2.359
Publication type: Paper in international publication
Authors: Gamez, Josep, Armstrong, Judith, Shatunov, Alexey, Selva-O'Callaghan, Albert, Ortega, Arantxa, Goldfarb, Lev, Ferrer, Isidre, Olive, Montse, Dominguez-Oronoz, Rosa et al.
DOI: 10.1016/j.jns.2008.10.019

Serum levels of soluble CD40 ligand at flare and at remission in patients with systemic lupus erythematosus.

PMID: 19332622
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2009
Reference: J Rheumatol. 2009 May;36(5):953-60.
Impact factor: 3.282
Publication type: Paper in international publication
Authors: Urquizu-Padilla, Maria, Balada, Eva, Cortes, Fina, Perez, Eduardo Hermosilla, Vilardell-Tarres, Miquel, Ordi-Ros, Josep et al.
DOI: 10.3899/jrheum.080978

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News

Researchers have used an innovative protocol to identify people with this autoimmune disease who have a higher risk of cancer.

It will allow the promotion of research on systemic autoimmune-based diseases that especially affect women of childbearing age and, therefore, can also appear during pregnancy.

The study showing how thrombocytopenia increases the risk of thrombosis in patients with antiphospholipid syndrome has been considered the best paper published in 2021.