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Systemic Diseases

The Systemic Diseases group performs translational research based on at least 300 patients with systemic lupus erytomatosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis, vasculitis, dermatomyitis, Sjörgen syndrome or autoinflammatory syndromes in order to better understand their pathogenesis (both at the immunological and genetic regulation level), study their clinical and biological expression (through the detection of new markers that help characterize each of the autoimmune diseases), study morbimortality (through epidemiological studies) and analyse patients' response to medications. With these goals in mind, we seek to improve the diagnosis, clinical monitoring, and prognosis of our patients.

Research lines

Proinflammatory cytokines TNF and IL-6 in cellular senescence. A HUVEC aging model.

Cells that are chronically exposed to inflammatory signals are more prone to aging than those which are not exposed to such signals. Human vascular endothelial cell (HUVEC) primary cultures activated with TNF-alpha probably increase the expression of ICAM and VCAM, synthesize ROS, and express senescence markers. It is not known what the principal intracellular pathway is (although it is thought that STAT may play a role) and it is unknown if one or more proinflammatory cytokines are needed to activate NF-KB. We are trying to find out the role that IFN-alpha and/or IL-6 and IL-1B may have on the aging inflammatory phenomena and we aim at detecting the intracellular signal pathways (STAT). We are also working on the characterization of the genes involved in these abnormal biologic responses.

IP: Jaume Alijotas Reig

Protein expression of small collagenase 3 and leucine-rich proteoglycans in cutaneous tissue of patients with diffuse scleroderma.

This study, carried out along with researchers from the Hospital del Mar and from the "Institut Municipal d'Investigació Mèdica", aims at correlating the expression of SLRPs and MMP-13 with the severity of cutaneous involvement, hand dysfunctional capacity, capillaroscopy patterns, and cutaneous ultrasonography of patients affected with diffuse scleroderma in different evolutive stages of the disease.

IP: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla

RECORD study (RECOmbinant allergens in diagnosis resolution).

This study aims at detecting the prevalence of specific IgE in polisensitized patients towards pollen in Barcelona by means of the "component resolved diagnosis" technique from ISAC® (IgE specific microarray).

IP: Victòria Cardona Dahl

Risk factors for ischemic events in biopsy-proven Giant Cell Arteritis (GCA).

The study aims to investigate the risk factors for ischemic complications in patients with GCA, and the role that some endothelial growth factors may play in its development. This study is coordinated by Dr. Gonzalez Gay from University Hospital of Valdecilla, Santander.

IP: Roser Solans Laque

Publications

Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study.

PMID: 37919733
Journal: Environmental Health
Year: 2023
Reference: Environ Health. 2023 Nov 2;22(1):77. doi: 10.1186/s12940-023-01028-0.
Impact factor:
Publication type: Paper in international publication
Authors: Alemany, Laia; Alguacil, Juan; Ansotegui, Ignacio J; Benavente, Yolanda; Bosch, Francesc Xavier; Brunet, Joan; Caminati, Marco; Campbell, Dianne E; Cano, Victor; Cardona, Victoria et al.
DOI: 10.1186/s12940-023-01028-0

Clinical and genetic features of patients suffering from CMT4J.

PMID: 37950760
Journal: JOURNAL OF NEUROLOGY
Year: 2023
Reference: J Neurol. 2023 Nov 11. doi: 10.1007/s00415-023-12076-4.
Impact factor:
Publication type: Paper in international publication
Authors: Aggarwal, Rohit; Amato, Anthony A; Andersson, Helena; Andrade-Ortega, Lilia; Ascherman, Dana; Attarian, Shahram; Beloribi-Djefaflia, Sadia; Benveniste, Olivier; Bonello-Palot, Nathalie; Callen, Jeffrey P et al.
DOI: 10.1007/s00415-023-12076-4

Improvements in quality of life over 2 years with cladribine tablets in people with relapsing multiple sclerosis: The CLARIFY-MS study.

PMID: 37978852
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Nov 18:13524585231205962. doi: 10.1177/13524585231205962.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Herrera, Marialbert; Alexandri, Nektaria; Brieva, Luis; Brochet, Bruno; Callejas, Jose L; Guillen-Del-Castillo, Alfredo; Hupperts, Raymond; Keller, Birgit; Kubala Havrdova, Eva; Langdon, Dawn et al.
DOI: 10.1177/13524585231205962

Real world data on the demographic and clinicopathological profile and management of patients with early-stage HER2-positive breast cancer and residual disease treated with adjuvant trastuzumab emtansine (KARMA study).

PMID: 37995519
Journal: Cancer treatment and research communications
Year: 2023
Reference: Cancer Treat Res Commun. 2023 Nov 1;37:100772. doi: 10.1016/j.ctarc.2023.100772.
Impact factor:
Publication type: Paper in international publication
Authors: Ales Martinez, Jose Enrique; Alijotas-Reig, Jaume; Antolin Novoa, Silvia; Anunciacion-Llunell, Ariadna; de la Morena Barrio, Pilar; Echavarria Diaz-Guardamino, Isabel; Escriva-de-Romani, Santiago; Esteve-Valverde, Enrique; Garate, Zita; Gonzalez-Cortijo, Lucia et al.
DOI: 10.1016/j.ctarc.2023.100772

Poly-L-Lysine-Based alphaGal-Glycoconjugates for Treating Anti-alphaGal IgE-Mediated Diseases.

PMID: 35432370
Journal: Frontiers in Immunology
Year: 2022
Reference: Front Immunol. 2022 Mar 31;13:873019. doi: 10.3389/fimmu.2022.873019. eCollection 2022.
Impact factor: 7.561
Publication type: Paper in international publication
Authors: Olivera-Ardid, Sara, Bello-Gil, Daniel, Tuzikov, Alexander, Araujo, Ricardo N, Ferrero-Alves, Yara, Garcia Figueroa, Blanca Esther, Labrador-Horrillo, Moises, Garcia-Perez, Ana L, Bovin, Nicolai, Manez, Rafael et al.
DOI: 10.3389/fimmu.2022.873019

Effect of tocilizumab versus standard of care in adults hospitalized with moderate-severe COVID-19 pneumonia.

PMID: 34147248
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Apr 8;158(7):301-307. doi: 10.1016/j.medcli.2021.03.005. Epub 2021 May 6.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Cardona-Pascual, Ignacio, Berlana, David, Martinez-Valle, Ferran, Campany-Herrero, David, Montoro-Ronsano, Jose Bruno et al.
DOI: 10.1016/j.medcli.2021.03.005

Angioedema Due to Acquired Deficiency of C1-Inhibitor: a Cohort Study in Spain and a Comparison With Other series.

PMID: 34844023
Journal: Journal of Allergy and Clinical Immunology-In Practice
Year: 2022
Reference: J Allergy Clin Immunol Pract. 2022 Apr;10(4):1020-1028. doi: 10.1016/j.jaip.2021.11.018. Epub 2021 Nov 26.
Impact factor: 8.861
Publication type: Paper in international publication
Authors: Garcia, M G, Laffond, E, Munoz-Bellido, F J, Nunez, R, Prior, N, Sala-Cunill, A, Saenz de San Pedro, B, Prieto-Garcia, A, Escudero, E, Castro, M et al.
DOI: 10.1016/j.jaip.2021.11.018

Mapping genomic loci implicates genes and synaptic biology in schizophrenia.

PMID: 35396580
Journal: NATURE
Year: 2022
Reference: Nature. 2022 Apr;604(7906):502-508. doi: 10.1038/s41586-022-04434-5. Epub 2022 Apr 8.
Impact factor: 49.962
Publication type: Paper in international publication
Authors: Fananas, Lourdes, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen et al.
DOI: 10.1038/s41586-022-04434-5

Bleeding and antithrombotic therapy during pregnancy in women with poor aPL-related obstetric outcomes: A survey of 1075 cases from EUROAPS registry *.

PMID: 34397526
Journal: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
Year: 2021
Reference: Eur J Anaesthesiol. 2021 Sep 1;38(9):916-922. doi: 10.1097/EJA.0000000000001484.
Impact factor: 4.33
Publication type: Paper in international publication
Authors: Pardos-Gea, Josep, Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Ferrer-Oliveras, Raquel, Saez-Comet, Luis, Lefkou, Elmina, Mekinian, Arsene, Belizna, Cristina, Ruffatti, Amelia, Tincani, Angela et al.
DOI: 10.1097/EJA.0000000000001484

Update on latex allergy: New insights into an old problem.

PMID: 34386153
Journal: World Allergy Organization Journal
Year: 2021
Reference: World Allergy Organ J. 2021 Jul 28;14(8):100569. doi: 10.1016/j.waojou.2021.100569. eCollection 2021 Aug.
Impact factor: 4.084
Publication type: Review in international publication
Authors: Ansotegui, Ignacio J, Gonzalez-Diaz, Sandra Nora, Bilo, Maria Beatrice, Cardona, Victoria, Park, Hae-Sim, Braschi, Maria Chiara, Macias-Weinmann, Alejandra, Piga, Mario A, Acuna-Ortega, Natalhie, Sanchez-Borges, Mario et al.
DOI: 10.1016/j.waojou.2021.100569

Role of autoantibodies in the diagnosis and prognosis of interstitial lung disease in autoimmune rheumatic disorders.

PMID: 34377160
Journal: Therapeutic Advances in Musculoskeletal Disease
Year: 2021
Reference: Ther Adv Musculoskelet Dis. 2021 Jul 27;13:1759720X211032457. doi: 10.1177/1759720X211032457. eCollection 2021.
Impact factor: 5.346
Publication type: Review in international publication
Authors: Kuwana, Masataka, Gil-Vila, Albert, Selva-O'Callaghan, Albert et al.
DOI: 10.1177/1759720X211032457

Circulating Cell Biomarkers in Pulmonary Arterial Hypertension: Relationship with Clinical Heterogeneity and Therapeutic Response.

PMID: 34359858
Journal: Cells
Year: 2021
Reference: Cells. 2021 Jul 4;10(7). pii: cells10071688. doi: 10.3390/cells10071688.
Impact factor: 6.6
Publication type: Paper in international publication
Authors: Barbera, Joan Albert, Peinado, Victor I, Blanco, Isabel, Garcia-Lucio, Jessica, Del Pozo, Roberto, Garcia, Agustin Roberto, Ferrer, Elisabet, Crespo, Isabel, Rodriguez-Chiaradia, Diego A, Simeon-Aznar, Carmen Pilar et al.
DOI: 10.3390/cells10071688

Comparison of the birmingham vasculitis activity score and the five factors score to assess survival in anca-associated vasculitis.

PMID: 31033198
Journal: ARTHRITIS CARE & RESEARCH
Year: 2020
Reference: Arthritis Care Res (Hoboken). 2020 Jul;72(7):1001-1010. doi: 10.1002/acr.23912. Epub 2020 Jun 12.
Impact factor: 4.056
Publication type: Paper in international publication
Authors: Rodriguez-Carballeira, Monica, Rios-Blanco, Juan Jose, Fraile, Guadalupe, Saez-Comet, Luis, Martinez-Zapico, Aleida, Frutos, Begona, Solanich, Xavier, Fonseca-Aizpuru, Eva, Pasquau-Liano, Francisco, Zamora, Monica et al.
DOI: 10.1002/acr.23912

Autoantibodies to stratify systemic sclerosis patients into clinically actionable subsets.

PMID: 32553611
Journal: AUTOIMMUNITY REVIEWS
Year: 2020
Reference: Autoimmun Rev. 2020 Aug;19(8):102583. doi: 10.1016/j.autrev.2020.102583. Epub 2020 Jun 14.
Impact factor: 7.767
Publication type: Review in international publication
Authors: Mahler, Michael, Roup, Fabrece, Beretta, Lorenzo, Simeon, Carmen Pilar, Guillen-Del-Castillo, Alfredo, Casas, Silva, Fritzler, Marvin J, Bentow, Chelsea, Hudson, Marie et al.
DOI: 10.1016/j.autrev.2020.102583

Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

PMID: 32558485
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2020
Reference: N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17.
Impact factor: 74.699
Publication type: Paper in international publication
Authors: My, Ilaria, Ellinghaus, David, Degenhardt, Frauke, Bujanda, Luis, Buti, Maria, Albillos, Agustin, Invernizzi, Pietro, Fernandez, Javier, Prati, Daniele, Baselli, Guido et al.
DOI: 10.1056/NEJMoa2020283

Impact of Comorbidity on Physical Function in Patients with Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics. Results from the CARdiovascular in rheuMAtology (CARMA) study.

PMID: 31033231
Journal: ARTHRITIS CARE & RESEARCH
Year: 2020
Reference: Arthritis Care Res (Hoboken). 2020 Jun;72(6):822-828. doi: 10.1002/acr.23910. Epub 2020 May 14.
Impact factor: 4.056
Publication type: Paper in international publication
Authors: Nolla, Joan M, Fernandez-Carballido, Cristina, Martin-Martinez, Maria A, Garcia-Gomez, Carmen, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Barril, Sara Marsal, Steiner, Martina, Munoz, Santiago et al.
DOI: 10.1002/acr.23910

Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project.

PMID: 30789151
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2019
Reference: Clin Exp Rheumatol. 2019 Sep-Oct;37(5):774-782. Epub 2019 Feb 15.
Impact factor: 3.238
Publication type: Paper in international publication
Authors: Garcia-Gomez, Carmen, Martin-Martinez, Maria A, Fernandez-Carballido, Cristina, Castaneda, Santos, Gonzalez-Juanatey, Carlos, Sanchez-Alonso, Fernando, Gonzalez-Fernandez, Maria J, Sanmarti, Raimon, Garcia-Vadillo, Jesus A, Fernandez-Gutierrez, Benjamin et al.
DOI:

Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA project.

PMID: 30620291
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2019
Reference: Clin Exp Rheumatol. 2019 Sep-Oct;37(5):731-739. Epub 2019 Jan 3.
Impact factor: 3.238
Publication type: Paper in international publication
Authors: Martin-Martinez, Maria A, Castaneda, Santos, Gonzalez-Juanatey, Carlos, Sanchez-Alonso, Fernando, Garcia-Gomez, Carmen, Lopez-Gonzalez, Ruth, Babio-Herraiz, Jesus, Juan-Mas, Antonio, Sanchez-Gonzalez, Carmen O, Romera-Baures, Montserrat et al.
DOI:

Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.

PMID: 31557429
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2019
Reference: N Engl J Med. 2019 Dec 5;381(23):2199-2208. doi: 10.1056/NEJMoa1906190. Epub 2019 Sep 26.
Impact factor: 70.67
Publication type: Paper in international publication
Authors: Heels-Ansdell, Diane, Thabane, Lehana, Walter, Stephen D, Devereaux, P J, HEALTH investigators, Guerra Farfan, Ernesto Melchor, Teixidor Serra, Jordi, Tomás Hernández, Jordi, Molero García, Vicent, Selga Marsà, Jordi et al.
DOI: 10.1056/NEJMoa1906190

Urinary Neuropilin-1: A Predictive Biomarker for Renal Outcome in Lupus Nephritis.

PMID: 31533337
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2019
Reference: Int J Mol Sci. 2019 Sep 17;20(18). pii: ijms20184601. doi: 10.3390/ijms20184601.
Impact factor: 4.183
Publication type: Paper in international publication
Authors: Torres-Salido, Maria Teresa, Sanchis, Mireia, Sole, Cristina, Moline, Teresa, Vidal, Marta, Vidal, Xavier, Sola, Anna, Hotter, Georgina, Ordi-Ros, Josep, Cortes-Hernandez, Josefina et al.
DOI: 10.3390/ijms20184601

The diagnostic work-up of cancer-associated myositis.

PMID: 29965856
Journal: CURRENT OPINION IN RHEUMATOLOGY
Year: 2018
Reference: Curr Opin Rheumatol. 2018 Nov;30(6):630-636. doi: 10.1097/BOR.0000000000000535.
Impact factor: 4.277
Publication type: Paper in international publication
Authors: Selva-O'Callaghan, Albert, Martinez-Gomez, Xavier, Trallero-Araguas, Ernesto, Pinal-Fernandez, Iago et al.
DOI: 10.1097/BOR.0000000000000535

Update in ethiopathogeny, diagnosis and treatment of the IgG4 related disease.

PMID: 29241876
Journal: MEDICINA CLINICA
Year: 2018
Reference: Med Clin (Barc). 2018 Jul 13;151(1):18-25. doi: 10.1016/j.medcli.2017.10.034. Epub 2017 Dec 11.
Impact factor: 1.168
Publication type: Review in national publication
Authors: Martinez-Valle, Fernando, Orozco-Galvez, Olimpia, Fernandez-Codina, Andreu et al.
DOI: 10.1016/j.medcli.2017.10.034

Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16(INK4a)-deficient epithelial cells.

PMID: 29930757
Journal: Oncotarget
Year: 2018
Reference: Oncotarget. 2018 Jun 5;9(43):27151-27170. doi: 10.18632/oncotarget.25502. eCollection 2018 Jun 5.
Impact factor: 0
Publication type: Paper in international publication
Authors: Tusell, Laura, Dominguez, Daniel, Bernal, Aina, Molto-Abad, Marc et al.
DOI: 10.18632/oncotarget.25502

Correction to: First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study.

PMID: 29931516
Journal: CLINICAL RHEUMATOLOGY
Year: 2018
Reference: Clin Rheumatol. 2018 Aug;37(8):2303-2304. doi: 10.1007/s10067-018-4179-y.
Impact factor: 2.141
Publication type: Letter or abstract
Authors: Callejas Moraga, E, Calvo, E, Carbonell, C, Castillo, M J, Chamorro, A J, Colunga, D, Corbella, X, Egurbide, M V, Espinosa, G, Fonollosa, V et al.
DOI: 10.1007/s10067-018-4179-y

Clinical and epidemiological differences between men and women with systemic sclerosis: a study in a Spanish systemic sclerosis cohort and literature review.

PMID: 28980905
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2017
Reference: Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):89-97. Epub 2017 Sep 18.
Impact factor: 2.634
Publication type: Review in international publication
Authors: Marin Ballve, Adela, Pla Salas, Xavier, Madronero Vuelta, Ana Belen, Ruiz Munoz, Manuel, Fonollosa Pla, Vicent, Simeon Aznar, Carmen Pilar, Rios Blanco, Juan Jose, Vargas Hitos, Jose Antonio, Saez Comet, Luis, Egurbide Arberas, Maria Victoria et al.
DOI:

Positive prayer sign in eosinophilic fasciitis.

PMID: 28934835
Journal: RHEUMATOLOGY
Year: 2017
Reference: Rheumatology (Oxford). 2017 Apr 1;56(4):628. doi: 10.1093/rheumatology/kew415.
Impact factor: 4.818
Publication type: Paper in international publication
Authors: Pardos-Gea, Jose et al.
DOI: 10.1093/rheumatology/kew415

Clinical utility of the ASDAS index in comparison with BASDAI in patients with ankylosing spondylitis (Axis Study).

PMID: 28918450
Journal: RHEUMATOLOGY INTERNATIONAL
Year: 2017
Reference: Rheumatol Int. 2017 Nov;37(11):1817-1823. doi: 10.1007/s00296-017-3814-2. Epub 2017 Sep 16.
Impact factor: 1.824
Publication type: Paper in international publication
Authors: Sellas I Fernandez, Agusti, Juanola Roura, Xavier, Alonso Ruiz, Alberto, Rosas, Jose, Medina Luezas, Julio, Collantes Estevez, Eduardo, Abad Hernandez, Miguel Angel, Carrasco Benitez, Virginia, Fisac, Cesar et al.
DOI: 10.1007/s00296-017-3814-2

Applying prevention concepts to anaphylaxis: A call for worldwide availability of adrenaline auto-injectors.

PMID: 28856836
Journal: CLINICAL AND EXPERIMENTAL ALLERGY
Year: 2017
Reference: Clin Exp Allergy. 2017 Sep;47(9):1108-1114. doi: 10.1111/cea.12973.
Impact factor: 5.264
Publication type: Editorail in international publication
Authors: Demoly, P, Tanno, L K, Simons, F E R, Sanchez-Borges, M, Cardona, V, Moon, H-B, Calderon, M A, Sisul, J C, Muraro, A, Casale, T et al.
DOI: 10.1111/cea.12973

Polypharmacy in elderly people with diabetes admitted to hospital.

PMID: 26607825
Journal: ACTA DIABETOLOGICA
Year: 2016
Reference: Acta Diabetol. 2016 Oct;53(5):857-8. doi: 10.1007/s00592-015-0818-9. Epub 2015 Nov 25.
Impact factor: 3.074
Publication type: Letter or abstract
Authors: Jose, Antonio San, Formiga, Francesc, Agusti, Antonia et al.
DOI: 10.1007/s00592-015-0818-9

PTPN22 is not associated with Behcet's disease. Study spanning the complete gene region in the Spanish population and meta-analysis of the functional variant R620W.

PMID: 27050764
Journal: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
Year: 2016
Reference: Clin Exp Rheumatol. 2016 Sep-Oct;34(6 Suppl 102):S41-S45. Epub 2016 Apr 1.
Impact factor: 2.495
Publication type: Paper in international publication
Authors: Garcia-Lozano, Jose-Raul, Conde-Jaldon, Marta, Ortego-Centeno, Norberto, Gonzalez-Leon, Rocio, Espinosa, Gerard, Grana-Gil, Genaro, Sanchez-Burson, Juan, Julia, Maria Rosa, Solans, Roser, Blanco, Ricardo et al.
DOI:

Defining disease activity states and clinically meaningful improvement in primary Sjogren's syndrome with EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI).

PMID: 25480887
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2016
Reference: Ann Rheum Dis. 2016 Feb;75(2):382-9. doi: 10.1136/annrheumdis-2014-206008. Epub 2014 Dec 5.
Impact factor: 12.384
Publication type: Paper in international publication
Authors: Praprotnik, Sonja, Sumida, Takayuki, Nishiyama, Sumusu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Meiners, Petra, Brito-Zeron, Pilar, Vitali, Claudio et al.
DOI: 10.1136/annrheumdis-2014-206008

Systemic activity and mortality in primary Sjogren syndrome: predicting survival using the EULAR-SS Disease Activity Index (ESSDAI) in 1045 patients.

PMID: 25433020
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2016
Reference: Ann Rheum Dis. 2016 Feb;75(2):348-55. doi: 10.1136/annrheumdis-2014-206418. Epub 2014 Nov 28.
Impact factor: 9.27
Publication type: Paper in international publication
Authors: Ramos-Casals, M, Retamozo, S, Gheitasi, H, Morera-Morales, M L, Brito-Zeron, P, Kostov, B, Solans, R, Fraile, G, Casanovas, A, Rascon, F J et al.
DOI: 10.1136/annrheumdis-2014-206418

[Renopulmonary syndrome, importance of an early diagnosis].

PMID: 25088654
Journal: MEDICINA CLINICA
Year: 2015
Reference: Med Clin (Barc). 2015 May 8;144(9):430-1. doi: 10.1016/j.medcli.2014.06.002. Epub 2014 Aug 1.
Impact factor: 1.417
Publication type: Letter or abstract
Authors: Mestre-Torres, Jaume, Salcedo-Allende, M Teresa, Martinez-Valle, Ferran, Solans Laque, Roser et al.
DOI: 10.1016/j.medcli.2014.06.002

Central nervous system involvement of granulomatosis with polyangiitis: clinical-radiological presentation distinguishes different outcomes.

PMID: 25187644
Journal: RHEUMATOLOGY
Year: 2015
Reference: Rheumatology (Oxford). 2015 Mar;54(3):424-32. doi: 10.1093/rheumatology/keu336. Epub 2014 Sep 3.
Impact factor: 4.475
Publication type: Paper in international publication
Authors: Puechal, Xavier, De Luna, Gonzalo, Terrier, Benjamin, Kaminsky, Pierre, Le Quellec, Alain, Maurier, Francois, Solans, Roser, Godmer, Pascal, Costedoat-Chalumeau, Nathalie, Seror, Raphaele et al.
DOI: 10.1093/rheumatology/keu336

Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behcet disease.

PMID: 25641891
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2015
Reference: J Rheumatol. 2015 Apr;42(4):695-701. doi: 10.3899/jrheum.140949. Epub 2015 Feb 1.
Impact factor: 3.187
Publication type: Paper in international publication
Authors: Ortiz-Fernandez, Lourdes, Garcia-Lozano, Jose-Raul, Montes-Cano, Marco-Antonio, Conde-Jaldon, Marta, Ortego-Centeno, Norberto, Garcia-Hernandez, Francisco-Jose, Espinosa, Gerard, Grana-Gil, Genaro, Sanchez-Burson, Juan, Blanco, Ricardo et al.
DOI: 10.3899/jrheum.140949

Validation of EULAR primary Sjogren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI).

PMID: 24442883
Journal: ANNALS OF THE RHEUMATIC DISEASES
Year: 2015
Reference: Ann Rheum Dis. 2015 May;74(5):859-66. doi: 10.1136/annrheumdis-2013-204615. Epub 2014 Jan 17.
Impact factor: 10.377
Publication type: Paper in international publication
Authors: Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu et al.
DOI: 10.1136/annrheumdis-2013-204615

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

PMID: 24952504
Journal: NAT IMMUNOL
Year: 2014
Reference: Nat Immunol. 2014 Aug;15(8):738-48. doi: 10.1038/ni.2919. Epub 2014 Jun 22.
Impact factor: 24.973
Publication type: Paper in international publication
Authors: Martin-Sanchez, Fatima, Gomez, Ana I, Martinez, Carlos M, Amores-Iniesta, Joaquin, Compan, Vincent, Barbera-Cremades, Maria, Yague, Jordi, Ruiz-Ortiz, Estibaliz, Anton, Jordi, Bujan, Segundo et al.
DOI: 10.1038/ni.2919

Epistatic interaction of ERAP1 and HLA-B in Behcet disease: a replication study in the Spanish population.

PMID: 25019531
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jul 14;9(7):e102100. doi: 10.1371/journal.pone.0102100. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Solans, Roser, Fanlo, Patricia, Carballeira, Monica Rodriguez, Camps, Teresa, Castaneda, Santos, Martin, Javier, Gonzalez-Escribano, Maria Francisca, Barnosi-Marin, Ana Celia, Gonzalez-Gay, Miguel Angel, Grana-Gil, Genaro et al.
DOI: 10.1371/journal.pone.0102100

A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.

PMID: 25409453
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Nov 19;9(11):e113476. doi: 10.1371/journal.pone.0113476. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Marquez, Ana, Solans, Roser, Hernandez-Rodriguez, Jose, Cid, Maria C, Castaneda, Santos, Ramentol, Marc, Rodriguez-Rodriguez, Luis, Narvaez, Javier, Blanco, Ricardo, Ortego-Centeno, Norberto et al.
DOI: 10.1371/journal.pone.0113476

Acute and long-term management of food allergy: systematic review.

PMID: 24215577
Journal: ALLERGY
Year: 2014
Reference: Allergy. 2014 Feb;69(2):159-67. doi: 10.1111/all.12314. Epub 2013 Nov 12.
Impact factor: 5.995
Publication type: Review in national publication
Authors: Akdis, C A, de Silva, D, Geromi, M, Panesar, S S, Muraro, A, Werfel, T, Hoffmann-Sommergruber, K, Roberts, G, Cardona, V, Dubois, A E J et al.
DOI: 10.1111/all.12314

Available evidence and outcome of off-label use of rituximab in clinical practice.

PMID: 23700188
Journal: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Year: 2013
Reference: Eur J Clin Pharmacol. 2013 Sep;69(9):1689-99. doi: 10.1007/s00228-013-1518-4. Epub 2013 May 23.
Impact factor: 2.741
Publication type: Paper in international publication
Authors: Cortes-Hernandez, J, Danes, I, Agusti, A, Vallano, A, Martinez, J, Alerany, C, Ferrer, A, Lopez, A, Bosch, J A et al.
DOI: 10.1007/s00228-013-1518-4

[Procalcitonine as a biomarker in patients with systemic lupus erythematosus.]

PMID: 23276619
Journal: MEDICINA CLINICA
Year: 2013
Reference: Med Clin (Barc). 2013 Mar 2;140(5):214-6. doi: 10.1016/j.medcli.2012.10.009. Epub 2012 Dec 29.
Impact factor: 1.399
Publication type: Editorial in national publication
Authors: Ordi Ros, Josep, Consiglio, Francisco Javier et al.
DOI: 10.1016/j.medcli.2012.10.009

Cell-derived microparticles and vascular pregnancy complications: a systematic and comprehensive review.

PMID: 23122952
Journal: FERTILITY AND STERILITY
Year: 2013
Reference: Fertil Steril. 2013 Feb;99(2):441-9. doi: 10.1016/j.fertnstert.2012.10.009. Epub 2012 Nov 2.
Impact factor: 4.174
Publication type: Review in international publication
Authors: Alijotas-Reig, Jaume, Palacio-Garcia, Carles, Llurba, Elisa, Vilardell-Tarres, Miquel et al.
DOI: 10.1016/j.fertnstert.2012.10.009

Idiopathic retroperitoneal fibrosis: a clinicopathological study in 24 Spanish cases.

PMID: 23515600
Journal: CLINICAL RHEUMATOLOGY
Year: 2013
Reference: Clin Rheumatol. 2013 Jun;32(6):889-93. doi: 10.1007/s10067-013-2225-3. Epub 2013 Mar 21.
Impact factor: 2.037
Publication type: Paper in international publication
Authors: Martinez-Valle, Fernando, Castro-Marrero, Jesus, Detorres, Ines, Vilardell-Tarres, Miquel, Ordi-Ros, Jose, Fernandez-Codina, Andreu et al.
DOI: 10.1007/s10067-013-2225-3

Registry of the Spanish Network for Systemic Sclerosis: Clinical Pattern According to Cutaneous Subsets and Immunological Status.

PMID: 22169458
Journal: SEMINARS IN ARTHRITIS AND RHEUMATISM
Year: 2012
Reference: Semin Arthritis Rheum. 2012 Jun;41(6):789-800. Epub 2011 Dec 12.
Impact factor: 4.969
Publication type: Review in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.semarthrit.2011.10.004

No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis.

PMID: 22742541
Journal: TISSUE ANTIGENS
Year: 2012
Reference: Tissue Antigens. 2012 Sep;80(3):254-8. doi: 10.1111/j.1399-0039.2012.01915.x. Epub 2012 Jun 29.
Impact factor: 2.588
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1399-0039.2012.01915.x

One hundred years of allergen immunotherapy European Academy of Allergy and Clinical Immunology celebration: review of unanswered questions.

PMID: 22309435
Journal: ALLERGY
Year: 2012
Reference: Allergy. 2012 Apr;67(4):462-76. doi: 10.1111/j.1398-9995.2012.02785.x. Epub 2012 Feb 6.
Impact factor: 6.271
Publication type: Review in international publication
Authors: Calderon, M, Cardona, V, Demoly, P et al.
DOI: 10.1111/j.1398-9995.2012.02785.x

Anti-PL-7 (Anti-Threonyl-tRNA Synthetase) Antisynthetase Syndrome: Clinical Manifestations in a Series of Patients From a European Multicenter Study (EUMYONET) and Review of the Literature.

PMID: 22732951
Journal: MEDICINE
Year: 2012
Reference: Medicine (Baltimore). 2012 Jul;91(4):206-11.
Impact factor: 4.35
Publication type: Review in international publication
Authors: , , , , , , , , et al.
DOI: 10.1097/MD.0b013e318260977c

Enhanced transcript levels of CD48 in CD4(+) T cells from systemic lupus erythematosus patients.

PMID: 21474199
Journal: IMMUNOBIOLOGY
Year: 2011
Reference: Immunobiology. 2011 Sep;216(9):1034-7. Epub 2011 Mar 12.
Impact factor: 4.114
Publication type: Paper in international publication
Authors: , , , , , et al.
DOI: 10.1016/j.imbio.2011.03.004

[Anti-synthetase syndrome.]

PMID: 21543090
Journal: MEDICINA CLINICA
Year: 2011
Reference: Med Clin (Barc). 2011 Jun 11;137(2):77-83. Epub 2011 May 4.
Impact factor: 1.413
Publication type: Editorial in national publication
Authors: , , et al.
DOI: 10.1016/j.medcli.2011.02.026

Synovial fibroblast hyperplasia in rheumatoid arthritis: Clinicopathological correlations and partial reversal by anti-tumor necrosis factor therapy.

PMID: 21547893
Journal: ARTHRITIS AND RHEUMATISM
Year: 2011
Reference: Arthritis Rheum. 2011 Sep;63(9):2575-83. doi: 10.1002/art.30433.
Impact factor: 8.435
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1002/art.30433

Xenotropic Murine Leukemia Virus-Related Virus (XMRV) in Patients with Systemic Lupus Erythematosus.

PMID: 21509625
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2011
Reference: J Clin Immunol. 2011 Aug;31(4):584-7. Epub 2011 Apr 21.
Impact factor: 3.326
Publication type: Paper in international publication
Authors: , , , , et al.
DOI: 10.1007/s10875-011-9535-5

Nitric Oxide Metabolite Production During Exercise in Chronic Fatigue Syndrome: A Case-Control Study.

PMID: 20469961
Journal: JOURNAL OF WOMENS HEALTH
Year: 2010
Reference: J Womens Health (Larchmt). 2010 Jun;19(6):1073-7.
Impact factor: 1.77
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1089/jwh.2008.1255

Development of a self-reporting tool to obtain a combined index of severity of fibromyalgia (ICAF).

PMID: 20055985
Journal: Health and Quality of Life Outcomes
Year: 2010
Reference: Health Qual Life Outcomes. 2010 Jan 7;8(1):2.
Impact factor: 2.456
Publication type: Paper in international publication
Authors: Vallejo, Miguel A, Rivera, Javier, Esteve-Vives, Joaquim, Alegre, C, Alperi, M, Ballina, F J, Belenguer, R, Belmonte, M, Beltran, J, Blanch, J et al.
DOI: 10.1186/1477-7525-8-2

Rheumatoid arthritis pharmacogenomics.

PMID: 20415547
Journal: PHARMACOGENOMICS
Year: 2010
Reference: Pharmacogenomics. 2010 May;11(5):617-9.
Impact factor: 3.893
Publication type: Paper in international publication
Authors: Marsal, Sara, Julia, Antonio et al.
DOI: 10.2217/pgs.10.53

Transcriptome profile in Williams-Beuren syndrome lymphoblast cells reveals gene pathways implicated in glucose intolerance and visuospatial construction deficits.

PMID: 20401492
Journal: HUMAN GENETICS
Year: 2010
Reference: Hum Genet. 2010 Jul;128(1):27-37. doi: 10.1007/s00439-010-0817-4. Epub 2010 Apr 17.
Impact factor: 4.042
Publication type: Paper in international publication
Authors: , , et al.
DOI: 10.1007/s00439-010-0817-4

[Concomitant lithium and methadone treatment in a bipolar patient: a case report]

PMID: 19578734
Journal: Adicciones
Year: 2009
Reference: Adicciones. 2009;21(2):167-72.
Impact factor:
Publication type: Letter or abstract
Authors: Rovira, Marc, Roncero, Carlos, Lopez-Ortiz, Cristina, Barral, Carmen, Saez-Francas, Naia, Casas, Miguel et al.
DOI:

Association of HLA Class II Genes with Systemic Sclerosis in Spanish Patients.

PMID: 19884273
Journal: JOURNAL OF RHEUMATOLOGY
Year: 2009
Reference: J Rheumatol. 2009 Dec;36(12):2733-6.
Impact factor: 3.282
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.3899/jrheum.090377

[Internal Medicine continues its trajectory.]

PMID: 19889318
Journal: REVISTA CLINICA ESPANOLA
Year: 2009
Reference: Rev Clin Esp. 2009 Nov;209(10):483-4.
Impact factor: 0.734
Publication type: Review or editorial in national publication
Authors: Vilardell Tarres, M et al.
DOI:

Metabotyping of biofluids reveals stress-based differences in gut permeability in healthy individuals.

PMID: 19736998
Journal: JOURNAL OF PROTEOME RESEARCH
Year: 2009
Reference: J Proteome Res. 2009 Oct;8(10):4799-809.
Impact factor: 5.684
Publication type: Paper in international publication
Authors: Rezzi, Serge, Martin, Francois-Pierre, Alonso, Carmen, Guilarte, Mar, Vicario, Maria, Ramos, Laura, Martinez, Cristina, Lobo, Beatriz, Saperas, Esteban, Malagelada, Juan Ramon et al.
DOI: 10.1021/pr900525w

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